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A Roman Villa near Rossett
Get PDFIn the light of the discovery of the Roman lead ingot near Rossett in 2019, a partnership project was established between the University of Chester and Wrexham Museum with the aim of investigating its wider archaeological context. As part of this, the footprint of a winged-corridor villa was identified. This article outlines the initial findings and their potential significance
Covid-19, the Second World War, and the Idea of Britishness
Get PDFThis is an Accepted Manuscript that has been published in [Covid-19, the Second World War, and the Idea of Britishness] edited by [Joanne Pettitt] in the series [British Identities since 1707]. The original work can be found at: [https://doi.org/10.3726/b17562]. © [copyright holder (in most cases this Peter Lang AG), 2021]. All rights reserved.This chapter considers the disruption of the funerary ritual during the Covid-19 pandemic and reflects on the connections between these disruptions and state intervention in funerary practice during the Second World War. Through an analysis of how such intervention has occurred, and the language of sacrifice that has been evoked in both instances, it will be suggested that the fracturing of the formal rituals of death and commemoration has not only led to complicated grief amongst individuals, but that it could also result in long- term societal trauma
Rates of turnover among general practitioners: a retrospective study of all English general practices between 2007 and 2019.
Get PDFFrom Europe PMC via Jisc Publications RouterHistory: ppub 2021-08-01, epub 2021-08-22Publication status: PublishedObjectiveTo quantify general practitioners' (GPs') turnover in England between 2007 and 2019, describe trends over time, regional differences and associations with social deprivation or other practice characteristics.DesignA retrospective study of annual cross-sectional data.SettingAll general practices in England (8085 in 2007, 6598 in 2019).MethodsWe calculated turnover rates, defined as the proportion of GPs leaving a practice. Rates and their median, 25th and 75th percentiles were calculated by year and region. The proportion of practices with persistent high turnover (>10%) over consecutive years were also calculated. A negative binomial regression model assessed the association between turnover and social deprivation or other practice characteristics.ResultsTurnover rates increased over time. The 75th percentile in 2009 was 11%, but increased to 14% in 2019. The highest turnover rate was observed in 2013-2014, corresponding to the 75th percentile of 18.2%. Over time, regions experienced increases in turnover rates, although it varied across English regions. The proportion of practices with high (10% to 40%) turnover within a year almost doubled from 14% in 2009 to 27% in 2019. A rise in the number of practices with persistent high turnover (>10%) for at least three consecutive years was also observed, from 2.7% (2.3%-3.1%) in 2007 to 6.3% (5.7%-6.9%) in 2017. The statistical analyses revealed that practice-area deprivation was moderately associated with turnover rate, with practices in the most deprived area having higher turnover rates compared with practices in the least deprived areas (incidence rate ratios 1.09; 95% CI 1.06 to 1.13).ConclusionsGP turnover has increased in the last decade nationally, with regional variability. Greater attention to GP turnover is needed, in the most deprived areas in particular, where GPs often need to deal with more complex health needs. There is a large cost associated with GP turnover and practices with very high persistent turnover need to be further researched, and the causes behind this identified, to allow support strategies and policies to be developed
Socio-economic and demographic impacts on the full awareness of the methods for controlling/preventing the spread of COVID-19 among social media users in some African countries at the onset of the pandemic.
Get PDFFrom Europe PMC via Jisc Publications RouterHistory: ppub 2021-08-01, epub 2021-08-27Publication status: PublishedObjectiveIn Africa, most countries continue to battle COVID-19 with cases of newly infected still being recorded. In this note, we investigate how socioeconomic and demographic factors affected individuals awareness on the methods for controlling/preventing the spread of COVID-19 in some parts of Africa at the onset of the pandemic.ResultsBased on regression modelling, we find that having full awareness does not depend on religious affiliation. Men, urban dwelling, holding bachelors or higher degrees, operating multiple social media accounts or being employed are associated with having full awareness of the recommended practices for the prevention and control of COVID-19 at the early stage of the pandemic. No occupation, business or older people are associated with not having full awareness
Good Practice in Action Fact Sheet 120
No full textThis practitioner factsheet looks at the factors that counsellors and psychotherapists need to keep in mind when working with clients who present at risk. Good practice indicators are outlined, as well as evidence-informed interventions
A novel averaging principle provides insights in the impact of intratumoral heterogeneity on tumor progression
Get PDF© 2021 by the authors. Licensee MDPI, Basel, Switzerland.Typically stochastic differential equations (SDEs) involve an additive or multiplicative noise term. Here, we are interested in stochastic differential equations for which the white noise is nonlinearly integrated into the corresponding evolution term, typically termed as random ordinary differential equations (RODEs). The classical averaging methods fail to treat such RODEs. Therefore, we introduce a novel averaging method appropriate to be applied to a specific class of RODEs. To exemplify the importance of our method, we apply it to an important biomedical problem, in particular, we implement the method to the assessment of intratumoral heterogeneity impact on tumor dynamics. Precisely, we model gliomas according to a well-known Go or Grow (GoG) model, and tumor heterogeneity is modeled as a stochastic process. It has been shown that the corresponding deterministic GoG model exhibits an emerging Allee effect (bistability). In contrast, we analytically and computationally show that the introduction of white noise, as a model of intratumoral heterogeneity, leads to monostable tumor growth. This monostability behavior is also derived even when spatial cell diffusion is taken into account.Mic2Mode-I2T; Grant(s): 01ZX1710B, 01ZX1308D, 01ZX1707C, 031L0085B, ZT-I- 392 0010, 96 73
Aridity-driven shift in biodiversity-soil multifunctionality relationships.
