26199 research outputs found
Sort by
Tumor-agnostic therapy – final step forward in the cure of human neoplasms?
Get PDFCancer accounted for 10 million deaths in 2020, nearly one in every six deaths annually. Despite advancements, the contemporary clinical management of human neoplasms faces a number of challenges. Surgical removal of tumor tissues is often not possible technically, while radiation and chemotherapy pose the risk of damaging healthy cells, tissues, and organs, presenting complex clinical challenges. These require a paradigm shift in developing new therapeutic modalities moving towards a more personalized and targeted approach. The tumor-agnostic philosophy, one of these new modalities, focuses on characteristic molecular signatures of transformed cells independently of their traditional histopathological classification. These include commonly occurring DNA aberrations in cancer cells, shared metabolic features of their homeostasis or immune evasion measures of the tumor tissues. The first dedicated, FDA-approved tumor-agnostic agent’s profound progression-free survival of 78% in mismatch repair-deficient colorectal cancer paved the way for the accelerated FDA approvals of novel tumor-agnostic therapeutic compounds. Here, we review the historical background, current status, and future perspectives of this new era of clinical oncology
Chest auscultation
Get PDFThe fundamentals series is a collection of articles that present key procedures and competencies, as outlined in the Nursing and Midwifery Council's Future nurse: standards of proficiency for registered nurses. In this article, David Collett outlines how to conduct a chest auscultation and interpret the results, as well as additional considerations in a mental health setting
Video Engagement Effectiveness on Climate Change: An empirical investigation on university students
Get PDFClimate change is one of the most vital issues humanity should deal with. Several natural disaster phenomena are greatly based on climate change. Awareness-raising towards its severity is a key goal in every aspect of our daily life; including education. The scope of this empirical study is to analyze university students’ engagement perceptions after they watched a number of videos on this topic. Specifically, the study aims to reveal which videos are more effective based on students’ demographics and their engagement perceptions towards them. Furthermore, it aims to reveal their general perceptions towards the utilization of YouTube videos in the learning process. A specific video selection procedure was conducted and an anonymous e-questionnaire was developed. Through content-based analysis, the average ratings of respondents’ engagement perceptions towards 12 selected videos were calculated, providing a clear indication of the level of interest among students. These findings offer valuable insights to educators and content creators aiming to tailor their materials to diverse audiences and provide even more customized and effective video content on climate change. By identifying differences in engagement levels among different student demographics, the study provides actionable recommendations for improving the impact of online video content in climate change education
Stories of People of Colour on Stigma, Racism and Severe Mental Distress
Get PDFThis thesis presents a qualitative exploration of the experiences of persons of colour who carry the label of ‘schizophrenia,’ focusing on stigma, help-seeking behaviours, and the efficacy of anti-stigma campaigns. The research comprises four interconnected studies, all utilizing the Interpretative Phenomenological Analysis (IPA) method to delve deeply into participants' perspectives. This research explored individual experiences of persons of colour living with ‘schizophrenia,’ uncovering the complex nature of stigma through in-depth semi-structured interviews. Trauma, fear of racism, and cultural barriers emerged as prominent factors inhibiting mental health support-seeking. The qualitative approach enriches our understanding of the challenges faced by people of colour living with ‘schizophrenia.’
This research also explored relatives' perspectives of individuals who carry the label of ‘schizophrenia’ revealing the impact of stigma on help-seeking behaviours within the family context. Qualitative analysis of family narratives highlights the profound effects of stigma, shame, and discrimination on seeking support for loved ones. The study emphasizes addressing family needs in mental health interventions. Study three assesses the effectiveness of anti-stigma campaigns targeting mental health stigma related to ‘schizophrenia’ within persons of colour. Through qualitative methods, including participant interviews, the study unveils scepticism among persons of colour, perceiving campaigns as performative and disconnected from systemic issues.
Tailored campaigns resonating with diverse communities are underscored. Furthermore, the thesis studies innovative approaches to addressing mental health stigma, incorporating a focus group discussion and performance art piece within a community context. The qualitative analysis captures unique insights and audience responses to the performance. Creative qualitative methods contribute to understanding stigma and its effects on persons of colour with ‘schizophrenia.’
In conclusion, this thesis offers a qualitative exploration of stigma, help-seeking behaviours, and anti-stigma campaigns concerning ‘schizophrenia’ among persons of colour. Utilizing IPA in all studies delves deep into participants' lived experiences. Culturally sensitive interventions addressing multifaceted challenges faced by marginalized populations are highlighted in the thesis.
