Complejo Hospitalario Universitario de Santiago
Repositorio Institucional da Universidade de Santiago de CompostelaNot a member yet
32415 research outputs found
Sort by
Los dominios del Hades: hacia una definición de la geografía del inframundo en el mundo clásico
Get PDFEl presente proyecto busca conocer la geografía del submundo griego, y su evolución, a través de un periodo histórico que abarca desde el siglo VIII a.C hasta principios del siglo II d.C. Con autores como Homero y el estudio de sus obras "La Ilíada" y "La Odisea" para una descripción temprana del submundo griego, conocido como El Hades . A través del estudio de su geografía y mitología que nos permita tener mayor comprensión acerca del mundo de los muertos y de como se concebía la muerte en el imaginario grecorromano. Así mismo se busca entender como el Hades, como un constructor de carácter social evoluciona a través de las necesidades políticas y sociales de la Antigua Grecia, y como Roma hereda toda una serie de temores, preocupaciones y problemáticas asociadas al mundo de los muertos
Investigation of drug use and exposure to polymer-related chemicals by wastewater and urine analysis
No full textThe aim of this thesis was to characterize exposure biomarkers and to determine the human exposure to polymer-related chemicals and drugs of abuse. Three different types of experiments were considered: in-vitro human liver metabolism studies, human biomonitoring through urine analysis, and wastewater-based epidemiology. In-vitro metabolism studies recreated the human body processes to identify potential exposure biomarkers of rubber-related chemicals. Human biomonitoring provided reliable stratified-population data and its relationship with human exposure to bisphenols. Finally, wastewater-based epidemiology allowed to monitor the use of drug of abuse and exposure to bisphenols and plasticizers. This thesis comprised Spanish and Portuguese samples and was driven by liquid chromatography hyphenated to (tandem) mass spectrometry.2025-03-2
Learn to teach in early childhood education with scientific video tutorials
No full textThe contents of this publication are the sole responsibility of the STEAMing Ahead consortium and can in no way be taken to reflect the views of the European Union.
Erasmus+ KA220 - Cooperation partnerships in school education -, funding contract number 2021-1-PT01-KA220-SCH-000029409.The following project document was produced in the scope of the project «STEAMing Ahead: Moving the STEAM Approach forward through teacher-led cooperation», an Erasmus+ KA220 - Cooperation partnerships in school education -, funding contract number 2021-1-PT01-KA220-SCH-000029409
Comunicación institucional y plurilingüismo en el Ecuador. Estudio de las lenguas ancestrales como soporte vehicular de la comunicación de Gobierno
No full textDurante los años 2019/2020 el Gobierno de Ecuador realizó 759
publicaciones en lengua ancestral a través de redes
sociales, lo que equivale al 0.14% de lo difundido. La lengua
más utilizada en el contexto de la comunicación gubernamental
es el kichwa (67%), de acuerdo a datos censales esta lengua
tiene 591.448 hablantes; le sigue la lengua wao tededo (15%)
que tiene apenas 1.766 hablantes en todo el país. La presente
investigación plantea el MODELO DE EVALUACIÓN DE
PUBLICACIONES EN REDES SOCIALES SEGÚN LA LENGUA
O IDIOMA EMPLEADO cuya ecuación arrojó como resultado
que las publicaciones emitidas por el Gobierno del Ecuador
dirigidas a la población que habla una lengua ancestral
corresponden a una tasa muy baja, se realizaron 0.001
publicaciones por habitante que habla una lengua indígena
Genome Wide Association Studies in Small-Cell Lung Cancer. A Systematic Review
Get PDFSmall cell lung cancer (SCLC) is one of the deadliest forms of lung cancer, but few information exists regarding the role of genetics, particularly on Genome Wide Association Studies (GWAS). The aim of the study is to explore the evidence available obtained through GWAS studies for SCLC using a systematic review. We performed a literature search in the main databases until July 31st, 2023. We included all human based studies on GWAS for lung cancer which presented results for SCLC. Only studies with participants diagnosed of SCLC with anatomopathological confirmation were included. Fourteen studies were identified; 8 studies showed a relationship between ASCL1 overexpression and SCLC, which may regulate CHRNA5/A3/B4 cluster, producing a consequent nAChR overexpression. Nine papers, including 8 of the previous, found a positive association between SNPs located in chromosome 15 and SCLC. The most important cluster of genes found is CHRNA5/A3/B4 but the mechanism for the role of these genes is unclear. Kyoto Encyclopaedia of Genes and Genome (KEGG) shows that these receptors were found to be overexpressed where nicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N’-Nitrosonornicotine (NNN) acts, involving different routes in SCLC carcinogenesisThis work was supported by PI15/01211 – ISCIII – co-financed FEDERS
Os solos urbanos de Santiago de Compostela
No full textO obxectivo da Tese é mellorar o coñecemento sobre os solos
urbanos de Santiago de Compostela. Para o estudo das
tipoloxías de solos urbanos analizáronse 13 perfís de solo
cunha gran variabilidade espacial. No estudo das propiedades
físicas, químicas e biolóxicas analizáronse 64 mostras
superficiais de solos formados a partir de distinto material
xeolóxico, e con diversidade de usos do solo e vexetación. En
canto á presenza de contaminantes, analizáronse as
concentracións totais e dispoñibles e a bioaccesibilidade de Cu,
Pb, Zn, Cr e As, así como a presenza de PAHs en
mostras superficiais de 55 solos urbanos. Os resultados obtidos
indican a importancia do estudo dos solos urbanos, pola
súa variabilidade e distinto grao de artificialización, así como
potencial contaminación, que poden comprometer a súa
xestión
Association of periodontitis with cognitive decline and its progression: Contribution of blood‐based biomarkers of Alzheimer's disease to this relationship
Get PDFAim
To assess whether periodontitis is associated with cognitive decline and its progression as well as with certain blood-based markers of Alzheimer's disease.
