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Hermeneutics of the judicial text: A construction based on Paul Ricoeur [Hermenéutica del texto judicial: Una construcción desde Paul Ricoeur]
No full text"The aim of this paper is to propose a hermeneutics of the judicial text based on Paul Ricoeur's philosophy. For this purpose, the paper will propose, firstly, how to approach the judicial decision as text; secondly, the paper will argue from Paul Ricoeur's notion of ""Hermeneutic Arc,"" how explanation and understanding as a hermeneutic method are given in the judicial decision. The final purpose is to show how in some cases the comprehension of ourselves could go through the hermeneutics made to the judicial text. © 2020 Universidad Panamericana. All rights reserved.
Understanding the disrupting mechanism of the Tau aggregation motif 306VQIVYK311 by phenylthiazolyl-hydrazides inhibitors
No full textAlzheimer's disease is a progressive neurodegenerative disorder characterized by the abnormal processing of the Tau and the amyloid precursor proteins. The unusual aggregation of Tau is based on the formation of intermolecular ?-sheets through two motifs: 275VQIINK280 and 306VQIVYK311. Phenylthiazolyl-hydrazides (PTHs) are capable of inhibiting/disassembling Tau aggregates. However, the disaggregation mechanism of Tau oligomers by PTHs is still unknown. In this work, we studied the disruption of the oligomeric form of the Tau motif 306VQIVYK311 by PTHs through molecular docking, molecular dynamics, and free energy calculations. We predicted hydrophobic interactions as the major driving forces for the stabilization of Tau oligomer, with V306 and I308 being the major contributors. Nonpolar component of the binding free energy is essential to stabilize Tau-PTH complexes. PTHs disrupted mainly the van der Waals interactions between the monomers, leading to oligomer destabilization. Destabilization of full Tau filament by PTHs and emodin was not observed in the sampled 20 ns; however, in all cases, the nonpolar component of the binding free energy is essential for the formation of Tau filament-PTH and Tau filament-emodin. These results provide useful clues for the design of more effective Tau-aggregation inhibitors. © 2020 John Wiley & Sons Lt
A Kerr magnetometer setup in the kHz regime based on open-hardware architecture
No full textA high sensitivity Kerr magnetometer (?I/I = 1/30) is presented, making use of open source hardware and software. By making time resolved measurements (up to 0.15 s/cycle) the signal quality has been greatly improved up to an order of magnitude, enabling us to compare our measurements with commercial vibrating sample magnetometers. We also present an additional setup to amplify the Kerr signal in a 25:1 scale, cleaning a large part of the electronic and trigger noise. © Published under licence by IOP Publishing Ltd
International standards effect on corporate sustainability: A senior managers' perspective [Incidência das normas internacionais na sustentabilidade corporativa: Uma perspectiva da alta administração] [Incidencia de estándares internacionales en la sostenibilidad corporativa: Una perspectiva de la alta dirección]
No full textInternational standards have an effect on corporate sustainability, contributing to the business performance and governance. The aim of this study is to analyse this effect from the senior manager's perception of a Colombian energy firm. The research methodology is an exploratory case study with 5 in-depth interviews. The results show that managers use standards seeking control and legitimacy from two complementary positions: a pragmatic one dealing with business performance and a prudent one dealing with business governance. It is concluded that the implementation of standards is the result of managers' leadership and values, giving identity to the company while making it face new social challenges. © 2016 Universidad ICESI. Published by Elsevier España, S.L.U. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Atrial Rotor Modulation by Localized Dofetilide Application: An in Silico Study
