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A Person-Centred Perspective on Suicide
No full textCopyright of Healthcare Counselling & Psychotherapy Journal is the property of British Association for Counselling & Psychotherapy.This article explores whether suicide has the potential to be considered an expression of the actualising tendency.N/
Corticomotor responses to experimental, acute, and chronic lower limb pain: A systematic review and meta‐analysis
Get PDF© 2025 The Author(s). Brain and Behavior published by Wiley Periodicals LLC.Background: Corticomotor adaptations are believed to contribute to persistent pain. However, prior reviews have lacked sufficient data to adequately explore these adaptations in lower limb pain. This restricts the generalizability of existing research given the distinct functional and neurophysiological differences between upper and lower limb musculature. This research gap has prompted increasing exploration of corticomotor adaptations in response to lower limb pain. Accordingly, this systematic review aimed to synthesize literature investigating corticomotor changes in response to experimental, acute clinical, and chronic lower limb pain. Methods: A comprehensive search of CINAHL, Ovid MEDLINE, PubMed, Scopus, and Web of Science was conducted. Transcranial magnetic stimulation (TMS) outcomes were separated into single‐site assessments of corticomotor excitability over the motor cortical hotspot, assessments of inhibitory/facilitatory mechanisms, and corticomotor organization (mapping) outcomes. Critical appraisals were performed using the Downs and Black checklist and the TMS methodological checklist. Meta‐analyses employed random effects models. Results: Analyses of 18 studies found no consistent effects of lower limb pain on motor evoked potentials. However, motor threshold data indicated that corticomotor responses may vary by region and diagnosis. Results from TMS mapping studies revealed consistent shifts in CoG for representations of painful lower limb muscles, as well as increased overlap of adjacent representations. Map volume findings differed between experimental and clinical pain, suggesting temporal variation in adaptations. Conclusion: This review highlights emerging evidence that corticomotor adaptations to lower limb pain are dynamic and region‐specific. These findings lay the groundwork for future research into pain‐related motor system plasticity.Unfunde
Exploring the relationship between personalization of care and participation in sport activities among people with severe Hemophilia A across Europe: Post hoc analysis of the CHESS II study
Get PDF© 2025 The Takeda Pharmaceutical Company Limited (Takeda). This work is published and licensed by Dove Medical Press Limited.To describe the demographic and clinical characteristics of patients with hemophilia A receiving different levels of treatment personalization (TP), and to assess the relationship between TP and sport active time (SAT). This post hoc analysis of the CHESS II study used data from physician-completed patient record forms and patient self-completion forms for adult males receiving prophylaxis for severe hemophilia A in Europe between November 2018 and October 2020. SAT was assessed using propensity score matching (PSM) across levels of TP, including pharmacokinetic (PK)-guided and non-PK-guided. Of 54 patients, 32 (59.3%) received TP. Of these, 22 (68.8%) and 10 (31.3%) received non-PK-guided and PK-guided treatment, respectively. Median age varied between the TP and no-TP groups (29.5 and 34.0 years, respectively). Median (IQR) annual bleeding incidence was higher with non-PK-guided vs PK-guided TP (4.0 [3.0-8.0] vs 3.5 [2.0-4.0]). Median (IQR) problem joints were similar with non-PK-guided and PK-guided TP (1.0 [0.0-1.0] and 1.0 [0.0-2.0]). Patients in the TP vs no-TP group had higher median (IQR) SAT per month (3.3 [1.8-6.2] vs 1.8 [0.7-5.0] hours). Median (IQR) SAT per month was higher with PK-guided vs non-PK-guided TP (4.0 [3.0-20.0] vs 3.0 [1.3-5.3] hours). After controlling for confounding in the PSM model, SAT remained higher with TP vs no-TP and with PK-guided vs non-PK-guided TP. In both PSM models, P values were <0.05 for the average treatment effect and <0.01 for the average treatment effect on the treated. Sensitivity analyses confirmed the robustness of the PSM. Patients receiving TP vs no-TP had higher median SAT. Of those with TP, those receiving PK-guided vs non-PK-guided TP experienced lower bleeding rates and higher SAT. PK-guided TP may help patients to be more active, potentially gaining the clinical and psychosocial benefits of exercise. [Abstract copyright: © 2025 The Takeda Pharmaceutical Company Limited (Takeda).]This study was funded by Takeda Development Center Americas, Inc., Lexington, MA, USA. The wider CHESS II study was supported by unrestricted research grants from BioMarin, Sanofi, and Takeda
