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Identifying Non-Traditional Slippery Sequences Associated with Translational Frameshifts
Get PDFGenetic frameshifts are a mutation in whicha nucleotide skip leads to a shift in thereading frame. In viruses, these frameshiftscan be programmed using a slipperysequence to bypass the stop codonassociated with the initial protein. Thisallows for variable control of proteinexpression. In bacteriophages, translationalframeshifts have been identified but only afew have been proven experimentally. Usingexperimental data and comparativegenomics, non-traditional slipperysequences can be identified as assisting incontrolling the protein coding throughoutviruses. Novel slippery sequences can aid inthe understanding of protein expression inbiological environments and further theunderstanding of how viruses utilize theframeshift to their advantage. Thisadvantage can potentially lead the way incontrolling the expression of select proteins in pharmaceutical industry
Nucleic Acid Detection of Live Pathogens on Contaminated Foods
Get PDFThe goal is to develop a point-of-care biosensor for the detection of live pathogens contaminating beef products. Biosensing of live pathogens is based on isothermal amplification of nucleic acid on a paper-based device. A colorimetric dye is employed as an indicator of the amplification product for visual result. The assay incorporates a compound Propidium monoazide (PMA) that makes the DNA from dead cells inaccessible for amplification. This approach is especially applicable for pathogens that can enter a viable but non-culturable state (VBNC)
Language, Science and Literature
Get PDFThe creativity of language Chomsky puts so much importance on must be questioned because the same creativity has produced lethal weapons such as atomic bombs. Modern science developed by the power of language has certainly produced many beneficial things, but we should not overlook its destructive side. Besides, language capable of inventing a new reality leads us to believe in it blindly. Let us remember philosophers such as Wittgenstein or Nagarjuna who warned us not to believe in the construct called “reality” made up by language power.Now, is it better and safer then to use a metaphorical language that composes poetry than a conceptual one that composes science and mathematics? Not necessarily, for so long as metaphors evoke a sense of reality in us, it can be as dangerous as the conceptual one. The problem today is that the conceptual and logical language that supports science and technology is predominant over the metaphorical and poetical one. Even if Rousseau, Adorno and Horkheimer alarmed us of the danger, our history has advanced ignoring their alarms. Science and technology are making progress day by day, and no one is capable of checking their progress because no one sees what is really happening in there.The wall between the “Two Cultures” is still there, but let us not forget the efforts of poetic scientists and scientific poets such as Kenji Miyazawa or Claude Lévi-Strauss, who try to diminish the gap. They surely help us to find a way out of the danger
The capillary length scale determines the influence of bubble-fin interactions and prediction of pool boiling from heat sinks
Get PDFImpact of pressure drop oscillations and parallel channel instabilities on microchannel flow boiling and critical heat flux
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Preparing for the Informed Workplace One Micro-Credential at a Time
No full textThe modern workplace is a transdisciplinary, information-rich environment, and this makes information literacy skills vital for students. With this grant funded project, we are developing, piloting, assessing, and promoting a suite of micro-learning modules for undergraduate engineering, technology, and business students at a large, public university. The modules revolve around information literacy topics relevant to the workplace, integrated into a scalable micro-credentialing platform. The topics covered include (1) effective information gathering strategies, (2) competitive analysis, (3) patent information, (4) industry standards, and (5) informed communication. We, the module creators, take a broad view of information literacy, including gathering information from other individuals in addition to published information sources. With this, a recurring theme throughout the modules is the importance of considering intercultural communication and inclusion within information literacy and the workplace. The goal is to provide students with foundational training relevant to their future careers (as well as transferable credentials that they can share with potential employers and post on badge-compliant platforms such as LinkedIn) and to provide instructors across campus a flexible set of information literacy tools that they can use to improve student outcomes. The modules are designed with accessibility in mind and are integrated into the campus learning management system. Stakeholders were consulted during project development, including creating content, scripting, and piloting the modules. These stakeholders included industry, business, and entrepreneurship professionals, as well as undergraduate students and course instructors. This poster presentation we will explain our module development and pilot course integration process and share preliminary results
Utility Coordination Deliverables and How to Get There
Get PDFFrom certification letters to special provisions, expectations of the utility coordination process are ever evolving. We would like to focus on the timing of when those deliverables should be submitted to limit the risk of letting exceptions. In our interactive session, we will also touch on how utility coordination affects the delivery of right-of-way, environmental, and time-set
Integrated Stormwater: Sustainable and Successful Campus Stormwater Management
Get PDFThrough strategic planning efforts and built projects, Purdue’s West Lafayette campus successfully integrated sustainable stormwater management. Engineers and planners will share how stormwater management practices have evolved over time to a layered approach, including surface treatments, engineering best management practices, and volume management. This presentation will include highlights from the university’s Stormwater Master Plan, a review of relevant case studies, and an overview of lessons learned as the campus continues to develop and densify