84404 research outputs found
Sort by
Disrupted Circadian Clocks in the Kidney: A Hidden Link Between Injury and Heart Disease
No full textAcute kidney injury (AKI) is a sudden loss of kidney function that can increase the risk of heart disease, even after the kidneys seem to recover. But why does this happen? One possible clue lies in the body’s internal clock, or circadian rhythm, which helps regulate many biological processes, including heart and kidney function.
In our study, we used a special type of mouse that glows in response to circadian activity, allowing us to track how the body’s clock behaves after AKI. Twelve weeks after injury, we found signs of damage in the heart’s blood vessels, similar to early-stage heart disease. Surprisingly, this damage wasn’t linked to high blood pressure, cholesterol, or long-term kidney failure.
Instead, we discovered that AKI disrupts the circadian rhythms in different parts of the kidney, weakening the rhythm in the inner medulla while strengthening it in the cortex. Other organs kept their normal rhythms. These findings suggest that kidney injury may trigger heart disease by disturbing the kidney’s internal clock, pointing to a new potential target for treatment.
About the Presenter
Bio: Dr. Lauren Douma is a Research Assistant Professor of Biochemistry and Molecular Biology in the College of Medicine at the University of Florida. Trained in biochemistry, genetics, and physiology, she takes an interdisciplinary approach to her research focusing on the regulation of gene expression and its effect on overall homeostasis. For her Ph.D. in Genetics and Genomics (2016), she focused on the mechanisms of DNA replication and repair proteins in Dr. Linda Bloom’s laboratory within the Department of Biochemistry & Molecular Biology at the University of Florida. This research sparked her interest in the timing of cellular processes relative to the whole body. As an American Heart Association Postdoctoral Fellow, she worked on circadian clock regulation of kidney gene expression in the laboratory of Dr. Michelle Gumz in the Department of Physiology and Aging at the University of Florida. Building upon her training in biochemistry and genetics, she incorporated physiology to connect the mechanisms of circadian clock transcription factors to the maintenance of blood pressure rhythms in both a sex- and tissue-specific manner. She is further exploring how circadian clock function changes with age and if circadian-based interventions can alter these age-related changes. Dr. Douma is also passionate about science education. Her primary teaching role is overseeing and teaching in BCH4024 – Introduction to Biochemistry & Molecular Biology, which has a yearly
enrollment of ~1500 students. In conjunction with this course, she manages the largest Supplementary Instruction (SI) Program at the University of Florida. The SI Program comprises motivated and supportive undergraduate students who performed well in BCH4024 and became SI Leaders to tutor current students in the course. She believes science is for everyone. It inspires creativity, critical thinking, and curiosity about the world around us. In her spare time, Dr. Douma loves reading fantasy books, playing with her dog, and trying new foods
Dominio de las Funciones del Maestro del Programa de Educación Especial y el Efecto en Su Desempeño Laboral Mediante la Plataforma Mi Portal Especial en Puerto Rico
No full textLos maestros de educación especial son clave en los procesos de enseñanza y aprendizaje de estudiantes con diversidad funcional para que alcancen su potencial académico y éxito personal. Además de cumplir con las normas, procesos, cartas circulares, estipulaciones, sentencia del caso de Caso Rosa Lydia Vélez (RLV) y políticas públicas, deben documentar y evidenciar su cumplimiento a través de la Plataforma Mi Portal Especial (MiPE).
La investigación se desarrolló con maestros adscritos al Programa de Educación Especial de la Región Educativa de Humacao del Departamento de Educación. El propósito fue examinar el dominio de las funciones del maestro del Programa de Educación Especial y su efecto en el desempeño laboral mediante la plataforma MiPE. Se analizaron cuatro preguntas de investigación utilizando métodos estadísticos descriptivos e inferenciales (ANOVA y Chi-cuadrado).
Los hallazgos permitieron evidenciar un alto dominio funcional del docente; en el uso de MiPE y en el caso de Rosa Lydia Vélez no se identificaron diferencias significativas. Tampoco se halló relación estadísticamente significativa entre el uso de MiPE y el desempeño normativo laboral, lo cual indica la necesidad de fortalecer la capacitación técnica y el apoyo institucional para una implementación efectiva.
