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Bilateral serous tubal intraepithelial carcinoma associated with high-grade serous carcinoma of the peritoneum: evidence for transcoelomic tumor spread by extended lymph node evaluation
Get PDFSerous tubal intraepithelial carcinoma (STIC) is now considered a putative precursor lesion of most extrauterine high-grade serous carcinomas (HGSC). It is frequently reported in high-risk women and women with advanced-stage serous carcinoma. This case study reports a serous high-grade carcinoma (HGSC) consisting of a bilateral STIC with a focus of stromal invasion in the left tube, and a peritoneal HGSC. The grossly normal-appearing tubes including the fimbriated ends were sectioned following the SEE-FIM protocol. In both tubes, tumor aggregates were exfoliated extensively to the tubal lumens. The neoplastic epithelia in any location were diffusely positive for p53 in strong nuclear patterns. Pelvic lymph nodes were negative for tumor on serial sections and keratin 7 immunohistochemistry, and there was no evidence of lymphatic vessel involvement. The lack of any evidence of lymphovascular invasion and regional lymph node metastases supports the interpretation of intraluminal and transcoelomic spread, and may be taken as evidence of dissemination of tubal neoplastic cells by exfoliation in this case. The biology of transcoelomic spread is reviewed in this manuscript
A Space of Her Own: Genderfluidity and Negotiation in The Life of Christina of Markyate
Get PDFThis paper draws on transgender studies and theories of gender performativity and genderfluidity to consider how twelfth-century holy woman Christina of Markyate resists traditional and third-gender binary policing. It argues that Christina is genderfluid, and that as a secular, masculinized, and religious virgin, she co-exists within and moves among multiple gender spaces that allow her to establish her own authority
Material Culture and Queenship in Fourteenth-Century France: The Testament of Blanche of Navarre (1331-1398)
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Surficial Geologic Map of the Salem 7.5\u27 Quadrangle, Henry and Lee Counties, Iowa
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Little Village February 6 - February 19, 2019
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The Catholic Church in Southwest Iowa
Get PDFReview of: The Catholic Church in Southwest Iowa, by Steven M. Avella
The Fall of Wisconsin: The Conservative Conquest of a Progressive Bastion and the Future of American Politics
Get PDFReview of: The Fall of Wisconsin: The Conservative Conquest of a Progressive Bastion and the Future of American Politics, by Dan Kaufman
Creating the Big Ten: Courage, Corruption, and Commercialization
Get PDFReview of: Creating the Big Ten: Courage, Corruption, and Commercialization, by Winton U. Solberg