Time discretization schemes for stochastic subdiffusion and fractional wave equations with integrated additive noise
Get PDFCrown Copyright © 2025 Published by Elsevier Ltd.In this paper, we introduce a time discretization scheme for solving the stochastic subdiffusion equation based on the two-fold integral-differential and two step backward differentiation formula (ID2-BDF2). We prove that this scheme attains a convergence rate of O ( τ α + γ − 1 / 2 ) for 1 / 2 < α + γ < 2 with α ∈ (0, 1) and γ ∈ [0, 1]. Our approach regularizes the additive noise through a two-fold integral-differential (ID2) calculus and discretizes the equation using BDF2 convolution quadrature, achieving superlinear convergence in solving the stochastic subdiffusion. Furthermore, we extend the scheme to solve the stochastic fractional wave equation, proving that the scheme achieves a convergence rate of O ( τ min { 2 , α + γ − 1 / 2 } ) for α ∈ (1, 2) and γ ∈ [0, 1]. Numerical examples are presented to validate the theoretical results for the linear problem. The numerical observations further indicate that the same convergence rates also apply to stochastic semilinear time-fractional equations.This research was supported by the Science Fund for Distinguished Young Scholars of Gansu Province under Grant No. 23JRRA1020 and National Natural Science Foundation of China under Grant No. 12471381
Institutional complexity and contestation in a local policing collaboration tackling exploitation
No full textPolicing in England and Wales is struggling to adapt to meet the modern challenges faced by our communities. Policing culture is often seen as part of the problem, contributing to an ongoing ‘permacrisis’. This case study of a local multi-agency partnership addressing exploitation adopts a critical realist philosophy to the entrenched perspectives of police and partners on the frontline of public services. Considering the national recognition of increasing workloads related to vulnerability and the need for more collaborative working arrangements, this case study offers insight into the institutional complexity of everyday multi-agency community safety work.
An insider-researcher employs thematic analysis of partners' interview data to identify three core institutional logics, revealing that tension exists within local police as much as between police and partners. A dominant cultural stance founded on the logics of managerialism and criminal justice is uncovered, underpinning sense-making and framing practices that prioritise efficiency through specialisation and simplistic victim-offender dichotomies. The implicit theories and mental schemata within these logics impede meaningful system-wide efforts to protect some of society’s most vulnerable. Further exploration indicates that an institutional tendency towards clarity, directness, and simplicity underpins both logics, which hinders the capacity to address increasingly complex issues such as exploitation.
However, a strategic logic is also observed in use by officers and partners, which, based on a broader view of the police role in society, is equipped with a wider range of mental frameworks to understand complex problems. This naturally leads to valuing a greater variety of options and responses as part of an extended, systemic mental model of public protection. Being subordinate to the dominant logics in a centralised bureaucracy, its practice is hindered and thus its impact limited; nevertheless, it holds promise as a model for policing to address the challenges of modernity better. The institutional logics and complexity approach helps shift the discourse around police reform away from simplistic discussions of values, standards, or leadership towards a deeper understanding of the institutionalised nature of police practice, and why it has proved so resistant to change
Advancing contemporary understandings of rural community flood experiences
No full textThis thesis examines the flood experiences of rural riparian communities along the River Severn catchment, addressing a significant gap in flood vulnerability research that has predominantly focused on urban contexts. Using an approach that integrates the principles of natural hazard management with rural geography perspectives, the study investigates how relational, and material factors shape human-flood system dynamics within diverse rural settings. Through a mixed-methods approach combining quantitative survey data (n=176) and qualitative interviews with community members including residents (n=18), business owners (n=7) and flood risk management (FRM) stakeholders (n=4), the research reveals the differentiated nature of rural flood vulnerability, risk perception, and resilience across varying settlement types. Findings demonstrate significant variations between villages and rural towns, with village residents experiencing greater direct flood impacts, higher mental health concerns, and stronger intra-community support networks, while