No full textThe rotor ablation has gained favor in recent years to treat chronic atrial fibrillation (CAF). However, it may cause complications in patients and the results remain suboptimal. Besides, antiarrhythmic drugs for the management of AF are not sufficiently effective and can cause significant cardiac and extracardiac side effects. To reduce the risk and increase the effectiveness, a rotor modulation via the localized release of dofetilide is proposed through an in silico study. A computational model of two-dimensional atrial tissue was implemented using human cell model under CAF conditions. Dofetilide was modeled blocking the ionic currents IKr and IKACH using Hill's equation. A CAF episode, sustained by a rotor, was simulated. Different concentrations of dofetilide were applied in specific distributions based on the rotor tip location, detected by phase map analysis. Non-localized application of dofetilide resulted in the benefit of CAF progression. In contrast, localized dofetilide liberation terminated the CAF episode. These results could have therapeutic implications in novel treatments of CAF. © 2018 Creative Commons Attribution
A Comparative Analysis of the Implementation of the Software Basic Profile of ISO/IEC 29110 in Thirteen Teams That Used Predictive Versus Adaptive Life Cycles
No full textThe growing of the software demand has created opportunities for software development organizations. Especially for very small entities (VSEs), because a large number of them produce software for medium and large companies as part of a production chain that provides products and services to satisfy market needs. This situation highlights the increasing need for improving their software development processes in order to stay in business by developing quality software products and services with limited resources. Unfortunately, a common issue faced by most of the VSEs is the lack of knowledge and practical experience regarding the implementation of current SPI models and software engineering standards. In this context, the ISO/IEC 29110 series of standards and guides have been developed to help VSEs to improve their development processes. One of the main features of this standard is that it can be adapted to the software lifecycle of VSEs. This paper presents the results of a comparative analysis of 13 software organizations with teams that work using predictive methodologies and those using adaptive methodologies during the implementation of the software Basic profile of the ISO/IEC 29110. The results show that after executing the method teams have a high level of coverage regarding the ISO/IEC 29110. © Springer Nature Switzerland AG 2019
An interferon gamma release assay specific for Histoplasma capsulatum to detect asymptomatic infected individuals: A proof of concept study
No full textHistoplasmosis is the most common endemic mycosis in the Americas. Currently, there is no laboratory test capable to detect subclinical or latent infections by Histoplasma capsulatum (Hc), which might develop as severe infections in immunocompromised individuals. For the first time to our knowledge, we explore the suitability of an interferon gamma release assay (IGRA) to detect latent Hc infection in asymptomatic individuals. A cohort of 126 volunteers was enrolled in the study, 13 of which underwent a Hc infection in the past, and 93 of them showing risk factors for this infection. The remaining 20 participants did not refer any risk factors of Hc infection, but eight of them showed evidences of infection with Mycobacterium tuberculosis. All participants were recruited in Medellin, Colombia, between January 2014 and December 2017. Whole blood samples were cultured with four different Hc crude antigens and phytohemaglutinin as positive control. The interferon (IFN)-? released by T lymphocytes upon antigen stimulation was quantified by ELISA. A defined cutoff value of 20 pg/ml for the IFN-? concentration allowed us to distinguish between the group with documented past infections and the group of noninfected individuals with high sensitivity (70-92%) and specificity (85-95%), for the four tested antigens. Positive 82-95% and negative 77-92% predictive values were also very high, comparable to those reported for commercially available IGRAs. The new test constitutes a promising screening method to detect individuals with latent Hc infection, even decades after the primary infection, as evidenced in this study. © The Author(s) 2018. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology
Trends in the use of information and communication technologies for international negotiation [Tendências no uso das tecnologias de informação e comunicação para a negociação internacional] [Tendencias en el uso de las tecnologías de información y comunicación para la negociación internacional]
