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Optimising sexual health and wellbeing services for raciosexual minorities in England using constructivist grounded theory
Get PDFBackground Racism, stigma, and discrimination can result in poor experiences, marginalisation, misinformation, and thus detrimental health outcomes for racially and sexually minoritised (Lesbian, Gay, Bisexual, Trans and Queer+ Black Persons of Colour (LGBTQ+ BPoC) identifying) individuals. By considering what culturally safe, sensitive, and inclusive services can look like, we can begin to advocate for better, more appropriate health service development. This study aims to examine the experiences of racially and sexually minoritised individuals in accessing sexual health services to develop a theoretical explanation of how to optimise sexual health and well-being services for raciosexual minorities in England. Design Charmaz's constructivist grounded theory was used to develop a theoretical explanation of how to optimise sexual health and well-being services for raciosexual minorities in England. Fourteen in depth interviews were used to collect data. Broun and Clarke's thematic analysis was used to analyse the data. Results From five fundamental themes, three key factors emerged from the data i) access to credible sexual health information, ii) culturally competent lived experience leadership, and iii) culturally safe environments and conditions. Findings highlight disparities with regards to access, outcomes, and experiences of care for raciosexual minority individuals in England. Factors such as the absence of lived experience practitioners, a lack of sensitivity and privacy, and a lack of diverse prevention options were said to compromise the accessibility and usability of existing sexual health services. Similarly, factors such as practitioner competency, trauma-informed approaches, access to practical information, were all said to optimise this experience, leading to greater openness and likelihood of service user engagement (see Figure 25). Conclusion In line with the recommendations made by the participants of this study, culturally safely, sensitivity, and inclusivity remain key drivers toward the design of more optimal sexual health provision in England. This will be achieved through an improved access to credible sexual health information, an increase in lived experience practitioners, provision of cultural competency training across the workforce, and the curation of culturally safe clinical environments and conditions. While it will require significant changes, where intersectionality is honoured, a shift will be observed toward a more optimal sexual health service delivery model. In turn, improved access, experiences, and overall health and wellbeing outcomes will be noted for raciosexual minorities in England
Les cartes et les territoires. Les ruralités dans les fictions françaises des XXe et XXIe
No full text© Verlag Königshausen & Neumann GmbH, Würzburg 2024.
This edited book has been archived and is not available to view on ChesterRep. Please consult the publisher's OA policy here: https://verlag.koenigshausen-neumann.de/open-access/#1650961289669-c5f08cc4-0592.The book explores the representation of rural spaces in contemporary French literature.unfunde
Phytochemical composition, in silico molecular docking analysis and antibacterial activity of Lawsonia inermis Linn leaves extracts against Extended Spectrum Beta-Lactamases-Producing strains of Klebsiella pneumoniae
Get PDFKlebsiella pneumoniae is an opportunistic Gram-negative bacterium in the Enterobacteriaceae family associated with a wide range of diseases, such as pneumonia, bloodstream infections, meningitis and urinary tract infections. Infections caused by drug-resistant strains of Klebsiella pneumoniae pose a significant threat to the effectiveness of conventional antibiotics. Hence, this has led to the need to explore alternative antimicrobial therapies, especially natural products derived from plant sources. This study assessed the phytochemical composition and antibacterial properties and performed a molecular docking analysis of Henna leaves (Lawsonia inermis L.) extracts on strains of Klebsiella pneumoniae. Crude ethanol and methanol extracts of L. inermis L. were prepared at different concentrations (25, 50, 75 and 100 mg/mL) and tested on extended spectrum beta-lactamases (ESBLs)-producing strains of Klebsiella pneumoniae. Phytocompounds were identified using gas chromatography–mass spectrometry (GC-MS) and further subjected to virtual ligands screening with DataWarrior (v05.02.01) and a molecular docking analysis using