rural towns benefit from better institutional engagement and protective infrastructure. The research identifies how life stage, place attachment, spatial location, rural function (distinguishing between residents and diverse business types including agriculture, hospitality, and service sectors), and community dynamics intersect to create distinctive patterns of vulnerability and resilience. Rural businesses, particularly agrarian enterprises, demonstrate heightened vulnerability due to their dependence on flood-exposed land, while non-agrarian businesses exhibit greater operational flexibility during flood events. Additionally, the study explores rural communities' perceptions of FRM agencies, highlighting issues of spatial justice and the potential for enhanced community participation in flood governance. By foregrounding lived rural experiences and recognising the differentiated nature of rural communities, this thesis advances both theoretical understanding of human-flood system dynamics and provides practical insights for more equitable, context-sensitive flood risk management approaches in rural areas
Guest editorial: Perspectives on sustainable practices in banking
Get PDFThis author accepted manuscript is deposited under a Creative Commons Attribution Non-commercial 4.0 International (CC BY-NC) licence. This means that anyone may distribute, adapt, and build upon the work for non-commercial purposes, subject to full attribution. If you wish to use this manuscript for commercial purposes, please contact [email protected] editorialUnfundedAAM supplied by author and uploaded to CR 05/02/202
Social goals versus business necessity: The nature and determinants of innovation in nancial inclusion
Get PDFThis is the post-review version of content which has been published in its definitive form in the Social Business. [Vik, P., McEachern, M. G., Curtis, J., Kane, K., & Dayson, K. (2023). Social goals versus business necessity: The nature and determinants of innovation in financial inclusion. Social Business, 11, 1-21. https://doi.org/10.1362/204440821X16206324311132]PURPOSE: This study aims to explore the extent to which social innovation is prioritised among a sample of organisations promoting nancial inclusion through the provision of a ordable credit, advice and nancial education. Additionally, we seek to understand the nature of the adopted innovation process and how this is perceived as in uencing social change (if at all). METHODOLOGY: This exploratory study uses a combination of qualitative, semistructured, face-to-face interviews with 35 managers in 29 di erent organisations and three focus groups with 16 practitioners and stakeholders.
FINDINGS: Innovation processes are in the main, largely incremental as opposed to radical with organisations focusing on process-led innovations. More notably, most organisations found that they often lacked the required social capital capacity, economic and technological resources and the necessary skills to develop, implement and capitalise on innovations, thus limiting the more radical forms of innovations.
IMPLICATIONS: To enhance the capacity of smaller organisations promoting nancial inclusion, there is significant potential to engage in more open, co-creational projects/partnerships to deliver greater social impact to vulnerable populations. CONTRIBUTION: We contribute to the under-researched literature on social innovation by highlighting the extent to which social innovation is given precedence within the sector promoting nancial inclusion. Given the contextual and organisational diversity of the sector, highlighting these behavioural practices and circumstances, enable researchers to theoretically advance social innovation theory further and provide more practice-based guidance for organisations to successfully shape social change.Unfunde
If X then Y, Z, ?: Using Twinery.org to teach interactive narrative development
Get PDFA discussion of digital pedagogy in the classroom, reflecting on the use of twinery.org as a tool in a class on interactive narrative.Unfunde
Knowledge and Skills Partnerships in Youth Justice
Get PDFThis is an Accepted Manuscript of a book chapter published by Routledge in [Knowledge and Skills Partnerships in Youth Justice] on [07/08/2024], available online: http://www.routledge.com/Knowledge-and-Skills-Partnerships-in-Youth-Justice/Price-Creaney/p/book/9781032Research in youth justice is vast and varied, meaning that those seeking to identify ‘good practice’ or ‘evidence’ must navigate multiple studies, large and small, from every jurisdiction and academic discipline. The scholarship has been produced using diverse methodologies and approaches, and although there is an increasing focus on policy impact and practitioner perspectives, its breadth and depth can make this vast literature difficult to access by those interested in an evidence-based approach.Unfunde
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