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Multiple pathways of SARS-CoV-2 nosocomial transmission uncovered by integrated genomic and epidemiological analyses during the second wave of the COVID-19 pandemic in the UK
Full text linkINTRODUCTION: Throughout the global COVID-19 pandemic, nosocomial transmission has represented a major concern for healthcare settings and has accounted for many infections diagnosed within hospitals. As restrictions ease and novel variants continue to spread, it is important to uncover the specific pathways by which nosocomial outbreaks occur to understand the most suitable transmission control strategies for the future.
METHODS: In this investigation, SARS-CoV-2 genome sequences obtained from 694 healthcare workers and 1,181 patients were analyzed at a large acute NHS hospital in the UK between September 2020 and May 2021. These viral genomic data were combined with epidemiological data to uncover transmission routes within the hospital. We also investigated the effects of the introduction of the highly transmissible variant of concern (VOC), Alpha, over this period, as well as the effects of the national vaccination program on SARS-CoV-2 infection in the hospital.
RESULTS: Our results show that infections of all variants within the hospital increased as community prevalence of Alpha increased, resulting in several outbreaks and super-spreader events. Nosocomial infections were enriched amongst older and more vulnerable patients more likely to be in hospital for longer periods but had no impact on disease severity. Infections appeared to be transmitted most regularly from patient to patient and from patients to HCWs. In contrast, infections from HCWs to patients appeared rare, highlighting the benefits of PPE in infection control. The introduction of the vaccine at this time also reduced infections amongst HCWs by over four-times.
DISCUSSION: These analyses have highlighted the importance of control measures such as regular testing, rapid lateral flow testing alongside polymerase chain reaction (PCR) testing, isolation of positive patients in the emergency department (where possible), and physical distancing of patient beds on hospital wards to minimize nosocomial transmission of infectious diseases such as COVID-19
‘...sure to delight every ballet fan.’ Consuming ballet culture through girls’ periodical Girl, 1952 to 1960
Full text linkThis article focuses on the ways that ballet was presented for girl readers to consume in Girl (Hulton Press 1952-1964). Girl was a weekly publication, part of girls’ periodical culture in Britain, which was thriving in the 1950s and 1960s. The ballet content it contained was one aspect of the growing British cultural engagement with ballet in the mid-twentieth century. This broader engagement took several forms, including watching films and attending performances. In addition, for younger participants, especially girls, this may have been accompanied by participation in ballet classes and reading about ballet in both fiction and non-fiction. Girl encompasses all these forms of engagement with ballet through key fictional comic strip ‘Belle of the Ballet’, photographs of performances, pin-ups featuring dancers and paintings about ballet, articles, and non-fiction companion volumes. Arnold Haskell, who was significant in changing how ballet was understood in Britain, was also involved with content in Girl. This connection resulted in readers having the opportunity to compete for an annual ballet scholarship and participate in ballet lessons. In exploring ballet in Girl, the article draws together considerations of how ballet practice, costume, other media involving ballet and dancers’ street clothes were portrayed, and the ways that class, ballet, and girls’ culture were intertwined
Prevalence and characterisation of microfibres along the Kenyan and Tanzanian coast
Full text linkMicroplastic pollution is ubiquitous, with textiles being a major source of one of the dominant microplastic types—microfibres. Microfibres have been discovered in the aquatic environment and marine biota, demonstrating direct infiltration in the environment. However, the impact of non-plastic microfibres has been overlooked until recently despite their prevalence and the ecotoxicological risk posed by chemical dyes and finishes used during processing. During an expedition from Lamu to Zanzibar (East Africa), a citizen science strategy was employed to innovate, educate and influence microfibre pollution reform through the Flipflopi project, a circular economy effort to stop the use of single-use plastic. Simple sampling methods were developed to replace costly equipment, which local citizens could use to partake in the collection and sampling of surface water samples from the previously understudied Kenyan and Tanzanian coast. To maintain the reliability of samples and to minimise contamination, a forensic science strategy was embedded throughout the methodology of the study, collection and analysis of the samples. A total of 2,403 microfibres from 37 sites were recovered and fully characterised with 55% found to be of natural origin, 8% regenerated cellulosic and 37% synthetic microfibres. Natural microfibres were in higher abundance in 33 of the 37 sampled sites. Congruent with recent studies, these findings further support the need for greater understanding of the anthropogenic impact of natural microfibres
