48674 research outputs found
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Kerndokumentation der regionalen kooperativen Rheumazentren - Versorgungstrends 2025
No full textThe results of the National Database of the regional cooperative arthritis centers for the reporting year 2023 are shown. There is information on disease activity, medication and non-pharmacolocial treatment. Many patient-reported outcomes on functional capacity, the impact of the disease, depressive symptoms and others are provided
Umsetzung ausgewählter Geschäftsmodelle
No full textZiel des Meilensteins M14 ist die Verstetigung der im Rahmen von Health-X entstandenen Strukturen und Geschäftsmodelle über die Projektlaufzeit hinaus. Für die nachhaltige Weiternutzung der Ergebnisse aus Health-X wurde ein aus drei Organisationen bestehendes „magisches Dreieck“ institutionalisiert, welches im Rahmen der European Health Data Space (EHDS) Gesetzgebung operieren wird.
Als erste Institution wurde der European Health Data Alliance Verein (EHDA e.V.) gegründet, der als gemeinwohlorientierte Interessensvertretung für europäische Gesundheitsdatenräume agiert, Kooperationen fördert und die Weiterentwicklung des entstandenen Tech Stacks unterstützt. Somit treibt der EHDA e.V. die Entwicklung von bürgerzentrierten Gesundheitsdatenräumen in Europa voran, wobei er Regeln für Standardisierung und
Interoperabilität definiert, um EHDS-konforme Gesundheitsprodukte und Services zu ermöglichen. Der EHDA e.V. legte außerdem 12 zentrale Regeln für unter anderem Datenschutz, -sicherheit und Governance fest, an die sich alle Vereinsmitglieder sowie
Organisationen im magischen Dreieck bei der Nutzung des Tech Stacks halten müssen.
Als zweite Institution ist derzeit die European Health Data Platform GmbH (EHDP) als mehrheitliche Tochter des EHDA e.V. in Gründung. Die EHDP wird den in Health-X initial entwickelten Tech Stack für föderierte Datenräume und sichere Verarbeitungsumgebungen im Sinne des EHDS kontinuierlich weiterentwickeln und gemeinwohlorientiert betreiben.
Somit bietet die EHDP die technisch-organisatorische Grundlage für interoperable Gesundheitsdatenräume. Als Intermediär zwischen Datenanbietern und -nutzenden stellt sie notwendige Infrastruktur- und Managementservices bereit und ermöglicht den Aufbau und
den Betrieb spezifischer EHDS-konformer Gesundheitsdatenräume.
Durch den Aufbau solcher Datenräume werden als dritte Instanz verschiedene kommerzielle Servicegesellschaften entstehen, die EHDS-konforme sichere Verarbeitungsumgebungen für verschiedene Anwendungsfälle anbieten. Dieses Modell sichert eine dezentrale und
partizipative Governance, die sich an Werten wie Datensouveränität, Fairness, Offenheit
und Transparenz orientiert. Somit schafft das magische Dreieck die Basis für eine nachhaltige
und föderierte Gesundheitsdatenökonomie im Sinne der Europäischen Union
Quantum many-body scarring in a non-Abelian lattice gauge theory
Get PDFQuantum many-body scarring (QMBS) is an intriguing mechanism of weak ergodicity breaking that has recently spurred significant attention. Particularly prominent in Abelian lattice gauge theories (LGTs), an open question is whether QMBS nontrivially arises in non-Abelian LGTs. Here, we present evidence of robust QMBS in a non-Abelian SU(2) LGT with dynamical matter. Starting in product states that require little experimental overhead, we show that prominent QMBS arises for certain quenches, facilitated through meson and baryon-antibaryon excitations, highlighting its non-Abelian nature. The uncovered scarred dynamics manifests as long-lived coherent oscillations in experimentally accessible local observables as well as prominent revivals in the state fidelity. Our findings bring QMBS to the realm of non-Abelian LGTs, highlighting the intimate connection between scarring and gauge symmetry, and are amenable for observation in a recently proposed trapped-ion qudit quantum computer
Boosting aerosol surface effects: strongly enhanced cooperative surface propensity of atmospherically relevant organic molecular ions in aqueous solution
