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Development of Physics Experiment for Students using Spectrum Analysis and Thermoelectric Conversion
Get PDF長崎大学教育学部紀要：自然科学 通巻 第86号（Bulletin of Faculty of Education, Nagasaki University: Natural Science, Vol.86
A Study on Collaborative Teaching Music by Teachers and Artists
Get PDF長崎大学教育学部紀要：教科教育学 通巻 第59号（Bulletin of Faculty of Education, Nagasaki University: Curriculum and Teaching, Vol.59
Fundamental Study on the Application of Anchoring Method for Prestressing Tendons Using Highly Expansive Material to Concrete and Steel Structures
No full text長崎大学学位論文 学位記番号:博(工)甲第62号 学位授与年月日:平成31年2月20
Multiple charged amino acids of Plasmodium falciparum SURFIN4.1 N-terminal region are important for efficient export to the red blood cell
No full textPlasmodium falciparum, an obligate intracellular protozoan parasite which causes the severe form of human malaria,
exports numerous proteins to the infected red blood cell that are important for its survival and of severe pathological effect to its host. These proteins and their export mechanisms are candidates for drug
and vaccine development, and among them is the Plasmodium SURFIN family of proteins. Previously we showed that the N-terminal region along with the sequence surrounding the transmembrane domain of SURFIN 4.1 is essential for its export to Maurer's clefts in the red blood cell cytoplasm. We proposed that this region is recognized by a machinery responsible for protein translocation across the parasitophorous vacuole membrane surrounding the parasite.
To understand the export mechanism further, we utilized a fluorescent protein-tagged mini-SURFIN 4.1 consisting of the minimum essential components for export. Alanine scanning of all charged amino acids
within the N-terminal region revealed that replacement of 3 glutamic acid and 2 lysine residues significantly impairs the export efficiency of this protein across the parasitophorous vacuole membrane. In addition,N-terminally Myc-tagged mini-SURFIN 4.1 and mini-SURFIN 4.2 with similar architectures were detected with anti-Myc antibody at Maurer's clefts, indicating that elements required for export to Maurer's clefts are conserved between SURFIN 4.1 and SURFIN 4.2 , and that N-terminal sequences of these SURFIN members are not cleaved during export. Our results implicate a conserved nature of SURFIN export
to the red blood cell, particularly an important role of multiple glutamic acid and lysine residues in the SURFIN N-terminal region
BODY COOLING EFFECTS OF IMMERSION IN HIGH-CONCENTRATION ARTIFICIAL CARBONIC ACID WATER
Get PDFThis study examines the body cooling effects of immersion in high-concentration artificial carbonic acid water. The subjects’ core (tympanic) temperature was increased by a pedaling ergometer. They then immersed their lower legs in carbonic acid water or tap water. The decrease in tympanic temperature was observed. The tympanic temperature significantly decreased more during immersion in stirred 25 / 30°C CO2 water than in tap water. The results suggest that immersing the lower legs in stirred 25 / 30°C carbonic acid water can suppress skin vascular constriction and reduce core temperature elevated by heat stress / exercise more effectively than stirred tap water of the same water temperature
肝細胞癌に対するTACE時の動脈損傷：損傷のリスク因子と残存狭窄の予測因子について
No full textPurpose: To investigate clinical features and results of follow-up in patients with arterial injury during transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma. Methods: From 2005 to 2015, 2219 TACE procedures were performed in 906 patients in our hospital. Iatrogenic arterial injury occurred during 38 TACE procedures (sessions) in 35 patients (24 men, 11 women; mean age 71.8 years). The incidence of arterial injury was 1.7%. We evaluated the characteristics of arterial injury, and evaluated the risk factors for incomplete recanalization of the injured artery at follow-up angiography conducted after 1–11 months (mean 102.5 days).
Results: Iatrogenic arterial injury was caused by the microcatheter in 34 of 38 cases (86.8%). There were 15 cases (39.5%) in which the replaced hepatic artery or the extrahepatic artery was the parasitic supply. Extravasation occurred in five cases. In 36 of 38 cases, follow-up angiography was performed. We divided 36 cases into two groups: complete reopening (n = 24) and non-complete reopening (n = 12). The two groups were compared regarding the factors associated with incomplete recanalization of the injured artery at follow-up. Injury length >3 cm (p = 0.0002) and proximal arterial injury (proximal to the segmental artery; p = 0.03) were significant risk factors for non-complete reopening of the injured artery. Conclusion:
Iatrogenic arterial injury frequently occurred in the extrahepatic artery or replaced hepatic artery. Recanalization rate of arterial injury was high; however, injury length >3 cm and proximal arterial injury were risk factors for non-complete reopening of the injured artery.長崎大学学位論文 学位記番号:博(医歯薬)甲第1167号 学位授与年月日:令和元年6月5日Author: Hironori Onizuka, Eijun Sueyoshi, Hideki Ishimaru, Ichiro Sakamoto, Masataka UetaniCitation: Abdominal Radiology, 42(10), pp.2544-2550; 201
