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A novel method to forecast nitrate concentration levels in irrigation areas for sustainable agriculture
No full textThis study developed an ANN-based model to predict nitrate concentrations in drainage waters using parameters that are simpler and more cost-effective to measure within the Lower Seyhan Basin, a key agricultural region in Turkey. For this purpose, daily water samples were collected from a drainage measurement station during the 2022 and 2023 water years, and nitrate concentrations were determined in the laboratory. In addition to nitrate concentrations, other parameters, such as flow rate, EC, pH, and precipitation, were also measured simultaneously. The complex relationship between measured nitrate values and other parameters, which are easier and less costly to measure, was used in two different scenarios during the training phase of the ANN-Nitrate model. After the model was trained, nitrate values were estimated for the two scenarios using only the other parameters. In Scenario I, random values from the dataset were predicted, while in Scenario II, predictions were made as a time series, and model results were compared with measured values for both scenarios. The proposed model reliably fills dataset gaps (Scenario I) and predicts nitrate values in time series (Scenario II). The proposed model, although based on an artificial neural network (ANN), also has the potential to be adapted for methods used in machine learning and artificial intelligence, such as Support Vector Machines, Decision Trees, Random Forests, and Ensemble Learning Methods.Scientific and Technological Research Council of Turkiye (TUBITAK); TUBITAK; [122Y007]This research was funded by Scientific and Technological Research Council of Turkiye (TUBITAK), Project number: 122Y007. The authors thank the TUBITAK for obtaining financial support for this work
LGS sınav sürecinde ailelerin öğrencilere manevi̇ destekleri̇
No full textBu araştırma, LGS sınav sürecinde ailelerin çocuklarına sağladığı manevi
desteklerin, öğrencilerin sınav kaygısını azaltma, iç huzuru bulma ve kendine güveni
artırma üzerindeki etkilerini incelemeyi amaçlamaktadır. Çalışma kapsamında, LGS
sınavına hazırlanan öğrencilerin aileleri ile derinlemesine mülakatlar yapılmıştır.
Toplamda on aile ile gerçekleştirilen bu mülakatlar, ailelerin çocuklarına sağladıkları
manevi destek türlerini ve bu desteklerin sınav sürecindeki etkilerini anlamamıza
olanak tanımıştır. Araştırmanın bulguları, ailelerin dua ve dini pratikler, olumlama ve
motivasyon konuşmaları, manevi danışmanlık ve rehberlik gibi çeşitli yöntemlerle
çocuklarına manevi destek sağladıklarını göstermektedir. Dua ve dini pratikler,
öğrencilerin iç huzurunu bulmalarına ve sınav kaygısını azaltmalarına yardımcı
olurken, olumlama ve motivasyon konuşmaları, öğrencilerin kendine olan güvenlerini
artırmada etkili olmuştur. Manevi danışmanlık ve rehberlik ise, öğrencilerin manevi
olarak güçlenmelerine ve sınav sürecinde daha huzurlu ve odaklanmış olmalarına
katkı sağlamıştır. Bu araştırma, manevi desteğin, öğrencilerin sınav kaygısını
azaltmada, iç huzuru bulmada ve kendine güveni artırmada önemli bir rol oynadığını
ortaya koymaktadır. Ailelerin çocuklarına sağladıkları manevi destek, öğrencilerin
sınav sürecinde daha başarılı olmalarına ve genel olarak daha iyi bir akademik
performans sergilemelerine yardımcı olmaktadır. Araştırma bulguları, gelecekte
benzer süreçlerden geçecek ailelere yol gösterici olmayı ve onların çocuklarına daha
iyi manevi destek sağlamalarına yardımcı olmayı hedeflemektedir.This study aims to examine the effects of the spiritual support provided by
families to their children during the LGS exam process on reducing students' exam
anxiety, finding inner peace, and increasing self-confidence. Within the scope of the
study, in-depth interviews were conducted with families of students preparing for the
