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Tanatologia e tecnologia. Metamorfosi del concetto e dei rituali di morte nella società post-umana e tecnofila. Thanatology and technology. Metamorphosis and the concept of death rituals In the post-human society and technophilic.
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Il ruolo dell'arte nella società post moderna. Sentimenti identitari, coesione sociale e spirito critico.
Aware of being part of an increasingly individualistic society where social cohesion and the struggle for shared ideals now seem to be a thing of the past, we see a possible cure for this spiritual squalor in contemporary art as a means of communication to create new symbolic paths which are understood and shared. The research focuses on the analysis of not only those artistic projects whose audience is art experts and the art market but on projects that target a wider audience. Works with a strong communicative purpose which, through the artist’s direction, intend to transmit a symbolic and participated meaning within the reality in which they come to life. The research essentially has the following objectives: in-depth analysis of the artist’s role in post-modern society in the light of the changes that this entails; understanding the direction in which art is evolving and seeing if its conception aimed at the sole purpose of exhibitions and museums can still exist.
The study was carried out mainly through an in-depth and targeted bibliographic study; the texts used were chosen according to a precise and multi-disciplinary method bearing in mind economic, managerial, artistic, social and psychological aspects. A number of Italian cases considered useful for understanding the theoretical part of the research are also presented and analyzed. During the preparation of the research work it was not considered important to focus our study on the current changes to artistic practices. Instead, we want to demonstrate how contemporary art is to all purposes a highly effective means of communication for creating shared feelings of identity and for increasing the level of social cohesion above all in communities where the artistic projects have a high level of visibility and credibility and are developed respecting precise parameters. We are also sure, today more than ever, that the artist has to take back a precise social role, a role which is more credible in the eyes of the public which must see in him a means to understanding society. Indeed, even if there can no longer be and there is no longer any sense in having a nostalgic vision of the artist since each one is called on to live their own times, speak to a contemporary public and do this with the means available, art must however be seen as a vocation just like a religion because, if practiced correctly, it holds and can hold an important and delicate role in society. Aware that the results obtained cannot be measured in absolute terms, we are however convinced that a good artistic production able to gain ground also outside the institutional places of art and to favor open and positive dialogue between artists, institutions and communities is a sign of an active and lively society, driver of a dynamic community able to reflect on itself
Persona e diritto nella Spagna visigota. La rielaborazione del pensiero classico sullo status libertatis nell'opera di Isidoro di Siviglia.
The research describes the re-elaboration of classical thought on the status personarum in the work of Isidore of Seville, with a specific focus on the status libertatis.
After a reconstruction of the context, made by a quick overview both of Visigothic Spain and of the life and works of St. Isidore, from which many legally relevant steps have been selected and translated, the analysis focuses on some basic concepts regarding freedom and slavery. It stresses their evolution, due to the revision that the Bishop of Seville performs according to his Christian faith, as well as the peculiar meaning that he assigns to certain categories, such as those of servi and famuli on one hand and ingenui, liberti and libertine on the other.
This is followed by the analysis of some passages that deal with the issues of the status civitatis, in which one can note how, always starting from the data of legal and literary tradition, the Author introduces substantial differences in accordance with his personal outlook on the world. Particularly relevant are both the associative purposes due to which St. Isidore thinks man organizes himself in societies and some key concepts, such as those of populus and plebs, peregrine and alienigena etc.
The work ends with a chapter on the status familiae, that highlights the re - interpretation, based on patristics, of the classic models of filiation and adoption.
Transversal to the three chapters are the linked concepts of pater, familia and paterfamilias
La nozione di neutralità nella consulenza di etica clinica. The notion of neutrality in clinical ethics consultation.
Ethics consultation as a function performed by ethics committees, small groups of ethicists or individual consultants has developed in North America starting from the ‘70s. Despite the increasing implementation of ethics support services globally and a great deal of effort towards professionalization in the field, it is still an open question whether or not the consultant should remain neutral when her intervention is requested to address ethical conflicts and uncertainties. In particular, it is not settled whether she is allowed to express an opinion, make a recommendation or give advice.