AutoDock4.2 (v4.2.6). The active compounds of L. inermis L. were determined by the docking analysis, including phytochemical, physicochemical, pharmacokinetics and docking score. The GC-MS analysis identified 27 phytoconstituents, including ethyl acetate, sclareol, 2-[1,2-dihydroxyethyl]-9-[β-d-ribofuranosyl] hypoxanthine, α-bisabolol and 2-Isopropyl-5-methylcyclohexyl 3-(1-(4-chlorophenyl)-3-oxobutyl)-coumarin-4-yl carbonate. The 27 compounds were then screened for their physicochemical and pharmacokinetic properties. The results revealed that the methanol extracts at 100 mg/mL showed significantly higher (p < 0.05) zones of inhibition (13.7 ± 1.2 mm), while the ethanol extracts at 50 mg/mL were significantly lower (6.3 ± 0.6 mm) compared to all the other treatments. The docking analysis revealed that out of the 27 compounds identified, only twelve (12) compounds have a drug-likeness activity. The 12 compounds were further subjected to docking analysis to determine the binding energies with the CTX-M protein of Klebsiella pneumoniae. Only one compound [CID_440869; (2-[1,2-dihydroxyethyl]-9-[β-d-ribofuranosyl] hypoxanthine)] had the best binding energy of −9.76 kcal/mol; hence, it can be considered a potentially suitable treatment for infections caused by ESBLs-producing strains of Klebsiella pneumoniae. This study has demonstrated that L. inermis L. extracts have antibacterial effects. Further research could explore the potential antimicrobial applications of L. inermis L. extracts to many bacterial strains.Unfunde
Active case finding and evaluation of IL-6 production among household contacts of pulmonary tuberculosis patients in a high disease setting
Get PDFBackground: Tuberculosis (TB) is a top infectious disease killer worldwide and remains a huge public health concern. However, most TB case findings are limited to self-referral (passive case finding), when individuals develop symptoms of TB. Only 15% of disease burden in Nigeria are reported. In view of this, it is important to assess the latent and active disease burden amongst HHC of TB patients suffering from pulmonary TB. In addition, it has been suggested that IL-6 levels could be used as a prognostic marker in exposed individuals. IL-6 levels were assessed in this cohort. Methods: A total of 205 subjects participated in this study, comprising 62 pulmonary TB index cases and 143 of their household contacts. Also, 54 apparently healthy subjects were recruited to serve as controls. Active case finding was performed amongst the HHC, using sputum and blood samples; they were tested for active TB. Blood samples were also collected for measuring IL-6 levels. Results: Findings reveal 6.3% previously undiagnosed active TB among the HHC of the TB patients and a significantly higher number of latently infected TB cases compared to the control population (p=0.0078). There were significant differences when comparing HIV co-infected index group to their HIV negative counterparts (P=0.032). Significantly different IL-6 levels were found among the study groups and sub-groups (p<0.0001), with significantly higher levels in TB mono-infection compared to in TB/HIV co-infection (p=0.031).Conclusions: These results demonstrate the importance of active TB case finding for TB control and the possible role of IL-6 as a diagnostic marker in TB control.Unfunde
Elvis Presley e a cultura popular do século XX
Get PDFA discussion of the question of Elvis and cultural appropriation in interview format in Portguese.Unfunde
The effect of vitamin D supplementation on markers of insulin resistance in women with polycystic ovarian syndrome: a systematic review
Get PDFThe version of record of this article, first published in [European Journal of Nutrition], is available online at Publisher’s website: http://dx.doi.org/10.1007/s00394-024-03489-6Insulin resistance (IR) is a common pathology in women with polycystic ovarian syndrome (PCOS) involved in increased rates of cardiometabolic disease such as diabetes and cardiovascular disease. Low serum vitamin D is often associated with insulin resistance but there is no consensus on whether vitamin D supplementation can ameliorate markers of IR in PCOS. We assessed evidence on the effects of vitamin D supplementation (≥ 1000 IU/day), without the use of additional supplements or other pharmacological treatments known to affect IR, on markers of IR and glycemic control in women with PCOS. A systematic search was conducted using PubMed, Medline and Web of Science databases from January 2000 up to November 2023. Randomized controlled trials that assessed the effects of vitamin D supplementation in women with PCOS, on fasting glucose, fasting insulin, glycated haemoglobin (HbA1c) or homeostatic model assessment for insulin resistance (HOMA-IR) were included. 