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シーベリー抽出物の生理機能に関する研究
Get PDF北見工業大学博士Sea buckthorn is a deciduous shrub of the Elaeagnaceae family native to Europe and Asia. Sea buckthorn berry (SBB) is pale yellow to dark orange in color, rich in nutrients, and many other researchers have reported a variety of biological functions associated with them. In this study, we have investigated the suppressive effect of sea buckthorn berry extract and its fractions on Type-I allergy using mast cell lines in vitro. An SBB fraction containing the highest amount of antioxidant polyphenols significantly inhibited the release of chemical mediators, such as histamine and leukotriene (LT) B4, from stimulated mast cells. This fraction also inhibited Ca2+ influx and phosphorylation of tyrosine residues of proteins, including spleen tyrosine kinase (Syk), which is associated with the signal transduction of chemical mediators released from stimulated mast cells. And we identified isorhamnetin, the predominant flavonol aglycon in this fraction. Isorhamnetin inhibited the histamine and LTB4 release from stimulated cells and suppressed intracellular Ca2+ influx. These results suggest that isorhamnetin is the primary substance responsible for the anti-allergic activity in SBB. In conclusion, SBB may alleviate Type-I allergy by inhibiting the release of chemical mediators from mast cells, and the polyphenols may contribute to this effect.doctoral thesi
Studies of Human Science vol.16 Cover / Contents / Publication Data
No full textdepartmental bulletin pape
氷板厚計算式に基づく実用的な解氷時期推定手法の開発
Get PDF本研究の目的は，アイスジャム発生前に現れる解氷時期の推定手法の開発である．解氷時期に氷板厚が減少するため，氷板厚の計算式の精度向上を試みた．積雪・融雪・降雨を考慮した氷板厚計算式は，計算値の精度が高いことを示し，支配的なパラメーターは計算上の最小水温であることが分かった．解氷時期を推定する指標として，氷板厚の変動加速度PBを提案した．6つの入力値を用いる実用的な解氷時期推定手法を開発した．本手法は，アイスジャム発生付近でPBのピークが現れており，安全側で解氷時期を推定した．本手法においては，全面結氷時の氷板厚も重要なパラメーターであることが分かった．journal articl
Equilibrium pressure measurements and Raman spectroscopic analysis of N2O hydrate
Get PDF本研究では N2Oハイドレートの4重点近傍における平衡圧の精密測定を行い，解離熱および水和数を求めた．平衡圧曲線からクラウジウス＝クラペイロン方程式を適用して，4重点における解離熱を求めた結果，24.3 ± 0.8 kJ mol−1（ハイドレート→ガス+氷），および68.1 ± 0.4 kJ mol−1（ハイドレート→ガス+水）となった．
熱量計を用いて直接測定された解離熱は22.5 ± 0.2 kJ mol−1（ハイドレート→ガス+氷）であり，平衡圧曲線から求めた値よりやや小さかった．また，4重点における2つの解離熱から推定された水和数は7.3 ± 0.2となり，大ケージ占有率 100％を仮定した場合，小ケージ占有率は 7～24％であることがわかった．また，4重点近傍の温度圧力にて生成した N2Oハイドレートの水和数をラマン分光分析によって求めた．その結果，水和数は6.6 ± 0.2の範囲にあり，４重点近傍の生成圧力では水和数が大きく変化することが示唆された．journal articl
センサーを伴うデジタルサイネージを利用した販売促進戦略に関する一考察
Get PDF本研究では，センサーを伴うデジタルサイネージを利用した販売促進戦略を検討する．統計的決定理論に基づいてベイズ基準のもとで期待売上を最大化する新しい販売促進戦略を提案し，その有効性を数値計算例で検証する．journal articl
Distinct color changes in hydrogen peroxide-responsive thin films consisting of boronic acid-containing polymers
No full textA novel methodology for the preparation of hydrogen peroxide (H2O2)-responsive thin-film sensors that display distinct color changes was developed. Boronic acid-containing films were obtained through the copolymerization of boronic acid and tertiary amine monomers, acrylamide, and a crosslinker on a pattern-printed microscope slide. After immersing the thin films in an aqueous H2O2 solution, they were colored with anionic dye solutions containing fructose. The color of the thin films changed depending on the H2O2 concentration in the solutions. When the H2O2 concentration is low, the thin film adsorbs a cationic dye, whereas at higher H2O2 concentrations, it adsorbs an anionic dye. This indicates that the thin film was negatively charged before reacting with H2O2 and that the charge converted to positive following the reaction with H2O2. Changes in the parameters such as monomer composition, pH, and fructose concentration might affect the color change behavior. The H2O2-responsive thin films presented herein are advantageous for the development of H2O2 sensors because of their relatively simple preparation and non-complex organic synthesis. In addition, there is virtually no limitation to choosing dyes, and any kind of color change can be realized. © 2023journal articl
