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    Evaluating the Reach of HelloType1- A Digital Innovative Educational Platform in Regional Languages for Diabetes Education in Southeast Asia (Preprint)

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    Background:Amidst the COVID-19 pandemic, Action4Diabetes (A4D), a non-profit organisation collaborating with local healthcare professionals across Southeast Asia (SEA), developed HelloType1 a digital educational platform for Type 1 diabetes (T1D) in regional languages. Launched sequentially in Cambodia (2021), Vietnam (2022), Thailand (2022), and Malaysia (2023) through Memorandums of Understanding (MOUs), the digital platform aimed to improve diabetes awareness, education, and access to credible local-language resources.Objective:This study aims to evaluate the usability, reach and online engagement of HelloType1 from 2021 to 2024.Methods:Website traffic data from Google Analytics (GA4) and Facebook metrics were analysed to assess user growth, traffic sources, and engagement trends across countries.Results:Total users increased by 645% between 2021 and 2022 and a further 31% between 2022 and 2023. By 2024, 78% of visits originated from search engines, 13% from social media, and 9% from direct access. Pageviews rose from 4,644 (2021) to 82,689 (2024). Facebook followers grew from 940 to 4,553, with engagement rates increasing from 8% (2022) to 29% (2024). Cambodia achieved the highest reach, while Vietnam showed strong engagement among younger female caregivers.Conclusions:HelloType1 demonstrates a scalable, low-cost digital model for delivering culturally adapted T1D education in resource-limited SEA settings. Clinical Trial: N

    Functionally Grouping Male Runners Based upon Individual Responses to Motion Control Running Shoes: A Laboratory Based Proof-of-Concept Study

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    Individual responses to different running shoes may offer a means of functionally grouping runners. Thus, the aim of this exploratory study was to explore whether changes in rearfoot eversion between running shoes with different motion control properties could be used to functionally group male runners and to explore the characteristics of each functional group. Fifty male participants ran at the same self-selected velocity, along a 20 m runway in standardised motion control and neutral/cushioned running shoes. Rearfoot motion was recorded using a 10-camera motion capture system. Functional groups were identified based upon changes in peak rearfoot eversion between footwear conditions. Positive responders displayed a reduction of ≥ 3°, negative responders an increase of ≥ 3° and non-responders changes within ± 3° when running in the motion control shoe. Eighteen participants were classified as positive, seven negative and 25 non-responders to the motion control running shoe. Exploration of participant characteristics, running velocity and rearfoot kinematics revealed that peak eversion in the neutral/cushioned running shoe and the change in peak eversion and eversion excursion between footwear conditions were significantly (p ≤ 0.021) different between responder groups. Positive responders displayed the greatest peak eversion in the neutral/cushioned running shoe and the largest reduction in both peak eversion and eversion excursion when running in the motion control shoe. In contrast, negative responders displayed the lowest peak eversion in the neutral/cushioned running shoe and smallest changes in eversion excursion in the motion control shoe. These findings highlight the feasibility of functionally grouping runners based upon their response to motion control running shoes and suggest that the magnitude of peak eversion influences responses to motion control running shoes

    Evidence on Carotenoid Supplementation to Improve Working Memory in Older Adults

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    As individuals age their levels of naturally occurring oxidative stress (OS) increase. Higher levels of OS have been identified as a key contributing factor into age-associated working memory decline. Consequently, dietary alterations and supplements which can mitigate these effects have gained significant research interest in recent years. The literature at present suggests that supplementation with carotenoids, especially those within the xanthophyll family, such as zeaxanthin, lutein and astaxanthin to be of potential benefit to working memory (WM) in older adults. This finding is suggested to stem from the established benefits of carotenoid consumption. These benefits are thought to include but are not limited to their strong antioxidant properties, benefits to neural plasticity and ability to reach brain regions which specifically contribute to markers of cognition. The present chapter explores the effects of carotenoid supplementation and consumption on working memory in older adults and discusses the underlying reasons for differences in study outcomes within the literature. Potential mechanisms for cognitive enhancement associated with the role of carotenoids in reducing oxidative stress and inflammation in the brain are also considered. Areas for future research including optimal carotenoid dose, carotenoid supplementation duration, issues with correlation versus causation, testing methodologies and subsequent critical recommendations, are also discussed.</p

    The obligation to prevent genocide

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    This briefing sets out the international and UK law on genocide and discusses recent cases on this issue. There will be a general debate on obligation to assess the risk of genocide under international law in relation to the Occupied Palestinian Territories in the Commons chamber on Thursday 5 February 2026

    Sensitivity of Flood Extent and Population Exposure to Variations in Bathymetry Across a Shallow Continental Shelf Lagoon