No full textThis article identifies key information and communication technologies (ICT) used in the international negotiation process, classifying them by phases and functionality. A literature review was conducted in recognized and high impact databases, building with this information a proposal of phases for the international negotiation process, and characterizing ICT by elements such as functionality, business tools, complexity and scope of use, among others. We conclude that there is a wide range of ICT to support the stages of international negotiations, offering various solutions to the specific needs of each company regarding to the management of information and communication. © 2015 Universidad ICESI. Published by Elsevier España, S.L.U. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Videoactivismo y construcción de identidades mediáticas, YouTube y #YoSoy132
Get PDFThe main goal of this paper is to analyze #YoSoy132 construction of mediatic identities through videoactivism, and to question if YouTube was determinant or simply instrumental in the implosion of the movement. During the 2012 “Mexican Spring”, students and citizens not only occupied the streets to quest for a “real democracy” or to express their dissent through very significant demonstrations, but they also occupied the internet to protest. First of all, identity features of the movement are analyzed in relation with the following variables: 1) nucleus of belonging, 2) main sociodemographic features, 3) forms of leadership, 4) interests, 5) collective identity, and 6) relationship with otherness. Second, through a qualitative methodology —content analysis—, this paper analyzes the most relevant pieces of videoactivism produced by young adults. This study focused on the role and function of the videos to know if social media was “instrumental” or “determinant”. Third, mediatic identities represented in the videos are analyzed by exploring the following aspects: a) protagonists appearing in the videos: main role, gender and age range, b) locations where these characters appear and c) type of identity represented: hegemonic or counterhegemonic, majority or minority. The main result of this research is that a resistence and contrahegemonic identity is created through YouTube videos by young Mexicans. Moreover, being #YoSoy132 goes far beyond being young, student or belonging to a specific university. In this regard, the scenario is not occupied by a single subject or specific group of people, but it belongs to the “oppressed” and to persons at risk or discrimination."El objetivo principal de este artículo es analizar la construcción de la identidad mediática a través del video activismo del #yosoy132 y cuestionar si YouTube fue determinante o simplemente instrumental en la implosión del movimiento. Durante la ""primavera mexicana"" del 2012, los estudiantes y demás ciudadanos no solo ocuparon las calles para pedir una ""democracia real"" o para expresar su disenso a través de manifestaciones muy significativas, sino que también ocuparon la internet para protestar. En primer lugar, las características del movimiento son analizadas desde su relación con las siguientes variables: 1) núcleo de pertenencia, 2)características socio demográficas principales, 3) formas de liderazgo, 4) intereses, 5) identidad colectiva, y 6) relación con la otredad. En segundo lugar, a través de una metodología cualitativa -análisis de contenido-, este artículo analiza las piezas de video activismo más representativas producidas por jóvenes adultos. Este estudio se enfoca en el rol y la función de los videos para saber si las piezas mediáticas sociales fueron ""instrumentales"" o ""determinantes"". En tercer lugar, las identidades mediáticas presentadas en los videos son analizadas desde los siguientes aspectos: a) protagonistas en los videos: rol principal, género y rango etario, b) locaciones en las que estos personajes aparecen y c) tipo de la identidad representada: hegemónica o contrahegemónica, mayoría o minoría. El resultado principal de esta investigación es que la resistencia y la identidad contrahegemónica es creada a partir de videos de YouTube hechos por jóvenes mexicanos. Más aún, teniendo en cuenta que #YoSoy132 trasciende el hecho de ser joven, estudiante o de pertenecer a una universidad específica. A este respecto, el escenario no es ocupado por un sujeto específico o un grupo específico de personas, sino que perteneces a los ""oprimidos"" y a las persones en riesgo o discriminadas.
