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Oscar Wilde, the Short Story Writer
No full textThis doctoral dissertation aims to validate Oscar Wilde as a
short story writer in the fullest extent of the expression. The
thirteen narratives of The Happy Prince and Other Tales (1888),
Lord Arthur Savile’s Crime and Other Stories (1891), and
A House of Pomegranates (1891) demonstrate that Wilde was
not just writing stories that were short: they display a
profound awareness of and playful attitude toward the
affordances of the short story form and the late Victorian
publishing industry. This aim is achieved through a combination
of 1) a critical literature review, 2) evidence-based
reconstructions of collections' histories and (con)texts, and 3)
analyses of the liminality in and of three selected short
stories: “The Selfish Giant”, “The Canterville Ghost”, “The
Birthday of the Infanta".2025-03-0
Second–order discontinuous ODEs and billiard problems
Get PDFe present an existence principle for boundary value problems involving discontinuous ordinary differential equations of the second order using the Krasovskii regularization technique. Especially we obtain sufficient conditions of transversality type for Krasovskii solutions to be also Carathéodory solutions of the original problem. This result is applied on a certain billiard problem, which can be thought as an ordinary differential equation with state-dependent impulses that is equivalent to certain discontinuous differential equation. In particular, we obtain new existence and multiplicity results for Dirichlet problems in billiard spaces with time-varying boundariesJorge Rodríguez–López was partially supported by Agencia Estatal de Investigación, Spain, and Feder, Project PID2020-113275GB-I00. Jan Tomeček was supported by Palacký University in Olomouc (grant no. IGA_PrF_2023_009)S
Descubrimiento y optimización de nuevos agentes antitumorales empleando reacciones multicomponente
No full textEsta Tesis Doctoral aborda la aplicación de diversas reacciones
multicomponente como herramientas de diversificación
estructural para la síntesis de fármacos con perfil antitumoral.
El trabajo estudia asimismo, la evaluación farmacológica
de las moléculas sintetizadas, el establecimiento de las
relaciones estructura-actividad preliminares y el análisis
computacional que establece el modo de unión fármaco-diana.
En la primera parte de la Tesis, se investiga el diseño, síntesis y
evaluación de prototipos directamente diseñados para la
inhibición de la diana antimitótica KSP (Kinesin Spindle
Protein) y que están basados en la estructura de tipo
bencimidazol.
En la segunda parte, se introduce una línea de investigación
basada en la búsqueda de antagonistas de los receptores A2B
de adenosina como agentes anticancerígenos
Sobre a narrativa breve de Carmen Blanco: Fada revolucionaria. Unha reescritura dos contos de fadas desde o feminismo libertario: "Vermella con lobos", de Carmen Blanco
Get PDFInclúe un retrato de Carmen Blanco pintado por Sara Lamas e "O lobo ouvea", debuxo de Carmen Blanco
Assessing Intel OneAPI capabilities and cloud-performance for heterogeneous computing
Get PDFThis work presents a performance-oriented study of a heterogeneous application developed with Intel OneAPI to solve two well-known diffusion problems: heat diffusion and image denoising. We have explored CPU+iGPU and CPU+FPGA schemes, applying dynamic load balancing and conducting experiments on Intel DevCloud. The results demonstrate that the CPU+iGPU scheme outperforms the execution times achieved by the fastest device when the problem is sufficiently computationally demanding. We also found that the performance of the CPU+FPGA scheme is heavily affected by bandwidth limitations and specific strategies to manage memory efficiently are required. Moreover, it was demonstrated that dynamic workload balancing is crucial due to possible performance fluctuations in any of the implicated devices. In conclusion, Intel OneAPI provides a helpful tool for multi-platform development using a unique high-level language, DPC++. However, developing specific code for each platform is necessary to achieve optimal performanceThis work has received financial support from the Consellería de Cultura, Educación e Ordenación Universitaria (accreditation ED431C 2022/16 and accreditation ED431G-2019/04) and the European Regional Development Fund (ERDF), which acknowledges the CiTIUS-Research Center in Intelligent Technologies of the University of Santiago de Compostela as a Research Center of the Galician University System. This work was also supported by the Ministry of Economy and Competitiveness, Government of Spain (Grants Nos. 28700 PID2019-104834GB-I00 and PID2022-141623NB-I00). Open Access funding provided thanks to the CRUE-CSIC agreement with Springer NatureS
Boosting Oxygen Reduction Reaction Selectivity in Metal Nanoparticles with Polyoxometalates
Get PDFThe lack of selectivity toward the oxygen reduction reaction (ORR) in metal nanoparticles can be linked to the generation of intermediates. This constitutes a crucial constraint on the performance of specific electrochemical devices, such as fuel cells and metal–air batteries. To boost selectivity of metal nanoparticles, a novel methodology that harnesses the unique electrocatalytic properties of polyoxometalates (POM) to scavenge undesired intermediates of the ORR (such as HO2−) promoting selectivity is proposed. It involves the covalent functionalization of metal nanoparticle's surface with an electrochemically active capping layer containing a new sulfur-functionalized vanadium-based POM (AuNP@POM). To demonstrate this approach, preformed thiolate Au(111) nanoparticles with a relatively poor ORR selectivity are chosen. The dispersion of AuNP@POM on the surface of carbon nanofibers (CNF) enhances oxygen diffusion, and therefore the ORR activity. The resulting electrocatalyst (AuNP@POM/CNF) exhibits superior stability against impurities like methanol and a higher pH tolerance range compared to the standard commercial Pt/C. The work demonstrates for the first time, the use of a POM-based electrochemically active capping layer to switch on the selectivity of poorly selective gold nanoparticles, offering a promising avenue for the preparation of electrocatalyst materials with improved selectivity, performance, and stability for ORR-based devices.This work has received financial support from the Ministry of Science of Spain (RYC-2016-20258, CNS2023-145421, PID2021-127341OB-I00, TED2021-131451BC21 and PDC2022-133925-I00 for M.d.C.G.-L., IJC2020-044369-I for J.M.V.-F. and FPU20/01072 for L.V.-A.), the European Research Council (ERC) (Starting Grant (NANOCOMP-679124) and ZABCAT (966743) for M.d.C.G.-L.), the Xunta de Galicia (for Predoctoral Fellowship (ED481A-2020/155) for E.P.Q.-D. and Centro singular de investigación de Galicia accreditation 2019–2022, ED431G 2019/03), and the European Union (European Regional Development Fund─ERDF).S