Special education teachers play a key role in the teaching and learning processes of students with functional diversity, enabling them to reach their academic potential and achieve personal success. In addition to complying with regulations, procedures, circular letters, stipulations, the court ruling of the Rosa Lydia Vélez (RLV) case, and public policies, they must document and provide evidence of such compliance through the Mi Portal Especial (MiPE) platform.
The study was conducted with teachers assigned to the Special Education Program of the Humacao Educational Region of the Department of Education. Its purpose was to examine teachers’ mastery of their professional functions within the Special Education Program and its effect on job performance through the use of the MiPE platform. Four research questions were analyzed using descriptive and inferential statistical methods (ANOVA and chi-square).
The findings demonstrated a high level of functional mastery among teachers. No statistically significant differences were identified regarding the use of MiPE or compliance related to the Rosa Lydia Vélez case. Likewise, no statistically significant relationship was found between the use of MiPE and normative job performance, indicating the need to strengthen technical training and institutional support for more effective implementation
Emotional Regulation Strategies Used by Indonesian Teachers in Thailand: Descriptive Qualitative Study
No full textThe significance of this study is to explore insights into the emotions experienced by Indonesian English teachers in Thailand, highlighting their emotional journeys and the emotion regulation strategies they use. Ten Indonesian English teachers from diverse elementary and secondary schools across Thailand voluntarily participated in this qualitative research. Through semi-structured interviews, the collected data were analyzed deductively, applying Richards\u27 (2020) framework to examine teacher emotions and Gross\u27 (1998) framework to analyze emotion regulation strategies. The findings reveal a wide range of emotions, including happiness, pride, anger, confusion, loneliness, and mixed emotions. Notably, emotion regulation strategies, situation modification, and response modulation emerged as the predominant emotion regulation strategies employed. The findings also revealed sub-strategies under these emotion regulation strategies. These insights underscore the imperative of integrating emotion regulation practices into English Language Teaching to optimize instructional effectiveness. It highlights the pivotal role of emotional experiences in navigating cultural differences and linguistic barriers in teaching abroad, offering practical and theoretical implications for teachers, trainers, and educational institutions in Thai and similar contexts
The Consequences of Attempted Human Perfection: Genetic Enhancement and Why It Is Immoral
No full textIn the field of biomedical ethics, genetic enhancement—the alteration of human DNA to increase characteristics beyond normal function—is a highly contested topic. Genetic enhancement presents serious ethical issues, especially when gene therapy seeks to treat or prevent disease. This paper makes the consequentialist case that genetic enhancement, whether somatic or germline, is intrinsically unethical because of its ethical, societal, and systemic ramifications. The autonomy of future persons is violated by germline enhancement, which also runs the risk of deepening socioeconomic gaps and escalating intergenerational inequity. Even though it only affects the individual, somatic augmentation undermines human diversity and agency by promoting social stratification and devaluing effort and achievement. Responsibility demands that we consider the broader consequences of such technologies, ensuring that scientific advancements align with ethical principles. Unlike gene therapy, which restores health, enhancement contradicts medicine’s purpose and jeopardizes equitable and just practices in society
Exploring Teacher Perspectives on the Self-Esteem of Students with Emotional and Behavioral Disorders: A Qualitative Study
No full textSelf-esteem affects many other abilities of students with Emotional and Behavioral Disorders (EBD). Teachers can play a crucial role in influencing the self-esteem of these students. This interpretive qualitative study aims to investigate teachers\u27 perceptions of the self-esteem of students with EBD, identify the factors they believe affect these students’ self-esteem, and explore the strategies they employ to enhance the self-esteem of these students. The results reveal three key themes: first, teachers perceive that students with EBD frequently face challenges related to self-esteem; second, they recognize that a variety of factors influence the self-esteem of these students; and third, teachers believe that effective classroom and student management can improve the self-esteem of students with EBD
Hands Across The World (concept sketch)
No full textBrother of the late noted architect August Schildbach,
Peter Schildbach has become known for his ceramic art, having begun working in the medium during high school. Before relocating to Florida, Schildbach taught ceramics at the University of Massachusetts Amherst. He would later run an art studio in Alexandria, Virginia where he expanded his work to include porcelain and stoneware and would exhibit his sculptures throughout Virginia, Maryland, and Washington D.C. From 2008–2009 Schildbach was selected by the Association for Biblical Research in collaboration with the Israel Antiquities Authority to reconstruct ancient pottery from an archaeological excavation site in Israel dating more than 4,000 years. Schildbach’s work has been featured in Art Basel Miami Beach and is included in the permanent collection of the Wilzig Museum in Miami Beach.
