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Safety of SARS-CoV-2 Vaccination in Patients with Vascular Malformations: Patient-Reported Adverse Vaccine Reactions
Get PDF三重大学博士(医学)application/pdf内容の要旨・審査結果の要旨 / 三重大学大学院医学系研究科 生命医科学専攻 臨床医学系講座 形成外科学分野thesi
Coordinated regulation of gene expression in Plasmodium female gametocytes by two transcription factors
Get PDF三重大学博士(医学)application/pdf内容の要旨・審査結果の要旨 / 三重大学大学院医学系研究科 生命医科学専攻 基礎医学系講座 医動物・感染医学分野thesi
Endplate and intervertebral disc injuries in acute and single level osteoporotic vertebral fractures: is there any association with the process of bone healing?
Get PDF三重大学博士(医学)application/pdfBackground: The endplate-intervertebral disc (IVD) complex is closely interrelated with the vertebral body (VB) in the structural integrity of the anterior spinal column, including biomechanical and biological functions. Endplate and IVD injuries are usually found in association with vertebral fractures (VFs); however, little is known about their relevance to the healing of osteoporotic VFs (OVFs). The first purpose of this study was to evaluate the incidence and occurrence pattern of endplate and IVD injuries associated with single- and acute-OVFs, and the second was to evaluate the influence of endplate and IVD injuries on the occurrence of delayed union.
Methods: Endplate and IVD injuries associated with single- and acute-OVFs were retrospectively evaluated using magnetic resonance imaging (MRI). Vertebrae of 168 patients were included in the study. The occurrence rate and type of endplate and IVD injuries were radiologically evaluated, and the association between endplate and IVD injuries was statistically analyzed. Vertebrae of 85 patients, who received conservative treatment for acute OVFs, were included in the study and classified into two groups, union and delayed union, at 6 months after injury. To identify factors predicting delayed union, uni- and multivariate statistical analyses were performed. Vertebral MRI signal alternation patterns and endplate and IVD injuries were included as candidate factors in the logistic model.
Results: In association with OVFs, endplate injuries were observed in 103 of the 168 vertebrae (61%), and IVDs lesions were observed in 101 of 168 OVFs (60%); the occurrence of both injuries was significantly associated. Although no significant association with endplate and IVD injuries was identified, multivariate analysis demonstrated that intravertebral signal alternation (focal high signal intensity) and posterior wall injury were independent risk factors that predicted delayed union.
Conclusions: The results of this study showed that endplate and IVD injuries were found in approximately 60% of single and acute OVFs. These results suggest that fracture healing of OVFs would be mainly attributed to vertebral factors, including mechanical stress and metabolic status, among the three components of the anterior spinal column.本文/Department of Orthopaedic Surgery, Murase Hospital, 3-12-10 Kanbe, Suzuka City, Mie 514-0801, Japan11pdoctoral thesi
地域探究型キャリア教育を通じた高校生の一般性自己効力感向上に関する研究-地域の社会人介入への検討にむけて-
Get PDFapplication/pdf三重大学大学院 地域イノベーション学研究科 博士前期課程 地域イノベーション学専攻94pthesi
高温超伝導体Bi-2212からの電界放出電子のエネルギー分析
Get PDFapplication/pdf本文/三重大学大学院 工学研究科 博士前期課程 電気電子工学専攻 量子エレクトロニクス研究室60pthesi
Myosin Light Chain Phosphatase Plays an Important Role in Cardiac Fibrosis in a Model of Mineralocorticoid Receptor-Associated Hypertension
Get PDF三重大学博士(医学)application/pdfBACKGROUND: Myosin phosphatase targeting subunit 2 (MYPT2) is an important subunit of cardiac MLC (myosin light chain) phosphatase, which plays a crucial role in regulating the phosphorylation of MLC to phospho-MLC (p-MLC). A recent study demonstrated mineralocorticoid receptor-related hypertension is associated with RhoA/Rho-associated kinase/MYPT1 signaling upregulation in smooth muscle cells. Our purpose is to investigate the effect of MYPT2 on cardiac function and fibrosis in mineralocorticoid receptor-related hypertension.
METHODS AND RESULTS: HL-1 murine cardiomyocytes were incubated with different concentrations or durations of aldosterone. After 24-hour stimulation, aldosterone increased CTGF (connective tissue growth factor) and MYPT2 and decreased p-MLC in a dose-dependent manner. MYPT2 knockdown decreased CTGF. Cardiac-specific MYPT2-knockout (c-MYPT2−/−) mice exhibited decreased type 1 phosphatase catalytic subunit β and increased p-MLC. A disease model of mouse was induced by subcutaneous aldosterone and 8% NaCl food for 4 weeks after uninephrectomy. Blood pressure elevation and left ventricular hypertrophy were observed in both c-MYPT2−/− and MYPT2+/+ mice, with no difference in heart weights or nuclear localization of mineralocorticoid receptor in cardiomyocytes. However, c-MYPT2−/− mice had higher ejection fraction and fractional shortening on echocardiography after aldosterone treatment. Histopathology revealed less fibrosis, reduced CTGF, and increased p-MLC in c-MYPT2−/− mice. Basal global radial strain and global longitudinal strain were higher in c-MYPT2−/− than in MYPT2+/+ mice. After aldosterone treatment, both global radial strain and global longitudinal strain remained higher in c-MYPT2−/− mice compared with MYPT2+/+ mice.
CONCLUSIONS: Cardiac-specific MYPT2 knockout leads to decreased myosin light chain phosphatase and increased p-MLC. MYPT2 deletion prevented cardiac fibrosis and dysfunction in a model of mineralocorticoid receptor-associated hypertension.本文/Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Mie, Japan24pdoctoral thesi
Estimation of rice plant coverage using Sentinel-2 based on UAV-observed data
Get PDFapplication/pdfVegetation coverage is a crucial parameter in agriculture, as it offers essential insights into crop growth and health conditions. The spatial resolution of spaceborne sensors is relatively limited, making it challenging to precisely measure vegetation coverage. Consequently, fine-resolution ground observation data becomes indispensable for establishing the correlation between remotely sensed reflectance and plant coverage. This study estimated rice plant coverage per pixel using time series Sentinel-2 Multispectral Instrument (MSI) data, which enables monitoring rice growth conditions over a wide area. Rice plant coverage was calculated using Unmanned Aerial Vehicle (UAV) data with a spatial resolution of 3 cm based on the spectral unmixing method. This plant coverage map was generated every two to three weeks throughout the rice growing season. Subsequently, the plant coverage was estimated at a 10 m resolution through the multiple linear regression, utilizing Sentinel-2 MSI reflectance data and these plant coverage maps. In this process, a geometric registration of MSI and UAV data was conducted to improve their spatial agreement. The coefficient of determination (R²) of the multiple linear regression model was 0.92 and 0.94 for the Level-1C and Level-2A products of Sentinel-2 MSI, respectively. The root mean squared error (RMSE) of the estimated rice plant coverage was 10.77% and 9.34%, respectively. This study highlights the potential of a satellite time series model for accurate estimation of rice plant coverage.三重大学 大学院工学研究科 情報工学専攻 データサイエンス研究室37pthesi
