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Assessing the behaviour, welfare and husbandry of mouse deer (Tragulus spp.) in European zoos
Get PDFMouse deer are primitive, forest ungulates found in Asia and Africa. Both the lesser mouse deer (Tragulus javanicus) and the Philippine mouse deer (T. nigricans) are managed in European zoos, but inconsistent breeding success between institutions, high neonatal mortality and a general lack of research on their husbandry and behaviour were identified by the coordinators of the European Endangered Species Programme (EEP) and the European Studbook (ESB) for each species, respectively. This study is the first to provide a behavioural description for the Philippine mouse deer and to compile a detailed behavioural repertoire for both species. Our aim was to identify the effects of current husbandry and management practices on the reproduction, behaviour and welfare of zoo-housed mouse deer. Questionnaires on husbandry and management practices were sent to all institutions in the EEP and ESB for the lesser and Philippine mouse deer, respectively, and behavioural data were collected in 15 of these zoos. For the lesser mouse deer, results show a positive effect of vegetation cover on breeding success, foraging and moving behaviours. The provision of enrichment and presence of water ponds also positively affected these behaviours. The time that pairs spent in close proximity had a negative effect on breeding success, but animals in more vegetated enclosures spent less time in close proximity to each other. Results could be partially explained by the natural habitat of this usually solitary species being tropical forest, which provides local water sources and undergrowth for cover from predators. For the Philippine mouse deer there were differences in activity measures recorded between zoos, but the sample size was small with differences in training, enrichment and vegetation cover likely to have been important. In conclusion, since mouse deer inhabit overlapping male and female territories, the usual practice of housing breeding pairs together may be appropriate, but we suggest that they should be provided with opportunities to avoid each other in complex enclosures with ample vegetation cover to maximise their natural behavioural repertoire and breeding success
The Salvation of Animals in a Christian Context: Future Beliefs and Current Challenges
No full textThe salvation of animals in a Christian context examining future beliefs and current challenges
Stephen Clarke: End of the Season
Get PDFA solo exhibition of an ongoing project that focused on family holidays at Rhyl, the seaside resort in North Wales. The exhibition at the Grosvenor Museum, Chester (25 July – 18 October 2015) comprised black & white digital photographic prints, vintage silver gelatin prints, and colour digital photomontages; a wall-mounted hand-drawn map and a DVD transfer of cine film footage; four themed vitrines that displayed photobooks, postcards and print ephemera from Clarke’s personal archive. The exhibition hinged on the artist’s photobooks of Rhyl published by the independent publisher Café Royal Books: Ocean Beach, Rhyl (2014); Rhyl Seafront (2015); and Rhyl Caravan Parks (2015). Accompanying the exhibition were two public lectures given by Stephen Clarke ‘Picturing the British Holiday’ (17 Aug. 2015) and ‘Holiday-ed in North Wales’ (17 Sept. 2015); and a public drawing performance titled ‘Drawing the End of the Season’ (25 and 26 July, 2015)
Reciprocal priming between receptor tyrosine kinases at recycling endosomes orchestrates cellular signalling outputs
Get PDFFrom Wiley via Jisc Publications RouterHistory: received 2020-10-29, rev-recd 2021-04-27, accepted 2021-04-28, pub-electronic 2021-06-04Article version: VoRPublication status: PublishedFunder: Wellcome Trust; Grant(s): 107636/Z/15/Z, 210002/Z/17/ZFunder: UKRI | Biotechnology and Biological Sciences Research Council (BBSRC); Id: http://dx.doi.org/10.13039/501100000268; Grant(s): BB/R015864/1, BB/M011208/1Funder: UKRI | Medical Research Council (MRC); Id: http://dx.doi.org/10.13039/501100000265; Grant(s): MR/T016043/1Funder: Cancer Research UK (CRUK); Id: http://dx.doi.org/10.13039/501100000289; Grant(s): A27445Funder: NIHR Manchester Biomedical Research Centre; Grant(s): IS‐BRC‐1215‐20007Funder: Breast Cancer Now; Grant(s): MAN‐Q2‐Y4/5Abstract: Integration of signalling downstream of individual receptor tyrosine kinases (RTKs) is crucial to fine‐tune cellular homeostasis during development and in pathological conditions, including breast cancer. However, how signalling integration is regulated and whether the endocytic fate of single receptors controls such signalling integration remains poorly elucidated. Combining quantitative phosphoproteomics and targeted assays, we generated a detailed picture of recycling‐dependent fibroblast growth factor (FGF) signalling in breast cancer cells, with a focus on distinct FGF receptors (FGFRs). We discovered reciprocal priming between FGFRs and epidermal growth factor (EGF) receptor (EGFR) that is coordinated at recycling endosomes. FGFR recycling ligands induce EGFR phosphorylation on threonine 693. This phosphorylation event alters both FGFR and EGFR trafficking and primes FGFR‐mediated proliferation but not cell invasion. In turn, FGFR signalling primes EGF‐mediated outputs via EGFR threonine 693 phosphorylation. This reciprocal priming between distinct families of RTKs from recycling endosomes exemplifies a novel signalling integration hub where recycling endosomes orchestrate cellular behaviour. Therefore, targeting reciprocal priming over individual receptors may improve personalized therapies in breast and other cancers
Advances in Biofabrication for Tissue Engineering and Regenerative Medicine Applications
Get PDFFrom MDPI via Jisc Publications RouterHistory: accepted 2021-04-25, pub-electronic 2021-05-09Publication status: PublishedBiofabrication strategies continue to gain considerable interest in the efforts to develop methods for better replicating in vitro models of human tissues [...
