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Sex-Dependent Affective and Cognitive Outcomes of Spinal Cord Injury: The Role of the Hippocampus and Effects of Systemically Administered Insulin-Like Growth Factor 1
No full textDepression and cognitive deficits among people with spinal cord injury (SCI) present at higher rates compared to the general population, yet these SCI comorbidities are poorly addressed. Sex and age appear to play roles in depression incidence, but consensus on the direction of their effects is limited. Systemic and cortical inflammation and disruptions in hippocampal neurogenesis have been identified as potential treatment targets, but a comprehensive understanding of these mechanisms remains elusive.
Presently, I used a rodent SCI model to interrogate previously identified post-injury depression-like behavior and cognitive deficits, in young and middle-aged male and female subjects, and their association through hippocampal neurogenesis. I investigated chronic systemic and hippocampal inflammation and their effects on hippocampal neurogenesis, affect, and cognition. Depression-like behavior manifested in male and female subsets of SCI rats irrespective of age, at rates commensurate with clinical depression incidence. Changes in components of behavior were driven by sex and age, and affective outcomes were independent of common postinjury pathophysiological outcomes including locomotor functional deficits and spinal lesion severity. However, only male depression-like SCI rats exhibited deficits in hippocampal associated spatial cognition and in hippocampal neurogenesis, which coincided with increases in neuroinflammation among middle-aged subjects.
I attempted to address these disruptions in affect, cognition, and neurogenesis with i.p. administration of IGF-1 within 24 hours of injury. IGF-1 administered i.c.v. has shown promise in recovering affect and cognition in SCI subjects. Although i.p. IGF-1 did not attenuate the manifestation of depression-like behavior in a subset of SCI rats or improve hippocampal neurogenesis responsible for affect, depression-like SCI subjects did exhibit cognitive function similar to non-depression-like SCI rats and improved hippocampal neurogenesis driving aspects of cognitive function. IGF-1 also robustly improved locomotor and weight recovery after injury, highlighting the pleiotropic effects of systemically administered IGF-1.
Overall, the present data suggest that post-SCI depression and cognition may in part be sex-differentially associated by hippocampal neurogenic and inflammatory processes, and that growth factors, administered judiciously, may play a beneficial role in the context of therapeutic strategies addressing psychological wellbeing after SCI
Economic Indicators of the College Station-Bryan MSA, November 2023
No full textThe Business-Cycle Index increased by a few decimal points in September and remained stable at 231 compared to the previous month. The local unemployment rate remained unchanged at 3.3% in September 2023 compared to August. Local nonfarm employment decreased by 0.05% from August to September. September��������s inflation-adjusted taxable sales were down by 2.3% from August. Cumulative Texas state tax revenues for fiscal year 2023 were 83.7 billion
Mitchell Interdiscipinary Studio Spring 2024
No full text3D Model of the neighborhood: The team organized, digitized, and spatialized historical information and present conditions of Tenth Street to create a Digital 3D model and physical model. 3D and 2D thematic maps were developed to showcase the complexity of the neighborhood's conditions over time, illustrating various aspects such as ownership patterns, vacancy rates, changes in topography, cultural landmarks, and socio-economic dynamics.
Exploration of Housing Typology: The team investigated and updated the established housing typology in the neighborhood. The objective was to explore speculative housing design strategies that preserve the community's distinct character and address vacancy through infill strategies. This exploration involved the hybridization of housing types found in the neighborhood, testing the roles of new construction and design in relation to established housing typologies.
Development of a Design Guideline Template: The team created a design guideline template to preserve the historical integrity of Tenth Street. Currently, there is no such document with the City of Dallas. This template will provide guidelines and standards to ensure that the district's new developments, renovations, or alterations align with its historical character and preservation goals.Oak Cliff's Tenth Street Neighborhood, a historic freedmen's town in South Dallas, listed on the National Register of Historic Places in 1994, is one of the nation's Freedmen's Towns known for its collection of modest folk and vernacular dwellings dating from the late 19th to the early 20th centuries. The neighborhood faces ongoing threats, including disinvestments, demolitions, and gentrification pressures, which makes it one of America's most endangered historic places (2019).
At the request of the Southern Dallas Progress CDC, Texas Target Communities received funding from Dr. Walter Peacock with Bryan Mitchell's Master Builder Endowment by hosting the Mitchell Interdisciplinary Studio 2024. This initiative was launched to advocate for housing, support and leverage academic research, and involve practitioners to assist with preserving and restoring historic landscapes, spaces, and buildings. The project spanned four graduate and undergraduate design studios, including joint virtual guest lectures, shared final presentations, and the exchange of self-generated documents and information. Students participated in a field trip, featuring two walking tour sessions led by a former landmark commissioner, visits to renovated historic houses, lunch discussions with residents, and a visit to Preservation Dallas where primary documents were shared in addition to a joint visit by the City of Dallas's current landmark commissioner, Chief Preservation Planner, and Senior Planner
Social Factory
No full textThe word industrial can be used to describe things that are cold, mass produced, fabricated, and repeated, but can industrial terminologies be used to reflect architecture that is as refined as the industrial process? The goal is to design a social factory that manufactures moments of interaction between people of different backgrounds within an industrial context. Detroit, a city founded on the great American dream and blue-collar workforce, now just a shell of its former glory it finds itself on the cusp of a revitalization movement. A city of industrial ruins searching to become a great American city once again, but lacking many of the infrastructure that can provide spaces for people to foster their curiosity and creativity