Materials and Methods
Data from a 2-year follow-up prospective cohort study (n = 101) was analysed. Participants with a previous history of hypertension and aged ≥60 years were included in the analysis. All of them received a full-mouth periodontal examination and cognitive function assessments (Addenbrooke's Cognitive Examination (ACE) and Mini-Mental State Examination [MMSE]). Plasma levels of amyloid beta (Aβ)1-40, Aβ1-42, phosphorylated and total Tau (p-Tau and t-Tau) were determined at baseline, 12 and 24 months.
Results
Periodontitis was associated with poor cognitive performance (MMSE: β = −1.5 [0.6]) and progression of cognitive impairment (hazard ratio [HR] = 1.8; 95% confidence interval: 1.0–3.1). Subjects with periodontitis showed greater baseline levels of p-Tau (1.6 [0.7] vs. 1.2 [0.2] pg/mL, p < .001) and Aβ1-40 (242.1 [77.3] vs. 208.2 [73.8] pg/mL, p = .036) compared with those without periodontitis. Concentrations of the latter protein also increased over time only in the periodontitis group (p = .005).
Conclusions
Periodontitis is associated with cognitive decline and its progression in elderly patients with a previous history of hypertension. Overexpression of p-Tau and Aβ1-40 may play a role in this associationThis study was partially supported by grants from the Xunta de Galicia (TS & JC: IN607A2018/3, TS: IN607D 2020/09 and IN607A2022/07), Institute of Health Carlos III (TS: PI22/00938 and CB22/05/00067) and Spanish Ministry of Science (TS: RTI2018-102165-B-I00 and RTC2019-007373-1). Furthermore, this study was also supported by grants from the INTERREG Atlantic Area (TS: EAPA_791/2018_NEUROATLANTIC project), INTER-REG V A España Portugal (POCTEP) (TS: 0624_2IQBIONEURO_6_E) and the European Regional Development Fund. Moreover, several members of the research team are supported by the Institute of Health Carlos III: MAN holds an iPFIS contract (IFI18/00008), DR-S and YL are recipients of a Sara Borrell fellowship (CD21/00166 and CD22/00051, respectively) and TS held a Miguel Servet contract (CPII17/00027). Finally, AC is supported by a predoc contract of Xunta de Galicia (IN606A-2021/015). The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscriptS
Anne Brontë’s The Tenant of Wildfell Hall (1848): an analysis of the novel and of its changing relevance over time
Get PDFTraballo Fin de Grao en Lingua e Literatura Inglesas. Curso 2022-2023Anne Brontë is a relevant representative of female Victorian Gothic fiction. Her novels, often
overshadowed by her sisters’ success and neglected by critics, convey a strong sense of
morality and a serious approach to real life issues, such as marriage and motherhood. Anne
Brontë’s characterisation of her female protagonists, the strength of their will and their abilityto face the situations they are confronted with, grant Anne’s fiction the title of one of the pioneer’s feminist novels. In The Tenant of Wildfell Hall (1848), her most controversial novel, Anne presents themes and topics that were not only relevant for 19th century life, but also resonate in contemporary times. The aim of this project is to identify the main themes of Anne Brontë’s The Tenant of Wildfell
Hall and situate them in their Victorian context, analyse her treatment of these themes,
compare the reception of the novel at the time of publication and in the 21st century, and
show its current relevance.