Get PDFThe effects of atmospheric aerosols are key uncertainties in climate models. One reason is the complex aerosol composition which includes a relatively large fraction of organics. Another reason is the small size of aerosols, which makes surface effects and processes important. These two factors make surface-active organics relevant for atmospheric aerosols, as they can affect crucial processes, such as chemical aging and water accommodation, as well as properties such as the surface tension, which drives droplet formation. Two exemplary types of atmospherically relevant organics are carboxylic acids and alkyl amines, and often both are found together within aerosols. In the most atmospherically significant pH range, these exist as alkyl-carboxylate ions and alkyl-ammonium ions. Using liquid-jet photoelectron spectroscopy, tuned to high surface sensitivity, we measured the alkyl-carboxylate anions and the alkyl-ammonium cations of alkyl chain lengths of 1 to 6 carbon atoms, both as single-component and mixed-component aqueous solutions. This enabled us to systematically study how their surface propensity is affected by the length of the alkyl chains and how cooperative ion–ion interactions result in strongly increased surface propensity. An exponential increase in surface propensity is found for the single-species solutions, with cooperative solute–solute effects in mixed solutions of 1 : 1 molar ratio drastically increasing the number of molecules present at the solutions' surfaces up to a factor of several hundred. This cooperative surface propensity is shown to strongly affect the amounts of organics at the surface. These changes can significantly influence radiative forcing via aerosol growth, cloud condensation nuclei activity, and aerosol chemical aging. Our results demonstrate the principal feasibility of a more advanced input of molecular details for creating parameterized descriptions of aerosol surface composition needed to properly account for their impacts in climate models
On the Facile Synthesis of Triazaarsoles Using Acyclic Precursors
Get PDFEasily accessible dichloroarsanes are suitable precursors for the synthesis of rarely explored triazaarsoles, the arsenic analogues of tetrazoles and triazaphospholes. Calculations on the DFT level gave insight into the electronic structure of such planar compounds, indicating a high degree of aromaticity. Our preliminary investigations pave the way for accessing and investigating a whole variety of new heterocycles, that contain a low-coordinated arsenic atom
Wind tunnel study on effect of wind directions on ventilation inside a naturally ventilated pig barn with an outdoor yard
Get PDFNaturally ventilated pig barns equipped with outdoor exercise yards (NVPBOYs) have the potential to alleviate issues related to poor animal well-being and excessive gaseous emissions compared with conventional intensive pig farming. However, as a novel pig housing system, the information on the ventilation process of NVPBOYs with respect to variable outdoor wind directions remains unclear. Therefore, the objective of this study is to investigate the influence of wind direction on the indoor airflow pattern and ventilation rate of NVPBOYs. The investigations were performed using a 1:50 scale model of an NVPBOY in a large boundary layer wind tunnel. Air velocities inside the scaled model under four wind directions (0 , 60 , 120 , and 180 ) were measured using a Laser Doppler Anemometer. The results indicate that: 1) Airflow patterns in the exercise yard are more sensitive to the changes in wind direction compared to those in the indoor room. 2) Oblique wind (60 and 120 ) results in lower ventilation rates, accounting for 50 %–65 % of the ventilation rate observed under perpendicular winds (0 and 180 ). 3)The yard directs the high-speed air stream to the upper part of the barn. The pitched roof and the gable wall of the indoor room lead the fresh air to the animal-occupied zone in the indoor room. The yard and the indoor room thus result in different local environments between them, supporting the intended purpose of the NVPBOYs to separate pigs’ excretion and sleeping areas. The results of this study contribute to a good understanding of the ventilation process of NVPBOYs to achieve a better design and control of their housing and ventilation systems
Not one inconvenient truth, but many: emergency narratives and climate change
Get PDFA crisis is a decisive moment that can provide an opportunity for a change, but also reaffirm power asymmetries. This conceptual article highlights the Janus-faced character of declaring a climate emergency. More than 2,300 municipalities worldwide have done so. On the one hand, climate crisis and emergency narratives imply a disruption in which the dominant economic system is collectively challenged, enabling citizens to exercise power with others for greater sustainability. On the other hand, climate knowledge is often perceived as conclusive, paving the way for greater power over citizens and towards authoritarianism
