Jammu and Kashmir Academy of Art, Culture and Languages

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    1128 research outputs found

    Modeling of Security Measurement (Metrics) in an Information System

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    Security metrics and measurement is a sub-field of broader information security field. This field is not new but it got very least and sporadic attention as a result of which it is still in its early stages. The measurement and evaluation of security now became a long standing challenge to the research community. Much of the focus remained towards devising and the application of new and updated protection mechanisms. Measurements in general act as a driving force in decision making. As stated by Lord Kelvin “if you cannot measure it then you cannot improve it”. This principle is also applicable to security measurement of information systems. Even if the necessary and required protection mechanisms are in place still the level of security remains unknown, which limits the decision making capabilities to improve the security of a system. With the increasing reliance on these information systems in general and software systems in particular security measurement has become the most pressing requirement in order to promote and develop the security critical systems in the current networked environment. The resultant indicators of security measurement preferably the quantative indicators act as a basis for the decision making to enhance the security of overall system. The information systems are comprised of various components such as people, hardware, data, network and software. With the fast growing reliance on the software systems, the research reported in this thesis aims to provide a framework using mathematical modeling techniques for evaluation of security of the software systems at the architectural and design phase of the system lifecycle and the derived security metrics on a controlled scale from the proposed framework. The proposed security evaluation framework is independent of the programing language and the platform used in developing the system and also is applicable from small desktop application to large complex distributed software. The validation process of security metrics is the most challenging part of the security metrics field. In this thesis we have conducted the exploratory empirical evaluation on a running system to validate the derived security metrics and the measurement results. To make the task easy we have transformed the proposed security evaluation into algorithmic form which increased the applicability of the proposed framework without requiring any expert security knowledge. The motivation of the research is to provide the software development team with a tool to evaluate the level of security of each of the element of the system and the overall system at the early development stages of the system life cycle. In this regard three question “What is to be measured?”, “where (in the system life cycle) to measure?” and “how to measure?” have been answered in the thesis. Since the field of security metrics and measurements is still in the its early stages, the first part of the thesis investigates and analyzes the basic terminologies , taxonomies and major efforts made towards security metrics based on the literature survey. Answering the second question “Where (in the system life cycle) to measure security”, the second part of the thesis analyzes the secure software development processes (SSDPs) followed and identifies the key stages of the system’s life cycle where the evaluation of security is necessary. Answering the question 1 and 2, “What is to be measured “and “How to measure”, third part of the thesis presents a security evaluation framework aimed at the software architecture and design phase using mathematical modeling techniques. In the proposed framework, the component based architecture and design (CBAD) using UML 2.0 component modeling techniques has been adopted. Further in part 3 of the thesis present the empirical evaluation of the proposed framework to validate and analyze the applicability and feasibility of the proposed security metrics. Our effort is to get the focus of the software development community to focus on the security evaluation in the software development process in order to take the early decisions regarding the security of the overall system

    Impact of Stratification on Nutrient Concentration in Manasbal Lake, Kashmir

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    The valley of Kashmir has a number of water bodies spread over its length and breadth. While most of them are very shallow and hence do not show any permanent stratification phenomenon, some have been reported to stratify. Lake Manasbal (34o14’40’’– 34o15’20’’N and 74o39’00’’– 74o41’20’’E and 1583 m amsl) has been reported to be the only warm monomictic lake in the valley (Hutchinson, 1957). The water body has been found to stratify during March – November/December and circulate for the brief period of December – February. The lake has been an important tourist spot, besides being a source of commercial fishing, and a number of economically important plants. Keeping in view, the economic and ecological importance of the lake, it was decided to have an insight into the process of thermal stratification in this water body and assess the impact of the thermal stratification on the nutrient distribution in it. The data collected during the year- long study are presented in the form of the present M.Phil. dissertation

    Gene Polymorphism Of Cyp1a1/Cyp2d6 And Their Association With Acute Lymphoblastic Leukemia (All) In Kashmiri Children

