17062 research outputs found
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Efforts for stable timber collection from the perspective of woody biomass power plants: A case study in Matsusaka area
No full textdepartmental bulletin pape
Tenascin-C in Tissue Repair after Myocardial Infarction in Humans
No full text三重大学博士(医学)application/pdf内容の要旨・審査結果の要旨 / 三重大学大学院医学系研究科 生命医科学専攻 基礎医学系講座 修復再生病理学分野thesi
Exploratory Evaluation of Circulating Microbiota-Derived Corisin Levels in Women with Adverse Pregnancy Outcomes
No full text三重大学博士(医学)application/pdfPreterm birth and low birth weight remain major contributors to neonatal morbidity and mortality, yet the underlying mechanisms are not fully understood. Maternal microbiota has been implicated in adverse pregnancy outcomes, but key mediators remain unidentified. We previously showed that the microbiota-derived peptide corisin induces epithelial apoptosis via mitochondrial membrane depolarization and reactive oxygen species accumulation. In this retrospective preliminary study, we evaluated the association between maternal serum corisin levels and pregnancy outcomes in 84 eligible women. Among them, 10 experienced preterm birth, and 22 delivered low-birth-weight infants. Corisin levels were significantly elevated in these groups compared with women with full-term, normal-weight deliveries. Preterm birth was associated with increased tissue factor, while low birth weight correlated with higher thrombin–antithrombin complex and soluble thrombomodulin and lower fibrinogen levels. Corisin concentrations showed negative correlations with maternal BMI, birth weight and length, and estimated fetal weight. Positive correlations were observed between corisin, myeloperoxidase, and several coagulation markers. These preliminary findings suggest that elevated maternal corisin levels are associated with adverse pregnancy outcomes and may reflect underlying mechanisms involving oxidative stress and coagulation activation. Further investigation is warranted to clarify its potential role as a microbiota-derived biomarker in pregnancy complications.本文 / Department of Obstetrics and Gynecology, Faculty and Graduate School of Medicine, Mie University, Mie University Hospital19pdoctoral thesi
Tenascin-C in Tissue Repair after Myocardial Infarction in Humans
No full text三重大学博士(医学)application/pdfAdverse ventricular remodeling after myocardial infarction (MI) is progressive ventricular dilatation associated with heart failure for weeks or months and is currently regarded as the most critical sequela of MI. It is explained by inadequate tissue repair due to dysregulated inflammation during the acute stage; however, its pathophysiology remains unclear. Tenascin-C (TNC), an original member of the matricellular protein family, is highly up-regulated in the acute stage after MI, and a high peak in its serum level predicts an increased risk of adverse ventricular remodeling in the chronic stage. Experimental TNC-deficient or -overexpressing mouse models have suggested the diverse functions of TNC, particularly its pro-inflammatory effects on macrophages. The present study investigated the roles of TNC during human myocardial repair. We initially categorized the healing process into four phases: inflammatory, granulation, fibrogenic, and scar phases. We then immunohistochemically examined human autopsy samples at the different stages after MI and performed detailed mapping of TNC in human myocardial repair with a focus on lymphangiogenesis, the role of which has recently been attracting increasing attention as a mechanism to resolve inflammation. The direct effects of TNC on human lymphatic endothelial cells were also assessed by RNA sequencing. The results obtained support the potential roles of TNC in the regulation of macrophages, sprouting angiogenesis, the recruitment of myofibroblasts, and the early formation of collagen fibrils during the inflammatory phase to the early granulation phase of human MI. Lymphangiogenesis was observed after the expression of TNC was down-regulated. In vitro results revealed that TNC modestly down-regulated genes related to nuclear division, cell division, and cell migration in lymphatic endothelial cells, suggesting its inhibitory effects on lymphatic endothelial cells. The present results indicate that TNC induces prolonged over-inflammation by suppressing lymphangiogenesis, which may be one of the mechanisms underlying adverse post-infarct remodeling.本文 / Department of Pathology and Matrix Biology, Graduate School of Medicine, Mie University16pdoctoral thesi
Biliary microbiome profiling via 16 S rRNA amplicon sequencing in patients with cholangiocarcinoma, pancreatic carcinoma and choledocholithiasis
No full text三重大学博士(医学)application/pdfRecent studies have revealed that oral, gut, and intratumoral microbial dysbiosis significantly affects tumor progression, therapy resistance, and prognosis in cholangiocarcinoma (CCA) and pancreatic ductal adenocarcinoma (PDAC) patients. However, the biliary microbiome, which directly interacts with malignant tissues, remains poorly understood. In this study, we analyzed the bile microbiota from 17 CCA, 15 PDAC, and 40 choledocholithiasis (CDL) patients using bacterial 16 S rRNA and fungal ITS sequencing. Principal coordinate analysis revealed significant differences in microbial communities between the cancer and CDL groups. The microbial community structure in each group demonstrated a specific pattern. Linear discriminant analysis revealed Streptococcus, Sphingomonas, and Bacillus enrichment in CCA patients, Neisseria, Sphingomonas, and Caulobacter in PDAC patients were more prevalent compared with CDL patients. Caulobacter was more prevalent, wheares Campylobacter was less in PDAC patients than in CCA patients. Fungal DNA was detected in ~ 50% of the samples, with CCA and PDAC patients. KEGG pathway analysis revealed altered metabolic pathways, including peptidoglycan, sphingolipid, and fatty acid metabolism and bile acid metabolism, in CCA and PDAC patients. These findings highlight the potential role of the biliary microbiome in CCA and PDAC pathogenesis, offering new insights into disease mechanisms and biomarkers.本文 / Department of Gastroenterology, Mie Prefectural General Medical Center12pdoctoral thesi
Studies on Sugar- and Starch-Rich Food By-products as Alternative Carbohydrate Sources for Ruminants
No full text三重大学博士(学術)application/pdf内容の要旨・審査結果の要旨/Sustainable Resource Sciencethesi
グループ活動を伴うオンライン授業における自己効力感の影響－社会的スキルに対する自己評価の変化に注目して－
Get PDF本研究では，大学教育におけるオンライン授業において，小グループを構成し，学生が順番に進行係を担うことで相互に働きかけを行いながら，社会的スキルについて学習する実践を行い，その実践を通して社会的スキルの自己評価がどのように変化するのか，そして，その変化に自己効力感がどのように影響しているのかを検討したものである．当該の実践を行った授業に参加していた大学生のうち，調査への協力が得られ，回答への同意がなされた106 名分のデータを用いて検討を行った．社会的スキルの測定には，ルーブリックによる自己評定を用いた．また，自己効力感に関しては，進行係のとき，あるいは，進行係ではないメンバーのときの，知識再構築に対する自己効力感，および，知識正確性に対する自己効力感をそれぞれ測定した．その結果，授業前後で測定した全ての社会的スキルの自己評価が高まっているとともに，事後の時点でのいくつかの社会的スキルの自己評価に知識再構築に対する自己効力感の正の影響が見られた．departmental bulletin pape
