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Faculty Advisory Council Meeting Minutes, June 17, 2025
No full textThe University Archives has determined that this item is of continuing value to OSU's history
Confrontation and Covid(eo): Analyzing and Understanding the Right to Confrontation In Response to a Global Pandemic, and Beyond
No full textMedieval Slavic Summer Institute at Ohio State: Celebrating a Quarter Century of a Unique Educational Experience
Full text linkThe first MSSI in 1999 was 3 weeks long, subsequent institutes have lasted 4 weeks. The most recent MSSI 2024 was the 12th biennial institute. There have been 133 full-time, in-person participants mostly from North American & European universities; the top 10 institutions represented are: Ohio State (40 participants), Univ. of Michigan (9), Universidad Complutense de Madrid (8), Univ. of Cambridge (6), Univ. of Toronto (5), Univ. of Chicago (4), Univ. of Kansas (3) & UCLA (3), Central European Univ. (2) & Harvard (2). In 2024, Atmoja Bose became the first participant from the Univ. of Delhi (India), and Aleksa Karajić (Univ. of Belgrade, Serbia) the first from a Slavic country. We had previously focused on instructing students who did not have access to experts and manuscripts in Slavic Cyrillic at their home universities such as in Serbia, Bulgaria, North Macedonia, and Russia. Predrag Matejic taught MSSI 1999-2017, Daniel E. Collins – MSSI 1999-2019; M.A. Johnson took over from Predrag in 2019, and Bojan Belić (MSSI 1999) has taught Church Slavonic since MSSI 2022. From the beginning there have been guest lecturers, including the Very Rev. Dr. Mateja Matejic in 2003. Professor Jenn Spock’s practicum in reading Muscovite cursive has been a staple since 2006, and Professor Eric J. Johnson’s Western manuscript codicology and printing since 2011. Whenever possible, MSSI alumni are hired as RCMSS graduate research associates; since 2015, MSSI alumni have been invited back as MSSI guest lecturers.Special report dedicated to twenty-five years of the Medieval Slavic Summer Institute (1999-2024) - 12 biennial MSSIs sponsored by the Resource Center for Medieval Slavic Studies [RCMSS], the Hilandar Research Library [HRL], and the Department of Slavic and East European Languages and Cultures [SEELC], formerly the Department of Slavic and East European Languages and Literatures [SEELL], at The Ohio State University (Columbus, Ohio). Predrag Matejic (University Libraries) taught "Slavic Palaeography," and Daniel E. Collins (SEELL) taught "Readings in Church Slavonic." RCMSS Coordinator Helene F. Senecal handled visitor logistics, and HRL Assistant Curator M.A. Johnson provided research and teaching support.
Photos by M.A. Johnson, Helene F. Senecal, Jessi Jones, Daria Safronova, and Hope M. Wilson25 years of the MSSI have been possible only with the generous contributions of our donors to the various Hilandar endowment funds supported by local Serbian American families and others. Early donors to the Hilandar Research Project include the Arsenovich, Kozabarich, Ostich, Papich, Popovich, Roslovic, Schmoll, Tumbas, Vukovich, and Zunich families. In 2024, donors included Sally Arsenovich, Daniel E. Collins, Nena Couch, M.A. Johnson, David E. Kos, Jeri H. Kozabarich, Michael Malyak, Rosa Maria Moreno, Kara J. Mozina, Delia Negulesco, Geraldine Ostich, Sophia Papich, Lorraine Swank, and Michael R. Zunich. Milica Matejic Brust donated in memory of The Very Rev. Dr. Mateja and Protinica Ljubica Matejic, and Dr. Janice Zunich Katic & Milan Katic who donated to the HRL in memory of the Very Rev. Dr. Mateja Matejic on the occasion of their daughter Milana's October 2024 wedding.Table of Contents
Page 3: "From the Director's Desk" by M.A. "Pasha" Johnson; Page 4: "MSSI 1999"; Page 5: "MSSI 2001"; Page 6: "MSSI 2003" ; Page 7: "MSSI 2006"; Page 8: "MSSI 2008"; Page 9: "MSSI 2011"; Page 10: "MSSI 2013"; Page 11: "MSSI 2015"; Page 12: "MSSI 2017"; Page 13: "MSSI 2019"; Page 14: "MSSI 2022"; Page 15: "MSSI 2024"; Back Cover: "Celebrating 25 years of the Medieval Slavic Summer Institute!
