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The Relationship of Pathological Response and Visceral Muscle and Fat Volume in Women With Breast Cancer Who Received Neoadjuvant Chemotherapy
No full textObjective: Differences in individual muscle/fat volumes may change the effectiveness of chemotherapy. In this study, the relationship between trunkal muscle and fat volume and body mass index (BMI) obtained before receiving neoadjuvant chemotherapy (NCT) in patients with breast cancer and complete pathological response (pCR) was investigated. Materials and Methods: The volumes of psoas, abdominal and paraspinal muscles, and trunkal subcutaneous and visceral fat were calculated using CoreSlicer AI 2.0 opensource program from the F-18 fluorodeoxyglucose positron emission tomography/computed tomography (CT) and CT images before NCT and postoperative pCR rates to NCT were recorded. Muscle/fat volumes and BMI prior to NCT were compared in terms of pathological pCR rates. Patients were followed up regularly for recurrence and survival. Results: Ninety-three patients were included with median (range) values for age, BMI, and body weights of 48 (28-72) years, 27 (16.8-51.6) kg/m2, and 71.94 (43-137) kg, respectively. The median follow-up time was 18.6 (6.7-59.6) months. No significant correlation was found between total muscle or fat volumes of patients with and without pCR. BMI [26.2 (16.8-51.6) kg/m2 vs. 24.6 (20.3-34.3) kg/m2, p = 0.03] and pCR rates in patients with low rightpsoas muscle volume [11.74 (7.03-18.51) vs. 10.2 (6.71-13.36), p = 0.025] were significantly greater. A significant relationship was found between right psoas muscle volume and disease-free survival (DFS) (11.74 cm3 (7.03-18.51) vs. 10.2 cm3 (6.71-13.36), p = 0.025). However, no significant relationship was detected between total muscle-fat volume, BMI and overall survival and DFS (p>0.05). Conclusion: This is the first published study investigating the relationship between the pCR ratio and body muscle and fat volume measured by CoreSlicer AI 2.0 in patients with breast cancer who received NCT. No correlation was found between the pCR ratio and total muscle plus fat volume. However, these results need to be validated with larger patient series. © 2024 by the Turkish Federation of Breast Diseases Societies
Impact of body weight-based dosing of palonosetron and ondansetron on postoperative nausea and vomiting following laparoscopic sleeve gastrectomy: a randomized, double-blind study
No full textBackground Postoperative nausea and vomiting (PONV) is a frequent adverse effect following laparoscopic sleeve gastrectomy. Palonosetron with a standard dosing (75 mu g) schedule has been questioned due to its low efficiency in obese patients. This study aimed to investigate the effectiveness and safety of the body weight-based dosing of palonosetron in managing PONV following laparoscopic sleeve gastrectomy. Methods A single-center, prospective, double-blinded randomized study was conducted between August 2021 and December 2021. Patients who underwent laparoscopic sleeve gastrectomy were prospectively recruited in the study. One hundred patients were randomly divided into palonosetron (Group P) and ondansetron (Group O). The demographic and clinical variables were recorded. The primary outcome of the study was the incidence of PONV between the two groups during the hospitalization. The secondary outcomes were the number of rescue anti-emetic and analgesic medications and the Functional Living Index-Emesis scores. Results There were 50 patients in each group (Group P and Group O). There were significant differences in the scores of POVN, nausea, and vomiting favoring Group P. In Group P, the rate of patients using rescue anti-emetics was significantly lower. The incidence of complete response and proportion of patients with higher Functional Living Index-Emesis scores were significantly higher in patients using palonosetron. Conclusions The use of palonosetron significantly reduced the incidence of PONV following laparoscopic sleeve gastrectomy. There was a significant improvement in the scores of Functional Living Index-Emesis in patients using palonosetron
Evaluating match of firm and customer resources to maximize value
No full textThis chapter discusses the fundamental role of the match of firm and customer resource utilization capabilities for organizational effectiveness in value co-creation with a marketing perspective. A model is developed by applying both internal and external approaches to provide firms with an integrative strategic tool for evaluating their current value creation effectiveness. The proposed model maps out the emergence of different types of value based on the extent that firm and customers' resource utilization capabilities match. © 2024, IGI Global. All rights reserved
The Effect of Artificial Intelligence on the Concepts of Death and Mourning: The Example of Thanabot
Get PDFÖZET: Günümüzde teknolojik gelişmeler, özellikle de yapay zekâ pek çok farklı alanda önemli etkilere sahiptir. Ölüm ve yas kavramları da bu gelişmelerden etkilenmekte, bir anlamda dönüşmektedir. Bu makalenin amacı; ölüm ve yas kavramlarının yaşadığı bu dönüşümde yapay zekânın etkisini thanabotlar üzerinden tartışmaktır. Bu amaçla ölüm ve yas kavramları literatür taraması yapılarak toplumsal ve tarihsel bağlamları içerisinde ele alınmış, devamında dijitalleşme ile yaşadıkları dönüşüme değinilmiştir. Çalışmanın sonunda thanabotların olası etkileri literatürden çıkarımlarla tartışılmıştır. Buna göre; thanabot kullanımının kişiden kişiye değişen etkileri olacağını söylemek mümkündür. Bu anlamda bu teknoloji özellikle yas tutanlar için olumlu etkilere sahip olabilir. Ancak thanabotların ticari boyutu, ölen kişiyi ne kadar temsil edeceği, yas tutanlar için ikincil kayıp riski, yazılım güvenliği gibi olası sorunlara sahip olduğunu söylemek mümkündür. Ayrıca bu teknolojiyle ilgili araştırmaların hem bireysel hem de toplumsal düzeyde farklılıkları dikkate alarak yapılmasının önem arz ettiği görülmüştür.ABSTRACT: Today, technological developments, especially artificial intelligence, have significant impacts in many different fields. The concepts of death and mourning are also affected by these developments and, in a sense, are transformed. The purpose of this article is to discuss the impact of artificial intelligence on