Complejo Hospitalario Universitario de Santiago
Repositorio Institucional da Universidade de Santiago de CompostelaNot a member yet
32415 research outputs found
Sort by
Interfacial Thermal Resistive Switching in (Pt,Cr)/SrTiO3 Devices
Full text linkThe operation of oxide-based memristive devices relies on the fast accumulation and depletion of oxygen vacancies by an electric field close to the metal–oxide interface. Here, we show that the reversible change of the local concentration of oxygen vacancies at this interface also produces a change in the thermal boundary resistance (TBR), i.e., a thermal resistive switching effect. We used frequency domain thermoreflectance to monitor the interfacial metal–oxide TBR in (Pt,Cr)/SrTiO3 devices, showing a change of ≈20% under usual SET/RESET operation voltages, depending on the structure of the device. Time-dependent thermal relaxation experiments suggest ionic rearrangement along the whole area of the metal/oxide interface, apart from the ionic filament responsible for the electrical conductivity switching. The experiments presented in this work provide valuable knowledge about oxide ion dynamics in redox-based memristive devices.This work was supported by the RYC Grant 2019-026915-I (R.R.), Project TED2021-130930B-I00, PID2019-104150RB-I00, and PID2022-138883NB-I00 funded by the MCIN/AEI/10.13039/501100011033 and by the ESF investing in your future, and the European Union NextGeneration EU/PRTR, Xunta de Galicia (ED431F 2022/04, ED431B 2021/013, Centro Singular de Investigación de Galicia Accreditation 2019-2022, and ED431G 2019/03), and the European Union (European Regional Development Fund─ERDF) A.S. and R.D. acknowledge support from the Federal Ministry of Education and Research (Project NEUROTEC, Grants No. 16ME0398K and No. 16ME0399).S
Maximizing sustainability by energy recovery in anaerobic treatment systems
Full text linkTraditionally, wastewater treatment systems require considerable energy input, but this has changed since modern
anaerobic treatment systems were developed in the second half of the last century. The production of biogas opens
the possibility to produce electric power, which may make these systems independent of external energy and may
even become net energy producers. A second source of energy production in wastewater treatment systems is sludge
production. After drying the sludge its combustion can generate energy, though less than the energy potential from
biogas, not only due to the reduced sludge mass, but also because solid fuel has a lower conversion efficiency than
gaseous fuel. It has been demonstrated that in an efficient anaerobic treatment system operating under favourable
conditions (warm climate, low-sulphate concentration in the influent) ∼1/6 of the influent organic material is converted
into sludge whereas 4/6 is converted into biogas and 1/6 leaves the anaerobic treatment system with the treated
effluent. Normally, the production of electric power from the biogas is more than sufficient to run the treatment
system and an external source energy is not required. However, this does not mean that energy production is always
a sound economic solution. Economic feasibility depends on the price of electric power and generally requires the
operation of a large treatment system. In this chapter, equations are derived to estimate the composition of biogas
and sludge in anaerobic wastewater treatment systems and specifically the influence of sulphate in the influent is
discussed. Moreover, the processes for collection and treatment of biogas and sludge are presented. The potential
for useful energy generation from anaerobic treatment systems is analysed and several examples are presented in
order to highlight the feasibility of the energy recovery under different operating conditions
Comparison of Clinical and Genetic Characteristics Between Younger and Older Lung Cancer Patients
Full text linkIntroduction
The aim of this study was to analyze the clinical and genetic characteristics of young lung cancer cases, and to compare them with those of older cases.
Methods
We used the Thoracic Tumors Registry (TTR) as a data source representative of lung cancer cases diagnosed in Spain, and included all cases registered until 9/01/2023 which had information on age at diagnosis or the data needed to calculate it. We performed a descriptive statistical analysis and fitted logistic regressions to analyze how different characteristics influenced being a younger lung cancer patient.
