Institutional Repository of Institute of Process Engineering, CAS (IPE-IR）
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Leverhulme Centre for Wildfires, Environment and Society through the Leverhulme Trust[EP/T000414/1]
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Schiff base nanoarchitectonics for supramolecular assembly of dipeptide as drug carriers
No full textDevelopment of peptide-based supramolecular materials with hierarchical morphology and tunable guest loading displays broad potential as drug carrier in view of biocompatibility and biodegradability. Herein, we report a facile Schiff base nanoarchitectonic for supramolecular assembly of diphenylalanine (FF) metastable gel. The addition of trace glutaraldehyde (GA)/H2O solution induces the Schiff base reaction between GA and FF accompanying by phase transition from gel to solution. FF nanoparticles and hierarchical beaded nanofibers with autofluorescence properties can be constructed by regulating the competitive assembly between FF-H2O and FF-GA oligomer. Moreover, various guest molecules with different hydrophilic and hydrophobic properties can be easily loaded into such assembled particles and its release can be triggered under weak alkaline conditions, which show the potential application of the assembled FF system as drug carriers. (c) 2022 Elsevier Inc. All rights reserved
Tailoring the Electronic Structure of Single Ag Atoms in Ag/WO3 for Efficient NO Reduction by CO in the Presence of O2
No full textDeveloping efficient catalysts for the selective catalytic reduction of NOx by CO (CO-SCR) is the key challenge for commercializing this technology. Ag-based catalysts with relatively low costs are promising but widely believed to be not efficient enough for this reaction. Here, we demonstrate that atomically dispersed Ag supported on ordered mesoporous WO3 (mWO3) can serve as a highly active catalyst for CO-SCR under O2-containing conditions. By altering the amount of the Ag precursor, the local environment of the Ag atom coordinated with the O atom can be tailored. Furthermore, at 250 degrees C and an O2/CO ratio of 2.5:1, 0.3Ag/m-WO3 (0.3 wt % Ag) with six-coordinated Ag-O exhibited much better catalytic performance than 5 Ag/m-WO3 (5 wt % Ag) with two coordinated Ag-O (e.g., 0.43 vs 0.02 molNO gAg -1 h-1 in the reaction rate) and previously reported Ag-based catalysts in the literature. The theoretical calculations confirm that the six-coordinated Ag atoms in 0.3Ag/m-WO3 possess a more positive oxidation state and a higher d-band center than the two-coordinated Ag atoms in 5Ag/m-WO3, promoting its bonding strength with co adsorption of the critical intermediates of N2O* and CO*. This work provides a feasible route for regulating the local environment of a Ag single atomic catalyst to enhance its catalytic property for CO-SCR
Pretreatment of deep-sea bacteria for reverse flotation of magnesite tailings: Cleaner production, behavior and mechanism
No full textAccording to the principle of cleaner production, strengthening the selectivity and separation effect of dode-cylamine (DDA) as a conventional reverse flotation agent is an effective way to realize the re-enrichment of magnesite tailings, reduce the cost of agents, recover valuable elements, improve the quality of products and industrialize high value-added utilization. In this study, we designed the technology of microbial pretreatment -reverse flotation of magnesite tailings, and used the deep-sea silicate bacteria SiBY-2 to pretreat magnesite tailings, which enhanced the separation efficiency of magnesite from silicon bearing gangues in the reverse flotation process. The results show that the SiBY-2 enhances the desilication effect of magnesite tailings mainly by secreting organic acids, polysaccharides and proteins, and intensifies the interaction between silicon bearing gangues and the collectors (DDA). Compared with the conventional reverse flotation, the concentrate grade and recovery of the SiBY-2 pretreatment-reverse flotation process is increased by 2.04% and 5.93% respectively, while the utilization rate of DDA is reduced by 9.0%. It is estimated that the production cost of magnesite can be reduced by 900-1350 yen /t, which achieves the purpose of clean production of magnesite high quality products
Novel artificial ionic cofactors for efficient electro-enzymatic conversion of CO2 to formic acid
No full textThe low yield of enzymatic conversion of CO2 to formic acid as well as the high cost and instability of using the natural cofactor (NADH) hamper the large-scale application of the CO2 enzymatic utilization. To address these issues and to improve the production of formic acid, six bipyridinium-based artificial cofactors were developed for the enzymatic conversion of CO2 and further integrated with the electrocatalytic regeneration of the cofactors for the formic acid production. All of them did show a higher catalytic performance compared to NADH. Particularly, 1,1 '-bis(2-(dimethylamino)ethyl)-4,4 '-bipyridinium bromine did exhibit the highest catalytic performance with a high formic acid concentration of 4.76 mM in 60 min, which is 47 times higher than that of the natural cofactor NADH and is also currently the highest performance among the reported artificial cofactors in literature. Thermodynamic analysis, electrochemical investigations, and molecular dynamics simulations were performed to clarify the structure-energy relationship of the functional bipyridinium-based salts and to rationalize how it is affected by the different functional groups. This study gives a deep insight into the role of artificial cofactors in enzymatic reactions and can clearly promote the development of novel bioelectrochemical conversion of CO2
A Short Peptide of Autotransporter Ata Is a Promising Protective Antigen for Vaccination Against Acinetobacter baumannii
No full textWith the emergence of multidrug-resistant strains, Acinetobacter baumannii infection is becoming a thorny health problem in hospitals. However, there are no licensed vaccines against A. baumannii. Acinetobacter trimeric autotransporter (Ata) is an important known virulence factor located on the outer membrane of bacteria. Herein, we carried out a series of experiments to test the immunogenicity of a short C-terminal extracellular region of Ata (Ata(alpha), only containing 39 amino acids) in a murine model. The short peptide Ata(alpha) was fused with the cholera toxin B subunit (CTB), which has been reported to have immunoadjuvant activity. The fusion protein showed no inflammation and organ damages, and have the ability to elicit both Th1 and Th2 immune responses in mice. The bactericidal activities against A. baumannii and prophylactic effects of the fusion protein were further evidenced by a significant reduction in the bacterial load in the organs and blood. In addition, the candidate vaccine could provide broad protection against lethal challenges with a variety of A. baumannii strains. Moreover, when CpG was added on the basis of aluminum adjuvant, the immune response, especially cellular immunity, could be further strengthened. Overall, these results revealed that the Ata(alpha) is a promising vaccine target against A. baumannii infection