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Transparency on YouTube for radon risk communication
Full text linkIntroducción: La evidencia científica ha demostrado la relación entre la exposición al radón en entornos interiores y el cáncer de pulmón. Por esta razón, el gas radón se considera una amenaza para la salud pública. Además, se ha confirmado que YouTube es una fuente de información médica. Metodología: Esta investigación examina YouTube como un medio para la difusión global de información sobre el radón. Se identifican todos los canales que contienen videos sobre este gas, junto con las áreas geográficas en las que operan, el idioma que utilizan para transmitir, el número de suscriptores y la cantidad de visualizaciones que acumulan. Utilizando una muestra de canales específicamente centrados en el radón, se examina la presencia de este tema en YouTube mediante un modelo metodológico que explora temas, narrativas y estrategias de difusión. Resultados: Los resultados revelan la ausencia de cámaras de eco y la falta de conciencia en esta red social con respecto a los problemas de salud pública relacionados con el gas radón. Discusión y Conclusiones: El estudio destaca la presencia limitada de vídeos relacionados con el radón en YouTube, con una predominancia de contenido en inglés, que restringe la accesibilidad en regiones no anglófonas. Los canales sobre el radón infrautilizan las funciones de YouTube y carecen de participación de la comunidad, revelando una brecha significativa en el reconocimiento del radón como un problema de salud pública en la plataforma. Aunque algunos canales exitosos demuestran buenas prácticas, la conciencia general sigue siendo insuficiente.Radon in Spain: Perception of public opinion, media agenda and risk communication (RAPAC). Nuclear Safety
Council (Consejo de Seguridad Nuclear) (SUBV-13/2021).S
Tribological behavior of electric vehicle transmission oils using Al2O3 nanoadditives
Full text linkAntifriction and antiwear performances of Al2O3 nanoparticles (NPs) as additives of an automatic transmission fluid, ATF, are presented in this research. For this purpose, four nanodispersions were formulated: ATF + 0.05 wt% Al2O3 NPs, ATF + 0.10 wt% Al2O3 NPs, ATF + 0.15 wt% Al2O3 NPs and ATF + 0.20 wt% Al2O3 NPs to identify the optimal concentration of additive. Tribological experiments were taken at pure sliding conditions, with the formulated nanolubricants and the ATF, under a working load of 20 N. The four nanolubricants tested resulted in lower friction coefficients than those obtained using ATF, reaching a maximum reduction of 6 % with the ATF + 0.10 wt% Al2O3 nanolubricant. The tribological pairs tested with the Al2O3 nanolubricants show lower wear than those tested with the ATF, having the best wear decrease with the ATF + 0.10 wt% Al2O3 nanolubricant, with reductions of 45, 57 and 78 %, respectively, in diameter, depth and area of the wear scar. Furthermore, by means of confocal Raman microscopy, roughness evaluation and SEM-EDX of the worn tribological specimens, it can be determined that mending, tribo-sintering as well as rolling mechanisms occur.This research is supported by Xunta de Galicia (ED431C 2020/10) and by MCIN/AEI/10.13039/501100011033 through the PID2020-112846RB-C22 project. JMLdR is grateful for financial support through the Margarita Salas program, funded by MCIN/AEI/10.13039/501100011033 and “NextGenerationEU/PRTR”. Furthermore, authors are also grateful to Repsol Lubricants for providing the ATF and to RIAIDT-USC for its analytical facilities.S
Variação semanal da osmolaridade do filme lacrimal em indivíduos saudáveis e com síndrome do olho seco
Full text linkPurpose: The possible variability in diagnostic test results is a statistical feature of dry eye disease patients. The clinician should consider tear film variations over time since the timing of tear film measurements is important for proper diagnosis. The purpose of the present study was to analyze the inter-week variation of osmolarity measurement in healthy and dry eye disease participants.
Methods: Based on the Dry Eye Workshop II (DEWS-II) diagnostic methodology report criteria, a battery of tests (Ocular Surface Disease Index [OSDI] questionnaire, breakup time, and corneal staining) was administered to rule out the presence of dry eye disease. A total of 40 qualified volunteers were recruited into two groups: with only 20 healthy and 20 dry eye disease participants. The inter-week variation of osmolarity in the two groups was measured using a TearLab osmometer in two sessions one-week apart. The differences between the results were calculated.