Evaluating the Role of MeCP2 on Regulating the Antiviral CD8+ T cell Response
No full textMethyl-CpG binding protein 2 (MeCP2) regulates gene transcription by reading DNA methylation patterns. Mutations in MECP2 cause Rett syndrome (RTT), a neurodevelopmental disease that renders patients susceptible to severe respiratory infection, but how the loss of MeCP2 affects the immune response to respiratory infection remains unknown. Using a murine model of RTT, we asked how the loss of MeCP2 (Mecp2-/y) impacts the host response to Influenza A virus (A/Puerto Rico/8/34; IAV). Infected Mecp2-/y mice were more susceptible to virus-induced lung disease and had a higher mortality rate than wild-type infected mice. Lung transcriptional profiling following infection revealed that Mecp2-/y mice showed significantly delayed induction of genes associated with CD8+ T cell responses. In line with our transcriptional findings, we observed significantly lower lung recruitment of IAV-specific CD8+ T cells, identified by flow cytometry, in Mecp2-/y mice compared to WT mice. As CD8+ T cells are essential for clearing infectious viruses, we measured viral burden in the lungs and observed delayed viral clearance in Mecp2-/y mice. These findings suggest a role of MeCP2 in regulating CD8+ T cells, particularly during IAV infection. To closely examine if MeCP2 impacts cell intrinsic mechanisms regulating CD8+ T cells, we examined the gene expression profiles of isolated naïve CD8+ T cells from the spleens of WT and Mecp2-/y mice. Gene set enrichment analysis revealed positive enrichment of cell death pathways and negative enrichment of T cell receptor signaling components, indicating that MeCP2 regulates CD8+ T cell survival and activation. Future work will leverage an in vitro CD8+ T cell activation model, in which levels of stimuli can be experimentally manipulated, to identify mechanisms by which MeCP2 regulates CD8+ T cell survival, activation, and proliferation. Overall, this project aims to distinguish between potential cell-intrinsic and cell-extrinsic processes regulated by MeCP2 that shape essential antiviral CD8+ T cell response. These findings could hold significant clinical implications by helping illuminate the mechanisms that lead to severe respiratory infection amongst RTT patients.A five-year embargo was granted for this item.Academic Major: Neuroscienc
Does Glyphosate-Resistance in Giant Ragweed (Ambrosia trifida) Influence the Efficacy of Other Active Ingredients in a Tank-mix?
No full textHerbicide-resistance in weeds, one of the most pressing concerns in modern agriculture, can manifest itself in many mechanisms, from metabolic resistance to rapid necrosis. A grower in western Ohio observed populations of giant ragweed (Ambrosia trifida L.) that had survived different burndown applications and suspected that a rapid necrosis glyphosate-resistant biotype was negatively influencing control efforts. This study examined two populations of giant ragweed for control by various tank-mixtures that did and did not include glyphosate. Population A was reported as a control failure from atrazine + s-metolachlor + mesotrione + bicyclopyrone + glyphosate. Population S was reported as a control failure from saflufenacil + atrazine + glyphosate. An experiment was initiated with these two populations of giant ragweed to evaluate control from different herbicide combinations to elucidate the control provided by these herbicide combinations. The giant ragweed seed was collected and stratified in damp sand for 8 weeks at 4°C. Seeds were treated with a 10% bleach solution and rinsed with water for 10 minutes before being placed in rolled germination paper and placed into a growth chamber. Germinated seeds were planted in soilless media. Treatments for population A included 1x labeled rate applications of glyphosate, atrazine, mesotrione, glyphosate + atrazine, glyphosate + mesotrione, atrazine + mesotrione, glyphosate + atrazine + mesotrione + bicyclopyrone, and an untreated control. Treatments for population S included 1x labeled rate applications of glyphosate, atrazine, saflufenacil, glyphosate + atrazine, glyphosate + saflufenacil, atrazine + saflufenacil, glyphosate + atrazine + saflufenacil, and an untreated control. These populations were sprayed with a single-nozzle track spray chamber and control ratings (%) were taken at 14 and 21 days after treatment (DAT). The trial was terminated 21 DAT and plants were harvested at the soil surface, dried down at 60°C for three days, and weighed to collect biomass data. This data was analyzed to assess control efficacy and examine trends. For population A, there was no difference in herbicide treatments, with or without the inclusion of glyphosate at 14 or 21 DAT, other than glyphosate alone and the untreated control which had reduced control. The biomass of plants in population A was greatest for the untreated, followed by glyphosate, then followed by the rest of the treatment groups, which were not significantly different than each other. There were similar responses observed with population S. Although both populations had characteristics that suggested the rapid response resistance trait to glyphosate, the results of this study suggest that this likely did not result in the control failures observed in the field.No embargoAcademic Major: Sustainable Plant System
Rock House Nature Center
No full textThe Ohio State University Denman Undergraduate Research Forum - Earth and Beyond: 1st PlaceThe Ohio Department of Natural Resources (ODNR) partnered with Ohio State Design to develop an integrated response to discourage park visitors from littering. The result is a proposed nature center at the Rock House trailhead in Hocking Hills. The project aims to foster environmental awareness and promote sustainable behaviors among park visitors through nature-centered learning.
The Rock House Nature Center design features interactive displays and play areas that mimic the surrounding landscape. The center aims to deepen park visitors’ appreciation for nature by educating them about the area’s wildlife, geology, and history, while visually illustrating the environmental impact of littering. Through this, the nature center fosters a stronger connection between visitors and the natural world, inspiring more sustainable behaviors.
Through the integration of play, education, and natural design, the Rock House Nature Center aims to inspire visitors to develop a deeper appreciation for the environment. By raising awareness of how individual behaviors can impact the world around us, the project seeks to encourage sustainable practices that extend beyond the park visit, fostering lasting environmental stewardship.The Ohio Department of Natural ResourcesNo embargoAcademic Major: Industrial Desig
Enhanced Preoperative Screening: Implementing Additional Marijuana Education to Heighten Awareness of Perioperative Complications
No full textPurpose
Marijuana use has become socially acceptable in the United States, leading to an increase in the number of active users who will be having elective surgery. Using marijuana on the day of surgery has put this population at risk for many perioperative complications, including myocardial infarction, strokes, poor pain control, and difficult ventilation. The American Society of Regional Anesthesia (ASRA) and Pain Medicine has created the first consensus guidelines on the management of perioperative patients using marijuana. Well-educated preoperative nurses are critical in screening for active users and increasing patient compliance.
Design
A quality improvement design was employed to evaluate the impact of an educational in-service on the knowledge of comprehensive preoperative assessment clinic (ComPAC) nurses concerning the ASRA marijuana guidelines.
Method
Using the marijuana guidelines, a 17-question multiple-choice Qualtrics survey was created. The test was administered before a 45-minute educational intervention to assess baseline knowledge of marijuana. A post-test and one-month retest were also administered to determine if knowledge had improved and been retained.
Findings
The baseline knowledge score averaged 63%, and the post-test score increased to 83%. A one-tailed correlated t-test yielded a p-value of 0.0087. The one-month retention test revealed sustainable improvement, with an average score of 87%.