The introduction will provide a historical background focusing on the sociocultural
conventions that most affected Anne as a female author. The main body of the project will
contain the analysis of The Tenant of Wildfell Hall: Chapter 1 will deal with the principal
themes addressed by Anne; Chapter 2 will study the critical reception of the novel, and
Chapter 3 will include a contrastive approach of the novel’s impact in the 19th century and
how its relevance has shifted over time. Chapter 4 will examine the current relevance of the
novel. The conclusion will focus on the attainments and resulting ideas of this project
Estudio sobre el valor pronóstico de los criterios GLIM en pacientes oncohematológicos: comparación de diferentes herramientas para la estimación de la masa muscular
Get PDFTraballo Fin de Grao en Nutrición Humana e Dietética. Curso 2022-2023Introducción: Los pacientes oncohematológicos son una población con un riesgo elevado de desnutrición, asociado a la propia enfermedad y sus tratamientos, que conduce a una alteración de la composición corporal manifestada como una disminución de cualquier marcador de masa muscular. Dada la falta de consenso sobre los criterios diagnósticos de desnutrición, la Global Leadership Initiative on Malnutrition (GLIM) propone la identificación de pacientes en riesgo mediante la utilización de cualquier herramienta de cribado validada y la posterior realización de una evaluación nutricional completa utilizando herramientas validadas para diagnosticar y clasificar la gravedad de la desnutrición.
Objetivos: Los objetivos de este Trabajo Fin de Grado son comparar la prevalencia de desnutrición según los criterios GLIM, utilizando diferentes métodos para estimar la masa muscular; así como establecer relaciones entre la dinamometría y valoración antropométrica, y la calidad de vida, la duración del ingreso y la mortalidad intrahospitalaria.
Material y métodos: Estudio observacional descriptivo con pacientes oncohematológicos en seguimiento por la Unidad de Nutrición Clínica y Dietética.
Resultados: Se han analizado los datos de un total de 25 pacientes. Existe relación directa y estadísticamente significativa (p=0,005) entre la desnutrición diagnosticada mediante criterios GLIM utilizando dinamopenia como marcador de masa muscular disminuida y usando análisis de impedancia bioeléctrica (BIA). Se observa una relación directa y estadísticamente significativa entre la dinamometría máxima y la puntuación global de calidad de vida en el cuestionario EuroQol-5D (p=0,007). La duración del ingreso se relaciona de manera inversa y estadísticamente significativa con el IMEA calculado por la fórmula de NHANES (p<0,001).
Conclusiones: El método con mejor capacidad predictiva respecto a BIA para el diagnóstico de desnutrición según los criterios GLIM es la dinamopenia como indicador de masa muscular disminuida
Inhibiting HER3 Hyperphosphorylation in HER2‐Overexpressing Breast Cancer through Multimodal Therapy with Branched Gold Nanoshells
Get PDFTreatment failure in breast cancers overexpressing human epidermal growth factor receptor 2 (HER2) is associated mainly to the upregulation of human epidermal growth factor receptor 3 (HER3) oncoprotein linked to chemoresitence. Therefore, to increase patient survival, here a multimodal theranostic nanoplatform targeting both HER2 and HER3 is developed. This consists of doxorubicin-loaded branched gold nanoshells functionalized with the near-infrared (NIR) fluorescent dye indocyanine green, a small interfering RNA (siRNA) against HER3, and the HER2-specific antibody Transtuzumab, able to provide a combined therapeutic outcome (chemo- and photothermal activities, RNA silencing, and immune response). In vitro assays in HER2+/HER3+ SKBR-3 breast cancer cells have shown an effective silencing of HER3 by the released siRNA and an inhibition of HER2 oncoproteins provided by Trastuzumab, along with a decrease of the serine/threonine protein kinase Akt (p-AKT) typically associated with cell survival and proliferation, which helps to overcome doxorubicin chemoresistance. Conversely, adding the NIR light therapy, an increment in p-AKT concentration is observed, although HER2/HER3 inhibitions are maintained for 72 h. Finally, in vivo studies in a tumor-bearing mice model display a significant progressively decrease of the tumor volume after nanoparticle administration and subsequent NIR light irradiation, confirming the potential efficacy of the hybrid nanocarrierE.V.-A. and I.G.-C. contributed equally to this work. This work was sup ported by the Agencia Estatal de Investigación (AEI) through Project
No. PID2019-109517RB-I00) and from the Xunta de Galicia, Project No.
ED431C2022/18. European Regional Development Funds are also ac knowledged. A.A.-M. and P.T. also thank the International Scientific Part nership Program ISSP at King Saud University for additional funding of
this research through Grant No. ISPP-144. This work also received fi nancial support from the ISCIII, Ministerio de Economía y Competitivi dad (Grant No. PI15/01129; J.A.C.), and the AEI (Grant No. PID2020-
113501RB-I00; J.A.C.). I.-G.C. thanks for financial support through Grant
No. PRE/2011/131, and the Centro Singular de Investigación de Galicia
accreditation Grant No. 2016–2019 ED431G/05)S