Institutional Repository of Institute of Process Engineering, CAS (IPE-IR）
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废弃SCR催化剂氧化酸洗除As工艺及机理研究
No full text砷(As)及其他杂质元素是导致燃煤电厂废弃SCR脱硝催化剂失活的主要原因,借助Fenton反应对废弃SCR脱硝催化剂中的有害杂质元素As及Fe、Al进行氧化酸洗脱除,探究了酸洗液种类、酸浓度、氧化剂浓度、反应温度、反应时间、液固比等因素对杂质浸出率的影响。结果表明,最佳的杂质浸出条件为:反应温度为50℃、H_2SO_4浓度为1.5 mol/L、H_2O_2浓度为1.5 mol/L、转速为500 r/min、反应时间为240 min、液固比为20 mL/g,此时As、Fe、Al的浸出率分别为99.58%、41.80%、 39.60%。废弃催化剂杂质元素浸出机理为过氧化氢与被硫酸浸出的Fe~(2+)形成了芬顿试剂,将As~(3+)氧化为As~(5+),使其氧化溶出,提高了As元素的脱除效率
Fc effector of anti-Aβ antibody induces synapse loss and cognitive deficits in Alzheimer's disease-like mouse model
No full textPassive immunotherapy is one of the most promising interventions for Alzheimer's disease (AD).However,almost all immune-modulating strategies fail in clinical trials with unclear causes although they attenuate neuropathology and cognitive deficits in AD animal models.Here,we showed that Aβ-targeting antibodies including their IgG1 and IgG4 subtypes induced microglial engulfment of neuronal synapses by activating CR3 or FcγRllb via the complex of Aβ,antibody,and complement.Notably,anti-Aβ antibodies without Fc fragment,or with blockage of CR3 or FcγRllb,did not exert these adverse effects.Consistently,Aβ-targeting antibodies,but not their Fab fragments,significantly induced acute microglial synapse removal and rapidly exacerbated cognitive deficits and neuroinflammation in APP/PS1 mice post-treatment,whereas the memory impairments in mice were gradually rescued thereafter.Since the recovery rate of synapses in humans is much lower than that in mice,our findings may clarify the variances in the preclinical and clinical studies assessing AD immunotherapies.Therefore,Aβ-targeting antibodies lack of Fc fragment,or with reduced Fc effector function,may not induce microglial synaptic pruning,providing a safer and more efficient therapeutic alternative for passive immunotherapy for AD
工业生产全过程减污降碳:方法策略与科学基础
No full text随着我国环境保护排放标准日益严格及行业园区化发展日渐成型,有毒有害污染物稳定达标与碳减排协同治理技术缺乏、末端无害化治理控制成本高等问题,开始严重制约我国社会经济可持续发展和碳达峰、碳中和目标的实现。文章以工业行业的重大环境保护需求为导向,提出“工业生产全过程减污降碳”的方法策略及科学基础。通过控制方法协同、跨介质协同,以及多领域统筹、多要素统筹建模优化,将分子水平或微观水平上的基础科学创造性发现与工程研究开发直接联系起来,为减污降碳协同增效提供新的科学支撑,为我国工业绿色发展和碳减排贡献理论方法
An improved EMMS model for turbulent flow in pipe and its solution
No full textBased on the existing energy-minimization multi-scale (EMMS) model for turbulent flow in pipe, an improved version is proposed, in which not only a new radial velocity distribution is introduced but also the quantification of total dissipation over the cross-section of pipe is improved for the dominant mechanism of fully turbulent flow in pipe. Then four dynamic equality constraints and some other constraints are constructed but there are five parameters involved, leading to one free variable left. Through the compromise in competition between dominant mechanisms for laminar and fully turbulent flow in pipe respectively, the above four constructed dynamic equality constraints can be closed. Finally, the cases for turbulent flow in pipe with low, moderate and high Reynolds number are simulated by the improved EMMS model. The numerical results show that the model can obtain reasonable results which agree well with the data computed by the direct numerical simulation and those obtained by experi-ment. This illustrates that the improved EMMS model for turbulent flow in pipe is reasonable and the compromise in competition between dominant mechanisms is indeed a universal governing principle hidden in complex systems. Especially, one more EMMS model for a complex system is offered, pro-moting the further development of mesoscience.(c) 2022 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved
Effect of ionic crosslinking on morphology and thermostability of biomimetic supercritical fluids-decellularized dermal-based composite bioscaffolds for bioprinting applications
No full textIn the present study, supercritical fluid was employed to prepare a kind of supercritical fluids-decellularized dermal-based scaffold (SFDDS) from porcine dermal tissue. Further, new composite bioscaffolds containing SFDDS were designed for bioprinting applications. Then, the effect of crosslinking functionality on microstructures and thermal properties of the composite bioscaffolds containing decellularized extracellular matrix were studied. The results of thermal stability from thermogravimetric analysis and difference thermogravimetry demonstrated the structural stability of the composite bioscaffolds. A method was designed to prepare bioinspired decellularized dermal-based composite bioscaffolds, which were further characterized by infrared spectroscopy, scanning electron microscopy, and thermogravimetry analysis