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ニトリル オヨビ アミノサン タイシャ カンレン コウソ ノ タンパクシツ コウガク ニ ヨル キノウ カイヘン オヨビ ユウキ ゴウセイ エノ オウヨウ ケンキュウ
Get PDF奈良先端科学技術大学院大学博士(バイオサイエンス)doctoral thesi
Applying Syntax-Prosody Mapping Hypothesis, Prosodic Well-Formedness Constraints, and Boundary-Driven Theory to Neural Sequence-to-Sequence Speech Synthesis
Get PDF奈良先端科学技術大学院大学修士 (工学)master thesi
A framework for conditional statement technical debt identification and description
No full textTechnical Debt occurs when development teams favour short-term operability over long-term stability. Since this places software maintainability at risk, technical debt requires early attention to avoid paying for accumulated interest. Most of the existing work focuses on detecting technical debt using code comments, known as Self-Admitted Technical Debt (SATD). However, there are many cases where technical debt instances are not explicitly acknowledged but deeply hidden in the code. In this paper, we propose a framework that caters for the absence of SATD comments in code. Our Self-Admitted Technical Debt Identification and Description (SATDID) framework determines if technical debt should be self-admitted for an input code fragment. If that is the case, SATDID will automatically generate the appropriate descriptive SATD comment that can be attached with the code. While our approach is applicable in principle to any type of code fragments, we focus in this study on technical debt hidden in conditional statements, one of the most TD-carrying parts of code. We explore and evaluate different implementations of SATDID. The evaluation results demonstrate the applicability and effectiveness of our framework over multiple benchmarks. Comparing with the results from the benchmarks, our approach provides at least 21.35, 59.36, 31.78, and 583.33% improvements in terms of Precision, Recall, F-1, and Bleu-4 scores, respectively. In addition, we conduct a human evaluation to the SATD comments generated by SATDID. In 1-5 and 0?5 scales for Acceptability and Understandability, the total means achieved by our approach are 3.128 and 3.172, respectively.journal articl
Systematic Review of Augmented Reality Training Systems
No full textRecent augmented reality (AR) advancements have enabled the development of effective training systems, especially in the medical, rehabilitation, and industrial fields. However, it is unclear from the literature what the intrinsic value of AR to training is and how it differs across multiple application fields. In this work, we gathered and reviewed the prototypes and applications geared towards training the intended user's knowledge, skills, and abilities. Specifically, from IEEE Xplore plus other digital libraries, we collected 64 research papers present in high-impact publications about augmented reality training systems (ARTS). All 64 papers were then categorized according to the training method used, and each paper's evaluations were identified by validity. The summary of the results shows trends in the training methods and evaluations that incorporate ARTS in each field. The narrative synthesis illustrates the different implementations of AR for each of the training methods. In addition, examples of the different evaluation types of the current ARTS are described for each of the aforementioned training methods. We also investigated the different training strategies used by the prevailing ARTS. The insights gleaned from this review can suggest standards for designing ARTS regarding training strategy, and recommendations are provided for the implementation and evaluation of future ARTS.journal articl
イッパンカ ソウゴ ワリアテ モンダイ ニ タイスル コウゴ ホウコウ ジョウスウホウ オ モチイタ カカク コウシン
No full text本研究では，組合せ最適化問題である一般化相互割当問題 (GMAP) に対する出来るだけ良い質の実行可能解を分散環境で求めることを目指す．先行研究では，実行可能解を求める手法として分散ラグランジュヒューリスティックアルゴリズムが提案されている．これは，ラグランジュ乗数と呼ばれる価格パラメータを基に実行可能解の候補を生成する手法で，ラグランジュ双対問題と呼ばれる凸最適化問題の解を用いて価格を更新すれば良い質の実行可能解が得られることが知られている．本研究は，価格を逐次的に更新するアルゴリズムに交互方向乗数法 (ADMM) を導入する．ADMMは凸最適化問題を分散環境で解くための解法で，近接写像を用いるのが特徴である．しかし，ラグランジュ双対問題の目的関数はブラックボックスであり，近接写像を容易に計算することは出来ない．そこで本研究では，目的関数を線形近似することによって近接写像を計算し，ADMMによる更新を可能とした．数値実験により，提案手法の有効性を確認する．conference pape
Seed Halopriming Improves Salinity Tolerance of Some Rice Cultivars During Seedling Stage
No full textBackground: Saline land in coastal areas has great potential for crop cultivation. Improving salt tolerance in rice is a key to expanding the available area for its growth and thus improving global food security. Seed priming with salt (halopriming) can enhance plant growth and decrease saline intolerance under salt stress conditions during the subsequent seedling stage. However, there is little known about rice defense mechanisms against salinity at seedling stages after seed halopriming treatment. This study focused on the effect of seed halopriming treatment on salinity
tolerance in a susceptible cultivar, IR 64, a resistant cultivar, Pokkali, and two pigmented rice cultivars, Merah Kalimantan Selatan (Merah Kalsel) and Cempo Ireng Pendek (CI Pendek). We grew these cultivars in hydroponic culture, with and without halopriming at the seed stage, under either non-salt or salt stress conditions during the seedling stage.
