137262 research outputs found
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Le prospettive metodologiche della storiografia costituzionale italiana. Introduzione al seminario del prof. Carlos Petit
No full textL'introduzione al seminario ha riguardato le principali chiavi di lettura della storiografia italiana che ha analizzato la storia costituzionale europea e american
Aspetti del controllo nelle società bancarie
No full textIl contenuto analizza i controlli nelle società bancarie per ciò che essi si discostano dal diritto comune. Lo studio si incentra sul dovere informativo degli organi di controllo, qualificabile come manus pubblicistico, e sulla sostituzione del controllo giudiziario con un procedimento amministrativo affidato alla Banca d'Italia
Lipid–Polymer Nanoparticles (LiPoNs) Mediated Codelivery of AntimiR-21 and Gadolinium Chelate in Triple Negative Breast Cancer Theranostics
No full textRNA-based interventions are particularly promising for next-generation therapeutic strategies and hold significant potential when integrated with diagnostic modalities. Among noncoding RNAs, microRNAs (miRNAs) regulate gene expression post-transcriptionally and represent compelling targets for cancer therapy. However, their clinical translation remains hindered by instability, off-target effects, and limited delivery efficiency. Here, we report the microfluidic synthesis of hybrid lipid–polymer nanoparticles (LiPoNs) that co-deliver an AntimiR-21 and the magnetic resonance imaging contrast agent gadolinium diethylenetriamine penta-acetic acid (Gd-DTPA). The LiPoNs were obtained using coupled Hydrodynamic Flow Focusing (cHFF), enabling precise control over lipid–polymer self-assembly and surpassing the compositional limitations reported with conventional micromixers. The resulting AntimiR-21–Gd-DTPA–LiPoNs exhibited an average hydrodynamic diameter of 124 nm, narrow polydispersity (PDI < 0.2), and encapsulation efficiency up to 60%. In MDA-MB-231 breast cancer cells, treatment with AntimiR-21–LiPoNs induced suppression of miR-21 and a corresponding decrease in migratory capacity, demonstrating effective functional delivery and gene expression modulation. These findings establish a versatile microfluidic platform for engineering multifunctional lipid–polymer nanostructures whose hybrid architecture combines the biocompatibility and membrane fusion capability of lipids with the structural robustness and controlled release properties of polymers, thereby advancing RNA-based theranostic design for precision oncology and related applications
Open-oriented algorithmic approach for BIM modelling of complex historic water infrastructure
No full textThe management of water resources has underpinned the history of settlement systems for centuries. The introduction of railways often led to neglect the previously fundamental hydraulic infrastructures that characterised the landscape. The “Naviglio” of the city of Pavia (Italy), an artificial water channel built to allow uphill navigation from Pavia to Milan, is the perfect example of a relevant historic infrastructure worth of management and refurbishment interventions. To this end, monitoring strategies and a digital ecosystem to implement them are required. Namely, the proposed methodological workflow integrates semi-automated modelling procedures for the fast development of a LOD 200 GeoBIM model of the “Naviglio” starting just from 2D cartographic data and literature information. The objective is indeed to set up a digital ecosystem, taking advantage of the strength of the BIM methodologies, optimised for implementing monitoring strategies both at architectural and urban scales. Furthermore, the approach seeks to employ open tools when possible, relying on a transferable parametrisation algorithm so as not to constrain further researchers to a specific BIM authoring tool
Detecting Morphological Change From DInSAR Data in Ephemeral, Braided, Gravel Bed Rivers. Application to the Ungauged Trionto River, Italy
No full textEstimating morphological change in braided gravel bed rivers is important to determine the geometry of the active part of the braidplain, that is the width of the area where bed material is transported and the number of active branches during a certain time interval. Repeated surveys and photogrammetry have been used to measure morphological change with different spatial and temporal resolution but characterizing the geometry of braided rivers remains a problem. Increased satellite coverage and frequency of revisiting times motivated satellite-based studies of river dynamics. Here we present a procedure to estimate morphological change in ephemeral, braided, gravel bed rivers from Differential Interferometry of Synthetic Aperture Radar (DInSAR) data conducted on Sentinel-1 SAR images, that is information on areas where ground displacement larger than 5–6 cm occurred. We hypothesize that such displacement is representative of bedload transport and can be used to describe the morphologically