the transformation of the concepts of death and mourning through thanabots. For this purpose, the concepts of death and mourning were examined in their social and historical context by conducting a literature review, and then the transformation they have with digitalization was mentioned. At the end of the study, the possible effects of thanabots are discussed with inferences from the literature. According to this; it is possible to say that the effects of using thanabot will vary from person to person. In this sense, this technology can have positive effects, especially for those who are grieving. However, it is possible to say that thanabots have potential problems such as their commercial size, how much they will represent the deceased, the risk of secondary loss for mourners and software security. In addition, it is important that research on this technology is carried out by taking into account differences at both individual and social levels
Outcomes of reconstructive techniques in breast cancer using BCCT. core software
No full textBackgroundSurgery remains a priority for breast cancer treatment. This study aimed to compare the cosmetic outcomes of oncoplastic patients who had undergone breast-conserving surgery, mini-LDF (latissimus dorsi flap), and immediate implant reconstruction using both the Japanese scale and the BCCT.core (The Breast Cancer Conservative Treatment cosmetic results software) program and to validate this program.Patients and methodsPatients who underwent surgery for breast cancer between 1997 and 2021 were retrospectively studied. Patients were divided into three groups: 1-those who had undergone breast-conserving surgery (245 patients, 71.3%), 2-those who had undergone mini-LDF after lumpectomy (38 patients, 11.02%), and 3- those who underwent reconstruction with implants after nipple-sparing mastectomy (61 patients, 17.68%). The patients were called for a follow-up examination, and their photos were taken. The photographs were shown to an independent breast surgeon and a plastic surgeon who was not included in the surgeries, and they were asked to evaluate and rate them according to the Japanese cosmetic evaluation scale. The same images were transferred to the computer and scored using BCCT.core.ResultsThe plastic and breast surgeon evaluation results showed no significant difference between the three cosmetic techniques (p = 0.99, 0.98).The results of BCCT.core software measurements were similar to the results of plastic and breast surgeons (p: 0.43).ResultsThe plastic and breast surgeon evaluation results showed no significant difference between the three cosmetic techniques (p = 0.99, 0.98).The results of BCCT.core software measurements were similar to the results of plastic and breast surgeons (p: 0.43).ConclusionPatients are more knowledgeable about cosmetic outcomes and expect more objective data. In this study, we used 3 different cosmetic evaluation scales. We found that these techniques give results that are compatible with each other in terms of evaluating the work done in a more concrete way. For this reason, we recommend the use of such software, which offers objective results in a subjective field such as aesthetics and is very easy to apply
Rereading Medea Across Borders-Cultural Encounters and Postcolonial Rewrites in Liz Lochhead’s Medea, Yüksel Pazarkaya’s Mediha and Cherríe Moraga’s The Hungry Woman: A Mexican Medea
No full textEuripides’ Medea is often studied as a revolutionary play for its representation of a controversial female character. Drawing on Medea and the myth of “Jason and the Argonauts”, Euripides’ story is not simply about a woman so blinded by extreme feelings of passion and revenge that she would victimize her own children. Euripides also invites the readers and audiences to think about Medea’s complex motivation within the context of an outsider, surrounded by powerful feelings of isolation and exclusion. Medea lends itself to adaptations as its plot makes a perpetual call for potential postcolonial and feminist rewriters. This chapter explores three contemporary cross-cultural adaptations of Medea’s story: Liz Lochhead’s Medea, Yüksel Pazarkaya’s Mediha and Cherríe Moraga’s The Hungry Woman: A Mexican Medea. Each of these authors raises questions about geographical and spiritual borders by adapting Euripides’ Medea to their Scottish-English, Chicanx or Turkish-German contexts. © 2024 selection and editorial matter, Ana Filipa Prata and Rodrigo Verano; individual chapters, the contributors
Capitalizing the future: opportunity capital as symbolic significance of an entrepreneur's future-venture story
No full textThis paper explores how a future - as something that can only be imagined but can inspire entrepreneurial action - can attract economic capital. We integrate Dor's (2015) model of language as a communication technology for the instruction of imagination with Bourdieu's theory of practice to account for how an entrepreneur's words can hold sway over an investor by virtue of meaning something significant. We introduce opportunity capital as the symbolic significance of the entrepreneur's future-venture story and the exchange counterparty to the investor's economic capital. Our portrayal of the future as a symbolic phenomenon inducing action by others offers foundational insights to research on the early stages of venturing and the acquisition of resources by entrepreneurs
'Behind bars, beyond borders': solidarity in the face of the criminalisation of a social work human rights defender
No full textThis commentary piece is written by Bilal Yildiz, a social worker in Turkey and a human rights defender. It tells the story of his arrest on trumped-up charges and the continuing threat to his freedom as a result of his social work activities. Bilal graduated from Istanbul University, Department of Social Work, and continues his master's programme in human rights law at Istanbul Bilgi University. He has been working as a social worker at the Human Rights Foundation of Turkey since 2016. In addition to his professional work, he has been active in many professional and human rights organisations. He is currently a board member of the Association of Social Workers, a member of the Human Rights Association, a member of the Kurdish Studies Association and a founding member of the Migration Monitoring Association