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Convergence and Asymmetry: Observations on the Current State of Jewish-Christian Dialogue
Get PDFThis is the version accepted for publication. It has not been copyedited or typeset. It may have been altered following reviewers' recommendations. It will probably be subject to further changes during the copyediting, design and typesetting processes at which point it will become the Version of Record.Drawing on a survey of forty-five statements on the status of Jewish- Christian dialogue, this article argues that the theme of convergence which underlies a substantial portion of this dialogue programme arises from an asymmetric power relationship, in which Christian institutions have been insufficiently attentive to the issue of Jewish self-understanding
Should you be using mobile technologies in teaching? Applying a pedagogical framework
Get PDFThis is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Geography in Higher Education on 10th June 2020, available online: https://doi.org/10.1080/03098265.2020.1773417The extent of how mobile devices, such as smartphones and tablets, are seamlessly incorporated into the personal day-to-day life is not often considered by University instructors. Unfocused incorporation of mobile technologies into the classroom can de-emphasize intended learning objectives if students struggle using the technology itself or by acting as a distraction. The effective inclusion of mobile technology is not a simple process as the inclusion needs to be purposeful and have the potential to improve the student learning environment, while working alongside more traditional face-to-face learning. This paper presents a pathway to help instructors address both pedagogical and technological considerations of incorporating mobile learning into the curriculum. The pathway developed through the adaptation of the iPAC framework, feedback from international practitioners and tested with worked examples. In all cases the instructors’ reflective responses to the eight pathway questions indicate a clear structured activity, engaged students, and considers equal access, prior experience and contingency planning. This pathway indicates an effective methodology for instructors to assess whether the mobile learning intervention is appropriate and adds value to their teaching. Further external evaluation of the pathway with additional teaching examples will enhance the effectiveness of the methodology
Conversations in Sculpture
Get PDFAn exhibition at Huddersfield Art Gallery during July ~September 2019 brining together members of the Royal Society of Sculptors from the north and the midlands to coincide with the 2019 Yorkshire Sculpture International. Ten members and fellows of the RSS took part in the show curated by Grant Scanlan. The exhibition was lottery funded by Arts Council England and Kirklees Council and featured an accompanying catalogue with foreword by Clare Burnett, President of the RSS and catalogue essay by Stephen Clarke, University of Chester. Nine artists talks, three workshops and one mentoring session were also schedules through the duration of the exhibition
Reading Across the Human-Animal Boundary: The Animalising Affliction of Nebuchadnezzar in Daniel 4
No full textA major aspect of the narrative in Daniel 4 is the imagery employed to describe the affliction received by Nebuchadnezzar when he is driven from his throne. It is plain that as part of his affliction he will live as an animal, however the degree to which
he actually becomes an animal is less clear. This unusual depiction of the king’s affliction has intrigued numerous subsequent readers and has provoked two predominant lines of interpretation: either that Nebuchadnezzar undergoes a
physical metamorphosis of some kind into an animal form; or diverse other ways of reading the text that specifically preclude or deny an animal transformation of the king. This thesis addresses such bifurcation of interpretative opinion about
Nebuchadnezzar’s affliction, examining why such interpretation is so divided and demonstrating ultimately how neither of these traditional interpretations best reflect the narrative events in Daniel 4. Firstly, I survey the range of previous
interpretations of Nebuchadnezzar’s affliction and how they can broadly be grouped into these two general trends. I examine in detail the various texts and forms of the narrative to show how metamorphic interpretations of Daniel 4 are largely reliant upon later developments within the textual tradition and are not present in the earliest edition of Nebuchadnezzar’s animalising affliction. However, while the various editions of Daniel 4 seem to contain no explicit evidence that a metamorphosis was ever intended, I also show that it is equally inadequate to state that the king does not undergo an animal transformation at all. Turning to the wider ancient Near Eastern context of the Danielic narrative, I examine a range of Mesopotamian texts which appear to conceive of the human-animal boundary as being indicated primarily in relation to possession or lack of the divine characteristic of wisdom. Demonstrating how various Hebrew Bible and Second Temple Jewish texts appear to reflect the same conceptual idea, I argue that the narrative in Daniel 4, through the king’s loss of reason, in fact represents a far more significant
categorical change from human to animal than has hitherto been recognised. This thesis therefore demonstrates that both traditional readings of Nebuchadnezzar’s animalising affliction are inadequate. Read instead in the context of this the
narrative of Daniel 4 describes a more subtle yet much more profound crossing of the human-animal boundary
Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer
Get PDFFrom Springer Nature via Jisc Publications RouterHistory: received 2020-02-21, rev-recd 2020-05-13, accepted 2020-05-15, registration 2020-05-16, pub-electronic 2020-05-30, online 2020-05-30, pub-print 2020-06-18Publication status: PublishedFunder: DH | National Institute for Health Research (NIHR); doi: https://doi.org/10.13039/501100000272; Grant(s): IS-BRC-1215-20007, IS-BRC-1215-20007, IS-BRC-1215-20007Funder: Breast Cancer Now; doi: https://doi.org/10.13039/501100007913; Grant(s): MAN-Q2Funder: National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs); doi: https://doi.org/10.13039/501100000849; Grant(s): NC/T001267/1Funder: RCUK | Medical Research Council (MRC); doi: https://doi.org/10.13039/501100000265; Grant(s): MR/K501311/1Abstract: Estrogen receptor (ER) positive breast cancer is frequently sensitive to endocrine therapy. Multiple mechanisms of endocrine therapy resistance have been identified, including cancer stem-like cell (CSC) activity. Here we investigate SFX-01, a stabilised formulation of sulforaphane (SFN), for its effects on breast CSC activity in ER+ preclinical models. SFX‐01 reduced mammosphere formation efficiency (MFE) of ER+ primary and metastatic patient samples. Both tamoxifen and fulvestrant increased MFE and aldehyde dehydrogenase (ALDH) activity of patient-derived xenograft (PDX) tumors, which was reversed by combination with SFX‐01. SFX-01 significantly reduced tumor-initiating cell frequency in secondary transplants and reduced the formation of spontaneous lung micrometastases by PDX tumors in mice. Mechanistically, we establish that both tamoxifen and fulvestrant induce STAT3 phosphorylation. SFX-01 suppressed phospho‐STAT3 and SFN directly bound STAT3 in patient and PDX samples. Analysis of ALDH+ cells from endocrine-resistant patient samples revealed activation of STAT3 target genes MUC1 and OSMR, which were inhibited by SFX-01 in patient samples. Increased expression of these genes after 3 months’ endocrine treatment of ER+ patients (n = 68) predicted poor prognosis. Our data establish the importance of STAT3 signaling in CSC-mediated resistance to endocrine therapy and the potential of SFX-01 for improving clinical outcomes in ER+ breast cancer
Patient‐relevant health outcomes for hemophilia care: Development of an international standard outcomes set
Get PDF© 2021 The Authors. Research and Practice in Thrombosis and Haemostasis published by ELSEVIER INC. on behalf of International Society on Thrombosis and HaemostasisBackground: Patient‐relevant health outcomes for persons with hemophilia should be identified and prioritized to optimize and individualize care for persons with hemophilia. Therefore, an international group of persons with hemophilia and multidisciplinary health care providers set out to identify a globally applicable standard set of health outcomes relevant to all individuals with hemophilia. Methods: A systematic literature search was performed to identify possible health outcomes and risk adjustment variables. Persons with hemophilia and multidisciplinary health care providers were involved in an iterative nominal consensus process to select the most important health outcomes and risk adjustment variables for persons with hemophilia. Recommendations were made for outcome measurement instruments. Results: Persons with hemophilia were defined as all men and women with an X‐linked inherited bleeding disorder caused by a deficiency of coagulation factor VIII or IX with plasma activity levels <40 IU/dL. We recommend collecting the following 10 health outcomes at least annually, if applicable: (i) cure, (ii) impact of disease on life expectancy, (iii) ability to engage in normal daily activities, (iv) severe bleeding episodes, (v) number of days lost from school or work, (vi) chronic pain, (vii) disease and treatment complications, (viii) sustainability of physical functioning, (ix) social functioning, and (x) mental health. Validated clinical as well as patient‐reported outcome measurement instruments were endorsed. Demographic factors, baseline clinical factors, and treatment factors were identified as risk‐adjustment variables. Conclusion: A consensus‐based international set of health outcomes relevant to all persons with hemophilia, and corresponding measurement instruments, was identified for use in clinical care to facilitate harmonized longitudinal monitoring and comparison of outcomes.Funder: Ministry of Health, Welfare and Sports, The Netherland
Shoots of equal marriage and partnership in the Church of England: a harvest rooted and nurtured through practical theology
No full textThis article is not available on ChesterRepFrom 2020 in England, civil marriage and civil partnership are legal for all couples. The Church of England is protected in civil law from change to its traditional theology of marriage between one man and one woman, so that only mixed-sex couples may marry in Church of England churches. A service is permitted for mixed-sex couples after a civil marriage, but no services are provided for same-sex couples or after civil partnerships. In this paper, qualitative research with practising members of the Church of England interrogates a widening gap in pastoral practice, between participants’ desire to welcome couples seeking a service with blessing and the lack of provision of liturgies by the Church. Interpretation of participants’ narratives of their own marriage or civil partnership as embodying mutuality and fidelity lead to consideration of liturgies of blessing for two people from the premodern era. I propose that contemporary marriage and civil partnership may be interpreted as unions of Christian harmony and peace which can be celebrated with blessing in church. I interpret emerging theologies of marriage and vowed friendship (expressed in civil partnership) within the Church of England as renewing the Church’s traditional three benefits of marriage: mutuality, fidelity, and choices for parenting and nurture, in ‘pro/creative’ relationships
The perceived psychological stressors and coping behaviours in university students, on a pre-registration programme.