Incidencia de los signos vestimentarios en la estrategia de mercadeo
No full textEl mundo empresarial ha enfrentado retos de tipo ambientales, políticos, económicos y sociales (Domínguez, 2011). Y se ha utilizado al mercadeo como herramienta para sortear los retos, por lo cual comprender los planteamientos del contexto empresarial sobre el mercadeo resulta esencial (Hernández & Mirón, 2002). En este sentido, el mercadeo es comprendido como el que influencia la relación del consumidor con la marca (Kim, Sung, & Ho Moon, 2020). Al reconocer este planteamiento, resulta atractivo centrarse en la industria de la moda, ya que esta industria ha permanecido a lo largo de los siglos (Lorenzo, 2007). Y el mercadeo ha permeado la industria de la moda para establecer mejores relaciones con los clientes (Curiel & Ortiz, 2018). Pero se ha identificado que desde el punto de vista de los profesionales del mercadeo, desde la perspectiva de los académicos y desde una lectura del entorno, el mercadeo presenta ineficiencias. Desde el punto de vista de los profesionales del mercadeo, estos han tenido que recurrir a modificar los planteamientos teóricos del mercadeo para su desempeño. En este sentido se encuentra que la mezcla de mercadeo no es suficiente, obligando a los profesionales a agregar nuevas P, como la personalización para adaptarse mejor a las necesidades de los consumidor (Conexión esan, 2020). Otro aspecto ineficiente del mercadeo que afecta a los profesionales es el branding. El branding se clasifica como inútil porque no se hace una construcción de marca adecuada (Amaury Castillo, 2018).
De forma complementaria, se ha identificado en el contexto empresarial que las ineficiencias del mercadeo conducen a las empresas a una pérdida del recurso, por ejemplo, a nivel global se estimó que el marketing digital generó una pérdida en 2019 de 42,000 mil millones de dólares a causa de las falsificaciones (Redacción, 2019). En el contexto colombiano una de las dificultades que presenta el marketing digital es la saturación de información y la persecución que le hacen a los clientes, al punto en que el 30% de los consumidores deciden instalar bloqueadores de anuncios. Este acoso lleva a que el 70% de los consumidores en línea no compren (Montes, 2019). A su vez, desde la perspectiva de los académicos se encuentran recomendaciones relevantes, como la de Makkar & Yap (2018) quienes recomiendan tener una muestra de estudio significativa, porque no existe una clasificación de los consumidores. Igualmente, Vischer & Yanacek (2015) recomiendan revisar la estética en la moda, vista desde la apariencia y significado. Los planteamientos presentados permiten detectar una desarticulación entre conceptos al llevarlos a la práctica y de esta manera se propone entender ¿Cómo inciden los signos vestimentarios en la estrategia de mercadeo?.
En el marco de esta discusión se propone el siguiente proyecto de investigación, que tiene como objetivo evaluar la incidencia de los signos vestimentarios en la estrategia de mercadeo. Para tal fin se toma como el punto de partida la revisión del conocimiento empírico que consiste en revelar la realidad del contexto de la práctica del mercadeo. Después, está la justificación donde se presentan las dinámicas del mercadeo en términos de cifras y estadísticas. Posteriormente está el conocimiento teórico, en donde se hace la revisión de las recomendaciones futuras de la comunidad académica sobre mercadeo, moda y signos para pasar luego al planteamiento de la pregunta de investigación, que va acompañada de un contexto para entender su alcance. Después, se presentan los objetivos del proyecto y posteriormente, se encuentra el marco teórico. El marco teórico se construye a través de un análisis bibliométrico, seguido de un análisis de contenido, que permite proponer un modelo conceptual y finaliza con la elección de los lentes teóricos. Tras el marco teórico se desarrolla la propuesta metodológica que guiará el trabajo de campo, su presupuesto y cronograma y concluye con el alcance esperado del proyecto. Para terminar, se referencia el alcance esperado del proyecto y la bibliografía utilizada.
Adicionalmente, el diseño y desarrollo metodológico llevado a cabo en el planteamiento del proyecto, permite construir un mapa de conocimiento en donde se evidencia la relación entre signos vestimentarios y estrategia de mercadeo. Por lo tanto, los resultados esperados a partir de la ejecución del proyecto son A. identificar el estado de la discusión sobre signos vestimentarios, B. revisar el estado de la discusión sobre estrategias de mercadeo de vestuario, para finalmente, C. evaluar la incidencia de los signos vestimentarios en la estrategia de mercadeo