Conclusion
Educational intervention improved the knowledge regarding the perioperative risks associated with marijuana use. This project reinforces the need for ongoing professional education to enhance intraoperative patient safety and compliance.A three-year embargo was granted for this item
Final Third Foundation Community Garden
Full text linkCourse Code: ENR 4900.01Final Third Foundation (F3) is a soccer-based nonprofit in Columbus, Ohio. Pathways Park, their home soccer fields located in Easton, currently has a 1.5-acre, no mow soccer field that is no longer used for play. F3 hopes to convert this space, known as field 13, into a thriving community garden space. F3 envisions the garden with community plots that can be used by individual families, a communal growing space cared for by F3, and with an open learning space that can be used by the F3 family and in specific F3 programming. The introduction of this report explains the impact that community gardens can have on improving community nutrition and reducing food insecurity. F3 can use the information within this report to demonstrate the importance of the community garden to potential partners. Because the garden is in its very early planning stage, our products are focused on creating a framework for determining what is needed, securing resources, planning physical conversions, and executing the conversion. The report contains the overviews of four different products: grants, potential community partners, map, and land conversion. The grants document is an extensive list of local, state, regional, and national grants that provide funding to projects related to some aspect of the community garden. It includes grants focused on environmental and garden education, community nutrition, food security, urban agriculture, and similar related areas. It shows how much funding the grants offer, their deadlines, and where to apply. A list of potential community partners in Columbus was created based off of the partnerships we found in successful benchmarking examples. It is organized into categories including corporate partnerships, community engagement partnerships, and expertise and maintenance partnerships. This will help F3 identify partners that can assist during different stages of the conversion and maintenance processes. The map addresses how different land use allocations will impact the produce yields, how many families can be served, and how much labor each family and F3 can expect to put in to maintaining the land. It includes a recommendation of how to allocate space in the garden based off of our understanding of F3’s resources and priorities. The land conversion document reviews soil testing results and includes recommendations for soil amendments based off of the testing. It also explores the pros and cons of different aspects of land conversion, such as grass removal, fencing, and planting recommendations. Finally, we review the lessons we learned as a group throughout working on this project and provide recommendations to future capstone groups. These are lessons in working with partners in a professional capacity, project planning and execution, and how to allocate time throughout the semester to maximize success. Our advice includes setting a realistic project scope, reaching out for informational interviews early, and asking project partners specific questions. Academic Major: Environmental Scienc
Investigating the Determinants of Antibody Binding Against a Cancer-Related Glycoprotein The Crucial Role of the Heavy Chain CDRs
Full text linkUnderstanding antibody-target interactions is essential for the efficient development of immune therapeutics. Antibody variable domains contain the Complementarity-Determining Regions (CDRs) responsible for antigen binding, and framework regions (FR) that provide structural support. Various antibody numbering schemes have been developed in hopes of better characterization of CDRs, but the binding hotspots identified are not consistent across schemes. This inconsistency can lead to delays in drug discovery screenings as possible binding epitopes may be untested or mutations of the FR destabilize potentially viable proteins. Here we studied the binding of the 3E8 single chain variable fragment (scFv), part of a family of antibodies that bind to the sialyl-Tn (STn) glycan antigen on proteins, using mutagenesis studies. There is relatively little known of how glycan-binding antibodies interact with antigens, which adds to the complexity of developing therapeutics targeting these interactions. The 3E8 scFv CDR mutants were developed based on Kabat numbering scheme and through alanine scanning, to assess biochemical properties. Mutants’ functions were evaluated via dot blots and surface-plasmon resonance (SPR) assays and structurally defined by thermostability melts and X-ray crystallography. Based on analysis of the 3E8 scFv, current numbering schemes cannot predict all crucial residues, and some identified residues were unessential for binding. Only heavy chain CDR loops were observed to be critical for binding, specifically HCDR3, as mutations in this loop lead to significant decrease in binding ability. HCDR2 was identified as a target for further optimization studies as single point mutations in this loop were well tolerated. Single point CDR mutants highlighted a precise side pocket for antibody binding that was not accurately identified by sequence databases. These findings underscore the critical role of heavy chain CDRs, in antibody binding affinity and specificity, highlighting the need for refined numbering schemes to enhance the development of immune therapeutics. Further research into glycan-binding antibodies is needed to better understand their mechanisms and improve therapeutic strategies targeting glycan antigens.No embargoAcademic Major: Biochemistr