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ALTERAZIONI DELL'EMOSTASI IN PAZIENTI AFFETTI DA EPATOPATIA CRONICA E CIRROSI EPATICA: INDIVIDUAZIONE DI NUOVI INDICATORI PROGNOSTICI
No full textDOMENICO ALVARO;MARIA ADELAIDE CONTINENZA; GIUSEPPE RICCIARD
Riassicurazione e rischi non indipendenti: un modello multivariato per il pricing di coperture di rischi aggregati
No full textD'Ortona Nicolino Ettore, Massabò Ivar, Vannucci Luig
Caratteri minero-genetici degli anfiboli fibrosi di interesse ambientale presenti nell'area di Biancavilla (CT, Italia).
No full textGianni Lombardi, Triscari Maurizio, Rocco Lavian
Applications of Nonlinear Dynamics and Complex Systems Theory to Finance
No full textSeravalli, Gilberto Mastromatteo, Giuseppe D'Ecclesia, Rita Laur
Functional characterization of the promoter and the gene product of pfg27, a Plasmodium falciparum gametocyte-specific gene
No full textMalaria kills every year 1 to 3 million people, mostly children under five years old. The situation is becoming increasingly dangerous as drug resistant malaria parasites are diffusing throughout the world. Malaria transmission depends on the formation of Plasmodium gametocytes in the human host and methods to prevent sexual differentiation would help containing the spread of drug resistant parasites.
This work concentrated on the poorly described early phases of gametocyte maturation, and particularly on the expression and the function of the gametocyte-specific protein Pfg27. This protein was reported to be essential for sexual development, as pfg27 gene disruption led to abolishment of parasite sexual differentiation.
The genomic upstream region of pfg27 was characterized in functional assays through deletion and 5’UTR substitution analysis, with the aim to identify genomic sequences necessary for the pfg27 promoter function. These experiments identified the pfg27 promoter and showed that the DNA sequence sufficient to drive the stage-specific expression of the reporter gene is 153 bp long. The most striking feature of this sequence is its unusual low complexity, and the presence of poly-dA and poly-dT tracts, both around 40 bp long. A functional analysis on the large 3’UTR region of the gene was also performed, and indicated that this element contributes to protect the pfg27 transcript from decay.
In order to investigate functional domains of the Pfg27 protein, we planned to introduce in a pfg27 knock-out strain constructs expressing wt and mutated forms of Pfg27. When such Ko strains were generated in our lab, a completely unexpected result was observed: parasites in which the Pfg27 protein was undetectable were still able to develop into gametocytes at levels comparable to the wild type parasites. Only ultrastructural analysis revealed that abnormal features in the subcellular structure were significantly more frequent in the Ko gametocytes than in the wt cells. For this reason, Pfg27 does not appear to be essential for gametocyte development, but it may be required for optimal production of sexual parasites
FOTOSENSORE DI PERMANENZA AMBIENTALE (ECOPERSISTENZA)
No full textAldo Roda, Marta Letizia Antonelli, Silvio Sammartan
Luce ed ombra nella rappresentazione. Rilettura storica e sperimentazioni eidomatiche.
No full textEmma Mandelli Giuseppe Pagnano Livio Sacch
Gli effetti della correlazione tra i rami assicurativi sul requisito patrimoniale di un'impresa di assicurazione Rami Danni
No full textNicolino Ettore D'Ortona, Ivar Massabò, Luigi Vannucc
Città Sensibile. Pratiche interattive nella metropoli contemporanea
No full textThe contemporary urban landscape is an emerging territory for interactive experiments by artists, architects and creatives of communication who design and realize installations which very often last only the time of a performance. The city thus looks to be dressed by a sensitive yet invisible and reactive skin able to perceive, decode, connect and store the multiple stimuli from the natural environment around. Its real time reactions often belong to an emotional, synaesthesic and almost irrational communication realm. The thesis’s goal is to decipher the phenomenon of the interactive experience within the city, seeking for genealogies in the experiences of the past and discussing the conceptual themes. The main idea is that the interactive design practice, through its operative and sense horizons, is an appropriate tool to interpret the many contradictions of our Contemporary urban condition in struggle with a still strong Modern vision of the world.
In the city of the Real Time, the pervasive interactive device modulates again, by means of time manipulation (synchrony/asynchrony of the communication) the concept of contiguity (tele-contiguity), presence (tele-presence, ubiquity), participation (hypervoyeurism), control (remote control) and spatial representation (1:1 mapping), extending the cognitive and operating abilities of men.
Within the Invisible City, the immaterial flows of information saturate the metropolitan air with fluid energies, ready to be “activated” by sentient and reactive membranes which make their aesthetics and sensuality visible with synesthetic restitutions.
The City of the Relations is a planetary playground where cooperative and participative social networking practices are consumed, which go indifferently from real to virtual territories because they are intimately connected by the pervasive layer of information technologies. It is an interface city, a subtitled city which is constantly deprived or increased of its memory and of its intrinsic values so that it becomes an anti-monument, for instance a non representative example of no power but only of the relations which it triggers among the people and of the narrative interconnections with other monuments.Tesi di dottorato in Composizione Architettonica (Teorie dell’Architettura), DiAR Dipartimento di Architettura, Facoltà di Architettura “Ludovico Quaroni” di Roma La Sapienza, XIX Ciclo, 2007 //// PhD Thesis in Theory of Architecture, DiAR Dipartimento di Architettura, Facoltà di Architettura “Ludovico Quaroni” di Roma La Sapienz