The pluralism of digital twins for urban management: Bridging theory and practice
Full text linkDigital twins have great potential for improving urban management. However, the way that they are formulated seems to vary according to the aims of the urban management taking place. For instance, digital twins are made sophisticated and innovative when the urban manager wants to demonstrate technological prowess; they contribute to generating useful interventionist strategies if social engineering is occurring; they emphasize exploratory and collaborative mechanisms if the urban manager wants to uncover people's attitudes; and they tend to focus upon citizen engagement and mechanisms for social improvements when societal reform is the main aim. Yet those who build digital twins seldom declare their worldviews or specify why they are doing so, and this leads to two problems. Firstly, it becomes difficult to evaluate and compare different digital twins. Secondly, since urban management projects often have several contrasting aims, many researchers construct seemingly pluralistic digital twins which are, in fact, severely afflicted with inconsistency and poorly measured priorities as to what needs to be included and addressed. In order to clarify the situation, this paper comprehensively analyses the research literature to conceptualize different approaches to implementing digital twins. It then assesses three alternative, theoretical paradigms upon which a pluralistic digital twin might be grounded and evaluated, and it concludes that "critical realism", rather than "post-modernism" or "ontological flexibility' is the most appropriate
How are Research for Development Programmes Implementing and Evaluating Equitable Partnerships to Address Power Asymmetries?
Full text linkThe complexity of issues addressed by research for development (R4D) requires collaborations between partners from a range of disciplines and cultural contexts. Power asymmetries within such partnerships may obstruct the fair distribution of resources, responsibilities and benefits across all partners. This paper presents a cross-case analysis of five R4D partnership evaluations, their methods and how they unearthed and addressed power asymmetries. It contributes to the field of R4D partnership evaluations by detailing approaches and methods employed to evaluate these partnerships. Theory-based evaluations deepened understandings of how equitable partnerships contribute to R4D generating impact and centring the relational side of R4D. Participatory approaches that involved all partners in developing and evaluating partnership principles ensured contextually appropriate definitions and a focus on what partners value
Seeing it my way: A perspective taking intervention alleviates psychological distress in caregivers of autistic children
Full text linkCognitively empathic caregivers are able to take the perspective of their autistic child(ren) without experiencing vicarious distressing emotions, and typically report lower psychological distress. Taking the perspective of the autistic child might, through fostering cognitive empathy, might relieve caregivers’ psychological distress. Here we explored whether autism perspective taking videos developed by the National Autistic Society (NAS), intended to raise public awareness about autism, might be effective, packaged as an intervention, for increasing caregivers’ cognitive empathy and reducing their psychological distress. A sample of 24 caregivers of autistic children completed questionnaires capturing psychological distress and cognitive empathy at baseline. For three consecutive days, for two-three minutes per day, caregivers watched perspective taking videos. Follow up assessments were collected 7, 14, and 21 days post intervention. Psychological distress was lower after seven days, and stayed lower 14 and 21 days post intervention compared with baseline. Cognitive empathy was higher after 14 days, and remained higher 21 days post intervention compared with baseline. Taking the perspective of the autistic child, achieved here with publically available NAS videos, seems to be effective for increasing caregivers’ cognitive empathy and reducing their psychological distress for up to three weeks. Future research might use more rigorous methodologies, incorporating control groups and larger samples, to explore moderators of intervention efficacy
Investigating individual privacy within CBDC: A privacy calculus perspective
Full text linkCentral Bank Digital Currencies (CBDC) are a digital innovation based upon distributed ledger and smart contract technology. In this paper we examine how potential users of CBDC technology willingly disclose their personal information. The researchers conducted an online quantitative survey which investigates the privacy perceptions of consumers. Using the privacy calculus theory lens, this study looks at the potential benefits of CBDC and how these influence user perceptions towards privacy disclosure. While this research suggests that participants in the study had negative perceptions in relation to the disclosure of personal information, many were willing to offset these concerns if there are significant benefits in the usage of CBDC. Factors such as ease of use, convenience, availability, and credibility were viewed as key benefits in this scenario. Thus, future banking strategies and marketing approaches need to consider these components to foster CBDC adoption
