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    Ilan Manouach’s 'Abrégé de bande dessinée franco-belge': ontography and the past and future of stories

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    This is an Accepted Manuscript of a book chapter published by Routledge in [Ilan Manouach in Review Critical Approaches to his Conceptual Comics] on [08/09/2023], available online: https://www.routledge.com/Ilan-Manouach-in-Review-Critical-Approaches-to-his-Conceptual-Comics/Moura/p/book/9781032399713This chapter will consider Manouach’s own explanation of the genesis of Abrégé de bande dessinée franco-belge (2018) in theorisations of cross-media visual correspondence systems (Bogost 2012), utilising the concept of the ontograph, or “a graphical […] representation that provides concise and detailed information about the units and the ways they relate with each other in a particular situation” (Manouach 2019: np). Instumentalising this concept, as a method of production, Abrégé tests a general hypothesis derived from Jean-Christoph Menu's 2005 polemical analysis of mainstream commercial bande dessinée. The chapter will interrogate this idea – and Manouach’s methods for producing the book – in terms of a range of related concepts: first, the use of social conventions as productive constraints, according to Jan Baetens' proposal that "“the study of constrained writing should no longer be restricted to the study of internal constraints in high-cultural texts that are detached from their cultural and historical context" (2010:76). Second, what Crucifix calls “undrawing”, or the disruption of “the relationship between drawing and storytelling to refocus attention on the social and political economy of the drawn image” (Crucifix 2019:7). Third, collage, as a method of interrogation or resistance (Brockelman 2011) and, finally, Wilde’s theorisation of characters without storyworlds, or kyara (Wilde 2019). The chapter will conclude that Abrégé de bande dessinée franco-belge accumulates redacted and arranged fragments, of which readers have memories that appear stylistically and discursively similar. These memories establish an identity for Manouache’s sources by identifying storyworlds, rather than stories. Then the storyworld not only includes the causes and consequences of the object of depiction, that is, its past and future, but also the pasts and futures of the ideas that the reader employs to make sense of the image

    An evolutionary perspective of lifespan and epigenetic inheritance

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    In the last decade epigenetics has come to the fore as a discipline which is central to biogerontology. Age associated epigenetic changes are routinely linked with pathologies, including cardiovascular disease, cancer, and Alzheimer's disease; moreover, epigenetic clocks are capable of correlating biological age with chronological age in many species including humans. Recent intriguing empirical observations also suggest that inherited epigenetic effects could influence lifespan/longevity in a variety of organisms. If this is the case, an imperative exists to reconcile lifespan/longevity associated inherited epigenetic processes with the evolution of ageing. This review will critically evaluate inherited epigenetic effects from an evolutionary perspective. The overarching aim is to integrate the evidence which suggests epigenetic inheritance modulates lifespan/longevity with the main evolutionary theories of ageing

    Challenges in the management of Non-Alcoholic Fatty Liver Disease (NAFLD): Towards a compassionate approach

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    Representing a growing ‘silent epidemic’, non-alcoholic fatty liver disease (NAFLD) affects around 25–30% of the general population. Alarmingly, NAFLD increases the risk of cardiovascular disease, both independently and through its strong associations with obesity, type 2 diabetes, and metabolic syndrome, whilst posing a substantial burden from an economic and health-related quality of life perspective. Moreover, growing evidence links NAFLD to common mental health disorders including depression, anxiety, and stress. In this context, recent clinical and research attention further focuses on potential additional problems faced by patients with NAFLD, such as perceived stigma, lack of awareness regarding the condition, and possible feelings of loneliness and isolation that might emerge from unmet support needs. To date, despite a wealth of literature on NAFLD, management of the condition remains challenging and not straightforward, with most cases in primary care being treated with lifestyle modification on top of any other comorbidity treatment. However, for many patients with NAFLD, weight loss is hard to accomplish and/or sustain (e.g., patients may lack the skills, confidence, and motivation required to adhere to dietary changes, and/or may have problems limiting opportunities for increased physical activity). Therefore, tailored interventions which are manageable from the perspective of the individual patient with NAFLD could glean greater results. Accordingly, although there is a lack of research exploring the potential benefits of person-centered and compassion-based approaches to the management of NAFLD, in the present review, we draw on evidence from methods utilized in the treatment of other chronic conditions in postulating the view that such approaches might prove beneficial in the future management of NAFLD

    Examining human-technological relationships and the pursuit of godhood in Battlestar Galactica

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    This thesis explores the extent to which science fiction conveys latent sociocultural attitudes about the human pursuit of godhood through technology. The use of myth as a conceptual lens becomes a means to negotiate different strategies for analysing popular culture, providing a rationale for the selection of methods which prioritise and emphasise certain narrative traits. The entities in this field (humanity, technology, God, culture) are located within a unifying framework and ontological scheme of process (process studies, process theology, and process philosophy). This thesis undertakes a theological engagement with fictional speculations about human divinity obtained, emulated, or performed by technological means. Theological appraisal of these exemplars against alternative conceptions of divine nature (such as those of process theism) exposes their (problematic) potential. Conceiving divinity solely in terms of creative provenance, ownership, dominion, and control alludes to the need for alternative configurations of human -technological relationships. The metaphor of myth-as-lens (described by Wendy Doniger) helps frame science fiction narratives for engagement at the level at which they are consumed. Using principles of processual research, a conception of myth is articulated to emphasise points of interest, and to facilitate both interdisciplinary dialogue, and theological research performed from an agnostic perspective. This approach recognises how some narratives seemingly solicit or call for engagement as though they were myth (in a mythical mode or manner), and how the use of myth (as a concept) is already established in theological engagements with popular culture. In this case, the mythoanalytical lens oscillates between broader genre analysis of science fiction, and more focused case study of Ronald D. Moore’s 2004-2009 re-imagined television series Battlestar Galactica. Theological appraisal of these fictional examples of relatedness exposes the truth they conceal and contain. This reveals the damaging potential of relationships conceived in techno-demonological terms of lost control, and the need for refigured relationships constituted through openness to technological agency and a nurturing encouragement of technology towards an optimal aim