Get PDFThe purpose was to investigate perceived stressors and coping behaviours in student nurses on a pre-registration programme of study. Stress in student nurses has been identified with decreased emotional well-being and poor academic achievement. The significance of stress and coping behaviours in students during training has implications for education and practice.
The present study recruited eighty seven pre-registration student nurses in a cross sectional design. Bivariate and multivariate analyses assessed the differences in field and year of study and the students’ perceived stress and coping behaviours.
The findings showed that stress is a significant issue in nurse training. Fifty-three percent of the participants had levels higher than the mean. Interestingly, the present study found that high perceived stress was associated with avoidance behaviours. The most common type of perceived stress and ranked by highest factor were from written assignments and a lack of professional skills and knowledge. Their peer group and everyday life activities were shown as potential ways of coping with stressors. Thus, it seems reasonable to focus support on decreasing avoidant and enhancing stress-reducing behaviours.
Psychological stress and coping behaviours must be considered together as perceived stress is bound by the ability to ameliorate stress by managing helpful and unhelpful behaviours.
The findings may suggest that a potential benefit could come from the provision of helpful strategies such as peer group support and reduction of avoidant behaviours. Also, there seems to be a need for greater mental health literacy in dealing with stress during training
A Trace of Actions Unseen: The Photographic Error as Photography ‘in performance’
Get PDFPublication of full article from conference paper delivered at Times and Movements of the Image conference, Lisbon November 2018In contemporary digital photography the accident or fault is an increasingly rare and unusual phenomenon, but it presents valuable insights into the practice of photography. This article discusses how the photographic error reveals qualities of the photographic experience normally hidden in conventional photographs, and proposes a reconsideration of time in relation to photography perceived through the accidental image. The error is conceived as a performance, extending the conventional time scales of the photograph from the ‘snap’ into three ‘acts’: the photographic event, the recording of an image and, lastly, interpretation by the viewer. In each stage the error’s relationship to time is shown to be ambiguous and multifaceted, counterpointing a simplified concept of time which prevails in the conventional photograph. The error exposes the entanglement of actors and relationships within the act of photographing and in so doing destabilises common assumptions about photographs as simple, immediate documents
Optimisation and management of energy generated by a multifunctional MFC-integrated composite chassis for rail vehicles
Get PDFWith the advancing trend towards lighter and faster rail transport, there is an increasing interest in integrating composite and advanced multifunctional materials in order to infuse smart sensing and monitoring, energy harvesting and wireless capabilities within the otherwise purely mechanical rail structures and the infrastructure. This paper presents a holistic multiphysics numerical study, across both mechanical and electrical domains, that describes an innovative technique of harvesting energy from a piezoelectric micro fiber composites (MFC) built-in composite rail chassis structure. Representative environmental vibration data measured from a rail cabin have been critically leveraged here to help predict the actual vibratory and power output behaviour under service. Time domain mean stress distribution data from the Finite Element simulation were used to predict the raw AC voltage output of the MFCs. Conditioned power output was then calculated using circuit simulation of several state-of-the-art power conditioning circuits. A peak instantaneous rectified power of 181.9 mW was obtained when eight-stage Synchronised Switch Harvesting Capacitors (SSHC) from eight embedded MFCs were located. The results showed that the harvested energy could be sufficient to sustain a self-powered structural health monitoring system with wireless communication capabilities. This study serves as a theoretical foundation of scavenging for vibrational power from the ambient state in a rail environment as well as to pointing to design principles to develop regenerative and power neutral smart vehicles
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