Results: There were no significant differences in osmolarity between the two sessions for either the healthy (paired t-test; p=0.085) or dry eye disease (paired t-test; p=0.093) participants. Moreover, there was no significant correlation between the means and differences in either session on healthy (Pearson correlation: r=0.020; p=0.935) or dry eye disease (Pearson correlation: r=-0.022; p=0.928) participants. In session 1, there was a significant difference in osmolarity values between groups (unpaired t-test; p=0.001), but no difference was found in session 2 (unpaired t-test; p=0.292).
Conclusions: The present study discovered no inter-week variation in the tear film osmolarity of healthy and dry eye disease participants classified based on the DEWS-II criteria.Objetivo:
A possível variabilidade nos resultados de testes diagnósticos é uma característica estatística dos pacientes com síndrome do olho seco. O médico deve considerar as variações do filme lacrimal ao longo do tempo, pois o momento em que o filme lacrimal é medido pode ser crítico para o diagnóstico adequado. O objetivo deste estudo foi analisar a variação semanal da osmolaridade do filme lacrimal em participantes saudáveis e em outros com síndrome do olho seco.
Métodos:
Com base nos critérios da metodologia de diagnóstico do relatório da Dry Eye Workshop II (DEWSII), foi aplicada uma bateria de testes (questionário do índice de doença da superfície ocular [OSDI], tempo de ruptura do filme lacrimal e coloração da córnea) para descartar a presença de síndrome do olho seco. Um total de 40 voluntários qualificados foi recrutado e distribuído em dois grupos de 20 participantes saudáveis e 20 participantes com síndrome do olho seco. A variação da osmolaridade entre semanas foi medida com um osmômetro TearLab em duas sessões com uma semana de intervalo nos dois grupos. As diferenças entre os resultados foram então calculadas.
Resultados:
Não foram encontradas diferenças significativas na osmolaridade entre as medidas obtidas nas duas sessões, nem no grupo de participantes saudáveis (teste de t pareado; p=0,085), nem no de participantes com síndrome do olho seco (teste de t pareado; p=0,093). Não foi detectada nenhuma correlação significativa entre as médias e diferenças entre as duas sessões entre participantes saudáveis (correlação de Pearson: r=0,020, p=0,935) e aqueles com síndrome do olho seco (correlação Pearson: r=-0,022, p=0,928). Foi encontrada uma diferença significativa nos valores de osmolaridade entre os dois grupos na primeira sessão (teste de t não pareado; p=0,001), mas nenhuma diferença foi encontrada na segunda sessão (teste de t não pareado; p=0,292).
Conclusões:
O presente estudo não encontrou variação entre semanas consecutivas na osmolaridade do filme lacrimal em participantes saudáveis e com síndrome do olho seco, classificados com base nos critérios do DEWSIIS
Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new anti-cancer strategy
Full text linkBackground
Previous studies by our group have shown that oxidative phosphorylation (OXPHOS) is the main pathway by which pancreatic cancer stem cells (CSCs) meet their energetic requirements; therefore, OXPHOS represents an Achille’s heel of these highly tumorigenic cells. Unfortunately, therapies that target OXPHOS in CSCs are lacking.
Methods
The safety and anti-CSC activity of a ruthenium complex featuring bipyridine and terpyridine ligands and one coordination labile position (Ru1) were evaluated across primary pancreatic cancer cultures and in vivo, using 8 patient-derived xenografts (PDXs). RNAseq analysis followed by mitochondria-specific molecular assays were used to determine the mechanism of action.
Results
We show that Ru1 is capable of inhibiting CSC OXPHOS function in vitro, and more importantly, it presents excellent anti-cancer activity, with low toxicity, across a large panel of human pancreatic PDXs, as well as in colorectal cancer and osteosarcoma PDXs. Mechanistic studies suggest that this activity stems from Ru1 binding to the D-loop region of the mitochondrial DNA of CSCs, inhibiting OXPHOS complex-associated transcription, leading to reduced mitochondrial oxygen consumption, membrane potential, and ATP production, all of which are necessary for CSCs, which heavily depend on mitochondrial respiration.
