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Residual stresses in cold-formed steel members: review of measurement methods and numerical modelling
No full textThe determination of residual stress distributions in cold-formed members is revisited considering both experimental and numerical methodologies. Destructive, semi-destructive and non-destructive techniques are reviewed with special emphasis on sectioning, hole drilling and X-ray diffraction; the particularities of each procedure on cold-formed sections are addressed. Theory on metal strip deformation and roll design is exposed before analytical and incremental closed-formed expressions are presented and compared to experimental results for press-braked sections. Finally, the most important works on finite element simulations of roll forming are revisited, highlighting the computational limitations and the capability for predicting residual stresses.FASTCOLD project (FAtigue STrength of COLD-formed structural steel details; Ref. 745982–2017) funded by Research Fund for Coal and Steel (RFCS) of the European Commissio
Influence of core extension and side chain nature in targeting G-quadruplex structures with perylene monoimide derivatives
Get PDFA structure–activity relationship (SAR) study in terms of G-quadruplex binding ability and antiproliferative activity of six fluorescent perylenemonoimide (PMIs) derivatives is reported. A positive charge seems to be the key to target G4. This study also reveals the importance of the element substitution in the potential biological activity of PMIs, being the polyethylene glycol (PEG) chains in the peri position responsible for their antiproliferative activity. Among them, the cationic PMI6 with two PEG chains is the most promising compound since its fluorescence is enhanced in the presence of G-quadruplex structures. Moreover, PMI6 binds to the human telomeric G-quadruplex hTelo with high affinity and displays a high antiproliferative potential towards HeLa (cervical adenocarcinoma), A549 (lung adenocarcinoma) and A2780 (ovarian adenocarcinoma) cells. Its fate can be followed inside cells thanks to its fluorescent properties: the compound is found to accumulate in the mitochondria.“la Caixa” Foundation (LCF/PR/PR12/11070003), Ministerio de Ciencia, Innovación y Universidades-FEDER (RTI2018-102040-B-100), Junta de Castilla y León-FEDER (BU305P18 and BU263P18) is gratefully acknowledged. N.B. is grateful to Aurore Guédin of the ARNA Laboratory for technical support and also to the financial support of the José Castillejo Program by the Spanish Ministry of Education, Culture and Sports (JC2015-00403). A.H. was funded by a Juan de la Cierva fellowship (FJCI-2015-26175) from the Ministerio de Economía y Competitividad. This research has made use of the high-performance computing resources of the Castilla y León Supercomputing Center (SCAYLE, https://www.scayle.es), financed by FEDER (Fondo Europeo de Desarrollo Regional). Networking support of NECTAR COST Action CA18202 is fully acknowledged. This work was supported by the SYMBIT project (reg. no. CZ.02.1.01/0.0/0.0/15_003/0000477) financed by the ERDF
Immersive virtual-reality computer-assembly serious game to enhance autonomous learning
Get PDFImmersive virtual reality (VR) environments create a very strong sense of presence and immersion. Nowadays, especially
when student isolation and online autonomous learning is required, such sensations can provide higher satisfaction and learning
rates than conventional teaching. However, up until the present, learning outcomes with VR tools have yet to prove their
advantageous aspects over conventional teaching. The project presents a VR serious game for teaching concepts associated
with computer hardware assembly. These concepts are often included in any undergraduate’s introduction to Computer Science.
The learning outcomes are evaluated using a pre-test of previous knowledge, a satisfaction/usability test, and a post-test
on knowledge acquisition, structured with questions on different knowledge areas. The results of the VR serious game are
compared with another two learning methodologies adapted to online learning: (1) an online conventional lecture; and (2)
playing the same serious game on a desktop PC. An extensive sample of students (n = 77) was formed for this purpose. The
results showed the strong potential of VR serious games to improve student well-being during spells of confinement, due to
higher learning satisfaction. Besides, ease of usability and the use of in-game tutorials are directly related with game-user
satisfaction and performance. The main novelty of this research is related to academic performance. Although a very limited
effect was noted for learning theoretical knowledge with the VR application in comparison with the other methodologies,
this effect was significantly improved through visual knowledge, understanding and making connections between different
concepts. It can therefore be concluded that the proposed VR serious game has the potential to increase student learning and
therefore student satisfaction, by imparting a deeper understanding of the subject matter to students.GruaRV project (Reference Number INVESTUN/18/BU/0002) of the Consejeria de Empleo of the Junta de Castilla y León (Spain), the Erasmus+ RISKREAL Project (Reference Number 2020-1-ES01-KA204-081847) of the European Commission and the SMART-EASY project (Reference Number IDI-20191008) funded by the Centro para el Desarrollo Tecnológico e Industrial (CDTI).Publicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCL
The European Foreign Language Teacher Training Programme: A Comprehensive Proposal
No full textTrabajo presentado en: International Conference on EUropean Transnational Educational, ICEUTE (11th. 2020. Burgos, Spain)Mobility has been a key and central concept for the Bologna Process. Labour mobility of the teaching and learning community within the European borders is in continuous growth. But so far, despite this dynamic reality, there is no unified format for teacher training at a European level. In the light of this, a virtual solution for a comprehensive and coordinated training for foreign language teachers in Europe is needed. Within the frame of the VIR_TEACH Erasmus+ project, this article outlines the creation of a digital tool to improve the postgraduate certificates on Masters on Education (Foreign Languages), and to provide teachers, researchers, student teachers and policy-makers with open-source tools and resources.Erasmus+ funded VIR_TEACH project (A
VIRtual Solution for a comprehensive and coordinated training for foreign language TEACHers in
Europe, Project Reference: 2018-1-ES01-KA203-050045)
Estudio sobre hibridación de tecnologías térmicas y eléctricas en edificios residenciales para minimizar la dependencia energética
No full textEl objetivo del trabajo es la reducción del consumo energético en edificios ya construidos. Para poder llevar a cabo esta reducción, se ha empleado un método de cálculo simplificado de la eficiencia energética de bloques de viviendas ya construidos. Este método es el implementado por el programa de simulación (reconocido por el Ministerio para este fin): CE3X. Mediante este programa se ha podido conocer en cada caso cuál es la demanda media global del edificio, la demanda de energías no renovables y otros datos representativos que se mostrarán y explicarán a lo largo del estudio. Las principales medidas para conseguir esta reducción son la implementación de medidas pasivas que reduzcan la necesidad de calefacción, la implementación de equipos con mejores rendimientos que los presentes en el caso inicial y el uso de energías renovables