Changes in physical activity and sedentary behaviour due to enforced covid-19-related lockdown and movement restrictions: A protocol for a systematic review and meta-analysis
Get PDFProlonged lockdown/restriction measures due to the COVID-19 pandemic have reportedly impacted opportunities to be physically active for a large proportion of the population in affected countries globally. The exact changes to physical activity and sedentary behaviours due to these measures have not been fully studied. Accordingly, the objective of this PROSPERO-registered systematic review is to evaluate the available evidence on physical activity and sedentary behaviours in the general population during COVID-19-related lockdown/restriction measures, compared to prior to restrictions being in place. Defined searches to identify eligible studies published in English, from November 2019 up to the date of submission, will be conducted using the following databases: CENTRAL, MEDLINE, EMBASE, CINAHL, SPORTDiscus, PSYCinfo, Coronavirus Research Database, Public Health Database, Publicly Available Content Database, SCOPUS, and Google Scholar. The applied inclusion criteria were selected to identify observational studies with no restrictions placed on participants, with outcomes regarding physical activity and/or sedentary behaviour during lockdown/restriction measures, and with comparisons for these outcomes to a time when no such measures were in place. Where appropriate, results from included studies will be pooled and effect estimates will be presented in random effects meta-analyses. To the best of our knowledge, this will be the first systematic review to evaluate one complete year of published data on the impact of COVID-19-related lockdown/restriction measures on physical activity and sedentary behaviour. Thus, this systematic review and meta-analysis will constitute the most up-to-date synthesis of published evidence on any such documented changes, and so will comprehensively inform clinical practitioners, public health agencies, researchers, policymakers and the general public regarding the effects of lockdown/restriction measures on both physical activity and sedentary behaviour
Tracheostomy for COVID-19: evolving best practice
Get PDFFrom Springer Nature via Jisc Publications RouterHistory: registration 2021-07-06, online 2021-08-31, pub-electronic 2021-08-31, collection 2021-12Publication status: PublishedAbstract: This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2021. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2021. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from https://link.springer.com/bookseries/8901
The role of attachment, coping style and reasons for substance use in substance users with psychosis
Get PDFFrom Wiley via Jisc Publications RouterHistory: received 2021-02-19, rev-recd 2021-08-20, accepted 2021-08-21, pub-electronic 2021-09-02Article version: VoRPublication status: PublishedFunder: Medical Research Council; Id: http://dx.doi.org/10.13039/501100007155; Grant(s): G0200471Abstract: Seventy substance users with psychosis who were participating in a clinical trial of a psychological therapy for psychosis were additionally assessed for attachment, coping styles and self‐reported reasons for substance use in order to test a hypothesized sequential mediation model. In this model the relationship between insecure attachment and problematic substance use was assumed to be sequentially mediated by dysfunctional coping and the use of substances to cope with distress. Hypothesized associations between insecure‐avoidant attachment and substance use were not supported, but the relationship between insecure‐anxious attachment and problematic substance use was confirmed and found to be fully mediated by dysfunctional coping and coping reasons for use. Findings suggest that fostering secure attachments in people with psychosis might promote more successful coping and could prevent or reduce substance use related problems in this group
This is how it feels: activating lived experience in the penal voluntary sector
Get PDFThis is a pre-copyedited, author-produced PDF of an article accepted for publication in British Journal of Criminology following peer review. The version of record [Buck, G., Tomczak, P., & Quinn, K. (2022). This is how it feels: Activating lived experience in the penal voluntary sector. British Journal of Criminology, 62(4), 822–839] is available online at: [https://academic.oup.com/bjc/advance-article/doi/10.1093/bjc/azab102/6407608?searchresult=1].Increasing calls for ‘nothing about us without us’ envision marginalised people as valuable and necessary contributors to policies and practices affecting them. In this paper, we examine what this type of inclusion feels like for criminalised people who share their lived experiences in penal voluntary sector organisations. Focus groups conducted in England and Scotland illustrated how this work was experienced as both safe, inclusionary and rewarding and exclusionary, shame-provoking and precarious. We highlight how these tensions of ‘user involvement’ impact criminalised individuals and compound wider inequalities within this sector. The individual, emotional and structural implications of activating lived experience therefore require careful consideration. We consider how the penal voluntary sector might more meaningfully and supportively engage criminalised individuals in service design and delivery. These considerations are significant for broader criminal justice and social service provision seeking to meaningfully involve those with lived experience
A comprehensive review of the composition, nutritional value, and functional properties of camel milk fat
Get PDFRecently, camel milk (CM) has been considered as a health-promoting icon due to its medicinal and nutritional benefits. CM fat globule membrane has numerous health-promoting properties, such as anti-adhesion and anti-bacterial properties, which are suitable for people who are allergic to cow’s milk. CM contains milk fat globules with a small size, which accounts for their rapid digestion. Moreover, it also comprises lower amounts of cholesterol and saturated fatty acids concurrent with higher levels of essential fatty acids than cow milk, with an improved lipid profile manifested by reducing cholesterol levels in the blood. In addition, it is rich in phospholipids, especially plasmalogens and sphingomyelin, suggesting that CM fat may meet the daily nutritional requirements of adults and infants. Thus, CM and its dairy products have become more attractive for consumers. In view of this, we performed a comprehensive review of CM fat’s composition and nutritional properties. The overall goal is to increase knowledge related to CM fat characteristics and modify its unfavorable perception. Future studies are expected to be directed toward a better understanding of CM fat, which appears to be promising in the design and formulation of new products with significant health-promoting benefits
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