This work is meant to analyze the notion of neutrality in ethics consultation through the critical assessment of different theoretical positions. The first chapter explains what ethics consultation is and deals with, by analyzing well-known American publications; the second explores the most common theses on the role or approach of the ethics consultant, as well as different interpretations of the terms “recommendation” and “advice”; the third focuses on the possibility and ethical acceptability of notions like ethics expertise and moral authority uncovering the main related critical positions; the last chapter offers an interpretation of the role of the consultant by considering the nature and goals of ethics consultation and it proposes four specifications of the term neutrality when it is applied: (1) to the parties involved in the consult, including the ethics consultant, (2) to the argumentations offered by the consultant to help parties make a decision, (3) to the values and norms in the case discussed, (4) to the outcome of the consultation proces
Probabilistic Semantics: Metric and Logical Character¨ations for Nondeterministic Probabilistic Processes
In this thesis we focus on processes with nondeterminism and probability in the PTS model, and we propose novel techniques to study their semantics, in terms of both classic behavioral relations and the more recent behavioral metrics.
Firstly, we propose a method for decomposing modal formulae in a probabilistic extension of the Hennessy-Milner logic. This decomposition method allows us to derive the compositional properties of probabilistic (bi)simulations.
Then, we propose original notions of metrics measuring the disparities in the behavior of processes with respect to (decorated) trace and testing semantics.
To capture the differences in the expressive power of the metrics we order them by the relation `makes processes further than'.
Thus, we obtain the first spectrum of behavioral metrics on the PTS model.
From this spectrum we derive an analogous one for the kernels of the metrics, ordered by the relation `makes strictly less identification than'.
Finally, we introduce a novel technique for the logical characterization of both behavioral metrics and their kernels, based on the notions of mimicking formula and distance on formulae.
This kind of characterization allows us to obtain the first example of a spectrum of distances on processes obtained directly from logics.
Moreover, we show that the kernels of the metrics can be characterized by simply comparing the mimicking formulae of processes
Multi-wavelength observations of variability characterizing magnetic activity in late-type stars.
The presence of magnetic fields in the atmosphere of the late-type stars determines the formation of small scale structures which make the atmosphere inhomogenous, causes excess heating of the atmospheric plasma with consequent excess thermal radiation, and also non-thermal radiation. This is what is referred to as magnetic activity, which gives essential information on the properties of the stellar magnetic fields and internal dynamos.
In the first work I present, I characterize the relation between magnetic activity (mainly X-ray activity) and the stellar rotation, which is a proxy for the internal dynamo mechanism of stars. For the first time, the measure of rotation period and of the X-ray activity is carried on in a fully homogeneous way on the whole sample. The results I obtain confirms previous results.
In the second work, I present the discovery of strong magnetic activity, in the form of an X-ray flare, from a very young (Class I) YSO, ISO-Oph 85; this latter work is focused on the characterization of this transient X-ray emission and on the classification of he evolutionary stage of ISO-Oph 85.
In this works, the study of X-ray activity plays a major role. The X-ray data I use are taken from the XMM-Newton observatory. I take advantage, for the time-resolved analsyis of the X-ray data, of algorithms and products by the EXTraS Project. In the first one of the two works presented, the observations performed by the Kepler mission have a crucial role
Anatomical and functional custom made restoration techniques with Direct Metal Laser Forming technology: systematic workflow and CAD-CAM
Introduction
Bone defects are usually repaired by the body’s healing process itself. If severe fracture, tumor or infection occur on large bones, it poses a serious challenge to the regeneration ability of the bones. One of the latest advancement in medical science is the rapid prototyping technologies. Therefore, the aim of the present study was the developing and testing of a reliable workflow to fabricate custom-made grafts in the field craniofacial surgery.
