4053 research outputs found
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Sacroiliitis in Systemic Lupus Erythematosus Revisited
No full textYazici, Ayten/0000-0003-2167-4509; Yilmaz, Neslihan/0000-0002-8574-5567WOS: 000538169900013PubMed: 32851375Objectives: This study aims to investigate the prevalence of inflammatory back pain (IBP) and sacroiliitis in a systemic lupus erythematosus (SLE) population as well as the association between IBP and the frequency of human leukocyte antigen B27 (HLA-B27). Patients and methods: the study included 281 SLE patients (16 males, 265 females; mean age 39.9 +/- 11.9 years; range, 20 to 69 years) and 100 healthy controls (HCs) (2 males, 98 females; mean age 41.2 +/- 10.1 years; range, 19 to 64 years). Participants were administered a five-item Assessment of SpondyloArthritis international Society-IBP questionnaire. Patients and controls with IBP underwent detailed clinical and laboratory examinations to detect sacroiliitis. Radiographic evaluations were performed by a blinded rheumatologist and radiologist. Interobserver reliability was assessed with Cohen's kappa test. Results: According to the questionnaire, IBP was present in 46 SLE patients (46/281; 16.3%) whereas none of the HC had IBP (p<0.001). in radiological assessment, 22 SLE patients (7.8%) had sacroiliitis detected by conventional X-ray and/or magnetic resonance imaging. Only one SLE patient with sacroiliitis had HLA-B27. Conclusion: Our study showed that IBP is increased in SLE patients and IBP in SLE is not associated with HLA-B27
Comparison of breast cancer patients who underwent partial mastectomy (PM) with mini latissimus dorsi flap (MLDF) and subcutaneous mastectomy with implant (M plus I) regarding quality of life (QOL), cosmetic outcome and survival rates
No full textWOS: 000531619400001PubMed: 32370753Purpose the latissimus dorsi muscle has long been used in breast cancer (BC) patients for reconstruction. This study aimed to compare early stage BC patients who had partial mastectomy (PM) with mini latissimus dorsi flap (MLDF) and subcutaneous mastectomy with implant (MI) with respect to quality of life (QoL), cosmetic outcome (CO), and survival rates. Patients and methods the data of patients who underwent PM + MLDF (Group 1) and M + I (Group 2) between January 2010 and January 2018 were evaluated. Both groups were compared in terms of demographics, clinical and pathological characteristics, surgical morbidity, survival, quality of life, and cosmetic results. the EORTC-QLQ C30 and EORTC-QLO BR23 questionnaires and the Japanese Breast Cancer Society (JBCS) Cosmetic Evaluation Scale were used to assess the quality of life and the cosmetic outcome, respectively. Results A total of 317 patients were included in the study, 242 (76.3%) of them in group 1 and 75 (23.6%) of them in group 2. Median follow-up time was 56 (14-116) months. There were no differences identified between the groups in terms of tumor histology, hormonal receptors and HER-2 positivity, surgical morbidity, and 5-year overall and disease-free survival. Group 2 patients were significantly younger than group 1 (p = 0.003). the multifocality/multicentricity rate was higher in group 2 (p <= 0.001), whereas tumor size (p = 0.009), body mass index (BMI, p = 0.006), histological grade (p <= 0.001), lymph node positivity (p = 0.002), axillary lymph node dissection (ALND) rate (p = 0.005), and presence of lympho-vascular invasion (LVI, p = 0.013) were significantly higher in group 1. When the quality of life was assessed by using the EORTC QLQ C30 and BR23 questionnaires, it was seen that the body image perception (p < 0.001) and nausea/vomiting score (p = 0.024) were significantly better in PM + MLDF group whereas physical function score was significantly better in M + I group (p = 0.012). When both groups were examined in terms of cosmesis with JBCS Cosmetic Evaluation Scale, good cosmetic evaluation score was significantly higher in patients in MLDF group (p = 0.01). Discussion the results of this study indicate that in comparison to M + I procedure, the PM + MLDF procedure provides significantly superior results in terms of body image and cosmetic result with similar morbidity and oncologic outcomes. in selected patients with small breasts and a high tumor/breast ratio, PM + MLDF may be an alternative to subcutaneous mastectomy and implant
Repeater F-waves in amyotrophic lateral sclerosis: Electrophysiologic indicators of upper or lower motor neuron involvement?