LGS exam. These interviews, conducted with a total of ten families, allowed us to
understand the types of spiritual support families provide to their children and the
effects of this support during the exam process. The findings of the study show that
families provide spiritual support to their children through various methods such as
prayer and religious practices, affirmation and motivational talks, spiritual
counseling, and guidance. While prayer and religious practices help students find
inner peace and reduce exam anxiety, affirmation and motivational talks were
effective in increasing students' self-confidence. Spiritual counseling and guidance
contributed to students' spiritual strengthening and being more peaceful and focused
during the exam process. This study reveals that spiritual support plays an important
role in reducing students' exam anxiety, finding inner peace, and increasing selfconfidence. The spiritual support that families provide to their children helps students
be more successful during the exam process and generally have better academic
performance. The research findings aim to guide families who will go through similar
processes in the future and help them provide better spiritual support to their children
Sıvı kromatografide kullanılan kolonların dolum süreçlerinin araştırılması
No full textBu çalışmada, ters faz sıvı kromatografi (RPLC) tekniği için kullanılan
kolonların dolum süreçlerinin optimizasyonu ve performans üzerindeki etkileri incelenmiştir. Araştırmanın temel amacı, kolon dolum parametrelerinin ayırma verimliliği, pik simetrisi ve teorik plaka sayısı gibi performans kriterlerine olan etkisini ortaya koymak ve mevcut yöntemlere yenilikçi bir yaklaşım getirmektir.Çalışma kapsamında, C18 sabit faz materyali kullanılarak kolon dolum işlemleri yüksek basınç altında (500 bar) gerçekleştirilmiştir. Dolum solventi olarak metanol ve metanol-su karışımları tercih edilmiş; doldurulan kolonların performansı kalite kontrol testleri (teorik plaka sayısı, pik genişliği ve pik asimetrisi) kullanılarak değerlendirilmiştir. Halihazırda kullanılan kolon ile yeni geliştirilen kolon, optik beyazlatıcı saflık analizleri ile karşılaştırılmıştır. Elde edilen bulgulara göre, yeni geliştirilen kolonun performansı iyileşmiştir. Özellikle teorik plaka sayısında artış gözlenmiş; pik genişliklerinde daralma ve pik asimetrisinde iyileşme sağlanmıştır. Bu sonuçlar, yeni dolum tekniklerinin kolon içi partikül dağılımını homojenleştirdiğini ve kolon verimliliğini artırdığını ortaya
koymaktadır Sonuç olarak, bu çalışma, kolon dolum parametrelerinin optimizasyonunun RPLC performansı üzerinde doğrudan etkili olduğunu göstermekte ve endüstriyel analizlerde yüksek verimlilik sağlayan yeni kolon teknolojilerine katkıda bulunmaktadır.This is the segments of the filling sections of the columns used for phase liquid chromatography (RPLC) technology and their distributions on performance. The main
purpose of the research is to reveal the performance criteria such as separation
differences, peak symmetry and theoretical plate numbers of column filling change
and to present the current calculations comprehensively.
Within the scope of the study, column filling pressures produced from C18 material
were carried out under constant pressure (500 bar). Methanol and methanol-water
mixtures were preferred as filling solvents; the performance of the filled columns was
evaluated using quality control tests (theoretical plate count, peak width and peak
asymmetry). The new column was compared with the currently used column by optical
brightener purity analyses.
According to the findings, the performance of the new detail column showed
improvement. In particular, an increase in theoretical plates was observed; changes in
peak width and peak asymmetry were improved. These results show that the new
filling techniques homogenize the problems in the column and increase the column
areas.
