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Canadians' travel knowledge acquisition during the pandemic: A cognitive mediation model approach
No full textThis study aimed to improve Canada's preparedness to rejuvenate the economy in public health crises by understanding how potential tourists acquire knowledge using the cognitive mediation model. We examined the effect of media motivations (i.e., surveillance gratification and anticipated interaction) in predicting two types of subjective knowledge (i.e., pandemic knowledge and travel health knowledge) through the mediation of media attention and elaboration. The study results supported all hypotheses except for the relationships between surveillance gratification and media attention, and media attention and travel health knowledge. This study provides implications for destination marketing organizations to understand Canadians' travel decisions during the pandemic.Mount Saint Vincent UniversityRapid-Response Internal Researc
Nanoparticle‐mediated delivery of Anti‐PU.1 siRNA via localized intracisternal administration reduces neuroinflammation
No full textNeuroinflammation is a hallmark of neurodegenerative disorders including Alzheimer's disease (AD). Microglia, the brain's immune cells, express many of the AD-risk loci identified in genome wide association studies and present a promising target for anti-inflammatory RNA therapeutics but are difficult to transfect with current methods. Here, several lipid nanoparticle (LNP) formulations are examined, and a lead candidate that supports efficient RNA delivery in cultures of human stem cell-derived microglia-like cells (iMGLs) and animal models of neuroinflammation is identified. The lead microglia LNP (MG-LNP) formulation shows minimal toxicity and improves delivery efficiency to inflammatory iMGLs, suggesting a preference for delivery into activated microglia. Intraperitoneal injection of the MG-LNP formulation generates widespread expression of the delivered reporter construct in all organs, whereas local intracisternal injection directly into the cerebrospinal fluid leads to preferential expression in the brain. It is shown that LNP-mediated delivery of siRNA targeting the PU.1 transcription factor, a known AD-risk locus, successfully reduces PU.1 levels in iMGLs and reduces neuroinflammation in mice injected with LPS and in CK-p25 mice that mimic the chronic neuroinflammation seen in AD patients. The LNP formulation represents an effective RNA delivery vehicle when applied intrathecally and can be broadly utilized to test potential neuroinflammation-directed gene therapies
Turning the natural world into a moral world: Michel Henry on the vocation of life
No full textIt has been widely argued that Michel Henry dismisses the importance of the subject’s worldly and intentional mode of existence in his account of the well-being of life. However, through a careful analysis of Henry’s theory of life and his study of culture and barbarism, I will demonstrate that the prevailing position on this point is both correct and incorrect: (i) correct in that absolute life does not require a moral transformation of the world; and (ii) incorrect inasmuch as Henry’s philosophy does not, for all that, deny that, from the perspective of human beings, the subject’s existence in the world does indeed matter to the well-being of their life. In my view, Henry’s work harbours the implication that, from the perspective of the subject’s existence in the world, the creation of a moral world through the development of the correspondence between one’s inner life and the natural world is humanity’s most pressing task, to the point that his entire phenomenology is oriented toward the achievement of this end. I will highlight two of the ways in which the subject’s existence is vital to life’s well-being: (i) as an expression of life; and (ii) as more or less befitting of life’s current needs. As part of this study, I argue that some of Henry’s conclusions regarding theoretical knowledge and its part in the aforementioned correspondence between life and the natural world do not entirely agree with his own analyses and therefore need to be reformed
Nickel complexes of allyl and vinyldiphenylphosphine
No full textMonodentate phosphine-ligated nickel compounds, e.g., [Ni(PPh3)4] are relevant as active catalysts across a broad range of reactions. This report expands upon the coordination chemistry of this family, offering the reactivity of allyl- and vinyl-substituted diphenylphosphine (PPh2R) with [Ni(COD)2] (COD = 1,5-cyclooctadiene). These reactions provide three-coordinate dinickelacycles that are intermolecularly tethered through adjacent {Ni}-olefin interactions. The ring conformation of such cycles has been studied in the solid-state and using theoretical calculations. Here, a difference in reaction outcome is linked to the presence of an allyl vs vinyl group, where the former is observed to undergo rearrangement, bringing about challenges in clean product isolation
Assessing the energy trap of industrial agriculture in North America and Europe: 82 balances from 1830 to 2012