The research's implications extend to mental health service providers, policymakers, and campaign designers seeking to create inclusive and effective mental health support systems for diverse communities. Amplifying the voices of persons of colour with ‘schizophrenia’ contributes to a comprehensive understanding of mental health experiences within marginalized populations
Developing the Cultural Tolerance Index and Examining its Impact on Psychic Distance and Firm Performance
No full textWhen a business pursues international expansion, it encounters a complex diversity of internationalisation factors and host-country aspects relevant to local adaptation, acceptance, and Cultural Tolerance (CT). CT is the concept of a nation accepting new and different values, different from those embedded in its culture through permission, co-existence, appreciation and respect for diversity. International enterprises face the effects of home-host Psychic Distance (PD) which obstructs the flow of information among countries and acts as a barrier on the International Small Medium Enterprise (SME)s’ learning processes (Dikova, 2009). The scope of this research is to identify the moderating role of CT on the effects of PD on SME performance. The primary objective of this research is to conceptualise a model and operationalise a measure of CT and test its impact on SME performance. This is accomplished through the development of a framework of CT by incorporating various dimensions and aspects into a complete CT model (CTM) followed by the construction of a composite index (CTI) encompassing multiple reliable indicators. Through a rigorous conceptual and empirical approach, the country-scores of EU countries are developed and presented into the CT Index (CTI), along with their evolution over years presenting considerable implications of upcoming trends. The CTI is then tested on international SMEs by focusing on a sample of 285 SMEs with 926 Foreign Subsidiaries (Fsubs) across the EU. The findings confirm the significance of CT in cross-cultural examinations through a positive impact on SME performance and a moderating impact on PD. This PhD addresses research gaps overlooking countries’ variation
and openness by introducing, developing and establishing CT as a critical determinant of the host-country environment and a vital concept in IB
Transgender Entrepreneurship Barriers and Support: A Qualitative Study
Get PDFThe core focus of this study is the exploration of the available barriers and possible support for transgender entrepreneurship in Pakistan. The twenty-five (25) transgender entrepreneur were interviewed, who had quit dancing, acting, begging and commercial sex work and stared a business venture. While employing the grounded theory (qualitative methodology), the finding of the study suggested the transgender entrepreneurs face unique barriers that can hinder their entrepreneurial journey, spanning across six (6) major dimensions including economic, social, legal, educational, market and psychological. On the other hand, the finding also suggest the possible support systems or mechanism, consisting of (6) main domains, including the government and legal support, financial support, non-governmental and non-profits organizational support, community and peer support, market access and visibility support, and finally psychological and emotional support. This article shed light on transgender entrepreneurship in Pakistan and also critical observed the major problems which restricting transgender individuals, to become entrepreneur, and their solutions which can help the transgender community to contribute in the ongoing social and economic progress of this country. The findings of this study also provide direction to the effort and support of government, civil society and none governmental organizations (NGOs) in promoting entrepreneurship among the transgender community of Pakistan. At the end of the study, the limitations and future research direction are discussed
Soccer Players’ Attitudes toward and Preferences for Male and Female Coaches
Get PDFThis study aims to determine soccer players’ attitudes toward and preferences for male and female coaches. One hundred and forty-five professional soccer players (male: 103, female: 42, age range 18–35 years) participating in Division 1 in the Eastern Mediterranean completed a modified Attitudes Toward Male and Female Coaches Questionnaire
(AAMFC-Q) in addition to their demographic characteristics, and general information. A 2 (athletes’ gender) x 2 (hypothetical coach’s gender) multivariate analysis of variance (MANOVA) indicated a significant two-way multivariate interaction [F(3, 141) = 22.79, p < 0.001] with significant main effects [F(3, 141) = 12.16, p < 0.001] for the gender of the
athlete or gender of the hypothetical coach. Our results demonstrated that male soccer players have a preference for male coaches, as indicated by item 12 (“I would prefer it if my new football (soccer) coach were a man”), while female soccer players demonstrated a preference for female coaches. Additionally, male soccer players had significantly (p < 0.01) less favorable attitudes toward female coaches on all items except for question 8 (“I could discuss things with her easily”). In contrast, female soccer players did not exhibit as many negative attitudes toward male soccer coaches. Based on the results of our study, it is evident that male players in sports such as soccer remain resistant to accepting female soccer coaches. This may be a result of greater exposure to male coaches, as none of the male players in our study had previously had a female coach
Politeness in British Correspondence: 1650-1920
Get PDFThis work has been undertaken as an attempt to examine changes in aspects of polite language between 1650 and 1920. Part of the research, discussed in Chapter 7: The Dative Alternation, was also carried out as a furthering of the hypothesis put forward in Flack (2018). This work looked at the dative alternation between 1410 and 1680 and posited that the prepositional dative construction was used to signify distance between correspondents who were socially or politically removed from one another. Other aspects of politeness investigated include honorific language, modal verbs, terms of deference and the lemmas pleas* and pray*.
Three research questions were selected to help evaluate the results of the analysis:
RQ1: Has the usage and/or frequency of deferential language changed during the time period of the study?
RQ2: Have markers of social deixis changed and/or declined during the time period of the study?
RQ3: Is the use of the Dative Alternation as a politeness marker evident from the 17th to early 20th centuries?
The data set from which language was analysed was created by searching the Archer and CLMET corpora for relevant search terms. Parameters of the search were ‘British’ ‘Letters’ and the date ranges of interest. The data was subdivided into 50-year sections so as to enable a picture of changing language to be created. Data was then analysed both qualitatively and quantitively to extract both numerical and social trends. Correspondents were also separated into four social groupings in order to investigate markers of social deixis.
Results showed that deferential language had partly changed during the time-period selected. Lemmas used for analysis of RQ1 were humbl*, beg*, troubl*, and worth*. Some of these lemmas showed a marked decrease during the 270 years, whereas others remained in fairly constant use. Markers of social deixis (RQ2) were found to have reduced greatly between 1650 and 1920, and the usage of the dative alternation (RQ3) was found to have changed; it was still being used to show respect but not necessarily social or political distance.
Overall, the findings show many changes in both the formality and language of British correspondence, and suggestions for further research are included within the relevant chapters