    An evaluation of Upton Rocks PMS pilot site

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    © University of ChesterOver the last decade the NHS has undergone many policy and organisational changes and the message of government policy initiatives during the 1990s was that the successful development of primary care depended on greater local flexibility and a reduction in central regulation. The NHS (Primary Care) Act 1997 allowed for the voluntary establishment of different methods for delivering general medical and other services through local, flexible contracting arrangements. One of the principles set out by the NHS (Primary Care) Act 1997 was that all Personal Medical Services (PMS) pilot sites thus established should be evaluated. This document presents the findings of the local evaluation of a ‘third wave’ PMS pilot site in North Cheshire

    Fgf signalling triggers an intrinsic mesodermal timer that determines the duration of limb patterning

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    Complex signalling between the apical ectodermal ridge (AER - a thickening of the distal epithelium) and the mesoderm controls limb patterning along the proximo-distal axis (humerus to digits). However, the essential in vivo requirement for AER-Fgf signalling makes it difficult to understand the exact roles that it fulfils. To overcome this barrier, we developed an amenable ex vivo chick wing tissue explant system that faithfully replicates in vivo parameters. Using inhibition experiments and RNA-sequencing, we identify a transient role for Fgfs in triggering the distal patterning phase. Fgfs are then dispensable for the maintenance of an intrinsic mesodermal transcriptome, which controls proliferation/differentiation timing and the duration of patterning. We also uncover additional roles for Fgf signalling in maintaining AER-related gene expression and in suppressing myogenesis. We describe a simple logic for limb patterning duration, which is potentially applicable to other systems, including the main body axis

    Development of online cancer resources to support pre-registration nurses and allied health professionals

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    This document is the Accepted Manuscript version of a Published Work that appeared in final form in [British Journal of Nursing], copyright © MA Education, after peer review and technical editing by the publisher. To access the final edited and published work see [https://www.magonlinelibrary.com/doi/abs/10.12968/bjon.2023.32.17.S14].Cancer rates are increasing, and more people are living with cancer and its consequences. Healthcare students will be caring for people affected by cancer in all clinical contexts. However, pre-registration programmes can include limited cancer education and not all students will have the opportunity for a clinical placement in a cancer setting. This can result in healthcare students feeling unprepared to care for people affected by cancer. To address this need, nine e-learning modules, collectively called The Foundations of Cancer Care, have been developed to support students' knowledge, understanding and confidence about cancer. This article outlines the development and peer review of The Foundations of Cancer Care. The resultant modules are freely available to all those with an Open Athens account or NHS or UK university email address via the NHS Learning Hub ( https://learninghub.nhs.uk ).AAM added to record on 9/11/2023

    Using EEG to measure resilience in postgraduate business students and its importance for future leaders

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    This paper aims to examine the time individuals take to recover from adverse effects presented to them. This is important because leadership, particularly transformational leadership, primarily focuses on an individual’s social interactions and their ability to exhibit resilience within their workplace. Zehir & Narcıkara (2016) identify the need for resilience of individuals as this culminates in increased levels of organisational resilience, which is a necessity for ensuring the ability to cope which a changing geo-political landscape

    The Influence of Polycystic Ovary Syndrome (PCOS) and Other Related Factors upon Health-Related Quality of Life in Women of Reproductive Age: A Case-Control Study

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    This study aimed to assess the impact of a polycystic ovary syndrome (PCOS) diagnosis and other factors on health-related quality of life (HRQoL) in women of reproductive age. Online questionnaires were completed and study groups compared. Potential causal relationships were evaluated using path analysis. Analyses revealed that a PCOS diagnosis alongside BMI had the largest effect on HRQoL. Higher levels of physical activity (PA) were not associated with greater HRQoL, and PA was not directly affected by any other outcome. However, reduced self-esteem was identified as a key factor in the promotion of physical and mental health.Part of a PhD funded project (CK) through Aston Universit

    Views about euthanasia and dementia: exploring perceptions utilising evidence from the Mass Observation Archive

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    This paper contributes to the ongoing discussion in the United Kingdom regarding euthanasia and assisted dying, using data specifically related to individuals with dementia. A qualitative approach was taken with data captured via a set of written questions in the form of a Mass Observation Archive Directive. The respondents, known as Observers, provided written responses; there was no limit to the length of the responses and the Observers were able to provide as much or as little detail as they chose. The data were analysed thematically utilising NVivo software. One-hundred and seven responses were received, representing a range of beliefs, and with opinions regarding euthanasia and dementia with pro, anti, and uncertain views being expressed. Five main themes emerged during our data analysis: capacity, legislation, agency and personal philosophies, disquietude, and incumbrance. Consistent with previous research capturing public views regarding euthanasia and assisted dying for people with dementia, the findings suggest policy makers may wish to consult the British public regarding legislation regarding euthanasia and dementia

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