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Open Funding Project of the State Key Laboratory of Biochemical Engineering[2021YFC2102300]
No full textExpression of TFRC helps to improve the antineoplastic effect of Ara-C on AML cells through a targeted delivery carrier
No full textCurrently, high doses of cytarabine arabinoside (Ara-C)-based combined chemotherapy are commonly used in acute myeloid leukemia (AML) therapy, but severe adverse effects and poor suppression effects in leukemia cells limit the clinical therapeutic efficiency of Ara-C-based chemotherapy due to a lack of targeting selectivity. To improve the therapeutic effect of Ara-C in AML, here, since we confirmed that transferrin receptor 1 (TFRC) expression in AML cells was constant, we generated Ara-C@HFn by encapsulating free Ara-C into self-assembled heavy ferritin chain (HFn, the ligand of TFRC) nanocages
Cleaner production of ammonium paratungstate by membrane electrolysis-precipitation of sodium tungstate solution
No full textThe production of ammonium paratungstate (APT) is riddled with the generation of wastewater,which causes environmental problems.To solve the problem of wastewater generation at source,a membrane electrolysis-NH_3·H_2O precipitation method,which prevents wastewater generation and recycles the reagents used in the process,was proposed and investigated in this study.The electrolysis process was investigated based on parameters such as initial cathodic and anodic NaOH concentrations,and current density.The results showed that an increase in current density and initial cathodic NaOH concentration and a decrease in the initial anodic NaOH concentration would enhance the separation of tungsten and sodium.The optimum condition was found at a current density of 666 A·m~(-2),initial anodic and cathodic NaOH concentrations of 69 g·L~(-1) and 40 g·L~(-1),with a current efficiency of 75.40%,and energy consumption for producing 1 ton of NaOH was 2184 kW·h.The precipitation process was investigated based on the acidic high W/Na molar ratio solution obtained by the electrolysis process with NH_3·H_2O as the precipitant.Parameters such as excessive coefficient,temperature,and W/Na molar ratio were studied.The result showed that the variation of excessive coefficient and solution temperature had an opposite effect on the purity of the APT,while an increase in the W/Na molar ratio would increase the product purity.The precipitation product obtained had a purity of 99.6% and was characterized using X-ray diffraction,inductively coupled plasma,and scanning electron microscopy.The methods proposed in this study could provide fundamental information for the design of a cleaner APT production process
单价选择性阴离子交换膜的改性研究进展
No full text详细介绍了表面改性法和膜基体改性法的原理、特点及其改性效果,总结了近3年来单价选择性阴离子交换改性的研究进展并对不同改性方法进行了评价。结果表明,膜改性是一种提高单价选择性阴离子交换膜的渗透选择性、离子通量和抗污染性能的有效方法。最后分析了限制单价选择性阴离子交换膜量产的因素,并展望了单价选择性阴离子交换膜可能的量产方向
Recent progress of hollow structure platform in assisting oxygen evolution reaction
No full textHydrogen production by water electrolysis has received extensive attention, mainly due to the fact that the process does not emit carbon dioxide and other pollutants. Whereas, the kinetic process of the anodic oxygen evolution reaction (OER) is very sluggish due to the four-electron proton coupling mechanism, which seriously affects the hydrogen production efficiency. The development and use of high-performance oxygen evolution electrocatalysts is an important way to improve the kinetics of OER processes. As an electrocatalyst platform, the hollow structure exhibits unique advantages in assisting the OER process. This review summarizes and discusses the advantages and disadvantages and improvement strategies of hollow structures, construction strategies, types of hollow structures and synthetic methods as well as unique advantages in facilitating the OER process. We focus on the role of hollow materials with different compositions and morphologies in promoting the OER reaction. In addition, this review also discusses the problems and challenges of hollow structure fabrics, and discusses the corresponding solution strategies and future development directions
Superior selective adsorption of trace CO2 induced by chemical interaction and created ultra-micropores of ionic liquid composites
No full textEffective capture of trace CO2 in atmosphere or confined spaces to ensure human beings safety draw a lot of attention, however, how to simultaneously improve CO2 capacity and selectivity still faces great challenge. Herein, combining porous molecular sieves (SBA-15 and MCM-41) and the anion-functionalized ionic liquid (IL) tetraethylammonium glycinate ([N-2222][Gly]), a series of hierarchically porous IL composites with different IL loadings were designed and prepared. Compared with pristine supports, the incorporation of [N-2222][Gly] simultaneously improves CO2 capacity and CO2/N-2 selectivity by orders of magnitude, especially for confined spaces (< 5000 ppm) and air (415 ppm). When the IL loading was 60 wt%, novel micropores were created, especially ultra-micropores (< 0.65 nm), which are not present in bare supports and other [N-2222][Gly]@SBA-15 (15, 30 and 45 wt%). Among them, 60 wt%[N-2222][Gly]@SBA-15 showed the highest CO2 uptake of 1.45 and 1.88 mmolCO(2)/g-adsorbent at 0.0005 and 0.005 bar under 313 K along with recyclability, which are much superior to the state-of-the-art reported values. Moreover, superb ideal CO2/N-2 selectivity of 11,545 at 0.005 bar and 288 K was achieved, which was 288 times that of SBA-15. Meanwhile, mixed gas breakthrough experiments demonstrated that 60 wt% [N-2222][Gly]@SBA-15 shows outstanding CO2 separation performance under simulative confined spaces and ambient air. The ultra-high CO2 separation performance was attributed to the synergy of chemical interaction between the IL anion and CO2 as well as newly created micro-and ultra-micropores effect. This work provides guidelines for the design of IL composites with ultra-micropores for efficient trace CO2 removal
Printability enhancement and mechanical property improvement via in situ synthesis of carbon nanotubes on aluminium powder
No full textA strategy of powder surface functional modification involving in situ synthesis of carbon nanotubes (CNTs) on Al powder is described to address the poor forming ability and inferior mechanical properties of Al parts produced by laser powder bed fusion. The obtained CNTs-Al composite powder exhibited a combination of high sphericity and flowability of powder, as well as good dispersion uniformity, bonding force and structural integrity of CNTs. The presence of CNTs significantly reduced the laser reflectivity and enhanced the printability of Al powder. The in situ synthesized CNTs contributed to reinforcement after printing and enhanced the tensile properties of printed sample. The printing behavior of powder, the distribution of reinforcement, and the tensile properties of printed sample were optimized by tuning the content of CNTs. The CNT-content in the composite powder was optimized at 0.96 wt% to achieve the synergy of high forming quality, densification and good tensile properties