As a result, this study shows that the performance of column filling parameters directly
affects the RPLC performance and contributes to new column technologies that
provide high efficiency in industrial analyses
Social studies-specific field skills acquired by primary school students in the process of virtual museum education
No full textErol, Ahmet/0000-0002-7538-952XThis study focuses on how virtual museum education (VME) can support elementary school students' social studies-specific domain skills (spatial perception, using evidence, location analysis, perceiving change and continuity, and perceiving time and chronology). For this purpose, the study was conducted using action research, one of the qualitative research traditions. The study participants consisted of fourth-grade students selected by convenience sampling. Data were collected through a pre-intervention interview form, a post-intervention interview form, an observation form, and student drawings. In this context, students participated in virtual museum training, one museum per week for seven weeks. The data obtained were analyzed using content analysis. According to the findings, VME improved students' using evidence, location analysis and spatial perception. Additionally, VME contributed to students' understanding of perceiving change and continuity and a deeper understanding of perceiving time and chronology. Therefore, these immersive experiences effectively help students acquire social studies skills
Nesfatin-1, Kisspeptin, 5-Alpha Reductase-1, and Aromatase in Men With Metabolic Syndrome and Hypogonadism
No full textObjective: Metabolic syndrome (MS)-associated hypogonadism in men is a prominent issue and occurs through complex pathogenetic pathways. We investigated levels of kisspeptin, nesfatin-1, aromatase, 5-alpha reductase-1 (5AR-1), and gene expressions of aromatase and 5AR-1 that affect these pathways. Methods: Twenty six hypogonadal males with MS (group 1), 26 eugonadal males with MS (group 2), and 26 healthy males (group 3) in Pamukkale University Hospital were included in this study. Serum kisspeptin, nesfatin-1, aromatase, and 5AR-1 levels were determined by ELISA, and gene expressions were determined by real-time polymerase chain reaction. Data were analyzed in the SPSS 25.0 program. Results: Kisspeptin and nesfatin-1 levels in groups 1 and 2 were similar but lower than in group 3 (P = .001). Aromatase and 5AR-1 levels were significantly lower in group 1 than in group 3 (P = .006, P .001). Aromatase levels of groups 1 and 2 were also similar. 5AR-1 and aromatase expressions were not statistically significant. Conclusions: Nesfatin-1 can be a mediator in the pathogenesis of MS but not directly for hypogonadism. As a regulator of the hypothalamic-pituitary-gonadal axis, kisspeptin may affect this pathogenesis just by MS. 5-Alpha reductase-1 may also act on hypogonadism. Hypogonadism may be a case affected by the process rather than its main result of aromatase.Scientific Research Projects Coor-dination Unit of Pamukkale University [2020TIPF002]Funding: This study was supported by the Scientific Research Projects Coor-dination Unit of Pamukkale University (Grant number 2020TIPF002)
Bor zenginleştirme proses atığı içeren nanokompozit katkılı çevre dostu kabloların üretilmesi
No full textDünya’da en zengin bor yataklarına sahip ülkemizde bor mineralleri üretimi esnasında yıllık ortalama 600.000 ton atık ortaya çıkmaktadır. Bu atıklardan elde edilen bor nanokilin (BNK) değerlendirilmesi hem çevre sorunlarının azaltılmasına hem de kablo sektöründe kullanılarak katma değeri yüksek ürün eldesine imkan sağlayacaktır.
Bor atıklarının farklı alanlarda kullanımına yönelik birçok çalışma bulunmaktadır. Ancak bu atıklardan nano bor elde edilmesi ve bunun kablo imalatında kullanımına yönelik çalışma ilk olacaktır.
BNK katkılı kablo üretimi ile başta yanmazlık olmak üzere, mukavemet, oksijen ve termal indeksi gibi özelliklerinin iyileştirilmiş çevre dostu, sürdürülebilir, düşük maliyetli, rekabetçi ve uluslararası standartları karşılayan bir kablo üretilmesi amaçlanmaktadır.In our country, which has the richest boron deposits in the world, an average of 600,000 tons of waste is generated annually during the production of boron minerals. Evaluation of boron nanoclay (BNK) obtained from these wastes will enable both to reduce environmental problems and to obtain products with high added value by using it in the cable industry.
There are many studies on the use of boron wastes in different areas. However, the study on obtaining nano boron from these wastes and its use in cable manufacturing will be the first.
