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EGFR Over-Expression in ERBB2 Independent Colorectal Cancer
Get PDFColorectal cancer (CRC) remains the second leading cause of cancer-related deaths in the United States. ERBB2, a transmembrane growth factor receptor, serves as a negative predictive biomarker for human CRC. My investigation revolves around understanding the role of ERBB2 deficiency in CRC and evaluating its potential as a target for clinical therapies. Previous research, employing Ingenuity Pathways Analysis (IPA) and Gene Set Enrichment Analysis (GSEA), revealed the upregulation of genes associated with the EGFR signaling pathway in ERBB2 deficient murine colon tissue. This suggests a potential direct connection between EGFR upregulation and ERBB2 deficient tumors. I investigated this by utilizing a Western blot assay analysis to characterize protein concentrations and a cleaved caspase-3 assay to quantify the levels of apoptosis in murine colon tissue samples. My results found that in ERBB2 deficient tumors, EGFR overexpression was observed, indicated by higher EGFR protein concentration levels, and reduced levels of apoptosis
2010 Alternative Crop Options after Failed Cotton and Late-Season Crop Planting for the Texas South Plains
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