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The SWI/SNF-related protein SMARCA3 is a histone H3K23 ubiquitin ligase that regulates H3K9me3 in cancer
No full textHistone ubiquitination is a crucial post-translational modification (PTM) regulating chromatin function, yet many histone ubiquitination sites and the enzymes that control them remain poorly understood. Here, we identify SMARCA3, a SWI/SNF-related protein frequently downregulated in colorectal cancer (CRC), as an E3 ubiquitin ligase that targets histone H3 at lysine 23 (H3K23). We demonstrate that SMARCA3 histone ubiquitination activity is stimulated by the repressive H3K9me3 mark. Loss of SMARCA3 reduces both H3K23Ub and H3K9me3, increasing chromatin accessibility at promoters and enhancers enriched for pioneer transcription factor motifs. This chromatin "rewiring" alters the transcriptional landscape, driving upregulation of cancer-promoting genes. We validate this mechanism in CRC cell lines and patient-derived organoids, where SMARCA3 loss reduces H3K23Ub and H3K9me3. In xenograft mouse models, overexpression of wild-type SMARCA3, but not a RING domain mutant, suppresses tumor growth. Together, our findings define SMARCA3 as a key chromatin regulator contributing to CRC pathogenesis through epigenetic mechanisms.2026-07-1
Toward Measuring Mechanisms of Transcranial Magnetic Stimulation With Dose-Dependent Target Engagement
No full text2026-08-0
YOUTH NAVIGATING PRECARITY THROUGH CLIMATE ACTION: CASE OF MATHARE
No full textThis study explores the environmental organizing of the youth in Mathare and its potential to transcend hustle into climate activism. It examines how the intervention of global climate actors and their agendas influence the youth's work. By building an empirical case through the stories and evolution of the youth, using observer participation and participant observation, the research analyzes potential pathways and possibilities for Mathare’s youth groups. Embedded in the discourse of hustle and climate adaptation in informal settlements, this paper argues that the youth's work is transitioning from opportunism to visionary practice. As the youth navigate their precarious employment situations and struggle to find identity and community through hustling, the paper explores their potential to expand their vision and scope, and to collectivize towards climate adaptation, is enabled by opportunities presented by global climate efforts. Finally, the paper invites further research on the potential of youth activism to contribute to effective climate adaptation
Data and scripts from: Measuring the ferromagnetic resonance cone angle via static dipolar fields using diamond spins
No full textPlease cite as: Brendan McCullian, Michael Chilcote, Huma Yusuf, Ezekiel Johnston-Halperin, Gregory Fuchs. (2025) Data and scripts from: Measuring the ferromagnetic resonance cone angle via static dipolar fields using diamond spins. [dataset] Cornell University Library eCommons Repository. https://doi.org/10.7298/w5q0-1g13These files contain data supporting all results reported in McCullian et al., Measuring the ferromagnetic resonance cone angle via static dipolar fields using diamond spins. In McCullian et al. we demonstrate quantitative measurement of the ferromagnetic resonance (FMR) precession cone angle of a micro-scale sample of vanadium tetracyanoethylene (V[TCNE]) using diamond spins. V[TCNE] is a low-damping, low-magnetization ferrimagnet with potential for scalable spintronics applications. Our study is motivated by the persistent need for quantitative metrology to accurately characterize magnetic dynamics and relaxation. Recently, diamond spins have emerged as sensitive probes of static and dynamic magnetic signals. Unlike analog sensors that require additional calibration, diamond spins respond to magnetic fields via a frequency shift that can be compared with frequency standards. We use a spin echo-based approach to measure the precession-induced change to the static stray dipolar field of a pair of V[TCNE] discs under FMR excitation. Using these stray dipolar field measurements and micromagnetic simulations, we extract the precession cone angle. Additionally, we quantitatively measure the microwave field amplitude using the same diamond spins, thus forming a quantitative link between drive and response. We find that our V[TCNE] sample can be driven to a cone angle of at least 6 with a microwave field amplitude of only 0.53 G. This work highlights the power of diamond spins for local, quantitative magnetic characterization.The design and fabrication of our device, all the measurements, and all data analysis were supported by the Department of Energy Office of Science, Basic Energy Sciences Quantum Information Sciences program (DE-SC0019250). The diamond substrate and microwave antenna fabrication made use of facilities at the Cornell NanoScale Facility, an NNCI member supported by the NSF (NNCI-2025233) and the Cornell Center for Materials Research Shared Facilities which were supported through the NSF MRSEC program (DMR-1719875). For the V[TCNE] disc fabrication, the authors acknowledge partial support from the NanoSystems Laboratory User Facility supported by the Center for Emergent Materials, an NSF MRSEC (DMR-2011876)
Enteric Methane Mitigation and Monitoring: Updates Regarding Sensor Technologies, Fatty Acids, and Bromoform
No full textWritten for and presented during 2025 Cornell Nutrition Conferenc
Senderovich, Savely
No full textMemorial Statement for Savely Senderovich who died in 2025. The memorial statements contained herein were prepared by the Office of the Dean of the University Faculty of Cornell University to honor its faculty for their service to the university
Bridging the Gap: Infrastructure improvements to improve economic development along the I-290 Corridor.