Get PDFFrom Europe PMC via Jisc Publications RouterHistory: ppub 2021-09-01, epub 2021-09-09Publication status: PublishedFunder: Biotechnology and Biological Sciences Research Council; Grant(s): BB/P022987/1Funder: National Natural Science Foundation of China; Grant(s): 31770430Relationships between biodiversity and multiple ecosystem functions (that is, ecosystem multifunctionality) are context-dependent. Both plant and soil microbial diversity have been reported to regulate ecosystem multifunctionality, but how their relative importance varies along environmental gradients remains poorly understood. Here, we relate plant and microbial diversity to soil multifunctionality across 130 dryland sites along a 4,000 km aridity gradient in northern China. Our results show a strong positive association between plant species richness and soil multifunctionality in less arid regions, whereas microbial diversity, in particular of fungi, is positively associated with multifunctionality in more arid regions. This shift in the relationships between plant or microbial diversity and soil multifunctionality occur at an aridity level of ∼0.8, the boundary between semiarid and arid climates, which is predicted to advance geographically ∼28% by the end of the current century. Our study highlights that biodiversity loss of plants and soil microorganisms may have especially strong consequences under low and high aridity conditions, respectively, which calls for climate-specific biodiversity conservation strategies to mitigate the effects of aridification
Altered protein O-GlcNAcylation in placentas from mothers with diabetes causes aberrant endocytosis in placental trophoblast cells
Get PDFFrom Springer Nature via Jisc Publications RouterHistory: received 2021-05-28, accepted 2021-09-27, registration 2021-10-06, pub-electronic 2021-10-19, online 2021-10-19, collection 2021-12Publication status: PublishedAbstract: Women with pre-existing diabetes have an increased risk of poor pregnancy outcomes, including disordered fetal growth, caused by changes to placental function. Here we investigate the possibility that the hexosamine biosynthetic pathway, which utilises cellular nutrients to regulate protein function via post-translationally modification with O-linked N-acetylglucosamine (GlcNAc), mediates the placental response to the maternal metabolic milieu. Mass spectrometry analysis revealed that the placental O-GlcNAcome is altered in women with type 1 (n = 6) or type 2 (n = 6) diabetes T2D (≥ twofold change in abundance in 162 and 165 GlcNAcylated proteins respectively compared to BMI-matched controls n = 11). Ingenuity pathway analysis indicated changes to clathrin-mediated endocytosis (CME) and CME-associated proteins, clathrin, Transferrin (TF), TF receptor and multiple Rabs, were identified as O-GlcNAcylation targets. Stimulating protein O-GlcNAcylation using glucosamine (2.5 mM) increased the rate of TF endocytosis by human placental cells (p = 0.02) and explants (p = 0.04). Differential GlcNAcylation of CME proteins suggests altered transfer of cargo by placentas of women with pre-gestational diabetes, which may contribute to alterations in fetal growth. The human placental O-GlcNAcome provides a resource to aid further investigation of molecular mechanisms governing placental nutrient sensing
Furred and feathered friends: How attached are zookeepers to the animals in their care?
Get PDFThis is the peer reviewed version of the following article: [Melfi, V., Skyner, L. J., Birke, L., Ward, S. J., Shaw, W. S., & Hosey, G. (2022). Furred and feathered friends: How attached are zookeepers to the animals in their care? Zoo Biology, 41(2), 122-129], which has been published in final form at [https://doi.org/10.1002/zoo.21656]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.Keeper-animal relationships (KARs) appear to be important in zoos, since they can enhance the well-being of both the animals and the keepers, can make animal husbandry easier, but conversely might risk inappropriate habituation of animals and possible risks to the safety of keepers. It is, therefore, important to know more about the variables involved in relationship formation. Here we use a modified version of the Lexington Attachment to Pets Scale (LAPS) to measure the strength of KARs between keepers and animals in their care, both in the zoo and in the home. LAPS questionnaires were completed by 187 keepers in 19 different collections across three countries. LAPS scores for attachment to zoo animals (ZA) were significantly lower than for pet animals (PA). There was no significant difference in ZA scores between different taxa, but there were significant taxon differences between PA scores. There were significant differences in both ZA and PA scores between different collections. Female respondents scored more highly than males for both ZA and PA. Multiple regression revealed that location, gender, and time spent with animals were significant predictors for ZA, while only gender and taxon were significant predictors for PA. It was concluded that PA scores were comparable with those for the general public, and reflected strong attachment of keepers to their pets, while ZA scores, although also reflecting attachment, were influenced by differences in institutional culture. [Abstract copyright: © 2021 Wiley Periodicals LLC.
Key Terms in Comics Studies_Cover Illustration
Get PDFThis entry is related to 'Key Terms in Comics Studies: Introductory Chapter' - http://hdl.handle.net/10034/625503 and 'Key Terms in Comics Studies: 22 Entries' - http://hdl.handle.net/10034/625597Cover image for the book 'Key Terms in Comics Studies'
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