Results
A total of 26,336 subjects were included. Lung cancer cases <50 years old had a higher probability of being women (OR: 1.38; 95% CI: 1.21–1.57), being in stage III or IV (OR: 1.32; 95% CI: 1.08–1.62), not having comorbidities (OR: 5.21; 95% CI: 4.59–5.91), presenting with symptoms at diagnosis (OR: 1.53; 95% CI: 1.29–1.81), and having ALK translocation (OR: 7.61; 95% CI: 1.25–46.32) and HER2 mutation (OR: 5.71; 95% CI: 1.34–24.33), compared with subjects ≥50 years. Among subjects <35 years old (n = 61), our study observed a higher proportion of women (59.0% vs. 26.6%; p < 0.001), never smokers (45.8% vs. 10.3%; p < 0.001), no comorbidities (21.3% vs. 74.0%; p < 0.001); ALK translocation (33.3% vs. 4.4%; p < 0.001) and ROS1 mutation (14.3% vs. 2.3%; p = 0.01), compared with subjects ≥35 years.
Conclusions
Lung cancer displays differences by age at diagnosis which may have important implications for its clinical management.S
Clinical application of liquid biopsy to identify predictive and resistance biomarkers in stage IV breast cancer patients treated with CDK4/6 inhibitors
Full text linkHR+/HER2- stage IV breast cancer patients are treated with a combination of CDK4/6 inhibitors plus endocrine therapy (ET). Nevertheless, all patients will develop intrinsic or acquired resistance, but there are not predictive biomarkers identified so far. Hence, in this thesis, it was proved that the study of circulating material lets monitor disease evolution and tailor-patient therapy. The transcriptomic characterization of CTCs classified patients according to therapy response and determine resistance mechanisms to CDK4/6i plus ET. The cfDNA levels can be used to longitudinally study therapy response. In addition, it was proposed the characterization of circulating immune cells to identify predictive biomarkers to CDK4/6i plus ET in HR+/HER2- stage IV BC patients
Evaluation of antimicrobial and non-steroidal antiinflammatory treatments for BRD on health and welfare in fattening bulls: a cross-sectional study
Full text linkOur study aimed to evaluate the effect of different treatments for BRD on health and welfare
in fattening bulls. A total of 264 bulls were enrolled. Welfare was assessed on day 2 (T0) and
day 15 (T1) after arrival. A decrease in the welfare level was observed from T0 to T1. All bulls
were inspected clinically at T0 and T1 revealing an increase of skin lesions and lameness in T1.
In both periods, a high incidence of respiratory disease was observed. A prevalence of 79.55%
and 95.45% of Mycoplasma bovis using RT-PCR and culture at T0 and T1 respectively was
observed. Blood samples were collected for haematology at T0 and T1. At T0, 36 animals were
individually treated for BRD with an antimicrobial (IT), 54 received a metaphylactic treatment
with tulathromycin (M), 150 received a metaphylactic treatment with tulathromycin plus a
second antimicrobial (M+IT) whereas 24 were considered healthy and therefore not treated
(NT). Additionally, 128 were treated with a non-steroid anti-inflammatory (NSAID). Neutrophils
of M+IT were significantly higher than groups NT and M and the lymphocytes of M+IT were
significantly lower than that of IT. White blood cells, neutrophils and N/L ratio of animals
treated with an NSAID was significantly higher than that not treated. Lung inspection of 172
bulls at the abattoir indicated that 92.43% presented at least one lung lesion. A statistically
significant effect of the NSAID treatment on the lung lesions was observed. Our findings
indicate that BRD was a major welfare and health concern and evidence the difficulties of
antimicrobial treatment of M. bovis.This work was partially funded by Virbac, Italy.S
Las competencias profesionales en la formación inicial de maestras y maestros del Grado en Educación Infantil: un análisis desde la perspectiva del alumnado
No full textLos datos han sido sometidos a diversos análisis estadísticos para ofrecer los resultados e interpretaciones pertinentes, así como las conclusiones. Los resultados obtenidos alertan de puntos fuertes y débiles en el desarrollo de las competencias organizadas en torno a cuatro dimensiones: docente, institucional, tutorial y personal. En las conclusiones incorporamos también algunos ejemplos de iniciativas adoptadas en uno de los centros para una mejor capacitación en relación con determinadas competencias que se estiman con menor desarrollo desde la percepción de los futuros docentes con la intención de adecuar y mejorar los procesos formativos.2025-01-3
