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Local Nursing Legends Class of 2025
Full text link2025 Annual Friends of Nursing History Lecture, "Local Nursing Legends: Class of 2025", May 15, 2025, Prior Hall, Room 550, The Ohio State University Medical Center Campus, Columbus, Ohio.The Local Nursing Legends program honors our fourth class of local nursing legends. Pioneers in their field, these five nurses were nominated by members of the central Ohio nursing community and approved by the Medical Heritage Center Friends of Nursing History Steering Committee for making a significant contribution to the nursing profession and the health care of people in central Ohio
On Rhetorically-Flavoured Speech Acts: A Case Study of Cantonese
Full text linkThis paper investigates the Cantonese sentence-final particle (SFP) aa1laa4, which appears in various clause types to enforce rhetorical readings. Drawing on Farkas and Bruce’s (2010) discourse model and subsequent works (e.g., Malamud and Stephenson 2015), this study examines the dynamics of discourse crises in interaction. Specifically, it identifies a scenario where Speaker X attempts to update the Common Ground (CG) with the proposition ¬, while Speaker Y remains committed to and seeks to update the CG accordingly, creating a Discourse Crisis. In such a context, the emergence of strong contextual evidence () supporting ¬ shifts the likelihood in favor of ¬ being true and being false. This resolution allows Speaker X to utter an aa1laa4 sentence, effectively leveraging the rhetorical force of the particle. The contributions of this study are threefold: (1) it refines our understanding of rhetorical question licensing by showing that aa1laa4 wh-questions rely on evidentiality rather than polarity to enforce rhetorical readings; (2) it broadens the scope of rhetorical speech act analysis, demonstrating that rhetoricity extends beyond questions to declaratives and imperatives, necessitating a unified theoretical framework; and (3) it proposes an expanded model of credence, ranging from [−1, 1], to better capture rhetorical dismissals and the rejection of alternatives in aa1laa4 utterances. These findings advance our understanding of rhetorical speech acts and the syntax-pragmatics interface
Lexical-Semantic Approach to the Unaccusative Mismatch in Japanese
No full textSince the discovery of the two classes of intransitive verbs, unaccusativity has been examined by extensive studies in many languages including Japanese. Despite the consensus among scholars that unaccusativity is universal, they remain perplexed by certain intransitive verbs exhibiting properties of both unergatives and unaccusatives, a phenomenon known as an “unaccusative mismatch.” In Japanese, unergatives (e.g., aruk-u ‘walk,’ oyog-u ‘swim’) behave like unaccusatives when accompanied by the goal phrase -made ‘as far as,’ which takes place when a numeral quantifier (NQ) is separated from its host NP subject (i.e., NQ floating). This study posits that this mismatch can be explained through a lexical-semantic approach. Moreover, this study suggests that its proposed explanation can be extended to elucidate the other two mismatches: the compatibility with the ‘for x time’ and ‘in x time’ adverbials, and two interpretations in the -teiru construction
Faculty Advisory Council Meeting Minutes, January 16, 2025
No full textThe University Archives has determined that this item is of continuing value to OSU's history
Searching for Solidarity: Revolutionary Dreams and Radical Social Movements
No full textOn orientation : disrupting erasure and ideologies of exceptionalism -- On testimony : reclaiming affective politics -- On postmemory : our hearts haven't been quenched yet -- On peripherality : mobilizing affective geographies -- On hope : bloom-spaces and the circulation of solidarityItem embargoed for three year
Reprogramming Senescent Cells via Extracellular Vesicle-based Delivery of Sirt1
No full textSenescence is a state of permanent cell cycle arrest, characterized by the secretion of senescence-associated secretory phenotype (SASP). Previous studies have identified that senescence is a key factor of aging and the overexpression of SASP to be pro-inflammatory, which can cause pulmonary fibrosis (PF) [1]. Current treatments to mitigate inflammation in PF are limited by poor targeting efficiency, highlighting the need for cell-targeting therapies. Here we aim to engineer extracellular vesicles (EVs) derived from human dermal fibroblasts (HDF) to deliver Sirt1 cargo to senescent cells. Sirt1 communicates anti-inflammatory signals to proliferating cells, yet its concentration decreases once they become senescent. HDF EVs can carry genetic cargo and facilitate intracellular communication with low immunogenicity and biocompatibility. The specific aims of this project will be assessed through beta-galactosidase (β-Gal) staining, western blot (WB), and quantitative PCR (qPCR). We expect the reintroduction of Sirt1 into the genome of senescent cells to promote the downregulation of SASP and inhibit pro-inflammatory signaling pathways. This will provide implications for cell-specific gene therapy at low risk for chronic inflammatory diseases beyond PF.A five-year embargo was granted for this item.Academic Major: Biomedical Engineerin