No full textsirin, Nermin Gorkem/0000-0001-8792-2929;WOS: 000502603500012PubMed: 31760213Objective: To extract insight about the mechanism of repeater F-waves (Frep) by exploring their correlation with electrophysiologic markers of upper and lower motor neuron dysfunction in amyotrophic lateral sclerosis (ALS). Methods: the correlations of Frep parameters with clinical scores and the results of neurophysiological index (NI), MScanfit MUNE, F/M amplitude ratio (F/M%), single and paired-pulse transcranial magnetic stimulation (TMS), and triple stimulation technique (TST) studies, recorded from abductor digiti minimi (ADM) and abductor pollicis brevis (APB) muscles of 35 patients with ALS were investigated. Results: Frep parameters were correlated with NI and MScanfit MUNE in ADM muscle and F/M% in both muscles. None of the Frep parameters were correlated with clinical scores or TST and TMS measures. While the CMAP amplitudes were similar in the two recording muscles, there was a more pronounced decrease of F-wave persistence in APB, probably heralding the subsequent split hand phenomenon. Conclusion: Our findings suggest that the presence and density of Freps are primarily related to the degree of lower motor neuron loss and show no correlation with any of the relatively extensive set of parameters for upper motor neuron dysfunction. Significance: Freps are primarily related to lower motor neuron loss in ALS. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved
Impact of an Established National Donor Registry on Transplant Outcome: Turkok Experience in Turkey
No full textTransplantation and Cellular Therapy (TCT) Meetings of ASTCT and CIBMTR -- FEB 19-23, 2020 -- Orlando, FLWOS: 000516887900445[No abstract available]Amer Soc Transplantat & Cellular Therapy, CIBMT
Maternal serum thiol/disulfide homeostasis in pregnancies complicated by fetal hypoxia
No full textPeker, Nurullah/0000-0002-3285-9990; Yildizhan, Recep/0000-0002-2841-0453; bademkiran, muhammed hanifi/0000-0002-9350-582X; bagli, ihsan/0000-0002-3195-9164WOS: 000502210400001PubMed: 31826686We aimed to evaluate maternal serum thiol/disulphide homeostasis in pregnancies complicated by fetal distress (FD). A total of 100 patients beyond the 34th week of pregnancy were included in this study, and they were divided into two groups. the study group included 50 patients who had been diagnosed with FD; the control group was composed of 50 patients who had shown no signs of FD and who had undergone an elective (previous) caesarean section (CS). the native thiol, total thiol and native thiol/total thiol (%) concentrations were lower in Group 1 patients than Group 2 patients (p < .001). the disulphide, disulphide/native thiol (%) and disulphide/total thiol (%) concentrations were higher in Group 1 patients than Group 2 patients (p < .001). This study suggests that maternal thiol/disulphide homeostasis is impaired in pregnancies complicated by FD.IMPACT STATEMENT What is already known about this subject? Oxidative stress (OS) has previously been investigated in FD. This study reports for the first time a new novel and automatic measurement method. What do the results of this study add? This study shows that the thiol balance shifts in the direction of disulphide in the cases of FD
Atorvastatin has therapeutic potential for the fatty liver-induced memory dysfunction in rats, likely via its antioxidant and anti-inflammatory properties
No full textWOS: 000526603200001PubMed: 32252617This study aimed to evaluate the memory function in a rat model of fatty liver and to investigate the effects of statins on fatty liver, neuronal inflammation, oxidative stress and memory. in this study, 24 male rats were used and were divided into four groups consisting of 6 animals in each. of them, 12 rats received liquid diet containing 35% fructose for 8 weeks in order to induce hepatosteatosis, while other animals had a normal nutrition. Group 1 served as controls and had a normal nutrition with no drug treatment. the animals in Group 2 had a normal nutrition and treated with atorvastatin. Group 3 received high-fructose diet with no drug treatment and Group 4 received high-fructose diet followed by atorvastatin treatment. After the two weeks of treatment period, passive avoidance tasks evaluating the memory were performed in both the study and control groups. the liver and brain were then removed for histologic, pathologic, and biochemical evaluation. in the non-treated rats with hepatosteatosis (Group 3), the lowest mean latency time and the highest mean histopathologic liver score, and brain TNF- alpha and MDA (Measurement of lipid peroxidation) were found (p < 0.00001). on the other hand, in the animals treated with atorvastatin, all these parameters were significantly higher than that of controls and significantly lower than that of Group 3 (p < 0.05). Fatty liver can increase inflammation and cause memory disorders, and atorvastatin may have a positive effect on cognitive disorders
