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Micro/nanoplastic-induced stress in microalgae: Latest laboratory evidence and knowledge gaps
No full textPollution by micro- and nanoplastics (MNPs) is a major concern today, with direct consequences for human health and the environment. Microalgae, among the main primary producers in aquatic ecosystems, suffer from MNPs contamination due to the worrying amount of plastic waste and its persistence in the environment. This problem has mobilized international organizations and raised awareness among the scientific community for the identification of effective solutions. Policies aimed at reducing plastic products, waste management, and recycling are attempting to limit this problem; however, plastic pollution appears to be irreversible. Therefore, a critical analysis of the effects of MNPs on various microorganisms (e.g., microalgae) is urgently needed. Therefore, the objective of this review was to identify the impact of micro- and nanoplastics on microalgal populations, based on the currently available literature. Particular attention was paid to available laboratory studies on MNPs effects on microalgae physiology - as growth rate, pigment content, photosynthetic activity, oxidative stress - and morphology, with the aim of providing an update on the state of the art
Componente della Task Force di Ateneo “Human & Future” dell’Università degli Studi “Federico II” di Napoli, istituito con D.R. n. 1648 del 09 maggio 2023, previa designazione del Consiglio di Dipartimento di Giurisprudenza con verbale n. 13 del 26 settembre 2022.
No full textRipensamenti lessicali e concettuali sulle disuguaglianze per integrare il mapping
No full textNel capitolo si da conto di una parte del lavoro condotto nell'ambito della Ricerca Prin "Mapping inequalities" a integrazione del lavoro di mappatura che ha consentito di mettere a fuoco riflessioni utili per: a) un possibile ripensamento del lessico per rinnovare categorie di interpretazione e, quindi, di policies; b) un contributo interpretativo sul nesso tra diseguaglianze e organizzazioni criminali (con particolare attenzione a Napoli) sempre in relazione al connaturato quanto inevitabile sfuggire a qualsivoglia rappresentazione basata su dati statistici e indicatori quantitativi. Tali elementi sono stati messi poi in relazione nella convinzione che sia necessario far saltare il nesso tra non dicibile e non trattabile, offrendo strumenti per la comprensione e, quindi, il contrasto alla riproduzione delle disuguaglianze
Shaping the future of postoperative recurrence in Crohn’s disease: personalised approaches with AI-enabled imaging and multi-omics
No full textPostoperative recurrence (POR) is a major challenge in the long-term management of Crohn’s disease (CD), affecting up to 70% of patients within the first year after surgical resection. The multifactorial pathogenesis of POR complicates prevention, while evolving surgical techniques and different anastomotic configurations further hinder accurate prediction and monitoring. Current surveillance strategies, including standard ileocolonoscopy and faecal calprotectin, remain limited by suboptimal accuracy, the absence of validated scoring systems and the lack of standardised monitoring intervals. Recent advances in high-resolution endoscopic imaging, such as confocal laser endomicroscopy and endocytoscopy, enable real-time, in vivo microstructural assessment of the anastomosis, offering opportunities for earlier and more precise detection of recurrence. In parallel, developments in intestinal ultrasound and cross-sectional imaging are reshaping non-invasive monitoring by providing transmural evaluation. Beyond imaging, multiomics approaches, spanning genomics, transcriptomics, proteomics, metabolomics and metagenomics, are uncovering novel biological pathways linked to POR, providing new mechanistic insights. Artificial intelligence (AI) has the potential to integrate clinical, endoscopic, imaging and omics data into predictive multimodal models for POR, supporting individualised risk stratification, early detection and personalised treatment strategies. While promising, these innovations require prospective validation, methodological standardisation and integration into clinical workflows before translation into routine practice. This review summarises the current understanding of POR, highlights emerging diagnostic and monitoring technologies and explores how AI-enabled endoscopy and multi-omics approaches may transform future management, paving the way towards precision medicine for POR in CD
Letrozole Co-Administration in Progestin-Primed Ovarian Stimulation (PPOS) Protocols for Patients Undergoing In Vitro Fertilization: A Systematic Review
No full text: Objective: To systematically analyze and synthesize the evidence from the literature, we compared outcomes of the PPOS + LE protocol versus standard PPOS in patients undergoing IVF. Materials and Methods: We systematically searched the MEDLINE, Scopus, EMBASE, and Science Citation Index databases to identify relevant studies. The clinical questions were developed according to the PICO framework. Quality assessment of the included studies was performed using the Newcastle-Ottawa Scale. Primary outcomes were ovarian stimulation outcomes (oocyte retrieved and mature oocytes). Secondary outcomes were hormonal levels during COS and pregnancy outcome. Results: Five retrospective studies compared oocyte yields between the PPOS and PPOS + LE protocols across diverse populations. While some authors reported significantly higher numbers of retrieved and mature oocytes with letrozole co-administration in a normal infertile population and in POSEIDON group 4, others found no benefit in the PCOS or POSEIDON 3 groups, indicating variable efficacy depending on patient characteristics. Conclusions: Incorporating letrozole counteracts the intense pituitary suppression typically associated with standard PPOS, increasing LH levels and the number of retrieved and mature oocytes in normal and poor responders, but not in PCOS women. Retrospective data do not allow for definitive conclusions to be drawn. Further studies are needed to confirm these results
Il voto alle donne in Russia e Finlandia
No full textPresentazione del libro sul diritto di voto alle donne pubblicato da il Mulino, nel quale si trattano numerosi casi nazionali in un quadro globale che abbraccia i diversi continenti
CLASSICI DELLA STORIOGRAFIA ANTICA, MEDIOEVALE, MODERNA E CONTEMPORANEA: Gabriel Monod, Du progrès des études historiques en France depuis le XVIe siècle(«Revue Historique», 1876)
No full textIl seminario ha preso in esame l'autocoscienza teorica della storiografia professionale francese di prima generazione, focalizzandosi sulla contraddizione, rilevabile in essa, tra pretesa di obiettività scientifica e finalità nazional-patriottica
Male Infertility: A Comprehensive Review of Urological Causes and Contemporary Management
No full textMale infertility is a prevalent global health issue, with urological disorders representing some of the most common and correctable causes. Key conditions such as varicocele, obstructive azoospermia, erectile dysfunction and Peyronie’s disease impair fertility through distinct pathophysiological mechanisms, including disrupted spermatogenesis, reproductive tract obstruction and failed sperm delivery. The effective management of these conditions hinges on a systematic diagnostic evaluation, which integrates clinical history, physical examination, semen analysis and specialized imaging. Modern management follows a logical progression, beginning with foundational lifestyle modifications, advancing to targeted medical or surgical interventions, and culminating, when necessary, in assisted reproductive technologies. Treatment strategies are therefore highly targeted, ranging from medical management and surgical correction—such as varicocelectomy or microsurgical reconstruction—to sperm retrieval techniques. Furthermore, evidence-based lifestyle modifications and a multidisciplinary clinical approach are fundamental to optimizing reproductive outcomes for affected couples. A comprehensive understanding of these urological etiologies is therefore essential for guiding appropriate intervention and improving the prospects of achieving pregnancy