Material and Methods
In this study 14 patients with different cranio-facial bone defects were enrolled. Two evaluation methods were associated to test the results of the workflow. Surveys were given to patients undergone surgery and their surgeons to have a subjective analysis of the workflow. For each patient the produced prosthesis was superimposed on the original prosthesis design, the displacement between was evaluated.
Results
Significant level of discomfort at 4 weeks after surgery compared to 2 days after surgery, aesthetic improvement significant improved 1 year after surgery compared to 4 weeks after surgery. Aesthetic improvement 1 year after surgery and aesthetic improvement according to expectations showed correlation, aesthetic improvement 1 year after surgery and aesthetic improvement according to expectations showed correlation. The mean distance of the printed model was significant smaller than the virtual model, with a mean difference of -0.075 mm.
Conclusion
According to the results of the present study custom made bone graft made with laser sintering technique represents a valid alternative to traditional bone grafts with high clinical accuracy and the advantage to avoid morbidity of the donor site or of the patient due to animal grafting
CIITA-induced MHC class II expression in tumor cells: a novel universal strategy of anti-tumor vaccination.
Priming and activation of CD4+ T helper (TH) cells against tumor associated antigens can be achieved after their recognition on antigen presenting cells (APC) only within the context of MHC class II (MHC-II) molecules. We previously reported successful triggering of TH-specific long lasting anti-tumor immune response in H-2d haplotype BALB/c mice using tumor cells genetically modified to express endogenous MHC-II genes (I-A and I-E) after transfection with CIITA (MHC-II transactivator). Now, we investigated the pertinence of this approach in H-2b haplotype C57BL/6 mice that only express I-A molecules due to a defect in their I-Eα gene.
MC38 colon carcinoma cells of the H-2b haplotype were stably transfected with CIITA. Selected MHC-II positive clones were injected into C57BL/6 mice. Complete rejection or significant growth retardation as compared to MHC-II negative parental tumor was obtained. Subsequent challenge of the protected mice with parental tumor proved that the CIITA-transfected tumor engendered efficient anti-tumor vaccination. Then, adoptive cell transfer from the vaccinated mice to naïve recipients demonstrated that CD4+ TH cells orchestrate the anti-tumor protection.
Finally, the use of CD11c.DTR transgenic mice in which conditional deletion of dendritic cells (DC) can be performed, and the use of Liposomal Clodronate as a depletion agent for macrophages, proved that CIITA-driven MHC-II positive tumor cells act as surrogate APC for priming and activating CD4+ TH cells, without the need of either DC or macrophages.
These results demonstrate the validity of CIITA-driven MHC-II+ tumor cells as anti-tumor vaccination tool in mouse models of different haplotypes. Moreover, they prove that expression of a single MHC-II restriction element in tumor cells is sufficient to trigger anti-tumor CD4+ TH cells and, more importantly, demonstrate for the first time that CIITA-driven MHC-II expressing tumor cells can act as professional APCs in vivo to prime naïve tumor-specific CD4+ TH cells
Transition metal-catalyzed alkoxylation and amination reactions involving propargyl or allyl derivatives.
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Prove legali e libero convincimento
After having re read both the method of the free conviction and that of the legal evidence under the historical – philososophical light, the thesis proposes to analyse and verify the efficiency of the rule of judgement of the (relatively new) code of criminal procedure. The experiences in term of the Rocco code through which the intime conviction had legitimated the use of the diverse probatory materials obtained, even in disregard of the fondamental human rights, are well known. The study examines if and in what measure the actual regulatory framework inspired by the free convinction, that has reconfigure the entire probatory system, is suitable to circumscribe those deviated judicial practices and to guarantee a just sentence. Under this reconstruction, the thesis analyses the evidentiary methods used by the judge even in relation to the so called scientific proof. Following the said analysis, the deduction is that to reach a just sentence it is necessary to retrive both the tradition of proof as argomentum and the probatory rules which, without detracting anything from the intime conviction, allow to regulate the probatory materials in the judge’s hands in the respect of the fundamental human rights, surpassing the disrepute commonly associated with the concept of “legal proof”