University of Münster
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PIEZO1 channels in cutaneous free nerve endings: novel insights into itch-scratch-mechanisms
No full textThe illustrative case of the HYBRIT fossil-free steel production initiative in the perspective of industrial symbiosis and convergence
No full textVisual perception of the optic flow and biological motion during locomotion
No full textVisuelle Navigation durch eine belebte Umgebung erscheint mühelos. Dennoch ist die gleichzeitige Verarbeitung der Eigenbewegung und der biologischen Bewegung von Menschen eine schwierige Aufgabe, bei der zwei unabhängige Arten von Bewegungen zu berücksichtigen sind. Die Eigenbewegung erzeugt ein globales Muster sich ausbreitender visueller Bewegung, die als optischer Fluss bezeichnet wird. Auf dieser Grundlage ist eine präzise Navigation mathematisch möglich und empirisch bestätigt. Menschliche Bewegung ist ein rhythmisches und doch komplexes Bewegungsmuster. Die biologische Bewegung von Menschen während der Eigenbewegung erzeugt ein Wechselspiel. Einerseits zerstört die biologische Bewegung die Struktur des optischen Flusses, was die Navigation erschwert und zu Fehlern führt. Andererseits enthält biologische Bewegung valide Hinweise auf Geschwindigkeit und Bewegungsrichtung, die zu einer genauen Fortbewegung beitragen. Diese Dissertation befasst sich mit der Doppelrolle der biologischen Bewegung in Kombination mit Eigenbewegung. In drei aufeinander folgenden Studien haben wir herausgefunden, dass die Bewegung der Gelenke bei der biologischen Bewegung eine besondere Rolle spielt, und wir konnten Verarbeitungsmechanismen aufzeigen, die über eine reine Vektoranalyse hinausgehen.Visual navigation through a busy, crowded environment seems to be effortless. Yet simultaneously processing self-motion and pedestrians' biological motion is a perceptually difficult task involving two independent types of motion. Self-motion creates a global pattern of expanding visual motion cues called optic flow. Based on the optic flow, precise navigation is mathematically feasible and empirically confirmed. The human gait cycle is a rhythmic yet complex motion pattern. Biological motion from pedestrians creates a two-sided interplay. On the one hand, biological motion destroys the optic flow field structure, impeding navigation and leading to heading biases. On the other hand, pedestrian motion contains valid cues about speed and motion direction that contribute to accurate locomotion. This dissertation takes up the dual role of biological motion when combined with self-motion. Throughout three consecutive studies, we found that the limb articulation of biological motion plays a specific role, and we could see evidence for drivers extending pure motion vector analysis
Assessment of the Ferroptosis Regulators: Glutathione Peroxidase 4, Acyl-Coenzyme A Synthetase Long-Chain Family Member 4, and Transferrin Receptor 1 in Patient-Derived Endometriosis Tissue
No full textFerroptosis, an iron-dependent form of non-apoptotic cell death, plays a pivotal role in various diseases and is gaining considerable attention in the realm of endometriosis. Considering the classical pathomechanism theories, we hypothesized that ferroptosis, potentially driven by increased iron content at ectopic sites, may contribute to the progression of endometriosis. This retrospective case–control study provides a comprehensive immunohistochemical assessment of the expression and tissue distribution of established ferroptosis markers: GPX4, ACSL4, and TfR1 in endometriosis patients. The case group consisted of 38 women with laparoscopically and histologically confirmed endometriosis and the control group consisted of 18 women with other gynecological conditions. Our study revealed a significant downregulation of GPX4 in stromal cells of endometriosis patients (M = 59.7% ± 42.4 versus 90.0% ± 17.5 in the control group, t (54) = −2.90, p = 0.005). This finding aligned with slightly, but not significantly, higher iron levels detected in the blood of endometriosis patients, using hemoglobin as an indirect predictor (Hb 12.8 (12.2–13.5) g/dL versus 12.5 (12.2–13.4) g/dL in the control group; t (54) = −0.897, p = 0.374). Interestingly, there was no concurrent upregulation of TfR1 (M = 0.7 ± 1.2 versus 0.2 ± 0.4 for EM, t (54) = 2.552, p = 0.014), responsible for iron uptake into cells. Our empirical findings provide support for the involvement of ferroptosis in the context of endometriosis. However, variances in expression patterns within stromal and epithelial cellular subsets call for further in-depth investigations
Alternative Transaxillary Access for Transcatheter Aortic Valve Implantation