With the production of BNK additive cable, it is aimed to produce a cable that is environmentally friendly, sustainable, low cost, competitive and meets international standards with improved features such as inflammability, strength, oxygen and thermal index
Hayatboyu öğrenme kurumlarında görevli öğretmenlerin teknoloji kullanımında temel yeterlilikleri ile teknostres düzeyleri arasındaki ilişki
No full textBu araştırmada hayat boyu öğrenme kurumlarında görevli öğretmenlerin teknostres düzeyleriyle teknoloji kullanımı yeterlikleri arasındaki ilişki araştırılmıştır. Araştırma ilişkisel tarama modelinde yapılmıştır. Araştırmada öğretmenlerin teknostres düzeylerine yönelik algı düzeyleri genel olarak orta düzeydedir. Öğretmenlerin teknoloji kullanımında yeterlilik algı düzeyleri temel teknolojik yeterlilikler orta düzeyde iken EBA kullanım yeterliliklerive genel teknoloji kullanımı yeterliği yüksektir. Kadın ve erkek öğretmenlerin teknostres düzeylerine yönelik algı düzeylerinin benzer olduğu görülmüştür. Öğretmenlerden temel teknolojik yeterlilikleri ve genel teknoloji kullanımı yeterlikleri erkek öğretmenlerin kadın öğretmenlerden yüksek çıkmıştır. Öğretmenlerin teknostres düzeyleri bütün alt boyut ve genel olarak 46 yaş ve üstündeki öğretmenler lehine farklılık göstermektedir. Öğretmenlerin teknoloji kullanımında yeterlilik düzeyleri 24-35 yaşlardaki öğretmenlerin lehine farklılık göstermiştir. Öğretmenlerin teknostres düzeyleri bütün boyutlarda ve genel olarak bekar öğretmenler lehine yüksektir. Öğretmenlerin teknoloji kullanımında yeterlilik düzeylerinin medeni durumlarına göre evli öğretmenlerin temel teknoloji yeterliklerinin bekarlardan yüksek iken bekar öğretmenlerin genel teknoloji kullanımı yeterliklerinin evli öğretmenlerden yüksektir. Öğretmenlerin genel tekno stresdüzeyleri lisansüstü mezunu öğretmenlerin lisans mezunu öğretmenlerden daha yüksek çıkmıştır. Öğretmenlerin teknoloji kullanımında yeterlilik düzeylerinin öğrenim düzeylerine göre farklılık göstermemiştir. Pozisyonlarına göre mesleğe yönelik stresleri ücretli öğretmenlerin kadrolu öğretenlerden yüksek ölçülmüştür. Kadrolu öğretmenlerin teknolojik yeterlilikleri ücretli öğretmenlerden yüksektir. 11 yıl ve üzeri kıdemi olan öğretmenlerin mesleğe yönelik stresleri 1-5 yıl kıdemlilere göre daha yüksek çıkmıştır.
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Öğretmenlerin teknoloji kullanımında yeterlilik düzeyleri 1-5 yıl okul kurum kıdemi olanların en yüksek düzeyde iken kıdem süresi arttıkça ortalamaların düştüğü tespit edilmiştir. Öğretmenlerin genel teknostres düzeylerine yönelik algıları ile genel teknoloji kullanımında yeterlilik düzeyleri arasında ters yönlü ve orta düzeyde ilişki olduğu görülmüştür
The roles of miR-101, miR-1183 and miR-1299 in acute rheumatic fever and rheumatic heart disease
No full textIntroduction: Acute rheumatic fever commonly causes carditis in children. It is critical to have biomarkers for diagnostic and prognostic purposes. We aimed to investigate the expressions of miR-101, miR-1183, and miR-1299 in children with acute rheumatic fever and rheumatic heart disease and determine their potential as diagnostic biomarkers. Methods: This cross-sectional study was conducted on 69 paediatric acute rheumatic fever patients and 27 gender and age-matched controls. The clinical findings were noted from medical records, echocardiography was repeated, and plasma miR-101, miR-1183, and miR-1299 expressions were studied using RT-PCR. Results: Out of 54 patients with carditis, 36 developed rheumatic heart disease with significant left-sided heart involvement. No significant demographic difference was present between rheumatic heart disease patients and controls (p > 0.05). miR-101 and miR-1183 expressions significantly reduced by 4.5-fold in acute rheumatic fever patients compared to controls (p : 0.029 and p : 0.024, respectively). Family history was found to be significantly associated with 9-fold reduced miR-1183 expression in acute rheumatic fever patients (p : 0.005). The expression of miR-1183 in acute rheumatic fever children with carditis in general and severe carditis was significantly reduced 4.5- and 9-fold, respectively (p : 0.024 and p : 0.007, respectively). In acute rheumatic fever cases with moderate-severe carditis and patients who did not develop rheumatic heart disease, miR-1183 expression significantly reduced 8.3-fold and 9-fold, respectively (p : 0.015 and p : 0.019, respectively). The ROC analysis revealed that miR-101 and miR-1183 were statistically significant for acute rheumatic fever diagnosis (AUC: 0.64 for both miRNAs). Conclusions: Significantly lower plasma expressions of miR-101 and miR-1183 in acute rheumatic fever patients, especially in cases with moderate-severe carditis, might indicate the potential use of these miRNAs as diagnostic biomarkers
Secukinumab Treatment in Patients With Hidradenitis Suppurativa in Real-World Clinical Settings: a Multicenter Study
