Publikationer från Örebro universitet
Not a member yet
18319 research outputs found
Sort by
Shy adolescents' perceptions of parental overcontrol and emotional coldness : examining bidirectional links
No full textTwo kinds of parental behaviors—overcontrol and emotional coldness—have been linked with children’s shy behaviors. The questions we addressed are whether this applies to adolescent shyness, and whether shyness in itself might also affect parental behaviors. The participants were 916 7th-9th graders in a longitudinal project. We used a cross-lagged path model with three time points. Shyness predicted an increase in feeling overly controlled by parents at Time 2, which then predicted an increase in shyness at Time 3. Shyness also predicted an increase in perceived coldness-rejection by parents at Time 2. Finally, shyness predicted decreases in parental warmth at both timepoints. The effects did not differ for boys and girls. These results show that adolescent shyness predicts parental behaviors, though perhaps less strongly than in childhood. They also suggest some bidirectional effects in which parental responses to shy youths might serve to strengthen the shyness.
Framtidsbild av elprisutvecklingen i Sverige 2011-2020
No full textdenna rapport har det undersökts vilka faktorer som påverkar elprisutvecklingen i Sverige och på vilket sätt. Målet har varit att få en framtidsbild av hur prisutvecklingen kan komma att se ut 2011-2020, utifrån de fakta som finns om elprisets utveckling den senaste 10- årsperioden 2001-2010. För undersökningen har Kumla Kommunfastigheter bidragit med fem studieobjekt: kontor, bibliotek, förskola, äldreboende och grundskola. Kumla Kommunfastigheters elavtal har använts som underlag för hela rapporten. Fem framtidscenarier har sammanställts för dessa objekt med syftet att visa hur förändring av utvalda parametrar påverkar kostnaderna för objekten. Referensår har varit 2009 eftersom det är ett så kallat normalår inom energibranschen. I samband med arbetet har kontakt upprättats med olika energibolag för intervju och en undersökande enkät, för att få deras åsikter om hur elprisutvecklingen kan komma att se ut i framtiden
The Importance of Research and Development in Relation to Parallel Trade of Pharmaceuticals
No full textDifferences in microRNA expression during tumor development in the transition and peripheral zones of the prostate
No full textBackground: The prostate is divided into three glandular zones, the peripheral zone (PZ), the transition zone (TZ) and the central zone. Most prostate tumors arise in the peripheral zone (70-75%) and in the transition zone (20-25%) while only 10% arise in the central zone. The aim of this study was to investigate if differences in miRNA expression could be a possible explanation to the difference in propensity of tumors in the zones of the prostate. Methods: The expression of 667 unique miRNAs was investigated in normal and malignant transition zone and peripheral zone prostate tissues using TaqMan low density arrays for miRNAs. Student’s t-test was used in order to identify differentially expressed miRNAs and hierarchical clustering and principal component analyses were used to note the separation of the tissues. A cross-validation test using the ADtree algorithm was used to test the generality of the identified miRNA signatures. Results: The Student’s t-tests revealed that the major differences in miRNA expression are found between normal and malignant tissues. Hierarchical clustering and PCA based on differentiallyexpressed miRNAs between normal and malignant tissues showed a perfect separation between samples while analyses based on differentially expressed miRNAs between the two zones showed several misplaced samples. A classification and cross-validation procedure confirmedt hese results and several potential miRNA markers were identified. Conclusions: The results of this study indicate that the major differences in the transcription programme are those arising during tumor development, rather than during normal tissue development. In conclusion, tumors arising in the TZ have more unique differentially expressed miRNAs compared to the PZ, indicating that the PZ are more prone to tumor development than the TZ. The results also indicate that separate miRNA expression signatures for diagnosis might be needed for tumors arising in the transition- or peripheral zone
High homocysteine and methylmalonate among demented and non-demented elderly receiving vitamin-B12 prescription and home help service
No full textBackground & Aims: Total homocysteine (tHcy) has been suggested as a dementia risk factor. Our aim was to investigate potential differences in tHcy and its determinants (mainly Serum-B12 and Serum-folate) in relation dementia. We examined the effect of vitamin-B12 prescription, whether a family history of dementia, or the need for home help service might have influence on tHcy. Methods: A cross sectional monocenter study comprising 926 consecutive subjects attending our Memory Care Unit. Results: Demented subjects being prescribed vitamin-B12 had higher Serum-B12 (p =0.025) but also higher tHcy (p =<0.001) and S-methylmalonate (p =0.032), and lower Serum-folate (p<0.001) than those who did not receive B12 prescriptions. tHcy levels were higher in subjects in need of home help service (non-dementia: p= 0.007), this group also had lower S-albumin (dementia: p<0.001; non-dementia: p=0.004). In multivariate logistic regression analysis with diagnosis of dementia as outcome, both vitamin-B12 prescriptions, family history of dementia, and existent home help service, predicted dementia (p=0.037; 0.044; 0.002 respectively). Conclusion: Elderly subjects on vitamin-B12 prescription appear to have unmet needs of nutritional support, causing elevated homocysteine levels. The home help service should pay a closer attention to nutritional aspects and drug compliance among geriatric patients
