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Il D.L. 36/25 in materia di cittadinanza alla luce delle due ordinanze di rimessione alla Corte costituzionale
No full textanalisi dei principali profili di legittimità sollevati in riferimento al DL 36/2025, guardando in particolare alla ragionevolezza della normativa introdotta
Towards the classification of maximum scattered linear sets of
No full textEvery maximum scattered linear set in is the projection of an -subgeometry of from a plane external to the secant variety to . The pair will be called a projecting configuration for the linear set. The projecting configurations for the only known maximum scattered linear sets in , namely those of pseudoregulus and LP type, have been characterized in the literature by B. Csajbók, C. Zanella in 2016 and by C. Zanella, F. Zullo in 2020. Let be a projecting configuration for a maximum scattered linear set in , let be a generator of , and , . If and are not both points, then the projected linear set is of pseudoregulus type. Then, suppose that they are points. The rank of a point is the vectorial dimension of the span of the orbit of under the action of . In this paper, by investigating the geometric properties of projecting configurations, it is proved that if at least one of the points and has rank 5, the associated maximum scattered linear set must be of LP type. Then, if a maximum scattered linear set of a new type exists, it must be such that . In this paper we derive two possible polynomial forms that such a linear set must have. An exhaustive analysis by computer shows that for , no new maximum scattered linear set exists
Innovation in healthcare systems
No full textThe chapter explores the Quadruple Helix model, which reframes innovation as the product of interactions among academia, government, industry, and civil society. The authors' analysis illustrates that successful healthcare innovation requires not only technological or financial investment but also the imaginative and cultural resources provided by the humanities
Il laboratorio come spazio di innovazione e cambiamento
No full textL’urbanistica è, per sua natura, una disciplina che si trasforma insieme ai contesti entro cui opera, sviluppandosi nei territori del cambiamento e della modificazione dello spazio fisico e sociale. La sua azione si fonda sulla conoscenza dei processi e delle dinamiche che strutturano tali trasformazioni, orientando un ruolo al tempo stesso critico e propositivo nella costruzione di visioni e scenari futuri.
I mutamenti della città – resi più intensi dalle crisi ambientali, economiche e sociali contemporanee – ridefiniscono costantemente il campo di indagine e di applicazione del sapere urbanistico. Emergono così interrogativi inediti sui metodi di analisi degli assetti territoriali, sull’impiego di strumenti e tecnologie, sull’interpretazione degli apparati normativi a supporto della pianificazione: in definitiva, sul ruolo del planner e del progetto nella condizione contemporanea.
In uno scenario in continua evoluzione, operare nella pianificazione territoriale e nella progettazione urbanistica significa confrontarsi con l’urgenza di interpretare fenomeni complessi che agiscono simultaneamente su più scale, incidendo in modo diretto sulle forme, sulle pratiche e sulle condizioni dell’abitare
Effect of Marital Status on Years of Life Lost From Metastatic Prostate Cancer According to Race/Ethnicity
No full textIntroduction: It is unknown whether marital status affects years of life lost (YLL) in metastatic prostate cancer (mPCa) according to race/ethnicity. Methods: Within the SEER database (2004–2021), unmarried and married mPCa patients aged 40–80 years were identified. Age- and sex-matched controls were generated (Social Security Administration life tables and Monte Carlo simulation). YLL were quantified for unmarried and married mPCa patients and controls according to race/ethnicity. Subsequently, multivariable competing risks regression (CRR) models were fitted to assess cancer-specific mortality (CSM) and other-cause mortality (OCM). Results: Among 34,202 mPCa patients, the distribution of unmarried patients according to race/ethnicity was as follows: 7267 (34.0%) in Caucasians; 3680 (57.0%) in African Americans; 1659 (37.0%) in Hispanics; and 478 (24.0%) in Asians/Pacific Islanders. YLL values in unmarried vs. married patients relative to age- and sex-matched population simulated controls, were as follows: 7.7 vs. 5.8 in Caucasians (Δ: 1.9), 9.6 vs. 7.9 in African Americans (Δ: 1.7), 7.9 vs. 6.7 in Hispanics (Δ: 1.2), and 6.3 vs. 4.7 in Asians/Pacific Islanders (Δ: 1.6). In multivariable CRR models, unmarried status independently predicted higher CSM (1.2-fold, p < 0.001) and OCM (1.2-fold, p < 0.001) in Caucasians, only higher CSM in African Americans (1.1-fold, p = 0.008) and in Asians/Pacific Islanders (1.2-fold, p = 0.02), but only higher OCM in Hispanics (1.5-fold, p < 0.001). Conclusion: Unmarried mPCa patients exhibited higher YLL values than their married counterparts, relative to age- and sex-matched population simulated controls, across all races/ethnicities. Interestingly, the YLL detriments originated from both CSM and OCM in Caucasians, only CSM in African Americans and Asians/Pacific Islanders, and only OCM in Hispanics