Climatic stability predicts the congruence between species abundance and genetic diversity
Get PDFUnified models of biological diversity across organizational levels (genes, species, communities) provide key insight into fundamental ecological processes. Theory predicts that the strength of the correlation between species abundance and genetic diversity should be related to community age in closed communities (i.e. abundant species accumulate more genetic diversity over time than rare species). Following this rationale, we hypothesize that historical climatic events are expected to impact assembly processes, hence affecting both the species abundance distribution (SAD) and the species genetic distribution (SGD) in continental communities. Therefore, we predict that, if the congruence between SADs and SGDs depends on community age, then higher congruence would be observed in localities where climate has been more stable since the Last Glacial Maximum (LGM). We tested this prediction using relative abundance and nucleotide diversity (cox1-5′) data from 20 communities of leaf beetles along a latitudinal transect in the Iberian Peninsula. We observed that the congruence between SAD and SGD curves, measured as the correlation between the species' rank orders in both distributions, was significantly related to the change in mean annual temperature since the LGM, but not to current climatic conditions. Our results suggest that, despite the high connectivity of continental communities, historical climatic stability is still a relevant predictor of the congruence between species abundance and genetic diversity. Hence, the degree of congruence between SADs and SGDs could be used as a proxy of community stability, related not only to historical climatic variation but also to any other disrupting factors, including human pressure.This work was supported by the Spanish Ministry of Science and Innovation through grant no. PID2020-112935GB-I00/AEI/10.13039/501100011033 and no. CGL2009-10111, and a FPI scholarship (ref. no. PRE2021-098920) to VF-F.S
Edoxaban treatment in a post-infarction experimental model
Get PDFBackground
The sequelae of myocardial infarction (MI) require specific pharmacological therapy to minimise the post-MI remodelling, which in many cases evolves into cardiovascular complications. The aim of this study was to analyse the effect of edoxaban, an oral anticoagulant, on cardiac recovery in a rat model of permanent coronary artery ligation.
Methods
An experimental method to assess the post-MI remodelling in rats for 4 weeks, based on cardiac magnetic resonance imaging (MRI) and final histological analysis of the hearts was performed. The influence of daily oral treatment with edoxaban (20 mg/kg/day) for 28 days post-MI was analysed in comparison to vehicle.
Results
In our model, edoxaban was shown to be safe and bleeding was observed in 1 of 10 animals. General physical recovery of the treated animals was shown by higher body weight recovery compared with non-treated animals (38.6 ± 2.9 vs. 29.9 ± 3.1 g, respectively, after 28 days). There was not a pronounced effect of edoxaban in post-MI cardiac remodelling, but mitigated fibrosis was observed by the reduced expression of vascular endothelial growth factor and tumour growth factor β1 in the peri-infarct zone.
Conclusions
Our analysis provided the experimental basis to support the feasibility of MRI to study cardiac function and characterise myocardial scarring in a rat model. Overall data suggested the safety of edoxaban in the model, and compared to placebo, it showed a better post-MI recovery, probably by reducing fibrosis of the heart. Further research on mid-term cardiac recovery with edoxaban after MI is justified.S
Standardization of functional and regulatory genomic annotation technologies in turbot (Scophthalmus maximus): Applications to improve fish production
No full textAquaculture production represents an important source of food
and employment, turning the sector
into a focal point for economic investment to improve
production while adressing its core problems,
such as diseases. The advances in genomic technologies have
opened the door to the disection of
the genetic basis and variation that underlies disease resiliance
and other productive traits. In this
thesis, maps of functional, regulatory and structural elements
in the turbot genome were updated and
generated. This thesis provides evidence of marks of selection
left in the turbot genome throughout
its process of domestication and lays out new targets for
selection programs by opening the door to
the unexplored regulatory elements throught the incorporation
of ATAC-Seq and ChIP-Seq
technologies
Instrucción 2/2024, de la Secretaria General de la Universidade de Santiago de Compostela, para la ordenación de los procedimientos a seguir en la realización de actividades docentes y de investigación con acceso a datos personales, intervenciones con seres humanos o muestras en centros docentes no universitarios
No full textPublicado no Taboleiro Electrónico o 11/04/2024Esta Instrución afecta á realización dos estudos científicos que se pretendan realizar
dende a Universidade de Santiago de Compostela nos que se vaian utilizar datos de centros
docentes públicos non universitarios ou dos distintos departamentos da Consellería, agás que os datos xa figuren publicados nos portais institucionais da Xunta de Galicia. Tamén afecta a actividades nas que o alumnado universitario entre en contacto con menores