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Towards a comprehensive approach for characterizing cell activity in bright-field microscopic images
Get PDFWhen studying physical cellular response observed by light microscopy, variations in cell behavior are difficult to quantitatively measure and are often only discussed on a subjective level. Hence, cell properties are described qualitatively based on a researcher’s impressions. In this study, we aim to define a comprehensive approach to estimate the physical cell activity based on migration and morphology based on statistical analysis of a cell population within a predefined field of view and timespan. We present quantitative measurements of the influence of drugs such as cytochalasin D and taxol on human neuroblastoma, SH-SY5Y cell populations. Both chemicals are well known to interact with the cytoskeleton and affect the cell morphology and motility. Being able to compute the physical properties of each cell for a given observation time, requires precise localization of each cell even when in an adhesive state, where cells are not visually differentiable. Also, the risk of confusion through contaminants is desired to be minimized. In relation to the cell detection process, we have developed a customized encoder-decoder based deep learning cell detection and tracking procedure. Further, we discuss the accuracy of our approach to quantify cell activity and its viability in regard to the cell detection accuracy.journal articl
Numerical simulation of wave energy converter based on stochastic resonance and variable magnetization
Get PDFThis paper introduces a wave energy converter (WEC) with stochastic resonance and variable magnetization system in order to effectively obtain electric energy from the ocean wave. Because nonlinear oscillation systems generally have wider frequency range in comparison with linear one, the proposed WEC is suitable for the power generation from ocean waves. Moreover, a numerical analysis method is also introduced to evaluate the characteristics of the proposed WEC. From the numerical simulations, it is shown that the proposed WEC has wider operational frequency range and the frequency characteristic can be changed by the field current.journal articl
科学技術人材育成費補助事業 女性研究者研究活動支援事業（一般型）平成25年度-27年度 活動報告書 2-11.男女共同参画推進に関するアンケート
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断面修復面に配筋された鉄筋コンクリート梁主筋の付着－すべりモデル
Get PDF寒冷地の鉄筋コンクリート（以下RC）構造物は凍結融解作用により表層部から劣化し，強度低下が危惧される．しかし劣化や補修による付着強度への影響は明らかでない．そこで本研究では，表層部が劣化したRC 梁試験体に対し断面修復工法を適用し，主筋の引抜き試験を行った．その結果，未補修では劣化程度による影響が，補修有りでは補修深さによる影響が大きかった．さらにリングテンション効果に基づき付着強度式を構築した後，付着すべり挙動をモデル化し実験結果を変動係数18%の精度で再現できた．journal articl
凍結融解作用と複数回の地震力を受けるRC柱の補修による力学性状の改善効果
Get PDF積雪寒冷地のRC 構造物は凍害劣化や複数回の地震動で損傷する恐れがあるが，凍害や補修が力学性状へ及ぼす影響は十分に明らかにされていない．そこでRC 柱を対象に補修または凍結融解作用を与える時期をパラメータとし，複数回の加力実験を行った．その結果，凍結融解作用によりせん断破壊先行型（Q 柱）と曲げ破壊先行型（M 柱）でそれぞれ水平耐力Q が35，9 %，エネルギー吸収量En が27，31 %低下したが，断面修復によりQ が24，36 %，En が33，25 %改善した．またひび割れ充填すると，Q 柱はEn が9 %，初期剛性k が7 %，M 柱でk が9 %改善した．journal articl
