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Regrouping reverses social impairments and prefrontal parvalbumin-perineuronal nets alterations induced by post-weaning social isolation in male mice
No full textSocial isolation during early development can lead to abnormal adult behavior. These behavioral deficits are often associated with disruptions of perineuronal nets (PNNs), a condensed form of the brain's extracellular matrix. PNNs regulate neuroplasticity by enwrapping parvalbumin-expressing (PV) interneurons, and abnormal maturation of PNN in early life has been associated with behavioral deficits reminiscent of those following isolation. Past studies demonstrate that social regrouping following early isolation can improve behavioral deficits, but the underlying mechanisms of this recovery are unknown. This study aims to establish the effects of regrouping on PNNs as a potential cellular mediator of the behavioral rescue. We hypothesize that regrouping mice during adolescence will rescue early isolation-induced behavioral deficits associated with PNN restoration. We assigned male mice to group-housed, isolated, or isolated/regrouped conditions from weaning age until end of adolescence (postnatal day 21 to 67; N=8-10/group). Behaviors were assessed in the open field, novel object recognition, Y-maze, and social interaction tests. The number of PV cells and PNNs were quantified in the prefrontal cortex (PFC), dorsal and ventral hippocampus. Our results showed that early isolation led to hypersociability, which was rescued by regrouping; however regrouping also increased anxiety. Furthermore, isolation reduced the proportion of PV cells surrounded by PNNs in the PFC, and regrouping reversed this effect and increased the total PNN count in PFC while it decreased PV/PNN count in the ventral hippocampus. These findings suggest that behavioral improvements in the social domain may be associated with region-specific changes in PV interneuron plasticity.Undergraduate Research Scholarship, OSU College of Arts and SciencesNo embargoAcademic Major: Neuroscienc
Council on Academic Affairs: Minutes (September 17, 2025)
No full textMinutes from the Council on Academic Affairs' meeting on September 17, 2025
Sample Questions: Skill Development "Quiz"
Get PDFThis is a supplementary file for an article published in Engaging Students: https://doi.org/10.18061/esm.698
The Ohio State University Libraries Faculty Meeting Minutes, February 25, 2025
No full textThe University Archives has determined that this item is of continuing value to OSU's history
A Jury of Your Peers: Why You Are Not Actually Tried by a Jury of Your Peers, A Step-by-Step Guide to Jury Selection
Get PDF"How Did You Reach the Advanced Level of Chinese?" – Case Study of Graduates from OSU Chinese Program
Get PDFDespite the large number of Chinese language learners in the United States, only a small proportion attain advanced level, which remains insufficient to meet the growing demand for deeper U.S.-China communication. This study investigates the factors contributing to the achievement of advanced Chinese proficiency by examining the experiences of graduates from Ohio State University’s (OSU) Chinese program who have reached this level. Through qualitative interviews, the study explores their learning trajectories, reflections on their language education at OSU, and the impact of advanced Chinese proficiency on their careers and personal lives. Additionally, the study revisits the definition of advanced Chinese proficiency and discusses effective strategies for enabling learners to reach this level
Waterman Agricultural and Natural Resource Laboratory Wildlife Management Plan
Get PDFCourse Code: ENR 4900.01This project worked with the Waterman Agricultural and Natural Resources Laboratory to develop a comprehensive, evidence-based wildlife management framework. The project aimed to reduce crop depredation and research disruption caused by focal wildlife species through the creation of actionable species-specific deterrence plans. Focusing on American crows, common pigeons, Canada geese, white-tailed deer, groundhogs, and eastern cottontails, on-site deterrent testing and existing literature review were conducted and a GIS map was developed based on the findings. The project also designed a reporting and evaluation process for researchers to document ongoing wildlife disruption. These resources will provide an organized framework to respond to and reduce future disruption and depredation of research and university programs.Academic Major: Environmental Policy and Decision MakingAcademic Major: Environmental ScienceAcademic Major: Natural Resource Managemen
2025 City of Columbus Community-Based Deer Management Strategy
No full textCourse Code: ENR 4900.01Students completing this project partnered with Columbus City Council to address concerns regarding the city's deer populations and increasing concerns over property damage and public safety for residents. The team aimed to support the City of Columbus in their deer management efforts by analyzing data from city surveys and providing policy recommendations based on public opinion and the actions of similar municipalities. Additionally, the team connected with The Ohio State University Extension and the Ohio Department of Natural Resources to base recommendations on professional expertise. Based on these sources and data analysis conducted by the team, the students recommended lethal deer management practices as well as supporting non-lethal tactics like education and increased regional relations. The final products include a Findings Report listing the basic survey results, a Data Analysis Report outlining the variables assessed, a Policy Recommendations Report detailing the city’s options for implementing a deer management program, and maps created with GIS for reference of spatial distribution of deer and community opinion. These materials were presented to the City Council for consideration and served as the basis for future public hearings and internal processes in the policymaking process.Academic Major: Environmental Policy and Decision MakingAcademic Major: Environmental ScienceAcademic Major: Natural Resource Managemen