9 studies were identified. Study populations ranged from 28 to 180 participants, with mean ages ranging from 22 to 30 years. Daily vitamin D doses ranged from 1714-12,000 IU. Of the included studies, 3 reported statistically significant reductions in fasting glucose, 2 reported reductions in fasting insulin, 2 reported reductions in HOMA-IR, none reported reductions in HbA1c and 5 reported no differences in any of the relevant outcomes. In conclusion, in RCTs of vitamin D supplementation in women with PCOS, the majority of studies do not report statistically significant improvements in fasting glucose, fasting insulin, HbA1c or HOMA-IR. However, as a minority of studies report some statistically significant results, further investigation may be warranted. PROSPERO ID: CRD42023486144. [Abstract copyright: © 2024. The Author(s).]UnfundedVoR added 30/09/2024
Tempered nonlocal integrodifferential equations with nonsmooth solution data
No full textThis work on the time discretization for the solution of the tempered nonlocal integro-differential equation with smooth and nonsmooth initial data are extended. We find the difficulty arising from theoretical analysis can be overcome by Laplace transform technique. A mount of proof skills have been provided based on Laplace transform technique for this kind of equations. The Laplace transform method is employed effectively to show that the proposed interpolating quadrature scheme is convergence for smooth and non-smooth initial data in both homogeneous and inhomogeneous cases.UnfundedAAM added to record 08/11/202
The feasibility and acceptability of an inoculative intervention video for gambling advertising: a focus group study of academics and experts-by-experience
Get PDF© The Author(s) 2024. Published by Oxford University Press on behalf of Faculty of Public Health.Gambling advertising employs a range of persuasive strategies. We therefore aimed to evaluate a counter-advertising intervention video to increase resilience to gambling advertising persuasion. Methods Three in-depth focus groups were conducted, and each group contained a mixture of gambling-related academics (N = 12) and experts with lived experience of gambling-related harm (N = 10). Participants were given access to the intervention video and provided feedback during the focus groups. Qualitative data were audio recorded and thematically analysed by the research team. Results Three main themes were identified. First, participants recommended a shorter video that had a simplified and digestible structure. Second, frequent real-world examples of gambling advertisements within the video were discouraged, and the inclusion of a relatable human voiceover was considered imperative to the receptiveness of the video. Finally, participants deemed it important to deliver psychologically grounded yet jargon-free content via a conversational style. An overall narrative framed by consumer-protection was also preferred in order to increase acceptance of the video content, rather than a more didactic framing. Conclusions Evaluating the acceptability of a counter advertising intervention video provided valuable insight from both an academic and lived-experience perspective. Such insight is instrumental to the meaningful co-design of counter-advertising interventions.Academic Forum for the Study of Gambling (AFSG
How is inclusion defined on the early childhood level in China, Germany and the UK: a systematic literature review
Get PDF© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis GroupIn the international context, including children with diverse needs and backgrounds in early childhood settings is at the heart of education policy and planning. Nevertheless, a lack of a consistent and clear definition of inclusive education will leave the concept wide open for different interpretations and sometimes misinterpretations, which potentially leads to exclusionary practices in the name of inclusion. Our study examined how early childhood inclusion is defined in China, Germany and the UK. Peer-reviewed studies between 2000 and 2020 were systematically examined under the framework of the four dimensions of inclusion of ‘access, acceptance, participation and achievement’. 15 studies were selected that showed various aspects of the definition. Discussions on the inconsistent and tokenism definition of inclusion from various stakeholders are presented. Implications for future research and practice are discussed.Unfunde
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