No full textBackground/Objectives: Currently, the transfemoral approach is recognized as the primary method for accessing transcatheter aortic valve implantation (TAVI). However, alternative techniques are needed when the transfemoral access is not suitable. We proposed that a modified transaxillary approach through the distal left axillary artery is both viable and safe for conducting TAVI, potentially offering benefits for patients. Methods: From December 2018 to February 2024, a total of 24 patients (7 women, average age 77.9 ± 8 years) received TAVI using transaxillary access via the left axillary artery. The participants suffered from symptomatic severe aortic stenosis and were deemed TAVI candidates with iliofemoral anatomy unsuitable for a transfemoral route. The patient group displayed a high perioperative risk profile, with significant peripheral artery disease or severe obstructive infrarenal aortic conditions. The implantation of the aortic prosthesis was carried out through the left distal axillary artery. A balloon-expandable valve was used in every instance. Results: In the examined cohort, the 30-day mortality rate was 4.2%. A new pacemaker was necessary for four patients (16.7%). One case exhibited a new moderate neurological dysfunction. Additionally, one patient required surgical revision of the access point due to ischemia. Conclusions: Our findings indicate that transaxillary TAVI via the distal left axillary artery has yielded encouraging outcomes. This approach is practicable and safe, does not prolong the procedure, minimizes surgical trauma, ensures excellent access regardless of chest anatomy, and is sparing for the brachial plexus. As a single-center pilot study, our findings require confirmation in larger, prospective cohorts with extended follow-up to fully validate the safety and long-term efficacy of this technique
Blood group O attributes to prolonged progression-free survival, overall survival, and 5-year survival in isocitrate dehydrogenase-wildtype glioblastoma patients with MGMT promoter methylation
No full textBackground. Glioblastoma (GBM) remains incurable despite multimodal therapeutic approaches. Here, we assessed the relevance of ABO blood groups for progression-free survival (PFS), overall survival (OS), and long-term survival in a large cohort of isocitrate dehydrogenase (IDH)-wildtype (wt) GBM patients. Methods. Consecutive GBM patients (2009-2020) at a large tertiary brain tumor center were included, and clinical data were retrospectively abstracted. We dichotomized patients into those with blood group O and those with a Non-O blood group. Patient, tumor, and treatment characteristics were compared between these groups. Association with outcomes was assessed in univariable and multivariable settings via log-rank tests and Cox proportional hazards regressions, respectively.
Results. Five hundred fifty-four GBM IDH-wt had available ABO information. There were no substantial differences in patient, tumor, or treatment characteristics between group O and group Non-O. In contrast, blood group O patients showed increased PFS, OS, and 5-year survivals in both univariable and multivariable analyses. Differences were strongly pronounced in patients with MGMT promoter methylated tumors receiving standardized radiochemotherapy (OS blood group O 24.6 months [95%CI 17.8-31.4] vs Non-O 17.7 months [14.1-21.3], P = .015 log-rank analysis, hazard ratio 0.70 [95%CI 0.53-0.94]), but not apparent in MGMT promoter unmethylated tumors and in patients without (standardized) adjuvant therapy. Conclusion. Blood group O status in conjunction with MGMT promoter methylation (including weak methylation) is an independent favorable prognostic marker in GBM IDH-wt patients receiving standardized radiochemotherapy. This finding is unprecedented, suggesting a linkage between the downregulation of a DNA repair protein and the absence of a functional blood cell surface glycosyltransferase
Calcium channel blockers and clinical outcomes in patients with continuous-flow left ventricular assist devices
No full textAims: Current guidelines suggest calcium channel blockers (CCBs) as the second or third option for blood pressure management in patients with left ventricular assist device (LVAD). However, the clinical outcomes of patients with LVAD who receive CCBs remain unclear. Our study aims to analyse the association of CCBs with clinical outcomes in patients after LVAD implantation. Methods and results:
This is a retrospective analysis based on the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) from 2006 to 2017, and adult patients who were alive with LVAD and CCB treatment information at 6 months after implantation were included. Among 10 717 patients, 1369 received CCBs 6 months after implantation, and there was an increasing trend of CCB use after LVAD. Patients receiving CCB therapy at 6 months had a similar 5 year survival rate to those not receiving CCB [49.6%, 95% confidence interval (CI): 47.5–51.7% vs. 51.1%, 95% CI: 45.3–56.7%]. In both Cox and competing risk regressions after adjusting for confounding factors, CCB treatment at 6 months after implantation was not associated with long-term mortality [hazard ratio (HR): 1.03, 95% CI: 0.91–1.17, P = 0.624 and subdistribution HR (SHR): 1.07, 95% CI: 0.95–1.22, P = 0.260]. Consistently, in time-varying models, CCB treatment was not linked to long-term mortality (HR: 0.97, 95% CI: 0.87–1.09, P = 0.682 and SHR: 1.05, 95% CI: 0.94–1.18, P = 0.359). This null association remained in subgroup analysis according to device strategy and propensity-matching analyses. Neurological dysfunction, stroke, bleeding, rehospitalization, and renal dysfunction were more likely to occur among those with CCB when compared with those without CCB treatment. Conclusions: In patients with LVAD, CCB therapy fails to show benefits in long-term survival and is associated with increased incidences of neurological dysfunction, bleeding, renal dysfunction, and rehospitalization
Der Zusammenhang zwischen bewusster Emotionsverarbeitung und Coping-Stilen (Rumination, Distraktion) bei Major Depressive Disorder
No full textRumination und gestörte Emotionsverarbeitung gelten als zentrale Merkmale der Major Depressive Disorder (MDD). Rumination lässt sich in symptom- (SYM) und selbstfokussiert (SELF) unterteilen und steht im Kontrast zur Distraktion (DIS). Ziel dieser Arbeit war es, Zusammenhänge zwischen diesen Coping-Stilen und der Amygdala-Aktivierung bei MDD während des Hariri-Paradigmas zu untersuchen. 181 akut depressive Patienten füllten den RSQ-D aus und wurden mittels fMRT untersucht. Regressions- und Extremgruppenanalysen prüften, ob SYM und SELF mit einer verstärkten, DIS mit einer reduzierten Aktivierung assoziiert sind. Zwar zeigten sich erwartungskonforme Aktivierungen bei emotionalen Reizen, doch kein signifikanter Zusammenhang mit den Coping-Stilen. Die Hypothesen konnten nicht bestätigt werden
Digitale Medien im Mathematikunterricht der Primarstufe 2025:Beiträge zur 8. PriMaMedien-Sommertagung 2025 in Gießen
No full textSeit 2007 tagt die Arbeitsgruppe PriMaMedien im Arbeitskreis Grundschule der Gesellschaft für Didaktik der Mathematik. Die Mitglieder dieser Arbeitsgruppe teilen das Interesse an der Entwicklung, der Konzeption, dem Einsatz und der Analyse digitaler Medien für den Mathematikunterricht in der Primarstufe.
Im Rahmen der Sommertagung 2025 der PriMaMedien-Arbeitsgruppe an der Justus-Liebig-Universität in Gießen fanden sich 30 Personen zusammen, um über Forschungs- und Entwicklungsarbeiten zum Einsatz digitaler Medien im Mathematikunterricht der Primarstufe zu diskutieren. Darüber hinaus wurden auch digital gestützte Lehr-Lernkonzepte in den Blick genommen. Gemäß des ‚Primats der Fachdidaktik’ erfolgte eine Auseinandersetzung mit Forschungsprojekten und Lehr- und Lernangeboten, die sich an den technischen Gegebenheiten und daraus resultierenden fachdidaktischen Potenzialen orientierten.
Im vorliegenden Tagungsband werden Projekte und Arbeiten aus der Forschung, der Schulpraxis und der Lehrkräftebildung dargestellt, die im Rahmen der PriMaMedien-Sommertagung 2025 vorgestellt wurden
Donor Proteinuria and Allograft Function in Kidney Transplantation: Short- and Long-Term Results From a Retrospective Cohort Study
No full textDonor proteinuria (DP) is a common but rarely evaluated aspect of today’s kidney transplant allocation process. While proteinuria after kidney transplantation is a risk factor for impaired graft function and survival, the long-term effects of DP in kidney transplantation have not yet been evaluated. Therefore, this study aims to investigate the impact of DP on the long-term outcome after kidney transplantation. A total of 587 patients were found to be eligible and were stratified into two groups: (1) those receiving a graft from a donor without proteinuria (DP−) and (2) those receiving a graft from a donor with proteinuria (DP+). At 36 months, there was no difference in the primary composite endpoint including graft loss and patient survival (log-rank test, p = 0.377). However, the analysis of DP+ subgroups showed a significant decrease in overall patient survival in the group with high DP (p = 0.017). DP did not adversely affect patient or graft survival over 36 months. Nevertheless, this work revealed a trend towards decreased overall survival of patients with severe proteinuria in the subgroup analysis. Therefore, the underlying results suggest caution in allocating kidneys from donors with high levels of proteinuria