A Crown as “A Speaking Picture”: Interspersed Images in Pamphilia to Amphilanthus
Get PDFLady Mary Wroth’s sonnet sequence, Pamphilia to Amphilanthus, contains a group of
sonnets entitled, “A Crowne of Sonnets Dedicated to Love.” This crown is written in an Italian
poetic form in which the last line of each stanza is succeeded by the first line of the following
stanza, giving it a very complicated structure. As the title suggests, it represents a crown which
is dedicated to Cupid, yet it further evokes the images of a labyrinth or miniature painting due
to its complexity and intricacy. It is well known that Wroth was influenced by her uncle, Sir
Philip Sidney, and in Crowne, she specifically adapted his poetic ideas to create her poetic style.
In this paper, I attempt to confirm the images portrayed in the crown of sonnets as “a speaking
picture,” considering the circumstances surrounding the speaker, Pamphilia.departmental bulletin pape
単画像多矩形物体検出のための特徴抽出
Get PDF北見工業大学博士（工学）Recently, object detection based on deep convolutional neural networks (CNNs) have achieved
remarkable result and successfully applied many real-world applications. However, scale variation
problem in multiscale object detection still is challenging problem, especially for small objects.
Concerning the above problem, we proposed a new detection network with an efficient feature fusion
module based on SSD using VGG-16 as backbone called Multi-path Feature Fusion Single Shot Multibox Detector (MF-SSD). The proposed feature fusion module consists of two newly designed modules
with dilated convolution, which fuses features from shallow layers (mainly contain boundary information)
to highRecently, object detection based on deep convolutional neural networks (CNNs) have achieved
remarkable result and successfully applied many real-world applications. However, scale variation
problem in multiscale object detection still is challenging problem, especially for small objects.
Concerning the above problem, we proposed a new detection network with an efficient feature fusion
module based on SSD using VGG-16 as backbone called Multi-path Feature Fusion Single Shot Multibox Detector (MF-SSD). The proposed feature fusion module consists of two newly designed modules
with dilated convolution, which fuses features from shallow layers (mainly contain boundary information)
to higher level features (mainly contain semantic reach information) without reducing the original
resolution of the feature map. We have conducted experiments on three datasets to explicate the efficacy
of our proposed detector. The proposed MF-SSD with input size 512×512 achieved 81.5% mAP and
34.1 % mAP on PASCAL VOC test set and MS COCO test-dev, respectively. Experimental results show
the proposed feature fusion module can improve both semantic and boundary information for object
detectioner level features (mainly contain semantic reach information) without reducing the original
resolution of the feature map. We have conducted experiments on three datasets to explicate the efficacy
of our proposed detector. The proposed MF-SSD with input size 512×512 achieved 81.5% mAP and
34.1 % mAP on PASCAL VOC test set and MS COCO test-dev, respectively. Experimental results show
the proposed feature fusion module can improve both semantic and boundary information for object detection.doctoral thesi