Conclusions
Overall, the coordination complex Ru1 represents not only an exciting new anti-cancer agent, but also a molecular tool to dissect the role of OXPHOS in CSCs. Results indicating that the compound is safe, non-toxic and highly effective in vivo are extremely exciting, and have allowed us to uncover unprecedented mechanistic possibilities to fight different cancer types based on targeting CSC OXPHOS.Open Access funding provided thanks to the CRUE-CSIC agreement with
Springer Nature. This study was supported by a Fero Foundation Grant
(B.S.,Jr.); Rámon y Cajal Merit Award (RYC-2012-12104) from the Ministerio de
Economía y Competitividad, Spain (B.S.,Jr.); funding from the Beca Carmen
Delgado/Miguel Pérez-Mateo from AESPANC-ACANPAN Spain (B.S.,Jr.); a
Conquer Cancer Now Grant from the Concern Foundation (Los Angeles,
CA, USA) (B.S.,Jr.); a Coordinated grant (GC16173694BARB; B.S.,Jr.) and SEED
grant (IDEAS222917FERN; M.A.F.-M.) from the Fundación Asociación Española
Contra el Cáncer (AECC); FIS grants PI18/00757 and PI21/01110 (B.S.,Jr.) and
PT20/00045 (A.M.T.R and B.S.,Jr.), (co-fnanced through Fondo Europeo de
Desarrollo Regional (FEDER) “Una manera de hacer Europa”); an IGNICIA
proof of concept grant (IN855A-2018/16) “RuCSC - targeting cancer stem
cells using ruthenium compounds”, an initiative of the Agencia Gallega de
Innovación (GAIN) to facilitate the access of I+D+i projects to the market
(J.L.M and B.S.,Jr.), a La Caixa Research Consolidate grant (CC21-20122; J.L.M
and B.S.,Jr.); Spanish national grants PID2019-110320RB-I00 (M.A.F.-M.) from
the Ministerio de Ciencia e Innovación (MCIN), IJC2019-040358-I funded by
MCIN/AEI/10.13039/501100011033 (J.R.), PID2019-108624RB-I00, PDC2021121508-I00, PID2022-137318OB-I00 and ORFEO-CINQA network RED2018102387-T (J.L.M.), the Consellería de Cultura, Educación e Ordenación Univer‑
sitaria 2015-CP082, IN855A 2018/16, ED431C-2021/25 and Centro Singular de
Investigación de Galicia accreditation 2019-2022: ED431G 2019/03 (J.L.M.), the
European Union (European Regional Development Fund-ERDF correspond‑
ing to the multiannual fnancial framework 2014-2020), and the European
Research Council Advanced Grant No. 340055, Proof-of-concept Grant No.
899334 (J.L.M.). a Max Eder Fellowship of the German Cancer Aid (111746)
(P.C.H.); the German Research Foundation (DFG, CRC 1279 “Exploiting the
human peptidome for Novel Antimicrobial and Anticancer Agents”) (P.C.H.).S
Sobre a poesía de Carmen Blanco: Da "Gaia" grega á "Galicia Gaia" de Carmen Blanco. O soño que precedeu ao soño
Full text linkInclúe un retrato de Carmen Blanco pintado por Sara Lamas e "Ámame anarquista", debuxo de Carmen Blanco
Temporal Progression of Entry Factors into the Vicious Circle of Dry Eye in Untreated Sufferers
Full text linkBackground: Dry eye disease (DED) is characterized by the loss of ocular surface homeostasis with specific signs and symptoms. Studying the progression of a multifactorial disease is exceedingly challenging for researchers because several factors can influence it. The present study aims to study changes in tear meniscus height (TMH), lipid layer pattern (LLP), and bulbar hyperemia over time in untreated DED participants. Methods: This retrospective longitudinal study included 73 participants (146 eyes) diagnosed with DED since at least 2013. Participants underwent new examinations between 2021 and 2023, grouped by 8-, 6-, or 4-year follow-up periods. TMH, LLP, and bulbar hyperemia were assessed in both examinations. No participant received pharmacological treatment for DED. Results: Differences in TMH, bulbar hyperemia, and LLP between sessions were obtained in the 8-year group (p ≤ 0.027). Differences in bulbar hyperemia and LLP between sessions were obtained in the 6-year group (p ≤ 0.022). The only differences in LLP between sessions were obtained in the 4-year group (p < 0.005). Conclusion: Changes in TMH were obtained after periods of eight years from the first eye examination. Also, changes in bulbar hyperemia were obtained at periods of 8 and 6 years; however, changes in LLP could be found from 4-year follow-ups.S
El campo conceptual “transferencia” en español y alemán. Estudio lexicológico contrastivo basado en corpus: análisis, estructuración y aplicación
No full textEste trabajo presenta el compendio de siete publicaciones,
todas ellas subordinadas a un tema común que las vincula: el
estudio lexicológico contrastivo basado en corpus enfocado en
el campo conceptual de TRANSFERENCIA/CAMBIO DE
POSESIÓN en español y alemán.