No full textThis paper examines the disamenities associated with the Eisenhower Expressway (I-290) along the Forest Park Branch of Chicago’s Blue Line, their impacts on economic development and neighborhood connectivity within the corridor, and potential policy interventions to mitigate these challenges. Despite the corridor’s access to major employment centers, significant regional attractions, and proximity to the Loop, development outcomes have lagged compared to other transit-served areas of the city. It argues that economic development along the corridor has been constrained by the barrier effects of the expressway, which isolates the transit line from surrounding neighborhoods and limits opportunities for transit-oriented growth. Through a review of literature, analysis of corridor conditions, and assessment of public policy, the study proposes and analyses interventions to address these issues. This project contributes to broader discussions of public policy interventions that can mitigate the disamenities associated with urban freeways, with particular attention to improving economic development around the unique configuration of a rapid transit line running within a highway corridor
Data and scripts from: Strong photon-magnon coupling using a lithographically defined organic ferrimagnet
No full textPlease cite as: Qin Xu, Hil Fung Harry Cheung, Donley S. Cormode, Tharnier O. Puel, Srishti Pal, Huma Yusuf, Michael Chilcote, Michael E. Flatté, Ezekiel Johnston‐Halperin, and Gregory D. Fuchs. (2025) Data from: Strong Photon‐magnon Coupling Using a Lithographically Defined Organic Ferrimagnet. [dataset] Cornell University eCommons Repository. https://doi.org/10.7298/0hq7-q893We demonstrate a cavity-magnonic system composed of a superconducting microwave resonator coupled to a magnon mode hosted by the organic-based ferrimagnet vanadium tetracyanoethylene (V[TCNE]x). This work is motivated by the challenge of scalably integrating a low-damping magnetic system with planar superconducting circuits. We take advantage of the properties of V[TCNE]x, which has ultra-low intrinsic damping, can be grown at low processing temperatures on arbitrary substrates, and can be patterned via electron beam lithography. Our devices operate in the strong coupling regime, with a cooperativity exceeding 1000 for coupling between the Kittel mode and the resonator mode at T∼0.4 K, suitable for scalable quantum circuit integration. Higher-order magnon modes are also observed with much narrower linewidths than the Kittel mode. This work paves the way for high-cooperativity hybrid quantum devices in which magnonic circuits can be designed and fabricated as easily as electrical wires.We thank Brendan McCullian for useful conversations. The resonator design and fabrication, V[TCNE]x growth and growth optimization, and theory of uniform magnon mode coupling were supported through the Center for Molecular Quantum Transduction (CMQT), an Energy Frontier Research Center supported by the Department of Energy Office of Science, Basic Energy Sciences (DE-SC0021314). The development and design of resonator V[TCNE]x integration and lithography, measurement techniques, and theoretical analysis of k̸ = 0 magnon modes were supported by the Department of Energy Office of Science, Basic Energy Sciences Quantum Information Sciences program (DE-SC0019250). All measurements were done using the CMQT low temperature facility at Cornell. This work also made use of facilities at the Cornell NanoScale Facility, an NNCI member supported by the NSF (NNCI-2025233) and the Cornell Center for Materials Research Shared Facilities which are supported through the NSF MRSEC program (DMR-1719875). We acknowledge the support of the NanoSystems Laboratory User Facility which is supported by the Center for Emergent Materials, an NSF MRSEC (DMR-2011876)
Bad Lieutenants: The Khmer Rouge, United Front, and Class Struggle, 1970–1997
No full textBad Lieutenants is a riveting account of how the Khmer Rouge remained a force to be reckoned with even after the fall of Democratic Kampuchea—and of the men behind the movement's strange durability. In 1979, the Vietnamese army seized Phnom Penh, toppling Pol Pot's notoriously brutal regime. Yet the Khmer Rouge did not disintegrate. Instead, the movement continued to rule over swathes of Cambodia for almost another two decades even as it failed to become a legitimate governing organization. Andrew Mertha argues that the Khmer Rouge's successes and failures were both driven by a refusal to dilute its revolutionary vision. Rather than take the moderate tack required for viable governance, it pivoted between only two political strategies: united front and class struggle. Through the stories of three key leaders—Ieng Sary, Son Sen, and Ta Mok—Mertha tracks the movement's shifting from one strategy to the other until its dissolution in the 1990s. Vividly written and deeply researched, Bad Lieutenants reveals the powerful grip political ideology can have over the survival of insurgent movements