No full textIntroduction: Treatment of hidradenitis suppurativa (HS) remains a challenge in clinical practice for dermatologists. Although the effectiveness and safety of secukinumab (SEC) in the treatment of HS have been demonstrated in phase III studies, real-world data is limited. Objectives: We conducted a retrospective multicenter study to evaluate the effectiveness and safety of SEC treatment in HS patients in real-world settings. Methods: Adult patients who were diagnosed with HS and used SEC for at least 3 months were included in the study. Results: A total of 31 patients were included in the study; 14 of them (45.2%) were female. The mean age was 39.32 +/- 10.26 years, and the mean disease duration was 11.77 +/- 7.99 years. Nine (29%) patients were biologic-naive and 10 (32.3%) were adalimumab-naive. Disease severity was Hurley Iin 7 patients (22.6%), Hurley II in 9 patients (29%), and Hurley III in 15 patients (48.4%). The Hidradenitis Suppurativa Clinical Response (HiSCR) was achieved in 20 patients (64.5%) in the third month of treatment. SEC treatment was discontinued due to primary ineffectiveness in 9 (29%) patients, secondary ineffectiveness in 1 (3.2%) patient, adverse effects in 1 (3.2%) patient, and loss of follow-up in 1 (3.2%) patient. Paradoxical pyoderma gangrenosum was observed as an adverse effect in 1 patient that resolved after discontinuing SEC and starting infliximab. Conclusions: SEC appears to be an effective and safe treatment option for HS, especially when used in the early and mild stages of the disease and in biologic-naive patients
Morphology and controls of the alluvial fan systems along the Zanskar Shear Zone, Northwest Himalaya, India
No full textTopal, Savas/0000-0001-7451-6606Alluvial fans are prominent geomorphic landforms that develop at the junction of mountain slopes and valley floors. This study investigates the morphological characteristics of alluvial fans along the Zanskar Shear Zone to identify the key variables influencing their development and morphodynamics. Despite being among the world's most significant semi-arid terrestrial fans, their morphology and controlling factors remain largely unexplored. Using advanced remote sensing and GIS techniques, combined with field investigations, we conducted a detailed spatial analysis of 37 fans, located on both sides of the Doda River. This approach enabled precise mapping and characterization of these fans within the complex depositional settings of the Doda Valley, particularly where fans coalesce into bajadas. Our analysis revealed significant variability in fan attributes, including Flow Expansion Angle (FEA), Fan Entrenchment (FME), Base length (BF), Fan Area (FA), Fan Slope (SF), and Radius (R). A morphometric analysis was then conducted to evaluate the correlation between the fans and their corresponding basins. To deepen this understanding, power law regression was applied, revealing both positive and negative relationships between fans and basin characteristics. The findings underscore the key role of upstream basins in regulating sediment delivery to the fans. Larger basins contribute to the development of larger, less steep fans, driven by higher sediment supply and greater flows from basins with denser drainage networks. Low values of Smf Index, Vf ratio and Drainage Basin Shape suggest that upstream basins are significantly influenced by tectonic forces. These forces result in linear mountain fronts, V-shaped valleys and elongated basins, indicative of active tectonic deformation. Along the mountain fronts of the Doda Valley, fan morphology is controlled by a complex interplay of long-term tectonic activity, climate, upstream lithology, and basin characteristics. Tectonic forces, particularly those associated with the NW-SE-trending ZSZ, exert a primary influence on fan morphology by controlling sediment-flux and accommodation space. This is evident in tectonically modified landforms, such as wine-glass valleys with narrow outlets, triangular facets with broad bases and active mountain fronts, all indicative of recent uplift and ongoing tectonic activity. These findings strongly suggest that tectonic structures like the ZSZ, which dips approximately 20 degrees NE and continuously responds to tectonic collision, play a pivotal role in shaping fan morphodynamics. Additionally, climatic factors, such as increased glacial melt and freeze-thaw cycles, enhance erosion in upstream basins, particularly those fed by glaciers on the southwestern side of the valley. This process amplifies sediment supply to the fans, highlighting the dual influence of climate and tectonics in shaping regional fan systems. Overall, the findings demonstrate that ZSZ exert a dominant influence on the geometry and evolution of these fans, with climatic factors significantly contributing to their formation