Results: The SES scoring assessment showed that the level of salinity tolerance in susceptible cultivar, IR 64, and moderate cultivar, Merah Kalsel, improved after seed halopriming treatment. Furthermore, seed halopriming improved the growth performance of IR 64 and Merah Kalsel rice seedlings. Quantitative PCR revealed that seed halopriming induced expression of the OsNHX1 and OsHKT1 genes in susceptible rice cultivar, IR 64 and Merah Kalsel thereby increasing the level of resistance to salinity. The expression levels of OsSOS1 and OsHKT1 genes in resistant cultivar, Pokkali, also increased but there was no affect on the level of salinity tolerance. On the contrary, seed halopriming decreased the expression level of OsSOS1 genes in pigmented rice cultivar, CI Pendek, but did not affect the level of salinity tolerance. The transporter gene expression induction significantly improved salinity tolerance in salinity-susceptible rice, IR 64, and moderately tolerant rice cultivar, Merah Kalsel. Induction of expression of the OsNHX1 and OsHKT1 genes in susceptible rice, IR 64, after halopriming seed treatment balances the osmotic pressure and prevents the accumulation of toxic concentrations of Na+, resulting in tolerance to salinity stress.
Conclusion: These results suggest that seed halopriming can improve salinity tolerance of salinity-susceptible and moderately tolerant rice cultivars.journal articl
Preclinical evaluation of pentagamavunone-1 as monotherapy and combination therapy for pancreatic cancer in multiple xenograft models
No full textWe previously reported that pentagamavunone-1 (PGV-1) effectively inhibited cell proliferation in many types of human tumors, including pancreatic cancer, by inducing M phase (prometaphase) arrest, senescence, and apoptosis with few side effects. However, a detailed evaluation of the effects of PGV-1 on pancreatic cancer cells in an in vivo setting has not yet been conducted. The present study investigated the potential efficacy of PGV-1 as both monotherapy and combination therapy for pancreatic cancer using multiple xenograft mouse assays. A cell-line derived xenograft model (CDX-M) with pancreatic cancer cell line and a patient-derived xenograft mouse model (PDX-M) using resected pancreatic cancer samples without neoadjuvant chemotherapy were established in both heterotopic and orthotopic manners. PGV-1 effectively suppressed tumor formation at the heterotopic and orthotopic sites in CDX-M than in untreated mice. Combination therapy with PGV-1 and gemcitabine more effectively suppressed tumor formation than monotherapy with PGV-1 or gemcitabine when administered after tumor formation. Monotherapy with PGV-1 or gemcitabine less effectively suppressed tumor formation in PDX-M than in CDX-M, whereas combination therapy with PGV-1 and gemcitabine more effectively suppressed tumor formation. PGV-1 as monotherapy and combination therapy with gemcitabine effectively inhibited tumor formation and has potential as an anticancer candidate for pancreatic cancer.journal articl