The importance of psychiatric nursing in the covid 19 pandemic process
No full text[No abstract available
Learning Needs of Patients and Their Caregivers After Ambulatory Surgery
No full textPubMed: 32007390Purpose: the purpose of this study was to determine the learning needs of ambulatory surgery patients and their caregivers. Design: the study was a cross-sectional and descriptive survey. Methods: the study was conducted between July 2017 and March 2018 in the outpatient units of a training and research hospital in Istanbul, Turkey. the sample consisted of 117 patients and caregivers dyads. the instruments included a Patient Information Form and the Patient Learning Needs Scale (PLNS). Findings: the mean total PLNS scores of ambulatory surgery patients were 193.54 ± 35.46 and that of the patient's caregivers was 199.88 ± 31.84. the highest mean PLNS subscale for patients and caregivers was treatment and complications. As the PLNS scores of the patients increase, the scores of the caregivers also increase. Conclusions: the learning needs of ambulatory surgery patients and their caregivers are high. Patients and caregivers must be well informed and well prepared to cope with possible problems at home. © 2019 American Society of PeriAnesthesia Nurse
Epileptic seizures in cerebral venous sinus thrombosis: Subgroup analysis of VENOST study
No full textAfsar, Nazire/0000-0001-8123-8560; Sahin, Sevki/0000-0003-2016-9965; UZUNER, NEVZAT/0000-0002-4961-4332; Kusbeci, Ozge Yilmaz/0000-0002-4048-210XWOS: 000537574100019PubMed: 32353818Purpose: the aim of this study is to evaluate the presence and prognostic impact of early seizures in cerebral venous sinus thrombosis patients (CVST). Method: VENOST is a retrospective and prospective national multicenter observational study. CVST patients with or without epileptic seizures (ES) were analyzed and compared in terms of demographic and imaging data, causative factors, clinical variables, and prognosis in a total of 1126 patients. Results: the mean age of the patients in the ES group was 39.73 +/- 12.64 and 40.17 +/- 14.02 years in the non-ES group (p > 0.05). Epileptic seizures were more common (76.6 %) in females (p < 0.001). Early ES occurred in 269 of 1126 patients (23.9 %). Epileptic seizures mainly presented in the acute phase (71.4 %) of the disease (p < 0.001). Majority of these (60.5 %) were in the first 24 h of the CVST. the most common neurological signs were focal neurologic deficits (29.9 %) and altered consciousness (31.4 %) in the ES group. Superior sagittal sinus (SSS) and cortical veins (CV) involvement were the most common sites of thrombosis and the mostly related etiology were found puerperium in seizure group (30.3 % vs 13.9 %). Patients with seizures had worse outcome in the first month of the disease (p < 0.001) but these did not have any influence thereafter. Conclusions: in this largest CVST cohort (VENOST) reported female sex, presence of focal neurological deficits and altered consciousness, thrombosis of the SSS and CVs, hemorrhagic infarction were risk factors for ES occurrence in patients with CVST
Urinary Findings and Biomarkers in Autosomal Dominant Polycystic Kidney Disease
No full textWOS: 000514116300012Autosomal dominant polycystic kidney disease (ADPKD), characterized by the development of multiple cysts in the kidneys and other organs, is the most common hereditary renal disorder and the fourth leading cause of end-stage renal disease. in adults with a positive family history, the diagnosis of ADPKD is made based on the radiologic evidence of bilateral, fluid-filled renal cysts. Furthermore, initial symptoms including pain, increased thirst, polyuria, nocturia, and increased urinary frequency may lead to the diagnosis of ADPKD. An easily accessible, applicable, and cost-effective biomarker is needed to predict the clinical course of ADPKD due to its progressive pattern. Urine is an easily obtainable and widely used test specimen for diagnosis and follow-up in several renal diseases. Thus, the aim of the present study was to review and assess new urinary biomarkers and urinary findings in ADPKD