En él se identifican divergencias sintácticas y semánticas entre
ambos idiomas que no están adecuadamente tratadas en
las herramientas pedagógicas, así como una carencia de
recursos que presenten información combinatoria de este léxico
en la interfaz semántico-sintáctica.
El objetivo principal es identificar y ejemplificar la necesidad de
información más detallada para producir en
español y alemán como lenguas extranjeras. Los estudios
presentados desde diferentes perspectivas han permitido
mostrar los resultados en una herramienta lexicográfica online
Optimising butyric and lactic acid yield from xylose by adjusting pH
Full text linkThis work studies the pH effect in xylose mixed culture fermentation, focusing on lactic and butyric acid production. Batch tests showed a complete substrate consumption at slightly acidic (pH 6) and alkaline conditions (pH 8), but a great inhibition of xylose conversion was observed at pH 4. Acetic acid was the only product at pH 8, while at pH 6, butyric and propionic acids were quantified as well with a large proportion of unidentified compounds. Continuous reactor operation showed that changes within the acidic pH range (pH 4.5 to pH 6) affect the acidification degree but not the product distribution, reaching the maximum butyric acid yield (0.38 Cmol/Cmol-s) at pH 5, while lactic acid was only detected when xylose conversion or butyric acid concentration dropped. Batch tests demonstrated that butyric acid was not inhibitory for xylose or lactic acid conversion and that the main product of lactic acid fermentation was butyric acid. Although pH is an essential variable steering the fermentation yield and selectivity, this study demonstrates that it must be combined with other operational conditions in order to obtain a stable production of lactic and butyric acids.This research was funded by the Spanish Government through the CELL4CHEM project (PCI2021-121989, ERACoBioTech 3rd call). The authors belong to a Galician Competitive Research Group (ED431C-2021/37).S
Síntesis y caracterización de nuevos nanomateriales porosos para aplicaciones catalíticas y energéticas
No full textEn esta Tesis Doctoral se investiga la síntesis, caracterización y
validación de nuevos materiales basados en ZIF-67 para
la remediación de contaminantes mediante catálisis y
fotocatálisis, así como de electrodos de ZIF-67 para su uso en
supercondensadores. Para ello, se incluye la síntesis de ZIF-67
puros y dopados con iones níquel, además de la
formación de nanoestructuras núcleo/coraza con nanopartículas
plasmónicas de oro recubiertas por ZIF-67. Se valida la
eficacia catalítica y fotocatalítica de los nanomateriales
mediante la degradación del tinte Rodamina B en presencia de
peroximonosulfato de potasio, en condiciones bulk y con
confinamiento entre nanoestructuras. Asimismo, se valida la
aplicabilidad de los nanomateriales y sus derivados como
electrodos para supercondensadores mediante medidas
electroquímicas.2025-05-1
Sistemas basados en las comunidades biológicas acuáticas para la evaluación del estado ecológico de los bofedales de la meseta andina de la Reserva de Producción de Fauna Chimborazo
No full textLos bofedales son turberas de altitud (3800 m.s.n.m.) que se
nutren del agua procedente de la lluvia y del deshielo del
nevado Chimborazo en el centro del Ecuador.
En el presente estudio se evaluó el estado ecológico de los 16
bofedales presentes en la Reserva de Producción de
Fauna Chimborazo, una de las mas importantes áreas
protegidas que cuenta el Ecuador continental; para ello se
analizaron parámetros físicos, químicos y biológicos
(macroinvertebrados, macrófitas y vegetación de ribera) que
determinaron la calidad ecológica de estos ecosistemas
acuáticos altoandinos. Se determinó que 9 de los 16 bofedales
presentan condiciones de alteración y baja calidad ecológica
debido a actividades de origen antrópico. Se debe
considerar el presente estudio a fin de garantizar la
conservación de estos bofedales.2025-01-3