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    Bathymetry is a critical input to storm surge models on coastlines fronted by lagoon systems, yet few studies explore how variations in bathymetry influence flood impacts, flooded extent, and exposed population across these globally widespread morphologies. Here, we investigate the influence of variations in bathymetry on storm inundation impact estimates across a continental shelf lagoon system. We explore how flooded extents and exposed population estimates from a 1% storm for Belize vary with estimated depths by comparing three existing bathymetries over a northern shallow, enclosed lagoon and a central deeper, open lagoon system with a newly developed bathymetry data set, Satellite‐Derived Bathymetry Enhanced Data set‐SDBED. We compare multiple bathymetric data sets to understand the influence on the flood uncertainties and the quantity of the impact of exposed population estimates. Our results show that greater estimated lagoon depths consistently result in lower predicted flood impacts for both lagoon systems in almost all cases. Unexpectedly, for one bathymetry with a median depth of 2 m in the northern lagoon, we find that a reduction in lagoon volume by 59% reduces total inundation volume by 45%. Our findings also show how vertical uncertainties in the SDBED bathymetry propagate through the model, resulting in variations of up to 12% in flood extents and up to 2% in exposed populations

    A Basque Auteur for a New Generation: The Case of Kepa Sojo

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    The work of Kepa Sojo offers an ideal window into the global dissemination opportunities available to contemporary Basque cinema through online streaming and international festival circuits. Sojo’s career as a filmmaker, academic and festival operator presents an exciting insight into ever-growing Basque film production as it negotiates regional and national boundaries. Sojo’s as yet critically under-addressed oeuvre furthermore provides insight into the pervading generic and stylistic trends of twenty-first century Basque filmmaking and their interaction with both the history and the future of this regional cinema

    Diabetes self‐management education and its association with hospital admissions and premature mortality: A scoping review and meta‐analysis

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    Type 2 diabetes is associated with increased all‐cause hospital admissions and premature mortality. Diabetes self‐management education (DSME) is internationally recommended but its impact on reducing hospital admissions and premature mortality is unclear. This scoping review followed the PRISMA extension for scoping reviews and explores the relationship between DSME, hospital admissions and mortality in adults with type 2 diabetes. Core search terms for type 2 diabetes were combined with terms for DSME, hospital admission, and mortality. Searches were conducted on 10 January 2024, and checked in September 2025, across three electronic databases: CINAHL, MEDLINE, and EMBASE. No restrictions were applied regarding study design, quality, location, or sex. The search yielded 294 records from databases and 66 from manual searches; 42 met inclusion criteria. Evidence regarding hospitalisation was inconsistent, with heterogenous outcome definitions and frequent reporting of admissions as a reason for attrition. Meta‐analysis showed a non‐significant 9% reduction in admission risk among DSME groups. By contrast, meta‐regression found that whether mortality was reported as a primary outcome significantly moderated the treatment effect (p = 0.0002), fully accounting for between‐study heterogeneity (τ2 = 0; I 2 = 0%; R 2 = 100%). A final pooled analysis, restricted to studies with mortality as a primary outcome, demonstrated a ~45% reduction in mortality risk (RR 0.55, 95% CI 0.47–0.63, p &lt; 0.0001). DSME may offer a survival benefit for adults with type 2 diabetes, but current evidence does not support an association with reduced hospitalisation. Standardisation of DSME content and outcome reporting is essential to improve comparability

    The Effects of the Arts and Arts Therapies on Mental Health Outcomes of Children and Young People:A Systematic Review and Meta-Analysis

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    Background: There is growing evidence on the positive effects of the arts and arts therapies for mental health (MH) outcomes. This review aims to fill a research gap by establishing the evidence on the effects of arts-based interventions on selected MH outcomes for children and young people (CYP).Methods: Our systematic review and meta-analysis included randomised controlled trials with CYP aged 5 to 24 years receiving any type of arts‑based intervention. Following PROSPERO registration (CRD420251015352), five databases (CINAHL, Embase.com, MEDLINE, PsycINFO, and Web of Science) were searched on 18/5/2025 for studies published from 2005-2025. Two reviewers independently screened all records and assessed risk‑of‑bias. Data were extracted using a combination of an AI-assisted review tool and two reviewers. Effect estimates for MH outcomes are summarised as Standardised Mean Differences (SMD) with 95% confidence intervals (CI).Findings: Seventy-seven trials across 25 countries were included involving CYP with health conditions alongside healthy populations. Based on studies with moderate to high risk-of-bias, arts-based interventions reduced depression by 1.06 SMD (95% CI 0.45-1.67, n=1655, I²=97%), anxiety by 0.74 SMD (95% CI 0.56-0.93, n=3898 I²=87% ), improved wellbeing by 0.53 SMD (95% CI 0.26-0.80, n=538 I²=49%) and quality of life by 0.54 SMD (95% CI 0.25-0.83, n=441 I²=53%) post-intervention. Results were supported by objective data on biomarkers.Interpretation: This international review provides the first comprehensive synthesis of evidence across all art forms for CYP, suggesting moderate to very large effects of arts-based interventions on key MH outcomes, although with considerable heterogeneity and bias concerns. Effects are comparable to those typically reported for psychosocial interventions, with implications for policy, research and practice, advancing discussions on effective, inclusive, and evidence-based strategies for CYP’s MH

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