Opportunities and challenges for Common Agricultural Policy reform to support the European Green Deal
Full text linkThe Common Agricultural Policy (CAP) is the European Union's main instrument for agricultural planning, with a new reform approved for 2023–2027. The CAP intends to align with the European Green Deal (EGD), a set of policy initiatives underpinning sustainable development and climate neutrality in the European Union (EU), but several flaws cast doubts about the compatibility of the objectives of these 2 policies. We reviewed recent literature on the potential of CAP environmental objectives for integration with the EGD: protection of biodiversity, climate change mitigation and adaptation, and sustainable management of natural resources. The CAP lacks appropriate planning measures, furthering instead risks to biodiversity and ecosystem services driven by landscape and biotic homogenization. Funding allocation mechanisms are not tailored to mitigate agricultural emissions, decreasing the efficiency of climate mitigation actions. The legislation subsidies farmers making extensive use of synthetic inputs without adequately supporting organic production, hindering the transition toward sustainable practices. We recommend proper control mechanisms be introduced in CAP Strategic Plans from each member state to ensure the EU is set on a sustainable production and consumption path. These include proportional assignment of funds to each CAP objective, quantitative targets to set goals and evidence-based interventions, and relevant indicators to facilitate effective monitoring of environmental performance. Both the CAP and the EGD should maintain ambitious environmental commitments in the face of crisis to avoid further degradation of the natural resources on which production systems stand
Encountering Berlant part two: Cruel and other optimisms
Full text linkPart 2 of Encountering Berlant amplifies the promise of Lauren Berlant's influential concept of ‘cruel optimism’. Cruel optimism names a double-bind in which attachment to an ‘object’ holds out the promise of sustaining/flourishing, whilst simultaneously harming. The lines between harming, sustaining, damaging and flourishing blur, sometimes collapsing entirely. By holding together opposites the concept exemplifies and performs the centrality of ambivalence to Berlant's thought, as well as their orientation to overdetermination and incoherence. Geographers and others have found in the concept a way of understanding the intersection between affective and political economies in the crisis-present following the 2008 financial crisis. Together with Berlant's linked concepts such as ‘crisis ordinariness’ and ‘impasse’, cruel optimism has offered a way of understanding why detachment can be so difficult and how damaging conditions endure. Contributors begin from these starting points, amplifying the concept's promise: a new way of researching and writing about the reproduction of ordinary damage and harm. By writing from diverse encounters with Berlant's work, they move the concept in multiple directions, juxtaposing it with other optimisms across a variety of empirical scenes and locations. The result is a repository of what cruel optimism, and Berlant's mode of thinking-feeling more broadly, offer geographers and others
Carbon-doped flower-like Bi2WO6 decorated carbon nanosphere nanocomposites with enhanced visible light photocatalytic degradation of tetracycline
Full text linkIn search of a recyclable catalyst with synergistic adsorption and photocatalysis, unique composite photocatalysts of flower-like bismuth tungstate (Bi2WO6) and carbon nanospheres (CSs) were composited using a hydrothermal synthesis method (named CSs-Bi2WO6). Notably, based on the high visible light utilization and a reasonable band gap (2.53 eV), CSs-Bi2WO6 have good photocatalytic properties. For example, the composite with an optimized ratio (2% CSs-Bi2WO6) showed good adsorption and photocatalytic performance. Under simulated natural light conditions, the degradation rate of tetracycline (TC) by 2% CSs-Bi2WO6 was 84.6% in 60 min, which is nearly 25% higher than pure Bi2WO6. After five cycles, the observed barely decreased TC degradation rate of 2% CSs-Bi2WO6 confirmed the high cyclability and reproducibility of the photocatalyst. The total organic carbon estimation of the post-degradation reaction medium corresponded to 68.2% mineralization. Furthermore, we determined the photocatalytic reaction path by LC–MS, which confirmed that the composite catalyst could effectively degrade TC molecules into small molecules. It can be concluded that the catalyst has a broad application prospect in the field of wastewater treatment