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Neopterin, β2-Microglobulin and Carbohydrate Antigen CA-19-9 in Sporadic Adult Amyotrophic Lateral Sclerosis
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In 38 patients diagnosed as adult sporadic amyotrophic lateral sclerosis (ALS), and negative for relevant anti -ganglioside, anti-borrelia or anti-Boma disease virus antibodies, we determined serum concentrations of neopterin, ~rmicroglobulin, immunoglobulin-G isotypes G1-G", carbohydrate antigen CA-19-9, as well as repeated enzyme linked immuno-assay (ELISA) serum antibodies to human spuma retrovirus (HSRV, human foamy virus=HFV) envelope plus gag./capsid antigen, and competition with maedi-visna virus antibodies in an blocking ELISA Confirmed by specific HFV-gag immunoblots and measured under code, 26% of tested ALS-patients and 4% of 195 other neurological controls reacted ELISA and immunoblot antibody-positive against HFV. In a maedi-visna virus blocking ELISA, 47/50 sera from 28/30 ALS patients competed with anti-visna lentivirus antibodies more than healthy controls (p<0.05). In serum, however, f3r microglobulin and neopterin concentrations were normal in different stages of motor neuron disease. Maximal individual mean values for serum CA-19-9, anti-visna competition or circulating IgG immune complexes associated with positive serum antibodies against human recombinant foamy retroviral antigen, while macrophage activation measured as serum neopterin did not © I
Neopterin, β2-Microglobulin, Tryptophan and Kynurenine In Sporadic Amyotrophic Lateral Sclerosis
No full textSummary In 62 patients diagnosed as sporadic amyotrophic lateral sclerosis (sALS), we quantitated serum concentrations of neopterin, β2-microglobulin. kynurenine and tryptophan. A linear increase with age was demonstrated by neopterin more than by β2-microglobulin, whereas neither parameter corresponded to individual progression or duration of disease at the time of examination. All serum (n = 79) and cerebrospinal fluid (CSF, n = 11 patients) concentrations remained within reference limits, and serum neopterin always exceeded CSF neopterin. Serum neopterin was not elevated in sALS. and we observed no correlation between circulating IgG isotype concentrations and serum neopterin. Total duration of sALS. as measured in months from the first clinical signs or symptoms to death, seemed. however. to inversely correlate with the mean patient serum neopterin before and after correction for age, and in the absence of any neoplastic process. If confirmed in a larger number of sALS patients, this would parallel a reportedly negative association of CSF neopterin and survival in human immunodeficiency virus (HIV1) infection