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    Acute lymphoblastic leukemia (ALL) is a type of cancer that affects immature lymphocytes developing in the bone marrow. Genetic susceptibility to leukemias can be related to the polymorphisms in CYP2D6 and CYP1A1 genes and consistent with this paradigm several polymorphisms have been identified in the pathogenesis of lymphoid malignancies.CYP2D6 and CYP1A1- the member of the cytochrome P450 mixed-function oxidase system, are the most important enzymes involved in the metabolism of various drugs in the body. To determine whether these genes played a similar role in childhood leukemogenesis in the Kashmiri children, we compared the allele frequencies of 120 childhood ALL patients and 110 controls for the CYP1A1 and CYP2D6 genes. Genotyping was done by PCR-RFLP technique and results were validated by direct sequencing of the PCR products. We observed that the CYP2D6 (G) allele frequency was 97.27% in the controls and 45% in cases and CYP2D6 (A) allele frequency was 2.72% in the controls and 55% in cases. While as in case of CYP1A1 the frequency of CYP1A1 (T) allele was 88.75% in the controls and 83.88% in cases and CYP1A1 (C) allele frequency was 11.25% in controls and 16.66% in cases. This difference in frequency was found to be statistically insignificant with a P>0.05. The CYP2D6 wild genotype frequency was found to be present in 33.33% of the cases and 96.36% of the controls, the hetero variant in 23.33% of the cases and 1.82% of controls, and the mutant genotype in 43.33% of cases and 1.82% of controls. While as in case of CYP1A1, the wild genotype was found to be present in 70.83% of cases and 85.45% in controls, the hetero genotype in 25% of the cases and 22.73% of controls and the mutant was found to be present in 4.17% of the cases and 0.9% of controls. We observed that an increased risk associated with CYP2D6 Mutant genotype 43.33% (OR = 68.90, 95% CI, 16.02-296.3; P = <0.0001 ) and Wild genotype 33.33% and low with hetero genotype 23.33% of CYP2D6 as compared to the controls and also increased risk is associated with CYP1A1 wild (T/T) genotype 70.83 % and hetero 25% (OR 1.33, 95% CI, 0.72- 2.43; P = 0.44) and low in case of mutant (C/C) genotype 4.17% ( OR = 5.53, CI 95% 0.63-48.31, P = 0.19) as compared to the controls. Thus, our study suggests that there is an association between gene polymorphism of CYP2D6 and CYP1A1 and the development of ALL in Kashmiri children

    In vivo study of anti-diabetic activity of Eremurus himalaicus

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    Diabetes mellitus is a most common endocrine disorder, affecting more than 300 million people worldwide. For this, therapies developed along the principles of western medicine (allopathic) are often limited in efficacy, carry the risk of adverse effects, and are often too costly, especially for the developing world. In order to identify complementary or alternative approaches to existing medications, we studied the antidiabetic potential of Eremurus himalaicus-An endemic plant of North-Western Himalayas. The acute oral toxicity studies of the extracts revealed no toxic effects up to the levels of 2000 mg/kg b. wt. The Ethyl Acetate, Methanol and Aqueous extracts of Eremurus himalaicus were screened for the presence of hypoglycaemic and antidiabetic activity. In this study diabetes was induced by a single IP dose Alloxan monohydrate. The study was carried out on a 14 day protocol and the blood glucose, SGOT, SGPT and ALP levels were measured on Day 0, Day 7 and Day 14 of the treatment, along with histopathological examination of pancreas on day 14. Maximum activity was shown by the ethyl acetate extract with a percent variation in blood glucose level of 30.78% and 48.78% followed by aqueous extract with a percent variation in blood glucose level of 25.43% and 38.77% at a dose level of 250 mg/kg b. wt. and 500 mg/kg b. wt. respectively. Glibenclamide was taken as the standard and the results were quite comparable with it. The histopathological studies also indicated that Eremurus himalaicus is effective in regeneration of insulin secreting β-cells and thus possesses antihyperglycaemic activity. The results also showed that Eremurus himalaicus protects significantly from other physiological aberrations i.e., polydypsia, polyphagia, weight loss and metabolic aberrations i.e., increase in SGOT, SGPT, ALP, cholesterol and triglyceride levels caused by diabetes, in a dose dependent manner. The aqueous extract also showed significant effect in increasing the oral glucose tolerance of rats and it also showed good hypoglycaemic activity in normoglycaemic rats. The preliminary phytochemical analysis of the extracts of Eremurus himalaicus revealed the presence of alkaloids, tannins, saponins, terpenoids, flavonoids, phenolics and glycosides as the possible biologically active principles

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