Liquid biopsy in Oncology: Results of a Delphi consensus study endorsed by the AIOM-SIAPEC/IAP-SIBioC-SIF Italian scientific societies
No full textLiquid biopsy (LB) offers a minimally invasive alternative to tissue biopsy by detecting tumor-derived analytes in biological fluids. Nonetheless, its adoption is limited by variability in methodologies. Therefore, this study used a modified RAND/UCLA approach involving 23 experts of the field, providing two questionnaires that assessed agreement on 22 items. Consensus was reached for all the pre- and post-analytical phase items, agreeing on the pivotal role of plasma cfDNA. Conversely, opinions varied regarding other biomarkers and biological samples. Furthermore, turnaround time and disease setting resulted as two of the most important analytical parameters for choosing testing methodology. Particularly, a complementary tissue-liquid approach with sampling interval ≤2 weeks was preferred. To conclude, a strong consensus on sample handling, biomarker prioritization, and clinical applications is achieved. However, significant heterogeneity remains regarding novel biomarkers, sampling strategies, and costs. Standardization and validation are needed to enhance the clinical adoption of LB
Serum copper, rubidium, selenium, strontium, and zinc and psychophysical health in adults of the Sarno river Basin: PREVES-STOP 2025 community biomonitoring results
No full textEvaluate associations between serum copper (Cu), rubidium (Rb), selenium (Se), strontium (Sr), and zinc (Zn) and psychophysical health in adults from Italy's Sarno River Basin within the 2025 PREVES-STOP program. Adults aged 30-65 completed validated questionnaires plus clinical evaluation and blood sampling. Elements were quantified by collision/reaction-cell inductively coupled plasma mass spectrometry (ICP-MS). Associations were evaluated using Spearman and partial Spearman correlations. Significant associations included Zn and Rb associated with lower odds (odds ratio, OR) of severe fatigue - Recognizing and Estimating Signs of Tiredness (REST): Zn OR=0.38, 95†̄% confidence interval (CI) 0.21-0.68, q=0.02; Rb OR=0.33, 95†̄% CI 0.15-0.71, q=0.03 - while Sr was associated with higher well-being - the World Health Organization-5 Well-Being Index (WHO-5) OR=1.36, 95†̄% CI 1.12-1.65, q=0.02. Findings support broader trace-element panels to inform psychophysical and cardiometabolic risk beyond classical toxic metals, complementing prior PREVES-STOP evidence on lead (Pb) and cadmium (Cd). Further investigation is warranted
What is new on the horizon for the biologics world: New kids of the block - WAO state of art
No full textBackground Advances in the understanding of type 2 inflammation have driven the development of novel biologics and small molecules for allergic diseases. New therapies targeting cytokines, receptors, and intracellular pathways offer opportunities to refine disease management and modify long-term outcomes. Methods The World Allergy Organization (WAO) Biologics Therapies in Allergic Diseases Committee conducted this state-of-the-art review. We analyzed current literature on investigational monoclonal antibodies, nanobody-based agents, kinase inhibitors, and small molecules with potential applications in asthma, chronic rhinosinusitis with nasal polyposis, atopic dermatitis, and chronic spontaneous urticaria. Mechanistic considerations, therapeutic targets, and clinical trial outcomes were evaluated to highlight emerging trends in biologic and small-molecule therapy. Results Biologics targeting IL-4, IL-5, IL-13, IL-31, TSLP, and IgE continue to expand therapeutic options across allergic disorders. Innovations such as Fc-engineered antibodies, bispecific antibodies, and nanobody platforms enhance efficacy, extend half-life, and improve tissue penetration. Novel intracellular inhibitors, including JAK, SYK, and STAT6 degraders, show promise as oral alternatives to injectable therapies. Clinical trials report high efficacy and favorable safety profiles, though variability remains across diseases and endotypes. Pediatric data are limited, and the long-term safety and cost-effectiveness of this approach require further evaluation. Conclusions Emerging biologics and small molecules are transforming the therapeutic landscape of allergic diseases, providing targeted and personalized interventions. Advances in molecular engineering, particularly nanobody technology and intracellular inhibitors, hold promise for improving patient outcomes and reducing treatment burden. Future research should prioritize long-term safety and standardized approaches to optimize integration of these therapies into clinical practice