Non-Markovian equilibrium and non-equilibrium barrier-crossing kinetics in asymmetric double-well potentials
Get PDFBarrier-crossing processes in nature are often non-Markovian and typically occur over an asymmetric double-well free-energy landscape. However, most theories and numerical studies on barrier-crossing rates assume symmetric free-energy profiles. Here, we use a one-dimensional generalized Langevin equation (GLE) to investigate non-Markovian reaction kinetics in asymmetric double-well potentials. We derive a general formula, confirmed by extensive simulations, that accurately predicts mean first-passage times from well to barrier top in an asymmetric double-well potential with arbitrary memory time and reaction coordinate mass. We extend our formalism to non-equilibrium non-Markovian systems, confirming its broad applicability to equilibrium and non-equilibrium systems in biology, chemistry, and physics
Between Feminist Killjoys and Happy Feminism
Get PDFThe overturning of Roe v. Wade and the repeal of Germany’s abortion advertisement ban in June 2022 represent a momentous shift in the global landscape of reproductive rights, amplifying contentious debates around bodily autonomy and women’s rights. Feminist activism, traditionally rooted in body politics, has adapted to digital platforms, utilising their affordances to mobilise around socio-political issues such as abortion rights. This paper investigates the affective dynamics, i.e., intensities and registers, of feminist digital activism through the lens of affect theory and feminist media studies, with a focus on the #mybodymychoice TikTok challenge. We examine how TikTok’s algorithmically driven, viral structure shapes the affective intensity of the challenge; and introduce the concept of affective registers to analyse how the platform’s multimodal affordances foster distinct types of memetic performances that privilege certain forms of feminist digital activism. Our findings reveal how affective registers of
joy, anger, shock, and solidarity circulate within the challenge, fuelling wide, intense, but ephemeral mobilisation while also exposing the risks of political dilution. Through our typology of affective registers, we examine the tension between popular feminist performances of “happy feminism”—where
joy and personal empowerment prevail—and more confrontational forms of “killjoy feminist activism,” shedding light on the potential and limitations of feminist activism on TikTok and the platform’s ability to foster affective solidarity while also commodifying affect and constraining sustained political impact. Thus, this study exemplarily delineates the broader dynamics and contours of contemporary feminist digital activism, illustrating how playful, intimate, and vivid memetic performances both amplify and reshape feminist activism in digitally networked societies
Isolation, characterization, and application of the novel polyvalent bacteriophage vB_EcoM_XAM237 against pathogenic Escherichia coli
Get PDFA novel polyvalent broad-spectrum phage, vB_EcoM_XAM237 (XAM237), was isolated from pig farm sewage. It can simultaneously lyse multiple strains of pathogenic Escherichia coli (E. coli), demonstrating a broad host range. When the enteropathogenic E. coli (EPEC) strain E711 was used as the host bacterium, the phage XAM237 exhibited a short latent period, high stability at different temperatures and pH values and good tolerance to chloroform. Moreover, phage XAM237 can efficiently adsorb and lyse host bacteria in vitro. Whole-genome sequencing revealed that XAM237 is a double-stranded DNA (dsDNA) phage consisting of 170 541 bp with a G + C content of 35%. Phylogenetic analysis confirmed that XAM237 belongs to the family Straboviridae, genus Tequatrovirus. In addition, the genome of XAM237 did not contain genes related to lysogenicity, virulence or antimicrobial resistance. The effects of phage XAM237 in treating EPEC infections in vivo were evaluated in a mouse model. Phage XAM237 was able to reduce the number of colonized aEPEC strain E711 in the small intestine, liver, spleen, and kidney. This study suggested that phage XAM237 may be a promising candidate biologic agent for controlling pathogenic E. coli infections