active braidplain. The procedure is applied to the Trionto River in Southern Italy. Results indicate that the proposed approach has the potential to capture different channel dynamics related to lateral confinement and flood hydrographs. In agreement with field and laboratory observations reported in the literature, narrower morphological active width and fewer active branches are estimated where the valley is most confined. In response to a relatively frequent flood, active width remains independent of lateral confinement and one or two active branches are predicted. Conversely, a large, less frequent flood results in the reorganization of the channel network with comparatively larger active width and more active branches in the widest portion of the braidplain
A stochastic frontier approach to nitrogen use and efficiency in soft wheat cultivation
No full textPurpose: This study evaluates the impact of nitrogen recommendations provided by a Decision Support Systems (DSS) on soft wheat production and technical efficiency in specialized Italian cereal farms. Methods: Employing a Stochastic Frontier Analysis, the research evaluates the relationship between adherence to DSS recommendations and farm performance. The analysis relies on real farm data from the Barilla Farming platform, agrarian year 2022/2023, covering 487 farms and 1,664 fields, including suggested and actual nitrogen applications and observed yields. Results: Findings indicate that compliance with DSS recommendations enhances output levels and efficiency, particularly for medium and large farms, whereas deviations, especially over-application, reduce efficiency with potential increase of costs and environmental risks. Notably, small farms maintain efficiency despite lower nitrogen applications, indicating the need for tailored DSS calibration. Results highlight the importance of site-specific nitrogen management strategies to optimize both economic and environmental outcomes. Conclusion: While promoting DSS adoption is essential, our findings suggest that ensuring farmers’ compliance with DSS recommendations is equally—if not more—critical to realizing its full benefits. Policymakers and extension services should not only encourage the uptake of DSS but also focus on strategies that enhance farmers’ adherence to recommended practices. Additionally, ensuring the adaptability of DSS to different farm structures is key to maximizing its impact across varying production scales
Decoding Roman construction techniques through a multiproxy study of pozzolanic mortars from the Brick Amphitheater of Nola (Campania, Southern Italy)
No full textThe long-lasting performance of ancient pozzolanic mortars highlights the advanced expertise of Roman builders. By intentionally mixing lime with specific volcanic materials, like ash or sand, the Romans developed hydraulic mortars and concretes that could harden even underwater and exhibit high mechanical strength. Furthermore, these pozzolanic additives accelerated the setting process via hydraulic reactions, offering a faster alternative to the slow carbonation of pure slaked lime. This study provides the first integrated reconstruction of the technological choices and historical evolution of the Brick Amphitheater of Nola by linking the provenance and compositional variability of volcanic aggregates to its different building phases. Due to the site's complex historical stratigraphy and multiple construction phases, a targeted, non-invasive sampling strategy was adopted. Eighteen bedding mortar samples from the Amphitheater structures and adjoining Late Antique walls were analyzed using an integrated analytical including Polarized Optical Microscopy, X-Ray Powder Diffraction, Field Emission Scanning Electron Microscopy with Energy-Dispersive X-Ray Spectroscopy, Mercury Intrusion Porosimetry, Differential Thermal Analysis and Thermogravimetric Analysis. The research aims to distinguish construction phases and trace the evolution of building techniques by i) identifying the geological provenance of raw materials, ii) analyzing the mortar mix design, and iii) reconstructing the site's chronology. Results confirmed that raw materials were locally sourced, employing aggregates from Somma-Vesuvius district, as well as recycled Neapolitan Yellow Tuff, highlighting the Roman builders' expertise in selecting and combining local volcanic aggregates with hydrated lime to produce natural hydraulic mortars. The observed hydraulicity is attributed to the binder-aggregate interaction, evidenced by reaction rims and the formation of calcium-aluminum-silicate-hydrate (C-A-S-H) gels. Mortars from the Amphitheater structures display optimized binder-aggregate ratios and well-compacted pore networks, contrasting with the greater heterogeneity, increased porosity and mixed aggregate origins of mortars from Late Antique walls. These findings reflect intentional and consistent material selection and formulation, also reflecting chronological and functional evolution of the site