Regulation of the ISG15 activity by SUMO
No full textISG15 is a Ubiquitin-like protein that plays important functions
in different pathologies but these functions depend on the
specie, cell type, viral type and ISG15 form. How ISG15
activities are regulated is unclear. Here we show that ISG15
can be SUMOylated and interacts with SUMO in a non-covalent
manner. SUMOylation of ISG15 is triggered by different types
of stress as well as upon overexpression of the tumor
suppressor p14ARF. We show that ISG15 can be detected at the
PML-NBs and that mutation of the SUMO binding sites
positively modulates its co-localization with PML-NBs. Finally,
we show that the interaction of SUMO with ISG15 positively
modulates the anti-apoptotic activity of ISG15 upon IFN
treatment, the pro-viral activity of ISG15 during VSV infection,
and is required for proper mitochondria biogenesis.2025-05-1
Synthesizing small-sized monodisperse molybdenum nanoparticles as potential precursors for medical radioisotopes
Full text linkMolybdenum-99 (99Mo) is used to produce technetium-99 m (99mTc), one of the most used medical radioisotopes in the world. 99Mo is currently created by fission of uranium-235 (235U) in a small number of research nuclear fission reactors. Several problems related to the use of 235U as primary source is causing a global 99Mo generation crisis. Therefore, we are facing the need of finding new viable and safe production alternatives. Neutron activation of molybdenum is a promising candidate in which the ideal target for 99Mo production are small monodisperse molybdenum nanoparticles (Mo NPs). However, the reported procedures for the obtention of Mo NPs present either the lack of simplicity of the employed synthetic methods or the inappropriate size and monodispersity of the synthesized Mo NPs. Here, we report a simple synthetic procedure for the obtention of small-sized monodisperse metallic Mo NPs. In the studied conditions, thermal decomposition of Mo(CO)6 produced oleylamine coated Mo NPs. The oleylamine layer was included with the purpose of avoiding oxidation. Although an oxide patina was still formed on the surface of the Mo NPs, the core remains in a metallic phase after several weeks from its production, as it was confirmed by X-ray photoelectron spectroscopy analysis (XPS). The described synthetic procedure provides a simple method for the obtention of Mo NPs with optimum characteristics as non-fission method for 99Mo productionWe thank Prof. Carlos Vázquez Vázquez for his invaluable advice. This work was supported by the Programa de Axudas de apoio á etapa predoutoral 2020 of Xunta de Galicia, by the European Commission under the BOW project (FETPROACT-EIC-05-2019, Grant 952183), CARTsol project (PLEC2022-009217 funded by MICINN/AEI/10.13039/501100011033 and NextGenerationEU/PRTR) and partially supported by the Spanish Ministry of Science and Innovation (ref PID2020-112626RB-C21), Modalities « Research Challenges» and «Knowledge Generation» and the Regional Consellería de Innovación Program for the Grupos de Referencia Competitiva 2021 —GRC2021 project of Xunta de GaliciaS
Pluriversidad. El futuro de la gestión educativa para las universidades públicas en México
Full text linkLa urgente transformación social poscapitalista y decolonial en México, puede encontrar viabilidad
mediante la deconstrucción del espacio universitario público. Esta idea se sustenta en el llamado
Fenómeno de Causalidad Bidireccional Socioeducativa, que presenta la autora como explicación
y fundamento del porqué el aparato nacional de las universidades públicas mexicanas permitiría la
participación ciudadana de la enorme diversidad cultural del país, reconstruyendo los fundamentos
universitarios en primer lugar. Mediante la traducción intercultural, es posible el encuentro de
intersecciones conceptuales que comuniquen las prácticas y conocimientos excluidos con los
conocimientos científicos, en un diálogo horizontal de justicia cognitiva, lo cual propicie la
transformación decolonial en México, sostenida en una sólida plataforma social.
En la segunda parte de la tesis, se analiza el tema de la ética académica con perspectiva de
equidad de género, el cual, es un debate con más vigencia que nunca en las universidades más allá
de la cultura mexicana, es un tema de interés y pertinencia mundial