This piece, Hands Across The World (2024), served as the conceptual reference for a forthcoming large scale public art sculptural being commissioned for a hospital in the Sebring area. The artwork concept was developed in collaboration with Cuban painter Marlene Marrero, a frequent artistic collaborator of Schildbach. The piece depicts a multicultural representation of outstretched arms from various parts of the earth joining at the center in a message of unity and healing.https://nsuworks.nova.edu/nsudigital_permuycollection/1024/thumbnail.jp
X-tructuras más Vivas #1
No full textBarcelo is an award-winning international Cuban artist. He is known as a Surrealist and his works advance the movement into the 21st century while maintaining a strong influence of psychology, particularly the unconscious, and what he described as “pictorial mysticism.” He drew comparisons to Salvador Dalí early in his career and has been covered in media including Art News, the Miami Herald, el Diario Yucatán, Caribbean Today as well as included in magazines and the Contemporary Latin American Artist Dictionary.
The subject of eight solo exhibitions, Barcelo has exhibited his work in several leading art markets including New York, Miami, and Coral Gables as well as internationally in Mexico and Cuba where he has also been commissioned to produce public art. His work has been featured in several museums including the Florida Latin American Museum Of Art, the Museo Nacional De Bellas Artes (National Museum of Fine Arts) of Cuba, and is in the permanent collection of the Wilzig Museum.https://nsuworks.nova.edu/nsudigital_permuycollection/1016/thumbnail.jp
Bette
No full textUnzueta was a major figure in Cuban and Spanish art in the early 21st century. His work was popular in Paris and in Spain and also had a presence in Miami, where he had a successful gallery. Unzueta was awarded the Key to the County of Miami-Dade during his first exhibition in South Florida, as well as a Distinguished Visitor Award to mark the notability of his work being shown there. He was the subject of two documentary films by filmmaker Ricardo Vega during his lifetime: Ramón Unzueta: Un peintre, un tableau (2008) and RAMON UNZUETA: en Ars Atelier (2010). His career was covered by various media outlets including the Artburst, the Miami Herald, Diario Las Americas and was the subject of two editions of the magazine Ars Atelier.
He ultimately died at the age of 50 in 2012, creating a scarcity of his work shortly afterwards. Since his death he has been the subject of a major book in 2016 and a museum career retrospective exhibition in 2023. His work is included in the permanent collection of the Frost Art Museum, the American Museum of the Cuban Diaspora, and the Wilzig Museum.
This piece is a rare surviving original work by the artist, and reflects the influence of film, and particularly the Golden Age of Hollywood, on his art, in this case depicting film legend Bette Davis.https://nsuworks.nova.edu/nsudigital_permuycollection/1014/thumbnail.jp
Beliefs of Beginner Pedagogical Researchers about Computer-Assisted Qualitative Data Analysis
No full textThis paper explores how computer-assisted qualitative data analysis appears in the beliefs and practical work of beginner researchers. The paper outlines the advantages of computer-assisted qualitative data analysis for beginner researchers, identifies the problems that may arise during this process, and discusses the topics where software capable of analysing multi-coded data can be utilised. The investigation was conducted through structured interviews. The text corpora were processed using a combined method that incorporated theory-driven deductive and data-driven inductive processes. The following were discussed: advantages and problems with computer-assisted qualitative data analysis, and topics where software for analyzing qualitative data can be used. Constructing the main codes was followed by an inductive exploration of text segments, during which subcodes corresponding to specific meanings were assigned to the main codes. Results confirmed that the software used contributed to the systematisation of qualitative analyses, made analysis quicker, and helped with data visualisation. Problems were the time factor, technical vocabulary, program use, and user awareness. If the software is used effectively, researchers can benefit from exploring the relationship between the method used and the software\u27s functions, as well as reflecting on the entire research process