83602 research outputs found
Sort by
Pharmacokinetics and Tissue Residence of Various Doses of Levamisole in Crucian Carp at Different Water Temperatures
Get PDFThe pharmacokinetics of levamisole in crucian carp, including the absorption, distribution, and clearance rates in different tissues, were studied at different temperatures and doses for the theoretical basis of proper usage and withdrawal time. The fish were divided into three groups denoted A, B and C. The A and B groups were treated once at a dosage of 5 mg/kg levamisole, at 19 ± 1°C and 26 ± 1°C water temperature, respectively. The C group was treated at a dosage of 20 mg/kg levamisole at 19 ± 1°C water temperature. Then plasma, muscle, hepatopancreas, and kidney tissues samples were collected and pretreated, then measured using an ultra performance liquid chromatography-ultraviolet method. Plasma data were analyzed using DAS 3.0 pharmacokinetics software. Total area under the curve (AUC0-t) and elimination half-life (t1/2z) had a negative correlation with water temperature, and a positive correlation with dosage. Apparent volume of distribution (Vz) and total clearance rate (CLz) was positively correlated with temperature, and
a negatively correlated with dosage. Levamisole was absorbed quickly to reach its peak concentration. The drug concentration and residence time in hepatopancreal and kidney were considerably higher and longer respectively than in the muscle and plasma suggesting that the hepatopancreas and kidney may be important metabolic organs for levamisole
The Effects of High Temperatures on Survival Rates and Immunity of Saltwater Clam Meretrix meretrix from Different Geographical Populations
Get PDFHigh temperature has significant effects on the survival and immunity of organisms. In order to conduct a detailed investigation into the response of the saltwater clam Meretrix meretrix from different geographical populations (GuangXi, JiangSu, ShanDong, LiaoNing) to high temperatures, we examined the survival rates and antioxidant enzyme activities of these clams that were exposed to different temperature treatments (25°C, 35°C, 37.5°C, 40°C). Results showed that the survival rate of clams from GuangXi was highest at 40°C, followed by JiangSu. SOD and CAT activities of all the clams increased with the increasing temperatures, and then gradually decreased at 40°C over time. The expression levels of Hsp70 of M. meretrix from four populations were analyzed by qPCR sampled from the hepatopancreas after 72 h under different temperatures. Higher Hsp mRNA expression of GuangXi at 40°C indicated that clams of GuangXi have stronger high temperature resistance than those of the other geographical populations. Our findings provide a basis for the choice of cultured clams with a high temperature tolerance
Vladivostok—Stambul: puteshestvie po Zolotomu Rogu ["Vladivostok and Istanbul": travels through the Golden Horn ]
No full textS mechtoi o vozvrashchenii na rodinu: Ukraintsy v Kitae [A dream of returning to the Motherland: Ukrainians in China]
No full textTitle on cover: S mechtoi o vozvrashchenii domoi: Ukraintsy v Kita
A Minimally-Technical Introduction to Producing Accessible Online Content
No full textFormer URI: http://hdl.handle.net/10125/59399Having inaccessible content on your library's website is not only a disservice to patrons with disabilities, but it can jeopardize your autonomy to manage your own website. Tools like Microsoft Word and LibGuides have accessibility features, but still require judgement and awareness on the part of content creators for best results. This session will give an overview of basic accessibility principles, and will demonstrate creating accessible Word and PDF documents. Basic web authoring concepts and accessibility techniques will be explained
Puka Puka Parade 2018 - Number 05
No full textDigital-only addendum included in same pdf file as main issue
Puka Puka Parade 2018 - Number 08
No full textDigital-only addendum included in same pdf file as main issue
Puka Puka Parade 2018 - Number 09
No full textDigital-only addendum included in same pdf file as main issue