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Can Once-Yearly Rituximab Dosing Be “Enough” for Most People With Relapsing Multiple Sclerosis?
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The Hellenistic pottery from the Southern Quarter, in of Elea-Velia (Salerno, Italy)
No full textThe Elea-Velia settlement is located along the Cilento coast, southern portion of Salerno bay, in the Southern Italy. The town was founded at the end of the 6th cent. B. C. by migrants from Phocaea. During the 5th cent. B. C. the city became renowned for the famous Eleatic philosophy school, founded by Parmenides and Zeno. The settlement reached its’ greatest extent of development in the Hellenistic and Roman Age (late 4th cent. B. C.–5th cent. A.D.), when its name was modified to Velia.
In this paper, we present two pottery research programs on black gloss ware from 20th and recent excavations, and Hellenistic age pottery (amphorae and coarse ware) from the excavations in the Souther Quarter lead by the University of Naples ‘Federico II’. The results of analysis of the Hellenistic ceramics suggest that the settlement was fully integrated in the Mediterranean maritime trade dynamics. The presence of fine wares and amphorae reveal long distance exchanges within the Mediterranean. Furthermore, our results also allow us to infer intense exchange with other settlements in southern Italy through the inland communication routes, or short distance maritime trade
Additive effect of multiple genetic variants in SEC23B and PIEZO1 on iron metabolism dyshomeostasis in hereditary anemias
No full textHereditary anemias encompass a genetically heterogeneous spectrum of disorders, often involving multi-locus inheritance, which can complicate clinical management and worsen disease severity. This study investigates the impact of the co-inheritance of SEC23B loss-of-function pathogenic variants, which lead to congenital dyserythropoietic anemia type II (CDA II), and PIEZO1 gain-of-function pathogenic variants, associated with dehydrated hereditary stomatocytosis type I (DHS1), on hematological parameters and iron metabolism. Among 583 patients with suspected hereditary anemia, 13 were found to carry both SEC23B and PIEZO1 variants, leading to a dual diagnosis of CDA II and DHS1. Compared to those with isolated CDA II, these patients exhibited a significantly higher absolute reticulocyte count and bone marrow responsiveness index, alongside an increased prevalence of elevated ferritin levels. Functional studies in Hep3B human hepatoma cells confirmed that SEC23B knockdown combined with PIEZO1 gain-of-function led to marked ferritin accumulation and reduced hepcidin expression, driven by altered BMP/SMAD signaling and ERK1/2 MAPK pathway. These findings demonstrate how multi-locus inheritance can modify disease severity, particularly by exacerbating iron overload. Our results underscore the clinical relevance of comprehensive genetic testing for enhanced risk stratification and personalized management of hereditary anemias
Il dialogo tra le Corti. Uniformità del diritto UE e rimedi interni: perché l’intervento accentrato della Consulta è talvolta necessario
No full textIl dialogo tra Corti costituzionali nazionali e Corti europee costituisce uno strumento essenziale per la creazione, il mantenimento e lo sviluppo di uno spazio giuridico europeo in cui, per favorire un processo di integrazione profonda, il rispetto delle singole identità nazionali si pone come coordinata ermeneutica
fondamentale delle norme europee
Pathways to maritime decarbonisation: analysing alternative fuels across vessel classes
No full textThe maritime industry must transition to alternative fuels to ensure efficiency, safety, and sustainability. This paper addresses critical questions regarding the feasibility of alternative fuels in delivering net-zero carbon power. It evaluates the readiness of some of the most promising zero-carbon fuels and examines their integration with land-based infrastructure for shore power connections. The study analyses the adoption of alternative fuels across various ship types, including passenger and merchant vessels, while accounting for future fuel availability. A key component of this research is a custom-developed tool that dynamically simulates ship operations to evaluate energy demands and emissions on a semi-quantitative basis. The tool leverages detailed ship data, including class and dimensions, to establish onboard load profiles and propulsion demands. In addition, a Python-based algorithm was developed to define ship routes by retrieving real-time position data. The study focuses on alternative fuels such as LNG and methanol, including their bio and e-fuel variants, to assess their potential in decarbonising the maritime sector. Key performance indicators are used to measure the environmental and operational impacts of these fuels across different vessel classes. The findings provide strategic insights into the implementation of zero-carbon fuels in the short, medium, and long term, offering a roadmap for achieving decarbonisation targets. Results highlight LNG as a more favourable solution compared to methanol, owing to its higher energy density and economic competitiveness. Moreover, incentives plays a pivotal role in supporting transition, with an average required value decreasing from approximately 1172 €/tCO2 in 2023 to 81.8 €/tCO2 by 2040
From Digital Twins to Immersive Manufacturing: XR and Gesture-Based Control for Enhancing Human–Robot Collaboration
No full textDigital twins (DTs) and immersive extended reality (XR) interfaces offer new opportunities for intuitive, human-centred interaction in smart manufacturing. However, implementations often lack rigorous validation, quantitative performance analysis and assessment of scalability and robustness, especially in small-scale or resource-constrained manufacturing settings. This work proposes a modular metaverse framework integrating ROS2, Unity and Meta Quest devices to develop interactive, bidirectional DTs enhanced with gesture-based and mixed reality (MR) control. The framework is demonstrated through a lab-scale case study combining a robotic Wire Arc Additive Manufacturing (WAAM) system and a collaborative robot-based laser-cleaning station, showing broad applicability across industrial robotics. To evaluate usability, a preliminary user study with 17 participants was conducted, comparing a standard teach pendant with the proposed XR interface for a tool-inspection task. Results show an 80% reduction in programming time and significant decreases in perceived workload. Measured end-to-end gesture-to-action latency ranged from 430 to 450 ms, representing suitable timeframe for high-level interaction and task initiation. The study provides empirical user-centred evidence for metaverse-enabled interaction and discusses scalability, latency and industrial constraints. Aligned with the human-centric intelligence principles of Industry 5.0, the proposed approach improves accessibility, operator well-being and adaptability, contributing towards more inclusive and robust smart manufacturing systems
