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Evaluating the Degradation Process of Collagen Sponge and Acellular Matrix Implants In Vivo Using the Standardized HPLC-MS/MS Method
No full textThe purpose of this study was to establish a collagen determination method based on an isotope-labeled collagen peptide as an internal reference via high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), and using the established method to evaluate the degradation process of collagen-based implants in vivo. The specific peptide (GPAGPQGPR) of bovine type I collagen was identified with an Orbitrap mass spectrometer. Then, the quantification method based on the peptide detection with HPLC-MS/MS was established and validated, and then further used to analyze the degradation trend of the collagen sponge and acellular matrix (ACM) in vivo at 2, 4, 6, 8, 12, 16, and 18 weeks after implantation. The results indicate that the relative standard deviation (RSD) of the detection precision and repeatability of the peptide-based HPLC-MS/MS quantification method were 3.55% and 0.63%, respectively. The limitations of quantification and detection were 2.05 x 10(-3) mu g/mL and 1.12 x 10(-3) mu g/mL, respectively. The collagen sponge and ACM were completely degraded at 10 weeks and 18 weeks, respectively. Conclusion: A specific peptide (GPAGPQGPR) of bovine type I collagen was identified with an Orbitrap mass spectrometer, and a standardized HPLC-MS/MS-based internal reference method for the quantification of bovine type I collagen was established. The method can be used for the analysis of the degradation of collagen-based implants in vivo
Experimental Study of Unsteady Drag Coefficient of Droplets in a Liquid-Liquid System
No full textIn liquid-liquid contact process, the motion of droplets relative to the surrounding fluid always involves accelerating and decelerating, which affects the mass, heat, and momentum transfer. The lack of experimental data of the unsteady drag coefficient has been one of the limitations on the prediction of the unsteady flow field. In this study, the accelerated and decelerated water droplets in an organic phase were measured by a high-speed camera. The results show that with a decrease in droplet diameter, the acceleration becomes more significant, while the absolute relative velocity decreases, causing a lower Reynolds number. The Basset force and add mass force were solved numerically and compared with drag force. The unsteady drag coefficient is always smaller than the corresponding steady drag coefficient in the case of accelerating relative flow and larger than that in the case of decelerating relative flow. A new unsteady drag coefficient model has been established, which has an acceptable agreement with the experimental data
Major scientific and technological achievements transformation project of Hebei Province[22293601Z]
No full textCooperation Project between Chongqing universities and the Chinese Academy of Sciences[HZ2021013]
No full text
Design and synthesis of high-silicon silicon suboxide nanowires by radio-frequency thermal plasma for high-performance lithium-ion battery anodes
No full textSilicon monoxide (SiO) is one of the most promising anode materials due to its high capacity and improved cycle stability. The lithium silicates (LixSiOy) and lithium oxide (Li2O) formed during the first lithiation can serve as a buffer matrix to restrain the volume change of internal silicon (Si), however, which also lows the initial coulombic efficiency (ICE). High-silicon silicon suboxide (SiOx) seems desirable due to the generation of less but enough LixSiOy/Li2O matrix. However, it is challenging to verify that all Si is protected by the matrix. In this work, SiO0.4 nanowires with Si shielded by SiOx are synthesized using thermal plasma. The interwoven structure composites of carbon-coated SiO0.4 and carbon nanotubes (SiO0.4/CNTs@C) are then synthesized. As an elec-trode with a high loading of 2.2 mg cm-2, SiO0.4/CNTs@C shows a 12.7 % increase in ICE (81.9 %) and a 34.6 % increase in capacity (1993 mAh/g/4.4 mAh cm-2 at 0.2 A/g for 300 cycles) in comparison to SiO1/CNTs@C. SiO0.4/CNTs@C also shows outstanding high-rate cycle performance (1440 mAh/g at 3.0A/g for 2000 cycles). Significantly, when 5 wt% SiO0.4/CNTs@C is added as an additive to commercial graphite (Gr), the capacity of a standard LiNi0.8Co0.15Al0.05O2//Gr 18,650 battery improves by 20.6 %