No full textEarly energy analyses of agriculture revealed that behind higher labor and land productivity of industrial farming, there was a decrease in energy returns on energy (EROI) invested, in comparison to more traditional organic agricultural systems. Studies on recent trends show that efficiency gains in production and use of inputs have again somewhat improved energy returns. However, most of these agricultural energy studies have focused only on external inputs at the crop level, concealing the important role of internal biomass flows that livestock and forestry recirculate within agroecosystems. Here, we synthesize the results of 82 farm systems in North America and Europe from 1830 to 2012 that for the first time show the changing energy profiles of agroecosystems, including livestock and forestry, with a multi-EROI approach that accounts for the energy returns on external inputs, on internal biomass reuses, and on all inputs invested. With this historical circular bioeconomic approach, we found a general trend towards much lower external returns, little or no increases in internal returns, and almost no improvement in total returns. This “energy trap” was driven by shifts towards a growing dependence of crop production on fossil-fueled external inputs, much more intensive livestock production based on feed grains, less forestry, and a structural disintegration of agroecosystem components by increasingly linear industrial farm managements. We conclude that overcoming the energy trap requires nature-based solutions to reduce current dependence on fossil-fueled external industrial inputs and increase the circularity and complexity of agroecosystems to provide healthier diets with less animal products
Cutaneous angiomatosis‐like presentation in koi carp ( Cyprinus carpio koi): Clinical–pathological investigations
No full textThe skin represents an indicator of an animal's health status. Causes of cutaneous diseases in fish most often trace back to biological agents. However, fish skin diseases can also arise from a complex interaction of infectious and non-infectious causes, making it more difficult to identify a specific aetiology. In the period between April and September of the years 2019–2022, four koi carp (Cyprinus carpio koi) from two European countries presented with multifocal, irregularly round, few mm to 1 cm, variably raised cutaneous reddened areas. The fish displayed good general condition. Cutaneous samples, investigated by microbiological and molecular methods and microscopy, did not indicate a primary pathogenic agent. Gross and histological findings of the cutaneous biopsies were consistent with a multifocal/reactive process centred on dermal vessels. The histological features were reminiscent of angiomatosis, a benign proliferative condition affecting the dermal vessels of mammals, including human patients. The clinical–pathological presentation and the dermatologic condition that affected the koi carp are discussed and compared with the veterinary and human literature
Early 21st century trends of temperature extremes over the Northwest Himalayas
No full textThe rising intensity and frequency of extreme temperature events are caused due to climate change and are likely to affect the entire world. In this context, the Himalayas are reported to be very sensitive to changes in temperature extremes. In this study, we investigate the variability of temperature extremes over the Northwest Himalayas in the early 21st century (2000–2018). Here, we used 14 temperature indices recommended by ETCCDI (Expert Team on Climate Change Detection and Indices). The present study reveals the trends of extreme temperature indices on the spatial scale for the western part of the Northwest Himalayas. The 14 temperature indices were used to assess the behavior of extreme temperature trends with their significance. This study reports that the northwestern region of the study area has a cooling effect due to an increase in the trends of cold spells, cold days/nights, and frost days, while the southwestern region significantly shows the warming effects due to the increasing trends in warm spells, warm days/nights, and summer days. On the other hand, the eastern region of the study area shows mixed behavior, i.e., some places show warm effects while some reveal cold effects in the early 21st century. Overall, this study implies the northwestern parts have cooling trends while the southwestern and southeastern parts have warming trends during the early 21st century
An assessment of Islanders information needs and preferences related to concussion care for children and youth
No full textDespite the recent rise in attention focused on concussions, there is a continued need to improve overall concussion education and awareness. Concussions have emerged as an important public health issue, especially among children and youth, as they are disproportionately more likely to suffer head injuries. It is critical that all stakeholders are aware of the signs and symptoms related to a mild traumatic brain injury, and have basic concussion knowledge, as most diagnoses rely on the self-reporting of symptoms. To determine the gaps related to perceived concussion knowledge and to identify educational gaps in Prince Edward Island (PEI), a community health needs assessment was completed using a descriptive, quantitative survey design. This study was the first known concussion community needs assessment targeting children and youth, performed in PEI. Study participants highlighted the need for more fundamental concussion information. Gaps related to specialized services offered in PEI, as well as information about return-to-sport and school protocols were identified. Implementation of strategies to facilitate translation of concussion information and improve perceived knowledge such as the development of a website repository for evidence-informed resources along with the identification of local concussion services offered in PEI, would be valuable
